• 제목/요약/키워드: hypoglycemic compound

검색결과 13건 처리시간 0.03초

혈당강하효과를 나타내는 상엽의 당지질 성분 (Galactolipids from Mori Folium and their Hypoglycemic Effect)

  • 김철영;강시현;정기화;정춘식;김박광;허훈
    • 생약학회지
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    • 제31권1호
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    • pp.95-100
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    • 2000
  • In order to find out hypoglycemic constituents from natural resources, Korean medicinal plants being used for the treatments of diabetes mellitus were tested with streptozotocin-induced diabetic rats. From the above screening, the $CH_2Cl_2$ fraction of 80% methanol extracts of Morus alba leaves showed hypoglycemic activity. The $CH_2Cl_2$fraction was chromatographed on silica gel, resulting in 9 subfractions, and tested hypoglycemic activity. The subfraction which had a strong hypoglycemic activity was rechromatographed and two galactolipids (compounds 1 and 2) were isolated along with a triterpene (compound 3) from other fractions. On the basis of spectroscopic data, acid hydrolysis, alkaline hydrolysis and enzyme hydrolysis results, compounds 1, 2 and 3 were identified as $1-O-(9Z,12Z,15Z-octatrienoyl)-2-O-(9Z,12Z,15Z-octatrienoyl)-3-O-{\beta}-D-galactopyranosyl$ glycerol, $2(R)-1-O-octadecanoyl-2-O-(9Z,12Z,15Z-octatrienoyl)-3-O-{\beta}-D-galactopyranosyl$ glycerol, and $3{\beta}-hydroxylup-20(29)-ene$ acetate, respectively. Compound 2 (1mg/kg p.o.) has approximately 16% hypoglycemic activity in streptozotocin-induced diabetic rats.

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Insulin secretory activity and mechanism of compound K

  • Choi, Yun-Suk;Han, Gi-Cheol;Sung, Jong-Hwan;Chung, Sung-Hyun
    • 고려인삼학회:학술대회논문집
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    • 고려인삼학회 2006년도 춘계학술대회
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    • pp.69-70
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    • 2006
  • Purpose: Panaxadiols are more potent than panaxatriols as far as insulin secretory activity is concerned. In this study, we examined insulin secretory activity and mechanism of compound K (CK), a major intestinal bacterial metabolite of ginsenosides. Method: Insulin secretory activity of CK was examined using pancreatic beta cells and in Oral Glucose Tolerance Test assay. In addition, insulin secretory mechanism was studied in terms of calcium dependent or independent pathways. Results: In vitro, CK enhanced the insulin secretion concentration-dependently when compared to glucose-stimulated control cells. Insulin secretory mechanism of CK seems to block ATP sensitive K channels, which was confirmed by diazoxide (K channel opener) but, insulin resistance ameliorating activity of CK can't be ruled out. In vivo, CK showed hypoglycemic effect in OGTT.

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The Mechanism of DNA Strand Scissions Induced by Brazilin : Involvement of Reactive Oxygen Species and Cu(II)/Cu(I) Redox Cycling

  • Lee, Sun-Young;Kim, Tae-Ho;Kim, Seog K.;Mar, Woong-Chon;Seo, Eun-Kyoung;Lee, Chong-Soon
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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    • pp.268.1-268.1
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    • 2003
  • Brazilin is the phenolic compound isolated from the Caesalpinia sappan. This compound has shown a wide range of physiological properties, such as hypoglycemic, anticonvulsant, vasorelaxing, and immunomodulating effects. In this study, we have found that brazilin induced DNA strand scissions in the presence of Cu(II) and this DNA cleavages were mediated by reactive oxygen species. (omitted)

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Role of Glyco-Persica® in Targeting Diabetes Type 2: an Integrative Approach

  • Dashtdar, Mehrab;Dashtdar, Mohammad Reza;Dashtdar, Babak;Khan, Saeed Ahmad
    • 대한약침학회지
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    • 제16권4호
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    • pp.14-21
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    • 2013
  • Objectives: The objective of this study was to examine how an integrated approach to type 2 diabetes mellitus treatment could improve glycemic control and immune-potentiating activities adherent to oral hypoglycemic agents along with a botanical compound, among primary care patients. Methods: In this study, we used the self-control and the group-control methods. Candidates meeting the trial conditions were selected from among volunteers who had taken the test substance for 45 days. During the trial, all groups were on a controlled diet; neither were the original medications nor their dosages changed. Results: The results showed that the botanical compound (Glyco-Persica$^{(R)}$) significantly reduced the main clinical symptoms in diabetes type 2. In the treatment group, 36 of 52 patients (69.23%) and in the control group 10 of 52 patients (19.23%) showed reduced symptoms, and this difference was statistically significant (P < 0.05). The fasting blood sugar in the treatment group after treatment compared with that before treatment and with that in the control group after treatment was statistically different (P < 0.05). The post-prandial glucose in the treatment group after treatment was significantly different from that before treatment and from that in the control group after treatment (P < 0.05); the post-prandial blood sugar in the treatment group was reduced by 8.98%. Conclusions: The results revealed that the botanical compound (Glyco-Persica$^{(R)}$) has significant hypoglycemic properties which affect main clinical symptoms in diabetes type 2. Body weight, blood pressure, heart rate, routine blood, stool and urine tests showed no meaningful negative changes after the course of treatment. There was no significant adverse reaction during the trial.

두릅나무 근피의 혈당강하 성분에 관한 연구(II) -유효성분의 분리 및 작용- (Antihyperglycemic Constituent of Aralia elata Root Bark(II) -Isolation and Action of the Constituents-)

  • 김옥경;이은방;강삼식
    • 생약학회지
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    • 제24권3호
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    • pp.219-222
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    • 1993
  • An antihyperglycemic compound in a model of alloxan induced diabetic rats was isolated from the root bark of Aralia elata. The compound identified to be oleanolic acid $28-O-{\beta}-_D-glucopyranoside$ was active at a dose of 100 mg/kg p.o. in the rats. It also has increased the contents of liver glycogen which were lowered by injection of alloxan in the rats.

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7-O-파라플루오로벤조일크라이신의 물성 및 혈당강하효과 (Properties and Anti-diabetic Effect of 7-O-p-Fluorobenzoylchrysin)

  • 심상희;신준수;김명범;김화정;김원기;김성진;김박광
    • Biomolecules & Therapeutics
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    • 제6권3호
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    • pp.256-260
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    • 1998
  • -7-o-p-Fluorobenzoylchrysin was synthesized by condensing p-flouorbenzoic acid with chrysin in organic solvent, and its structure was identified by NMR, MS, UV, and IR. We also investigated the physicochemical properties, hypoglycemic effect, and the quantitative analysis method of this compound. The correlation coefficient of calibration curve on this compound was approximately 0.9945 by absorption spectrophotometry and 0.9989 by high perfornance liqid chromatography 7-o-p-Fluorobenzoylchrysin was resolved in 6.014 min by reversed-phase HPLC column with solvents consisting of methanol (80%) and 10mM phosphoric acd. Its blood glucose inhibition rate is 20.7%.

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Effect of Tectorigenin obtained from Pueraria thunbergiana Flowers on Phase I and -II Enzymes and Tissue Factor in the Streptozotocin-induced Diabetic Rat

  • Choi, Jong-Won;Shin, Myung-Hee;Park, Kun-Young;Lee, Kyung-Tae;Jung, Hyun-Ju;Park, Hee-Juhn
    • 대한약학회:학술대회논문집
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    • 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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    • pp.386.2-386.2
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    • 2002
  • We investigated the effect of tectorigenin (1) with hypoglycemic and hypolipidemic effects on Phase I and II enzymes and TF activity to elucidate the action of an immunosuppressive compound (1) in the diabetic rat. Compound 1 was obtained from the hydrolysis of tectoridin easily isolated from the flower of Pueraria thunbergiana(Leguminosae). Puerariae Flos has been used as therapeutics for diabetes mellitus in traditional medicine of Korea. (omitted)

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화살나무(Euonymus alatus)로 부터 α-glucosidase 저해 물질의 분리 및 동정 (Isolation and Characterization of α-glucosidase Inhibitors from Euonymus alatus)

  • 김신덕
    • 한국미생물·생명공학회지
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    • 제45권4호
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    • pp.311-315
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    • 2017
  • 화살나무 가지로부터 activity based fractionation에 의해 ${\alpha}$-glucosidase 저해 활성 물질 compound 1-4을 분리하였고, $^1H$ NMR, $^{13}C$ NMR, $^1H-^1H$ COSY와 HMBC 등의 spectral data에 의해 구조를 결정하였다. Compound 1-4는 모두 flavonol 물질로 ${\alpha}$-glucosidase에 대해 $IC_{50}$ 값이 각각 25.3, 17.1, 47.3과 $35.1{\mu}M$로 positive control로 사용한 acarbose 보다 강한 활성을 나타내었다. 화살나무의 혈당 저하 기능의 유효성분으로 처음 동정된 Compound 1-4는 ${\alpha}$-glucosidase에만 특이적 활성을 갖는 물질로 당뇨병 치료제로의 개발 가능성이 높은 물질로 사료된다.

레이저 제2형 당뇨동물모델에서 macelignan과 한약제 열수 추출물의 병용효과 (The Hypoglycemic Effect of Complex of Chinese Traditional Herbs (CTH) and Macelignan in Type 2 Diabetic Animal Model)

  • 여지영;조수인;정명호
    • 생명과학회지
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    • 제20권7호
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    • pp.1113-1120
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    • 2010
  • 본 연구는 macelignan과 CTH를 제2형 당뇨병동물모델에 3주간 병용 투여하여 macelignan을 단독으로 투여했을 때보다 더 나은 효과가 있는지를 살펴 보았다. Macelignan과 CTH의 병용 투여는 공복혈당과 내당능을 비롯하여 혈중 free fatty acids, HTR, 그리고 AI에서는 macelignan 단독 투여군과 비교하여 유의적으로 나타나는 큰 차이를 발견할 수는 없었다. 그러나, HbA1c, insulin 민감도, 그리고 혈중 triglyceride 함량에서는 유의적인 변화를 보이며 효과가 있는 것으로 나타났다. 따라서, macelignan의 단독 투여보다 CTH를 병용 투여하는 것이 당뇨병 합병증을 예방하거나 개선시킬 수 있는 잠재력이 있을 것으로 판단된다. 이에 보다 명확하게 검증하기 위해 혈당 및 대사조절 기전연구를 위한 further study가 진행되어야 할 것으로 사료된다.

Effects of glycyrrhizinic acid, menthol and GA: Mt (2: 1), GA: Mt (4: 1) and GA: Mt (9: 1) supramolecular compounds on mitochondrial functional activity IN VITRO experiments.

  • L. A., Еttibaeva;U. K., Abdurahmonova;A.D., Matchanov;S., Karshiboev
    • 통합자연과학논문집
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    • 제15권4호
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    • pp.137-144
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    • 2022
  • This paper presents the effect of the supramolecular complex of GA (Glycyrrhizic acid) and Mt(menthol) and GA: Mt (4: 1) obtained on their basis can restore functional dysfunction of the liver mitochondria in alloxan diabetes, ie, inhibit lipid peroxidation. The hypoglycemic activity and mitochondrial membrane stabilizing properties of the supramolecular compound GA: Mt (4: 1) in alloxan diabetes were more pronounced than those of menthol, GA and its GK: Mt (2: 1) and GA: Mt (9: 1) compounds. According to the results obtained, the concentration of GA did not affect the peroxidation of lipid membranes of the liver mitochondria. However, a concentration of 15 μM of GA was found to reduce LPO (lipid peroxidation) formed by the effect of Fe2+ / ascorbate on the mitochondrial membrane by 58.0 ± 5.0% relative to control. The inhibitory effect of GA and its supramolecular compounds in different proportions with menthol on the peroxidation of lipids in rat heart and brain tissue has been studied