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http://dx.doi.org/10.5352/JLS.2010.20.7.1113

The Hypoglycemic Effect of Complex of Chinese Traditional Herbs (CTH) and Macelignan in Type 2 Diabetic Animal Model  

Yeo, Ji-Young (School of Korean Medicine, Pusan National University)
Cho, Soo-In (School of Korean Medicine, Pusan National University)
Jung, Myeong-Ho (School of Korean Medicine, Pusan National University)
Publication Information
Journal of Life Science / v.20, no.7, 2010 , pp. 1113-1120 More about this Journal
Abstract
This study investigated the efficacy of macelignan and hot water with Chinese traditional herb (CTH) extract on altering severe diabetic conditions in C57BL/KsJ-db/db mice. Previously, the anti-diabetic effects of macelignan were partly reported as a PPAR $\alpha/\gamma$-dual agonist. Here, we futher studied whether a combination of macelignan and CTH had more beneficial effects or not. The macelignan and CTH compound significantly decreased fasting blood glucose and HbA1c compared to macelignan-treated mice, and also significantly improved postprandial glucose, insulin sensitivity, and plasma lipid profiles (FFA, and TG). On the other hand, insulin levels were not significantly changed compared to the diabetic control group. There were no significant changes in the concentrations of total cholesterol and HDL-cholesterol, but there were changes in HTR and AI. These results suggest that the macelignan and CTH compound ameliorates hyperglycemia and efficiently improves postprandial glucose, insulin sensitivity, and hyperlipidemia compared with macelignan in db/db mice. Moreover, the macelignan and CTH compound seems to be more potent in affecting diabetic complications than macelignan.
Keywords
Type 2 diabetes; db/db mice; macelignan; Chinese traditional herbs (CTH); blood glucose; hyperglycemia; hyperlipidemia;
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1 Waisundara, V. Y., M. Huang, A. Hsu, D. Huang, and B. K. Tan. 2008. Characterization of the anti-diabetic and antioxidant effects of rehmannia glutinosa in streptozotocin-induced diabetic wistar rats. Am. J. Chin. Med. 36, 1083-1104.   DOI
2 Wild, S. and C. D. Byrne. 2004. The role of treatment to increase HDL-cholesterol and decrease triglyceride concentrations in prevention of coronary heart disease in Type 2 diabetes. Diabet Med. 21, 8-11.
3 Woo, W. S., K. H. Shin, H. Wangner, and H. Lotter. 1987. The structure of macelignan from Myristica fragrans. Phytochemistry 26, 1542.   DOI
4 Yamahara, J., T. Yamada, T. Kitani, Y. Naitoh, and H. Fujimura. 1989. Antianoxic action and active constituents of evodiae fructus. Chem. Pharm. Bull. (Tokyo) 37, 1820-1822.   DOI   ScienceOn
5 Yamauchi, T., J. Kamon, H. Waki, Y. Terauchi, N. Kubota, K. Hara, Y. Mori, T. Ide, K. Murakami, N. Tsuboyama-Kasaoka, O. Ezaki, Y. Akanuma, O. Gavrilova, C. Vinson, M. L. Reitman, H. Kagechika, K. Shudo, M. Yoda, Y. Nakano, K. Tobe, R. Nagai, S. Kimura, M. Tomita, P. Froguel, and T. Kadowaki. 2001. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat. Med. 7, 941-916.   DOI
6 Shafrir, E. 1992. Animal models of non-insulin-dependent diabetes. Diabetes Metab. Rev. 8, 179-208.   DOI
7 Shokuhin, K. H. 2000. Market trend of health foods and health ingredients. Shokhin to Kaihatsu 35, 18-34.
8 Steinmetz, A. 2003. Treatment of diabetic dyslipoproteinemia. Exp Clin Endocrinol Diabetes. 111, 239-245.   DOI
9 Suneetha, W. J. and T. P. Krishnakantha. 2005. Cardamom extract as inhibitor of human platelet aggregation. Phytotherapy Research 19, 437-440.   DOI
10 Stumvoll, M., B. J. Goldstein, and T. W. van Haeften. 2005. Type 2 diabetes: principles of pathogenesis and therapy. Lancet 365, 1333-1346.   DOI
11 Thorens, B. Glucose sensing and the pathogenesis of obesity and type 2 diabetes. 2008. Int. J. Obes. (Lond) 32, S62-S71.
12 Tominaga, M., H. Eguchi, H. Manaka, K. Igarashi, T. Kato, and A. Sekikawa. 1999. Impaired glucose tolerance is a risk factor for cardiovascular disease, but not impaired fasting glucose. The Funagata Diabetes Study. Diabetic Care 22, 920-946.   DOI
13 Turner, R. C., C. A. Cull, V. Frighi, and R. R. Holman. Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group. 1999. JAMA 281, 2005-2012.   DOI
14 Wagner, A. M., A. Perez, J. L. Sanchez-Quesada, J. Ordonez-Llanos. 2005. Triglyceride-to-HDL cholesterol ratio in the dyslipidemic classification of type 2 diabetes. Diabetes Care 28, 1798-1800.   DOI
15 Lee, Y. M., D. K. Kim, S. H. Kim, T. Y. Shin, and H. M. Kim. 1996. Antianaphylactic activity of Poncirus trifoliata fruit extract. J. Ethnopharmacol. 54, 77-84.   DOI   ScienceOn
16 Lim, J. I. 2003. Recent research trends of diabetes drug. Health Industry and Technology Trends Spring. 28-38.
17 Medical Economics Company. 2000. PDR for herbal medicine. 984.
18 Park, I. B. and S. H. Baik. 2009. Epidemiologic characteristics of diabetes mellitus in Korea: current status of diabetic patients using Korean health insurance database. Korean Diabetes J. 33. 357-362.   DOI
19 Ministry of Health, 2009. Welfare and Family Affairs; Korea Centers for Disease Control and Prevention: The 4th national health and nutrition examination survey. Seoul, Korea Centers for Disease Control and Prevention.
20 Moon, E. J., Y. E. Jo, T. C. Park, Y. K. Kim, S. H. Jung, H. J. Kim, D. J. Kim, Y. S. Chung, and K. W. Lee. 2008. Clinical characteristics and direct medical costs of type 2 diabetic patients. Korean Diabetes J. 32. 358-365.   DOI
21 Park, S. K., M. K. Park, J. H. Suk, M. K. Kim, Y. K. Kim, I. J. Kim, Y. H. Kang, K. J, Lee, H. S. Lee, C. W. Lee, B. H. Kim, K. I. Lee, M. K. Kim, and D. K. Kim. 2009. Cause-of-Death trends for diabetes mellitus over 10 years. Korean Diabetes J. 33. 65-72.   DOI
22 Rai, P. K., D. Jaiswal, S. Mehta, and G. Watal. 2009. Anti-hyperglycaemic potential of Psidium guajava raw fruit peel. Indian J. Med. Res. 2009. 129, 561-565.
23 Scott, D. K., R. M. O'Doherty., J. M. Stafford., C. B. Newgard, and D. K. Granner. 1998. The repression of hormone-activated PEPCK gene expression by glucose is insulin-independent but requires glucose metabolism. J. Biol. Chem. 273, 24145-24151.   DOI
24 Jin, D. Q., C. S. Lim, J. K. Hwang, I. Ha, and J. S. Han. 2005. Anti-oxidant and anti-inflammatory activities of macelignan in murine hippocampal cell line and primary culture of rat microglial cells. Biochem. Biophys. Res. Commun. 331, 1264-1269.   DOI
25 Khan, B., M. S. Arayne, S. Naz, and N. Mukhtar. 2005. Hypogylcemic activity of aqueous extract of some indigenous plants. Pak. J. Pharm. Sci. 18, 62-64.
26 Klein, R., B. E. Klein, S. E. Moss, M. D. Davis, and D. L. DeMets.1988. Glycosylated hemoglobin predicts the incidence and progression of diabetic retinopathy. JAMA 260, 2864-2871.   DOI
27 Kim, K. J. and Y. N. Han. 2002. Lignans from Myristica fragrans. Yakhak Hoeji 46, 98-101.   과학기술학회마을
28 Kim, S. H., E. J. Shin, and C. K. Hyun. 2005. Enhancing effect of extracts of phellodendri cortex on glucose uptake in normal and insulin-resistant 3T3-L1 adipocytes. Kor. J. Pharmacogn. 36, 291-298.   과학기술학회마을
29 Kim, S. H., D. H. Lee, S. H. Kwon, B. H. Lim, S. H. Lee, and B. C. Min. 2007. Isolation and quantitative determination method validation of myristicin from Myristica fragrans Houttuyn. Kor. J. Pharmacogn. 38, 19-21.   과학기술학회마을
30 Korea Pharmaceutical Traders Association. 2000. Korea Drug Test Laboratory Chinese medicine (herb) REGULATION. 370.
31 Korean Diabetes Association, Health Insurance Review & Assessment Service. 2008. Report of Task Force Team for Basic Statistical Study of Korean Diabetes Mellitus: Diabetes in Korea 2007. 1st ed., Goldfishery, Seoul. Korea.
32 Lee, J. Y., Y. B. Han, W. S. Woo, and K. H. Shin. 1990. Antioxidant activity of diarylbutanes. Kor. J. Pharmacogn. 21, 270-273.   과학기술학회마을
33 Faraj, M., G. Beauregard, A. Tardif, E. Loizon, A. Godbout, K. Cianflone, H. Vidal, and R. Rabasa-Lhoret. 2008. Regulation of leptin, adiponectin and acylation-stimulating protein by hyperinsulinaemia and hyperglycaemia in vivo in healthy lean young men. Diabetes Metab. 34, 334-342.   DOI
34 Han, K. L., J. S. Choi, J. Y. Lee., J. Song, M. K. Joe., M. H. Jung, and J. K. Hwang. 2008. Therapeutic potential of peroxisome proliferators-activated receptor-alpha/gamma dual agonist with alleviation of endoplasmic reticulum stress for the treatment of diabetes. Diabetes 57, 737-745.   DOI   ScienceOn
35 Fasshauer, M. and R. Paschke. 2003. Regulation of adipocytokines and insulin resistance. Diabetologia 46, 1594-1603.   DOI
36 Flyvbjerg, A., L. Denner, B. F. Schrijvers, R. G. Tilton, T. H. Mogensen, S. R. Paludan, and R. Rasch. 2004. Long-term renal effects of a neutralizing RAGE antibody in obese type 2 diabetic mice. Diabetes 53, 166-172.   DOI
37 Friedman, J. E., Y. Sun, T. Ishizuka, C. J. Farrell, S. E. McCormack, L. M., Herron, P. Hakimi, P. Lechner, and J. S. Yun. 1997. Phosphoenolpyruvate carboxykinase (GTP) gene transcription and hyperglycemia are regulated by glucocorticoids in genetically obese db/db transgenic mice. J. Biol. Chem. 272, 31475-31481.   DOI   ScienceOn
38 International Diabetes Federation. 2003. International Diabetes Federation: Diabetes Atla. pp. 17-71, 2nd eds., Belgium.
39 Jeong, H. J., H. Y. Kwon, J. T. Han, Y. J. Kim, and A. K. Lee. 2008. Cost-effectiveness analysis of type 2 DM screening program of national health insurance corporation. Kor. J. Health Economics and Policy 14, 29-50.
40 American Institute of Nutrition: Report of Ad Hoc Committee on Standards for Nutritional Studies. 1980. J. Nutr. 110, 1717-1726.
41 American Institute of Nutrition: Report of the American Institute of Nutrition ad hoc Committee on Standards for Nutritional Studies. 1977. J. Nutr. 107, 1340-1348.
42 Coleman1, D. L. 1978. Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 14, 141-147   DOI
43 Crapo, P. A., G. Reaven, and J. Olefsky. 1977. Postprandial plasma-glucose and -insulin responses to different complex carbohydrates. Diabetes 26, 1178-1183.   DOI
44 Doda, R. F. 1996. Diabetes mellitus in clinical chemistry, pp. 613-641, In Kaplan, L. A., J. P. Amadeo (eds.), Mosby-Year Book. St Louis, Mo.
45 Duarte, N. L., S. Colagiuri, T. Palu, X. L. Wang, D. E. Wilcken. 2003. Obesity, Type II diabetes and the Ala54Thr polymorphism of fatty acid binding protein 2 in the Tongan population. Mol. Genet. Metab. 79, 183-188.   DOI