• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1985년도 춘계학술대회
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• pp.9-12
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• 1985

This paper covers the design and implementation process of RF hypertermia system for cancer therapy. Among many hyperthermic methods, RF capacitive heating method is discussed because it can heat the deep-seated tumors selectively. The RF power oscillator and its applicators were designed and implemented. And the experiments were performed with agar phantom and dog to prove that the system can heat any depth selectively. And the electrical safety and appropriateness of clinical application was proved through the human living-body test.

• 한국자기학회:학술대회 개요집
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• 한국자기학회 2008년도 Asian Magnetics Conference
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• pp.249.2-249.2
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• 2008

• 한국전자파학회논문지
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• 제23권2호
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• pp.244-250
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• 2012

본 논문에서는 소형화된 대칭형 다이폴 안테나와 이를 이용한 배열 구조를 제안하였다. 제안된 안테나 배열 구조는 표재성 암 치료를 위한 고온 온열 치료의 전자기파 방사체에 사용된다. 소형화된 다이폴 안테나는 가온 균일성 향상을 위하여 양 갈래 다이폴과 정합 구조가 대칭형으로 설계되었고 이를 이용하여 $2{\times}2$ 배열 구조가 제작 및 측정되었다. 제작된 배열 구조는 전자파 흡수율과 생체열 방정식에 의하여 모의 실험되고, 다중 채널 온도계를 사용하여 30분 및 60분 간의 온도 분포가 측정되었다. 그 결과, 다이폴 안테나에 각각 2 W의 전력을 공급하였을 때 2.7도와 3.3도의 온도가 상승하였다. 측정 환경에서의 모의 실험 결과와 측정 결과가 일관성을 보였으며, 실제 치료 환경을 가정한 모의 실험을 통하여 실제 의료 기기 활용에 많은 도움이 될 것으로 기대된다.

• Radiation Oncology Journal
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• 제6권2호
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• pp.155-161
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• 1988

The usefulness of hypertermia for cancer therapy have well been established. The purpose of the present investigation was to ascess the effect of step-up $(42^{\circ}{\rightarrow}44^{\circ}C$ sequence) and step-down $(44^{\circ}{\rightarrow}42^{\circ}C$ sequence) heating on the skin of the hind foot of the mouse. Hyperthermic treatments were given by immersion the hind foot of the mouse in circulating water baths. Skin response was studied by the leg reaction, which was scored according to a numerical scoring system proposed by Urano et al (1980). The results were as follows 1. The skin damage of $44^{\circ}C$ control group was more severe than $42^{\circ}C$ control group (P<0.05), except for 15 min. heating group. 2. The Skin damage of step-down group was more severe than step-up group (P<0.05). 3. The skin damage of $44^{\circ}C$ control group was more severe than step-up group when there is no difference in $44^{\circ}C$ heating time of step-up group from $44^{\circ}C$ control group (P<0.05). 4. In step-down group, the skin damage was more severe than $44^{\circ}C$ control group after preheating 45 min at $44^{\circ}C$ (P<0.05). Therefore, the above findings suggest the normal tissue damage by step-up heating was correlated with heating time of post step-up. The dropping of heating temperature in late phase had more severe damage of the skin than that in early phase during hyperthermia, and so contineous control of satisfactory temperature should be considered as the one of the most important factor for prognosis, complications of clinical hyperthermia

• Bulletin of the Korean Chemical Society
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• 제35권6호
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• pp.1806-1808
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• 2014

We report the successful preparation of gold nanoparticles (Au NPs) using a novel electroreduction process, which is simple, fast, and environmentally friendly (toxic chemicals such as strong reducing agents are not required). Our process allows for the mass production of Au NPs and adequate particle size control. The Au NPs prepared show high biocompatibility and are non-toxic to healthy human cells. By applying radio-frequency (RF) ablation, we monitored the electro-hyperthermia effect of the Au NPs at different RFs. The Au NPs exhibit a fast increase in temperature to $55^{\circ}C$ within 5 min during the application of an RF of 13 MHz. This temperature rise is sufficient to promote apoptosis through thermal stress. Our work suggests that the selective Au NP-mediated electro-hyperthermia therapy for tumor cells under an RF of 13 MHz has great potential as a clinical treatment for specific tumor ablation.

• 대한화학회지
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• 제47권3호
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• pp.257-264
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• 2003

본 연구에서는 외부온열 온도$(~40^{\circ}C)$에서 항암약물(doxorubicin)이 방출되는 온도민감성 리포좀에 대하여 연구하였다. 온도민감성 리포좀은 외부온열온도에서 하한임계용액온도의 성질을 나타내는 N-isopropylacrylamide (NIP-AAm)와 Acrylamide(AAm)의 합성고분자에 의하여 변형되었다. 변형된 리포좀으로부터 약물(doxorubicin)의 방출은 온도와 시간의 변화에 따라서 형광강도를 측정하여 결정하였다. Poly(NIPAAm-co-AAm) copolymer에 의하여 변형된 리포좀으로부터 약물(doxorubicin)의 방출은 Poly(NIPAAm-co-AAm) copolymer가 온열온도 범위$(~40{\pm}2^{\circ}C)$에서 적절한 전이를 나타내기 때문에 증가하였다. 또한, 리포좀으로부터 약물의 방출은 5분 이내에 완료되었고, 변형된 리포좀의 크기는 120~170 nm 이었다. 본 연구에서는 온도에 의하여 제어 할 수 있는 온도민감성 리포좀을 제조하였다. 이것은 온도 제어에 따른 종양 표적화에 대한 약물전달시스템에서 활용 될 수 있을 것이다.

• Animal cells and systems
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• 제1권1호
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• pp.77-80
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• 1997

DOantrolene is a primary specific therapeutic drug for prevention and treatment of malignant hyperthermia symptoms. The mechanisms underlying the therapeutic effects of the drug are not well understood. The present study aimed at the characterization of the effects of azumolene, a water soluble dantrolene analogue, on ryanodine binding to sarcoplasmic reticulum (SR) from normal and malign::lnt hyperthermia susceptible (MHS) swine muscles. Characteristics of $[^3H]ryanodine$ binding were clearly different between the two types of SR. Kinetic analysis of eH]ryanodine binding to SR in the presence of $2{\mu}M$ $Ca^{2+}$ showed that association constant $(K_{ryanodine}_7$ is significantly higher in MHS than normal muscle SR $(2.83 vs. 1.32{\times}10^7 M^{-1}$, whereas the maximal ryanodine binding capacity $(B_{max})$ is similar between the two types of SR. Addition of azumolene $(e.g. 400{\mu}M)$ did not significantly alter both $K_{ryanodine}$ and $B_{max}$ of $[^3H]$ryanodine binding in both types of SR, indicating that the azumolene effect was not on the ryanodine binding sites. Addition of caffeine activated $[^3H]$ ryanodine binding in both types of SR, and caffeine sensitivity was significantly higher in MHS muscle SR than normal muscle SR $(K_{caffeine}:3.24 vs. 0.82 {\times} 10^2 M^{-l}). Addition of azumolene $(e.g.400{\mu}M)$ decreased Kcaffeine without significant change in $B_{max}$ in both types of SR suggesting that azumolene competes with caffeine binding site(s). These results suggest that malignant hyperthermia symptoms are caused at least in part by greater sensitivity of the MHS muscle SR to the $Ca^{2+}$ release drug(s), and that azumolene can reverse the symptoms by reducing the drug affinity to $Ca^{2+}$ release channels.

• 센서학회지
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• 제18권5호
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• pp.377-384
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• 2009

The ultrasonic hyperthermia for oncology has been developed and studied. The HIFU(high intensity focused ultrasound) is the most recent method to treat the tumor by using ultrasound. In this study, an insertion-type transducer for treating a prostate cancer, which can focus the ultrasonic beam mechanically and electrically, was designed and developed. The developed transducer was composed of three arrays, and each array has 32 elements. For the purpose of the mechanical focusing, both side arrays are slanted to the center array by $15^{\circ}$. With this structure, NFL(near field length) was set up as 30 mm. The PZT-4 and two matching layers were used, and the backing layer was excepted to prevent energy losses. The acoustic field analysis and the heating test were performed to evaluate the performance of developed transducer. The shape of an acoustic field, peak pressure, and acoustic pressure distribution were compared with numerical simulation. The NFL was 32 mm, the beam width was 5 mm, focal area was $40\;mm^2$, and peak pressure was 5.5 MPa. With heating by using developed transducer, the temperature increased up to $33^{\circ}C$ at focal zone. As a result of this study, the usefulness of suggested transducer for prostate cancer hyperthermia was confirmed by the acoustic field analysis and the heating test with TMM(tissue mimicking) phantom.

• 한국재료학회지
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• 제22권7호
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• pp.362-367
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• 2012

Magnetite nanoparticles(NPs) have been the subject of much interest by researchers owing to their potential use as magnetic carriers in drug targeting and as a tumor treatment in cases of hyperthermia. However, magnetite nanoparticles with 10 nm in diameter easily aggregate and thus create large secondary particles. To disperse magnetite nanoparticles, this study proposes the infiltration of magnetite nanoparticles into hybrid silica aerogels. The feasible dispersion of magnetite is necessary to target tumor cells and to treat hyperthermia. Magnetite NPs have been synthesized by coprecipitation, hydrothermal and thermal decomposition methods. In particular, monodisperse magnetite NPs are known to be produced by the thermal decomposition of iron oleate. In this study, we thermally decomposed iron acetylacetonate in the presence of oleic acid, oleylamine and 1,2 hexadecanediol. We also attempted to disperse magnetite NPs within a mesoporous aerogels. Methyltriethoxysilicate(MTEOS)-based hybrid silica aerogels were synthesized by a supercritical drying method. To incorporate the magnetite nanoparticles into the hybrid aerogels, we devised two methods: adding the synthesized aerogel into a magnetite precursor solution followed by nucleation and crystal growth within the pores of the aerogels, and the infiltration of magnetite nanoparticles synthesized beforehand into aerogel matrices by immersing the aerogels in a magnetite nanoparticle colloid solution. An analysis using a vibrating sample magnetometer showed that approximately 20% of the magnetite nanoparticles were well dispersed in the aerogels. The composite samples showed that heating under an inductive magnetic field to a temperature of $45^{\circ}C$ is possible.

• Childhood Kidney Diseases
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• 제7권2호
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• pp.229-233
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• 2003

악성 고열증은 succinylcholene과 같은 유발약제의 사용을 피하고, 조기 진단과 dantrolene의 조기 투여에 의해 사망률과 이환률이 현저히 감소하게 되었다. 본 증례는 전신 마취 후 호기말 이산화탄소 분압 증가, 빈맥, 고혈압 등의 조기 징후로 악성 고열증이 발견된 14세 남자 환아에 대한 보고이다. Dantrolene의 조기 투여 후 profopol과 midazolam으로 수숱을 지속할 수 있었다. 횡문근 융해증이 발생하였으나 수액 투여와 요의 알칼리화를 유도하여 신부전이 발생하지 않았다. 환아는 수술 10일 후에 합병증 없이 퇴원하였다.