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A study for implementation of ultrasonic transducer in the prostate cancer hyperthermia

전립선암의 온열치료를 위한 초음파변환기 개발에 관한 연구

  • 박문규 (바이메드 시스템(주) 프로브 사업부) ;
  • 노시철 (인제대학교 의용공학과) ;
  • 박재현 (인제대학교 의용공학과) ;
  • 최흥호 (인제대학교 의용공학과)
  • Published : 2009.09.30

Abstract

The ultrasonic hyperthermia for oncology has been developed and studied. The HIFU(high intensity focused ultrasound) is the most recent method to treat the tumor by using ultrasound. In this study, an insertion-type transducer for treating a prostate cancer, which can focus the ultrasonic beam mechanically and electrically, was designed and developed. The developed transducer was composed of three arrays, and each array has 32 elements. For the purpose of the mechanical focusing, both side arrays are slanted to the center array by $15^{\circ}$. With this structure, NFL(near field length) was set up as 30 mm. The PZT-4 and two matching layers were used, and the backing layer was excepted to prevent energy losses. The acoustic field analysis and the heating test were performed to evaluate the performance of developed transducer. The shape of an acoustic field, peak pressure, and acoustic pressure distribution were compared with numerical simulation. The NFL was 32 mm, the beam width was 5 mm, focal area was $40\;mm^2$, and peak pressure was 5.5 MPa. With heating by using developed transducer, the temperature increased up to $33^{\circ}C$ at focal zone. As a result of this study, the usefulness of suggested transducer for prostate cancer hyperthermia was confirmed by the acoustic field analysis and the heating test with TMM(tissue mimicking) phantom.

Keywords

References

  1. 보건복지부, 2002년 한국 중앙 암 등록 사업 연례 보고서
  2. M. R. Bailey, V. A. Khokhlova, and O. A. Sapozhnikov, 'Physical mechanisms of the therapeutic effect of ultrasuond(A Review)', Acoustic Physics, vol. 49, pp. 437-464, 2003
  3. K. Y. Saleh and N. B. Smith, 'A 63 element 1.75 dimension ultrasound phased array for the treatment of benign prostatic hyperloasia', BioMed Central, vol. 4, pp. 39-53, 2005
  4. E. S. Ebbini and C. A. Cain, 'Experimental evaluation of a prototype cylindrical section ultrasound hyperthermia phased-array applicator', IEEE Transaction on ultrasonics, Ferroelectric, and Frequency control, vol. 38, no. 5, pp. 510-520, 1991 https://doi.org/10.1109/58.84298
  5. 한국기술표준원, KS-C-61102 ; 0.5 MHz-15 MHz 주파수 영역에서 수중 청음기를 사용한 초음파 음장 측정 및 특성화, 2004
  6. 한국기술표준원, KS-C-60601-2-37 ; 초음파 진단 및 감시 기기의 안전에 관한 개별 요구 사항, 2005
  7. C. W. Connor and K. Hynynen, 'Bio-acoustic thermal lensing and nonlinear propagation in focused ultrasound surgery using large focal spots: a parametricstudy', Phys Med Biol, vol. 47, no. 11, pp. 1911-1928, 2002 https://doi.org/10.1088/0031-9155/47/11/306
  8. K. Mahoney, T. Kjield, and N. McDannold, 'Comparison of modelled and observed in vivo temperature elevations induced by focused ultrasound: implications for treatment planning', Phys Med Biol, vol. 46, pp. 1785-1798, 2001 https://doi.org/10.1088/0031-9155/46/7/304
  9. M. D. Hurwitz, I. Kaplan, and G. K. Svensson, 'Feasibility and patient tolerance of a novel transrectral ultrasound hyperthermia system for treatment of prostate cancer', Int J Hyperthermia, vol. 17, pp. 31-37, 2001 https://doi.org/10.1080/02656730150201570
  10. E. B. Hutchinson and K. Hynynen, 'Intracavitray ultrasound phased arrays for noninvasive prostate surgery', IEEE Transaction on ultrasonics, Ferroelectric, and Frequency control, vol. 43, no. 6, pp. 1032-1042, 1996 https://doi.org/10.1109/58.542048
  11. S. Sokka and K. Hynynen, 'The feasibility of MRI guided whole prostate ablation with a linear aperoidic intracavitray ultrasound phased array', Phys Med Biol, vol. 45, pp. 3373-3383, 2000 https://doi.org/10.1088/0031-9155/45/11/319