• Journal of Korean Medical classics
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• v.29 no.2
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• pp.187-202
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• 2016

Objectives : In this study, the relation of pathologic mechanisms of Samcho(三焦) in Hwangdineijing and Samcho-Sanghwa(三焦相火) is investigated for the purpose of understanding the concept of Samcho. Methods : The diseases and symptoms about Samcho(三焦) in Hwangdineijing and many important medical literatures including Sanghanlun(傷寒論) and Jinguiyaolue were selected and analyzed to overview the historical changes of pathologic mechanism about Samcho. Results : In comparison of the Pathologic Mechanisms of Samcho, the explanation of that in many medical literatures is different from that in Hwangdineijing, that is to say, the cause of diseases related to hyperactivity of Sanghwa became the main conditions of pathogenesis about Samcho while the blockage of qi stream through Samcho. Conclusions : The clinical expression of Samcho pathogenesis is fever with perspiration that means exhaustion of body fluid not only general fever of whole body.

• Advances in Traditional Medicine
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• v.6 no.1
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• pp.34-38
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• 2006

The hot water extract of the seeds of Vernonia anthelmintica Kuntze (Compositae) in a dose of 10 ml/kg body weight of mice, showed significant analgesic activity on the hot plate analgesic method throughout the 4 h experimental period. The hole cross scores and the climbing out scores are of lower than the control animals. The hot water extract reduced the defecation in hole board study and significantly reduces the exploratory ambulation and head dipping behaviour. The seed also showed significant depressant activity on the exploratory ambulation of the open field scores. The drug decreased the spontaneous locomotion activity on brick-chip displacement method up to 45 min and also showed the ability to lessen the amphetamine induced hyperactivity up to 20 min. But it didn't show any effect on pentobarbital induced sleeping time test. The extract reduced gastrointestinal motility.

• Clinical and Experimental Pediatrics
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• v.59 no.10
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• pp.414-420
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• 2016

Purpose: We investigated behavioral problems, attention problems, and cognitive function in children and adolescents born small for gestational age (SGA). Methods: Forty-six SGA children born at term and 46 appropriate for gestational age (AGA) children born at term were compared. Psychiatric symptoms were examined with reference to the Korean-Child Behavior Checklist, Korean-Youth Self Report, and Attention Deficit Hyperactivity Disorder Rating Scale (ADHD-RS). Cognitive function was estimated using the Wechsler Intelligence Scale. Sociodemographic data were recorded from interviews. Results: SGA children had high scores on delinquent behavior, aggressive behavior, and the externalizing scale, and they also showed a propensity for anxiety and depression. The SGA group had a higher mean ADHD-RS score than the AGA group ($10.52{\pm}8.10$ vs.$9.93{\pm}7.23$), but the difference was not significant. The SGA group had a significantly lower verbal intelligence quotient (IQ) than the AGA group, but the mean scores of both groups were within normal limits. Conclusion: This study indicates marked behavioral problems, such as delinquency, aggressiveness, and anxiety and depression, as well as low verbal IQ in the SGA group than in the AGA group. Even in cases in which these symptoms are not severe, early detection and proper treatment can help these children adapt to society.

• Korean Journal of Acupuncture
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• v.25 no.1
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• pp.99-111
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• 2008

Objective : This study was performed to evaluate oriental medical treatment for ADHD in childhood Methods : We analyzed DSM-4 and ADS scores before and after the treatments, such as acupuncture, decoction of medical ingredients, correction treatment and oriental kinesitherapy, of ADHD in 12 elementary school students who have been visited Byon oriental medical clinic (Dogok-dong Seoul) from March to October, 2007. And all patients were treated 2 times a week for 3 month. Results : In this study, oriental medical treatments, such as acupuncture, decoction of medical ingredients, correction treatment and oriental kinesitherapy, to balance left and right brains, which is based on oriental medicine theory, was not only effective for treating attention deficit and hyperactivity which is the major problem of children in ADHD, but also effective for resistance, sociality, homology and communication. And we concluded that oriental medical treatments, which treats imbalance disorder of brain, were effective for treating ADHD.

• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.2
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• pp.438-443
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• 2007

The purpose of this research is to examine the effects of Kamijihwang-tang(KJHT) on CD+4 T cells and CD8+ T cell ovalbumin (OVA)-induced asthmatic mice. C57BL/6 mice were injected, inhaled and sprayed with OVA for 12 weeks (four a week) for asthma induction. Two experimental groups were treated with different concentrations of KJHT (400 mg/kg and 200 mg/kg) extract and cyclosporine A (10 mg/kg) for the later 8 weeks. At the end of the experiment, the mice lung, peripheral lymph node (PLN), and spleen were removed and CD4+ T cells and CD8 + T cells for analyzed by flow cytometer. Number of CD4+ T cells in lung, PLN, spleen of the KJHT group (400 mg/kg) were significantly decreased compared with that of control group. Number of CD8+ T cells in lung, PLN, spleen of the KJHT group (200 mg/kg) were significantly decreased compared with that of control group. The results of this study suggest that KJHT alleviated asthmatic hyperactivity through CD4+ and CD8+ T cells. Further study of relative cytokines is expected.

• Korean Journal of Acupuncture
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• v.19 no.2
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• pp.1-12
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• 2002

Objectives : Assuming That the Characteristic of Meridian System Has Been Similar to This of Electric Potentials in Human Body and That Measurements of Electric Potential at Well and Sea Points in Branches of the Twelve Meridians Will Be Representative of Measurements of the Twelve Meridians, to Measure the Electric Potentials in Healthy Volunteers(HG), Patients Diagnosed As a Cerebral Infarction(CG), a Arrhythmia(AG), a Other Intervertebral Disc Disorder(IG), and a Joint Disorder(JG), and Then to Find Out the Characteristic of Biophysical Meridian System, Finally to Compare with the Results of the Electric Potential in Those Groups. Methods : We Selected Who HG Were Diagnosed by a Blood Test, Urine Examination and Differentiation of Syndromes by Five Viscera among Volunteers, CG by CT and Wind-Syndrome Caused by Hyperactivity of the Liver-Yang, AG by EKG, CT, and Deficiency or the Heart Blood, IG by X-ray or CT and Pain in Waist, and JG by X-ray and Knee Pain. Their Electric Potential of Well and Sea Points in the Meridians Were Measured by hysiograph. Results and Conclusions : Measurements Were Analyzed by Factor Analysis, Analysis of Variance, and Logistic Regression Model, We Obtained That Most of the Results, In Conclusion, Hold Good for the Classical Meridian Doctrine.

• Korean Journal of Child Studies
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• v.15 no.1
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• pp.91-108
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• 1994

This study investigated the relation between verbal abuse by parents and children's maladjusted emotional behavior. The sampling consisted of 628 children in 16 classes out of every three elementary schools and one middle school. Instruments used for this study were the Verbal Abuse Measure, Parent-to-child violence items of the Conflict Tactics Scales, Emotional Maladjustment Behavior Scale, and Socioeconmic Status. Methods applied to data analysis were multiple regression, logistic regression and logistic curve graphic display. The major findings were ; (1) Of all subjects, almost 20% experienced at least one instance in which they were victims of verbal abuse during the year covered by this study. (2) As the amount of physical abuse by parents increased the verbal abuse by parents increased. The older children experienced more verbal abuse than the younger ones. (3) Verbal abuse by parents was more highly related to maladjusted emotional behavior of the children than physical abuse by parents. (4) Regardless of the physical violence by parents, verbal abuse by parents was associated with maladjusted emotional behavior of children. Children who were subjected to both verbal and physical abuse were more strongly related to withdrawal, hyperactivity, and obsessive-compulsions than children experienced either one or the other.

• Journal of the Korean Chemical Society
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• v.62 no.2
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• pp.106-112
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• 2018

Ice-binding proteins have an affinity for ice. They create a gap between the melting and freezing points by inhibiting the growth of ice, known as thermal hysteresis (TH). Interestingly, moderately active LeIBP and hyperactive FfIBP are almost identical in primary and tertiary structures, but differ in TH activity. The TH of FfIBP is tenfold higher than that of LeIBP, due to a subtle difference in their ice-binding motifs. To further evaluate the difference in TH, the interactions were investigated by ice-etching and molecular docking. Ice-etching showed that FfIBP binds to the primary and secondary prism, pyramidal, and basal planes; previously, LeIBP was found to bind to the basal and primary prism planes. Docking analysis using shape complementarity (Sc) showed that the hyperactive FfIBP had higher Sc values for all four ice planes than LeIBP, which is comparable with TH. Docking can be used to describe the hyperactivity of IBPs.

• Communications for Statistical Applications and Methods
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• v.24 no.6
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• pp.663-671
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• 2017

Some genetic association tests include an unidentifiable nuisance parameter under the null hypothesis of no association. When the mode of inheritance (MOI) is not specified in a case-control design, the Cochran-Armitage (CA) trend test contains an unidentifiable nuisance parameter. The transmission disequilibrium test (TDT) in a family-based association study that includes the unaffected also contains an unidentifiable nuisance parameter. The hypothesis tests that include an unidentifiable nuisance parameter are typically performed by taking a supremum of the CA tests or TDT over reasonable values of the parameter. The p-values of the supremum test statistics cannot be obtained by a normal or chi-square distribution. A common method is to use a Davies's upper bound of the p-value instead of an exact asymptotic p-value. In this paper, we provide a unified sine-cosine process expression of the CA trend test that does not specify the MOI and the TDT that includes the unaffected. We also present a closed form expression of the exact asymptotic formulas to calculate the p-values of the supremum tests when the score function can be written as a linear form in an unidentifiable parameter. We illustrate how to use the derived formulas using a pharmacogenetics case-control dataset and an attention deficit hyperactivity disorder family-based example.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.23 no.2
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• pp.49-56
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• 2012

Methylphenidate is a widely used stimulant for treatment of attention-deficit hyperactivity disorder (ADHD). In addition to core symptoms of attention and behavioral symptoms, methylphenidate is even effective for executive functions. However, abuse and misuse of stimulants, including methylphenidate, for the purpose of cognitive enhancement is an issue of concern worldwide. Some prejudices and misunderstandings against methylphenidate are popular ; however, little attention has been given to the neuropsychiatric evidence of methylphenidate for enhancement of cognitive function among healthy populations. In this article, our aim was to conduct a review of previous studies investigating the effect of methylphenidate in healthy populations. Findings from several recent studies have demonstrated the effectiveness of methylphenidate for enhancement of cognitive function in healthy populations. The mechanisms of cognitive enhancement are thought to be associated with motivation and the reward circuit in the brain. However, when considering the risk to benefit, an official discussion of the use of methylphenidate among healthy members of the population would be premature. Instead, investigation of epidemiological studies of the prevalence of misuse of stimulants among healthy members of the population, particularly adolescents and college students, is needed. In addition, based on achievements reported in previous studies, investigation of the effect of an approach using non-pharmacological enhancing motivation, which will in turn result in increased cognitive function would be helpful.