• The Journal of Natural Sciences
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• v.17 no.1
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• pp.13-29
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• 2006

Most redox-active proteins have thiol-bearing cysteine residues that are sensitive to oxidation. Cysteine thiols oxidized to sulfenic acid are generally unstable, either forming a disulfide with a nearby thiol or being further oxidized to a stable sulfinic acid, which have been viewed as an irreversible protein modification. However, recent studies showed that cysteine residues of certain thiol peroxidases (Prxs) undergo reversible oxidation to sulfinic acid and the reduction reaction is catalyzed by sulfiredoxin (Srx1). Specific Cys residues of various other proteins are also oxidized to sulfinic acid ($Cys-So_2H$). Srxl is considered one of the oxidant proteins with a role in signaling through catalytic reduction of oxidative modification like in the reduction of glutathionylation, a post-translational, oxidative modification that occurs on numerous proteins. In this study, the role of sulfiredoxin in cellular processes, was investigated by studying its interaction with other proteins. Through the yeast two-hybrid system (Y2HS) technique, we have found that Ams1 is a potential and novel interacting protein partner of Srxl. $\alpha$-mannosidase (Ams1) is a resident vacuolar hydrolase which aids in recycling macromolecular components of the cell through hydrolysis of terminal, non-reducing $\alpha$-D-mannose residues. It forms an oligomer in the cytoplasm and under nutrient rich condition and is delivered to the vacuole by the Cytoplasm to Vacuole (Cvt) pathway. Aside from the role of Srxl as a catalyst in the reduction of cysteine sulfenic acid groups, it may play a completely new function in the cellular process as indicated by its interaction with Ams1 of the yeast Saccharomyces cerevisiae.

• Journal of Veterinary Clinics
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• v.37 no.3
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• pp.163-167
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• 2020

A 13-month-old, 3.3 kg castrated male Shih-tzu presented with right hindlimb lameness. The physical examination revealed atrophy of the right thigh muscles, hyperextension of the stifle joint and external torsion of the tibia. On the radiographic examination, patella alta and genu recurvatum were observed. A biapical deformity of the tibia and external torsion of the distal tibia were detected by computed tomography (CT). A three-dimensional (3D) printed bone model was designed and constructed for the preoperative plan prior to surgery. Rectus femoris muscle transposition, femoral shortening ostectomy and open wedge osteotomy of the distal tibia were performed using hybrid external skele/t0al fixation (hybrid-ESF). A dynamic stifle flexion apparatus was used to prevent recurrence of a quadriceps contracture (QC). Intense physiotherapy was administered postoperatively. The dog began to use the affected limb one week after surgery. Functional improvement in the affected limb was observed, and full weight-bearing was possible at 3 months after surgery. Union of the osteotomy lines was observed at 3 months, and the stifle joint was fully movable at 7 months after surgery. Regarding the treatments for QC, these methods may be excellent candidates, as they do not lead to severe damage to the limb or amputation.

• International Journal of High-Rise Buildings
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• v.4 no.1
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• pp.9-25
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• 2015

Field measurements of various structures have been conducted for many purposes. Measurement data obtained by field measurement is very useful to determine vibration characteristics including dynamic characteristics such as the damping ratio, natural frequency, and mode shape of a structure. In addition, results of field measurements and modal identification can be used for modal updating of FEM analysis, for checking the efficiency of damping devices and so on. This paper shows some examples of field measurements and modal identification for structural health monitoring. As the first example, changes of dynamic characteristics of a 15-story office building in four construction stages from the foundation stage to completion are described. The dynamic characteristics of each construction stage were modeled as accurately as possible by FEM, and the stiffness of the main structural frame was evaluated and the FEM results were compared with measurements performed on non-load-bearing elements. Simple FEM modal updating was also applied. As the next example, full-scale measurements were also carried out on a high-rise chimney, and the efficiency of the tuned mass damper was investigated by using two kinds of modal identification techniques. Good correspondence was shown with vibration characteristics obtained by the 2DOF-RD technique and the Frequency Domain Decomposition method. As the last example, the wind-induced response using RTK-GPS and the feasibility of hybrid use of FEM analysis and RTK-GPS for confirming the integrity of structures during strong typhoons were shown. The member stresses obtained by hybrid use of FEM analysis and RTK-GPS were close to the member stresses measured by strain gauges.

• Journal of Korean Foot and Ankle Society
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• v.18 no.3
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• pp.115-118
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• 2014

Purpose: The purpose of this study is to report on the result of repairing Achilles tendon using absorbable suture under nerve block. Materials and Methods: We retrospectively reviewed 20 patients with acute Achilles tendon rupture who were followed up for at least six months after the operation. We repaired Achilles tendon using two absorbable sutures using the Krackow technique for the proximal stump and the Kessler technique for the distal stump. A programmed postoperative management including non-weight bearing with a short leg cast for four weeks after the operation was applied for all patients. We evaluated clinical results using American Orthopaedic Foot and Ankle Society (AOFAS) ankle-hindfoot score, visual analogue scale (VAS) for satisfaction, range of motion of ankle, functional recovery rate, and the starting time of single heel raise. Results: The mean VAS score for satisfaction and AOFAS score was 9.2 and 93.0, respectively. The affected ankle showed a mean dorsiflexion rate of 90% and plantar-flexion rate of 94% compared to the uninjured side. The single heel raise could start at a mean of 3.5 months after the operation. Conclusion: Treatment of Achilles tendon rupture with absorbable suture material using the hybrid suture technique of proximal Krackow and distal Kessler showed sufficient stability and minimal chronic inflammatory reaction.

• Journal of Biomedical Engineering Research
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• v.26 no.5
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• pp.319-330
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• 2005

Over the past few decades, much effort has been made to improve the mechanical and biological performance of HA, in order to extend its range of applications. As a major inorganic component of human hard tissues, hydroxyapatite bioceramic is regarded as being one of the most biocompatible materials. Numerous in vitro and in vivo studies have confirmed its excellent bioactivity, osteoconductivity and bone forming ability. However, because of its poor mechanical properties, its use in hard tissue applications has been restricted to those areas in which it can be used in the form of small sized powders/granules or in the non-load bearing sites. A number of researchers have focused on improving the mechanical and biological performance of HA, as well as on the formulation of hybrid and composite systems in order to extend its range of applications. In this article, we reviewed our recent works on HA-based biomaterials; i) the strengthening of HA with ceramic oxides, ii) HA-based bioactive coatings on metallic implants, iii) HA-based porous scaffolds and iv) HA-polymer hybrids/composites.

• Journal of IKEEE
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• v.24 no.3
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• pp.814-820
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• 2020

In the M-ary DCSK system up to now, as M increases, the distance between constellation signal points becomes closer and performance deteriorates. we propose a hybrid modulation scheme based on PPM and DCSK to improve the BER performance. one part of the bit is modulated by the PPM and the other part by DCSK. Thus, the information bearing signal is modulated simultaneously according to the selected pulse position of the PPM determined by the information bit and the additional information bit. The analytical BER performance of the proposed plan is derived and verified by simulation. The results show that the proposed scheme outperforms conventional M-DCSK, code index modulation DCSK and rectified code index DCSK in additional white Gaussian noise and multipath Rayleigh fading channels.

• Smart Structures and Systems
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• v.17 no.5
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• pp.691-708
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• 2016

Recently, number of smart material are investigated and widely used in civil construction and other industries. Present study investigates the application of smart semi-active piezoelectric friction damper (PFD) made with piezoelectric material for the seismic control of the horizontally curved bridge isolated with lead rubber bearing (LRB). The main aim of the study is to investigate the effectiveness of hybrid system and to find out the optimum parameters of PFD for seismic control of the curved bridge. The selected curved bridge is a continuous three-span concrete box girder supported on pier and rigid abutment. The PFD is located between the deck and abutments or piers in chord and radial directions. The bridge is excited with four different earthquake ground motions with all three components (i.e. two horizontal and a vertical) having different characteristics. It is observed that the use of semi-active PFD with LRB is quite effective in controlling the response of the curved bridge as compared with passive system. The incorporation of the smart damper requiring small amount of energy in addition with an isolation system can be used for effective control the curved bridge against the dynamic loading.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.24 no.8 s.179
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• pp.1931-1939
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• 2000

Operating excitation forces of the linear vibratory system are normally determined by direct measurement techniques using load cells, strain gauges, etc. But, hydraulic forces of the rotating turbomachinery such as centrifugal pumps are exerted on an impeller due to asymmety of the flow by the interaction between pump impeller and volute. So, investigations of wide range of hydraulic designs and geometric deviations are difficult by direct method. This paper presents a hybrid approach for fourier transformed operational excitation forces, which uses pseudo-inverse matrix of the transfer matrix for the system and the measured vibrational data with standard installed pump. The determination of the transfer function matrix is based on a linear rotor/stationary system and steady state harmonic response in finite element analysis. And, vibrational data is collected in both vertical and horizontal directions at inboard and outboard bearing housings. The results of the process may be enhanced by making acceleration measurements at many more locations than there are forces to be determined.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.27 no.11
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• pp.1949-1957
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• 2003

A hybrid finite element analysis was used to analyze the influence of ring gear rim thickness and spline number on the static properties of a planetary gear system with manufacturing errors. Both of these parameters affected the bearing force and critical stress. The effect of changes in the rim thickness on the load sharing between the gears depended on the type of manufacturing error. Ring flexibility improved the load sharing between planetary gears only in systems with planet tooth thickness or planet tangential errors; for other types of error, ring flexibility worsened the load sharing. To improve load sharing, rim thickness and spline number should be controlled within a specific range. The minimum rim thickness limit should be determined considering not only the critical stress but also the load sharing. The effect of the ring gear boundary condition was more apparent in a system with errors than in a normal system.

• Macromolecular Research
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• v.17 no.8
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• pp.603-608
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• 2009

Novel ultra-high molecular weight polyethylene (UHMWPE)/zirconia composites were previously prepared by the in situ polymerization of ethylene using a Ti-based Ziegler-Natta catalyst supported on to the surface of zirconia, as a bearing material for artificial joints. Tribological tests revealed that a uniform dispersion of zirconia in UHMWPE markedly increased the wear resistance. The effects of zirconia content on the oxidation behavior of the ${\gamma}$-ray-treated UHMWPE/zirconia composite surfaces were examined. The oxidation index that estimates the oxidation degree as the content of total carbonyl compounds was monitored using Fourier transform infrared spectroscopy-attenuated total reflectance. The changes in the surface composition due to the oxidation were confirmed by electron spectroscopy for chemical analysis. The extent of oxidation decreased with increasing zirconia content, which was attributed to the increased crystallinity as well as the decreased polymer portion of the UHMWPE/zirconia composites.