• Proceedings of the KSME Conference
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• 2008.11a
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• pp.1484-1486
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• 2008

Characteristics of pulsatile flow in 3-dimensional elastic vessel wall should be investigated in order to understand the physiological blood flow in human body. In this study, the modelling of the physiological blood flow in the elastic blood vessel is proposed. Variation of the pressure and the velocity wavefroms are obtained using the FSI method

• Transactions of the Korean Society of Mechanical Engineers B
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• v.37 no.5
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• pp.449-457
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• 2013

In this study, we performed a numerical analysis to investigate the effect of rotation on the blood flow and arterial wall behavior by using the FSI (fluid-structure interaction) technique. The geometry of the artery included 50% stenosis at the center. To simulate the rotational effect, 2-6 rps of axial velocity was applied to the arterial model. A spiral wave and asymmetric flow occurred due to the stenosis and axial rotation both in the rigid body model and in the FSI model. However, the arterial wall motion caused periodic and transient blood flow changes in the FSI model. The FRZ (fluid recirculation zone) decreased in the FSI model, which is a known predictor for the formation and vulnerability of plaque. Therefore, it is observed that arterial wall motion also influences the generation of the FRZ.

• IMMUNE NETWORK
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• v.2 no.3
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• pp.150-157
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• 2002

Background: Although Tat plays a role as a potent transactivator in the viral gene expression from the Human Immunodeficiency Virus type 1 long terminal repeat (HIV-1 LTR), it does not function efficiently in rodent cells implying the absence of a human specific factor essential for Tat-medicated transactivation in rodent cells. In previous experiments, we demonstrated that one of chimeric forms of TAR (transacting responsive element) of HIV-1 LTR compensated the restriction in rodent cells. Methods: To characterize the nature of the compensation, we tested the effects of several upstream binding factors of HIV-1 LTR by simple substitution, and also examined the role of the configuration of the upstream binding factor(s) indirectly by constructing spacing mutants that contained insertions between Sp1 and TATA box on Tat-mediated transactivation. Results: Human Sp1 had no effect whereas its associated factors displayed differential effects in human and rodent cells. In addition, none of the spacing mutants tested overcame the restriction in rodent cells. Rather, when the secondary structure of the chimeric HIV-1 TAR construct was destroyed, the compensation in rodent cells was disappeared. Interestingly, the proper interaction between Sp1 and TATA box binding proteins, which is essential for Tat-dependent transcription, was dispensable in rodent cells. Conclusion: This result suggests that the human-specific Tat cofactor acts to allow Tat to interact effectively in a ribonucleoprotein complex that includes Tat, cellular factors, and TAR RNA, rather than be associated with the HIV-1 LTR upstream DNA binding factors.

• YAKHAK HOEJI
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• v.43 no.6
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• pp.743-750
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• 1999

Human and bovine dopamine transporters (DAT) demonstrate discrete functional differences in the dopamine (DA) transport and cocaine binding. The functional analyses on the chimeras of human and bovine DAT have revealed that the region from the $133^{rd}{\;}to{\;}186^{th}$ residue(encompassing the $3^{rd}$ trans-membrane domain (TM) is responsible for the substrate transport and cocaine binding. The present studies have been done to find out the specific amino acid(s) which is essential for the binding of cocaine to DAT by interchanging the amino acids in that region between human and bovine DAT. When isoleucine, the $152^{nd}$ residue of chimera B3 (bovine DAT sequence) was transformed back to valine, the human DAT residue at the identical position, the cocaine binding was remarkably recovered to 98% of the human DAT values. In addition, the cocaine binding of the human DAT was decreased by 57% by substituting isoleucine for valine at position 152. When isoleucine at position 152 of the chimera B3 was converted to the other amino acids to provide an possible molecular basis for the functional role of the $152^{nd}$ residue, only the conversion to alanine among acids tested significantly the cocaine by 34%, but these effect were not as much as those by the conversion to valine. In conclusion, valine at position 152 is a crucial amino acid for the interaction of cocaine to the DAT.

• Structural Engineering and Mechanics
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• v.74 no.5
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• pp.711-722
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• 2020

In this study, on-site testing was carried out to investigate the vibration serviceability of a composite steel-bar truss slab with steel girder system. Impulse excitations (heel-drop and jumping) and steady-state motion (walking and running) were performed to capture the primary vibration parameters (natural frequency and damping ratio) and distribution of peak acceleration. The composite floor possesses low frequency (<8.3Hz) and damping ratio (<2.47%). Based on experimental, theoretical, and numerical analyses on fundamental natural frequency, the boundary condition of SCSS (i.e., three edges simply supported and one edge clamped) is deemed more comparable substitutive for the investigated composite floor. Walking and running excitations by one person (single excitation) were considered to evaluate the vibration serviceability of the composite floor. The measured acceleration results show a satisfactory vibration perceptibility. For design convenience and safety, a crest factor β_rp describing the ratio of peak acceleration to root-mean-square acceleration induced from the walking and running excitations is proposed. The comparisons of the modal parameters determined by walking and running tests reveal the interaction effect between the human excitation and the composite floor.

• Journal of Biomedical Engineering Research
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• v.35 no.2
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• pp.14-18
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• 2014

This study is about e-Book program based on human-computer interaction(HCI) system for physically handicapped person. By acquiring background knowledge of HCI, we know that if we use vision-based interface we can replace current computer input devices by extracting any characteristic point and tracing it. We decided betweeneyes as a characteristic point by analyzing facial input image using webcam. But because of three-dimensional structure of glasses, the person who is wearing glasses wasn't suitable for tracing between-eyes. So we changed characteristic point to the bridge of the nose after detecting between-eyes. By using this technique, we could trace rotation of head in real-time regardless of glasses. To test this program's usefulness, we conducted an experiment to analyze the test result on actual application. Consequently, we got 96.5% rate of success for controlling e-Book under proper condition by analyzing the test result of 20 subjects.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.20 no.41
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• pp.203-212
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• 1997

The interface of computer software has to promote human-computer interaction. The one quality of interface to promote HCI should be evaluted with regard to user's information processing. The usability of interface is one of the main components of it's quality, and it is straightforwardly concerned with learnability, especially when users want to use a software at the first stage. In this paper, word processors, wide spreadly used in OA environments is studied in respect to menu structure on the interface. An cognitive menu structure is suggested by user's conceptual network of the main functions of word processor. Two word processors is selected to compare with the cognitive menu structure and to evalute learnabilities by teaming model.

• Journal of Information Processing Systems
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• v.20 no.3
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• pp.328-336
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• 2024

Visual communication is widely used and enhanced in modern society, where there is an increasing demand for spirituality. Museum robots are one of many service robots that can replace humans to provide services such as display, interpretation and dialogue. For the improvement of museum guide robots, the paper proposes a human-robot interaction system based on visual communication skills. The system is based on a deep neural mesh structure and utilizes theoretical analysis of computer vision to introduce a Tiny+CBAM mesh structure in the gesture recognition component. This combines basic gestures and gesture states to design and evaluate gesture actions. The test results indicated that the improved Tiny+CBAM mesh structure could enhance the mean average precision value by 13.56% while maintaining a loss of less than 3 frames per second during static basic gesture recognition. After testing the system's dynamic gesture performance, it was found to be over 95% accurate for all items except double click. Additionally, it was 100% accurate for the action displayed on the current page.

• Structural Engineering and Mechanics
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• v.89 no.5
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• pp.525-538
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• 2024

An explosion from a specific source can generate high pressure, causing damage to structures and people in and around them. For the design of protective structures, although explosion overpressure is considered the main loading parameter, parts are only considered using standard design procedures, excluding special installations. Properties of the explosive, such as molecular structure, shape, dimensional properties, and the physical state of the charge, determine the results in a high-grade or low-grade explosion. In this context, it is very important to determine the explosion behaviors of the structures and to take precautions against these behaviors. Especially structures in areas with high explosion risk should be prepared for blast loads. In this study, the behavior of non-anchored blast resistant modular buildings was investigated. In the study, analyzes were carried out for cases where modular buildings were first positioned on a reinforced concrete surface and then directly on the ground. For these two cases, the behavior of the modular structure placed on the reinforced concrete floor against burst loads was evaluated with Stribeck curves. The behavior of the modular building placed directly on the ground is examined with the Pais and Kausel equations, which consider the structure-ground interaction. In the study, head and neck injuries were examined by placing test dummies to examine human injury behavior in modular buildings exposed to blast loads. Obtained results were compared with field tests. In both cases, results close to field tests were obtained. Thus, it was concluded that Stribeck curves and Pais Kausel equations can reflect the behavior of modular buildings subjected to blast loads. It was also seen at the end of the study that the human injury criteria were met. The results of the study are explained with their justifications.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.263-263
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• 1994

Annexin I is a member of the in family of calcium dependent phospholipid banding proteins and is an in vitro phospholipase $A_2$ (PLA$_2$) inhibitor. The mechanism of PLA$_2$ inhibition by annexin I is still ambiguous. The structure of annexin I was studied at the atomic level by using nuclear magnetic resonance (NMR), circular dichrotsm (CD) and fluorescence spectroscopy. Recombinant human annexin I and N-terminally truncated annexin I (1-31 deleted: d-annexin I) were purified and their NMR spectra were compared. The NMR spectra of the two were similar. When $Ca^{2+}$ ion added to annexin I ad d-annexin I, peak broadening occurred, but no significant spectroscopic change was observed. When porcine pancreatic PLA$_2$ was added to deuterium labeled annexin I, an interaction of annexin I with PLA$_2$ was observed as indicated by the disappearance and shift of several peaks in the NMR spectrum. This result supports a protein-protein interaction mechanism for PLA$_2$ inhibition by annexin I.I.