• Biomedical Science Letters
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• v.16 no.4
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• pp.207-212
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• 2010

Archivillin, a muscle-specific isoform of supervillin, is a component of the costameric cytoskeleton of muscle cells. The purpose of this study was to determine which protein in the skeletal muscle collaborates with archvillin C-terminus. For this purpose, a yeast two-hybrid screening of human skeletal muscle cDNA library was performed using the C-terminal region of archvillin as bait. This study shows that seven human skeletal muscle proteins, namely, nebulin, xeplin, archvillin, GAPDH, TOX4, PITRM1, and YME1L1 interact with archvillin C-terminus. Especially, xeplin is a newly discovered protein interacts with archvillin C-terminus. These results indicate that archvillin C-terminus acts as a bridge between nebulin and xeplin at costameres. Archvillin C-terminal region interacts with nebulin C-terminal region at Z-discs and interacts with xeplin at the vicinity of sarcolemma. I propose that these interactions may contribute to formation of costameric structure and muscle contraction.

• IE interfaces
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• v.10 no.3
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• pp.197-208
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• 1997

In workplace design, an ergonomic solution should ensure low postural stress in the operator during his/her work. Stress caused by awkward working postures of the trunk, shoulders and legs can result in fatigue, discomfort, musculo-skeletal disorders and nerve entrapment syndromes. Since discomfort and musculo-skeletal disorders are both related to exposure to biomechanical load on the musculo-skeletal system, minimization of discomfort will contribute to reduction of the risk for musculo-skeletal disorders as well. Therefore, in this study, perceived discomfort on the human body joints was measured in the standing postures using the magnitude estimation in order to have a standardized numerical scale for joint discomfort. Nine healthy graduate students participated voluntarily in the laboratory study. The results revealed that perceived discomfort of all the joints increased as the joints deviated from neutral position. Especially, it showed drastic increment on perceived discomfort when deviation from neutral position in each human body joint increased from 75% to 100%. in terms of relative range of motion(R0M). On the basis of these experimental results, a preliminary ranking for assessment of stressfulness of non-neutral postures around the human body joints was suggested.

• Journal of the Korean Society for Precision Engineering
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• v.25 no.9
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• pp.126-134
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• 2008

Kendo is one of the popular sports in modem life. Head, wrist and thrust attack are the fast skill to get a score on a match. Human muscle skeletal model was developed for biomechanical study. The human model was consists with 19 bone-skeleton and 122 muscles. Muscle number of upper limb, trunk and lower limb part are 28, 60, 34 respectively. Bone was modeled with 3D beam element and muscle was modeled with spar element. For upper limb muscle modelling, rectus abdominis, trapezius, deltoideus, biceps brachii, triceps brachii muscle and other main muscles were considered. Lower limb muscle was modeled with gastrocenemius, gluteus maximus, gluteus medius and related muscles. The biomechanical stress and strain analysis of human muscle was conducted by proposed human bone-muscle finite element analysis model under head, wrist and thrust attack for kendo training.

• Korean Journal of Exercise Nutrition
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• v.25 no.2
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• pp.15-19
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• 2021

[Purpose] Skeletal muscle glycogen is a determinant of endurance capacity for some athletes. Ginger is well known to possess nutritional effects, such as anti-diabetic effects. We hypothesized that ginger extract (GE) ingestion increases skeletal muscle glycogen by enhancing fat oxidation. Thus, we investigated the effect of GE ingestion on exercise capacity, skeletal muscle glycogen, and certain blood metabolites in exercised rats. [Methods] First, we evaluated the influence of GE ingestion on body weight and elevation of exercise performance in rats fed with different volumes of GE. Next, we measured the skeletal muscle glycogen content and free fatty acid (FFA) levels in GE-fed rats. Finally, we demonstrated that GE ingestion contributes to endurance capacity during intermittent exercise to exhaustion. [Results] We confirmed that GE ingestion increased exercise performance (p<0.05) and elevated the skeletal muscle glycogen content compared to the nonGE-fed (CE, control exercise) group before exercise (Soleus: p<0.01, Plantaris: p<0.01, Gastrocnemius: p<0.05). Blood FFA levels in the GE group were significantly higher than those in the CE group after exercise (p<0.05). Moreover, we demonstrated that exercise capacity was maintained in the CE group during intermittent exercise (p<0.05). [Conclusion] These findings indicate that GE ingestion increases skeletal muscle glycogen content and exercise performance through the upregulation of fat oxidation.

• Biomedical Science Letters
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• v.10 no.1
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• pp.23-29
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• 2004

Nebulin is a (Mr 600∼900 kDa) large actin-binding protein specific to skeletal muscle and thought to act as a molecular template that regulates the length of thin filaments. Cardiac muscles of higher vertebrates have been shown earlier to lack nebulin. Recently, full-length nebulin mRNA transcripts have been detected in heart muscle, but at lower levels than in skeletal muscle. Nebulin expression also was detected in the kidney, eye, and otic canal, suggesting that nebulin isoforms may also be expressed in these organs. We have searched for nebulin isoforms in brain of human using PCR and Northern blot. Here, we provide evidence that nebulin mRNA transcripts are expressed in brain. Seven nebulin isoforms (B, C, D, E, F, G and H form) are obtained in human skeletal muscle and four isoforms (B, C, G and H form) in human brain cDNA library. We cloned the 1.3 kb of nebulin fragment from human adult brain library by PCR. The identity of the PCR product was confirmed by sequence analysis. The partial brain nebulin sequence was 99% identical to the skeletal muscle cDNA as determined by Blast alignment. It contains two simple-repeats HR1, HR2 and linker-repeats exon l35∼143 except exon 140. It was different from skeletal muscle B form, which contain HR1 and HR8. These data suggest that nebulin isoform diversity occurs even more extensively than previously known, likely contributing to the distinct thin filament architecture of different striated muscles.

• Journal of the Korea Fashion and Costume Design Association
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• v.17 no.3
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• pp.13-27
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• 2015

The purpose of this study is to understand the general process from textile design till fashion design and to understand the relation between the body structure by using the x-ray technique. The research method was to see background of the anatomic feature and human skeletal X-ray projection through historical aspect of publications, the Internet, and paper. In terms of production, in order to present a design that takes into account the unique silhouette of the human body without distorting the shape of the human skeleton, X-ray images that were reconstituted using a computer graphic tool (Photoshop CS) were reproduced into the fabric as intense images through the digital Textile Printing technique that is capable of expressing fine and delicate details, and applied into the design. An original design was developed that emphasized the impression of the human body being projected and the shape of the human skeleton realistically expressed in terms of silhouette and detail. The results are as follows: First, Body has a anatomic formative characteristic and its formativeness becomes as a great motive for the artistic expression and thereby it becomes more unique and available for new design expression. Second, Using the 'body frame' as the motive of the research, there's mainly tried to make an unique expression. Third, according to reconstructing human skeletal X-ray projection by using Adobe Photoshop CS2, it can be expressed strong and unique design. Forth, DTP which is being used as an essential technique, expresses the body frame realistically and being used the special type of functional product and silk. Likewise by discovering the diverse formativeness of our body frame and reflecting the sense of humanity into the pieces there's been able to make and develop an unique fashion design. I sincerely hope there is a hug progress in this research in this area.

• Journal of the Korean Society for Precision Engineering
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• v.24 no.11
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• pp.116-125
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• 2007

Human muscle skeletal model was developed for biomechanical study. The human model was consists with 19 bone-skeleton and 122 muscles. Muscle number of upper limb, trunk and lower limb part are 28, 60, 34 respectively. Bone was modeled with 3D beam element and muscle was modeled with spar element. For upper limb muscle modelling, rectus abdominis, trapezius, deltoideus, biceps brachii, triceps brachii muscle and other main muscles were considered. Lower limb muscle was modeled with gastrocenemius, gluteus maximus, gluteus medius and related muscles. The biomechanical stress and strain analysis of human was conducted by proposed finite element analysis model under Kumdo head hitting motion. In this study structural analysis has been performed in order to investigate the human body impact by Kumdo head hitting motion. As the results, the analytical displacement, stress and strain of human body are presented.

• International Journal of Internet, Broadcasting and Communication
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• v.12 no.4
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• pp.83-92
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• 2020

A recent study to determine the fall is focused on analyzing fall motions using a recurrent neural network (RNN), and uses a deep learning approach to get good results for detecting human poses in 2D from a mono color image. In this paper, we investigated the improved detection method to estimate the position of the head and shoulder key points and the acceleration of position change using the skeletal key points information extracted using PoseNet from the image obtained from the 2D RGB low-cost camera, and to increase the accuracy of the fall judgment. In particular, we propose a fall detection method based on the characteristics of post-fall posture in the fall motion analysis method and on the velocity of human body skeleton key points change as well as the ratio change of body bounding box's width and height. The public data set was used to extract human skeletal features and to train deep learning, GRU, and as a result of an experiment to find a feature extraction method that can achieve high classification accuracy, the proposed method showed a 99.8% success rate in detecting falls more effectively than the conventional primitive skeletal data use method.

• Transactions on Control, Automation and Systems Engineering
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• v.4 no.1
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• pp.43-48
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• 2002

We show that humans execute the postural control ingeniously by regulating the impedance properties of the musculo-skeletal system as the motor command against the alteration of the environment. Adjusting muscle activity can control the impedance properties of the musculo-skeletal system. To quantify the changes in human arm viscoelasticity on the vertical plane during interaction with the environment, we asked our subject to hold an object. By utilizing surface electromyographic(EMG) studies, we determined a relationship between the perturbation and a time-varying muscle co-activation. Our study showed when the subject lifts the object by himself the muscle stiffness increases while the torque remains the same just before the lift-off. These results suggest that the central nervous system(CNS) simultaneously controls not only the equilibrium point(EP) and the torque, but also the muscle stiffness as themotor command in posture control during the contact task.

• Journal of Mechanical Science and Technology
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• v.15 no.7
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• pp.982-994
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• 2001

Commercially available software packages permit to position human models of various geometries in practical scenarios while respecting the anatomical constraints of the skeletal joints and of the bulk of the bodies. Beyond such features, the PAM-Comfort(sup)TM software has been conceived to provide direct access to the muscular forces needed by humans to perform physical actions where muscle force is required. The PAM-Comfort(sup)TM human models are made of multi-body linked anatomical skeletons, equipped with finite elements of the relevant skeletal muscles. The hyper-static problem of determination of muscle forces is solved by optimisation technique. Voluntary stiffening of muscles can be added to the basic contraction levels needed to perform a specific task. The calculated muscle forces obey Hills model. The model and software have been applied in several interesting scenarios of various fields of application, such as car industry, handling of equipment and sports activities.