• Molecular & Cellular Toxicology
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• v.4 no.4
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• pp.267-277
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• 2008

Benzene and ethylbenzene (BE), the volatile organic compounds (VOCs) are common constituents of cleaning and degreasing agents, paints, pesticides, personal care products, gasoline and solvents. VOCs are evaporated at room temperature and most of them exhibit acute and chronic toxicity to human. Chronic exposure of benzene is responsible for myeloid leukemia and also ethylbenzene is also recognized as a possible carcinogen. To evaluate the BE effect on human, whole human genome 35 K oligonucleotide microarray were screened for the identification of the differential expression profiling. We identified 280 up-regulated and 201 down-regulated genes changed by more than 1.5 fold by BE exposure. Functional analysis was carried out by using DAVID bioinformatics software. Clustering of these differentially expressed genes were associated with immune response, cytokine-cytokine receptor interaction, toll-like signaling pathway, small cell lung cancer, immune response, apoptosis, p53 signaling pathway and MAPKKK cascade possibly constituting alternative or subordinate pathways of hematotoxicity and immune toxicity. Gene ontology analysis methods including biological process, cellular components, molecular function and KEGG pathway thus provide a fundamental basis of the molecular pathways through BEs exposure in human lymphoma cells. This may provides a valuable information to do further analysis to explore the mechanism of BE induced hematotoxicity.

• Journal of the Korea Society of Computer and Information
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• v.21 no.5
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• pp.127-133
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• 2016

In this paper, an intelligent dimming control system is designed and implemented with the human visual response function using CDS sensor, PIR sensor and temperature sensor, etc. The proposed system is designed to detect a moving object by PIR sensor and to control the LED dimming considering the human visual response. Also, the dimming of LED light can modulate on the app, and simultaneously control dimming in real-world environments with smart phone app. A high-temperature warning or a fire hazard information is transmitted to user's smart phone according to sensor values and Data graph are provided as part of data visualization. Connecting the hardware controller, the proposed intelligent smart dimming control system is expected to contribute to the power reduction interior LED, smart grid building and saving home combining with internet of things.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2004.04a
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• pp.65-72
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• 2004

Long span structures with low natural frequencies such as shopping malls, large offices, and assembly rooms may experience signification dynamic responses due to human activities. In this study, equations to estimate the magnitudes of group walking loads are derived and a simple procedure to estimate and evaluate the corresponding response of the existing and new building structures subjected to human loads is proposed. The effectiveness of the proposed method is verified analytically using a simple floor and experimentally on a footbridge measuring the structural response induced by group pedestrians. Results indicatethat the amplitudes of group walking loads can be easily estimated if the mode shapes are available, and that the corresponding structural responses can be estimated easily by the simple response measurement using the proposed method.

• International Journal of Human Ecology
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• v.5 no.2
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• pp.13-29
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• 2004

Ryff's(1989) psychological well-being measure is used to assess and sometimes compare Korean and American adults, however, there is no information regarding whether its dimensions are psychometrically invariant across, whether its items provide sufficient information for, and whether each item measures identical trait levels in, the two nations. Confirmatory factor analysis on response 1,696 Korean and 3,669 American adults, gave to the measure revealed lack of fit and absence of factorial invariance across the two nations. Item response theory revealed significant variance for items on each factor across two countries that most items yielded limited psychometric information. And that each item measure different trait levels, suggesting that in its present form, the measure might lead to misleading results for, and across the two nations.

• Journal of Biomedical Engineering Research
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• v.16 no.4
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• pp.491-498
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• 1995

A numerical human head/neck model was constructed for analyzing the implication in decleration injuries. This model consists of nine rigid bodies representing the head, cervical vertebrae C1-C7, and T1. These rigid bodies were connected by intervertebral disks described by massless beam elements. Muscles and ligaments were also incoperated in the model represented by nonlinear spring and viscoblastic element respectively Agreement of the analytical kinematic response with the results of experimental data from a volunteer run was satisfactory. Moreover, possible injury estimation from the calculated moment, force variations in the disc, and force variation in ligaments matched well with clinical observations.

• Mycobiology
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• v.39 no.4
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• pp.249-256
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• 2011

Microorganisms are significantly affected when the ambient pH of their environment changes. They must therefore be able to sense and respond to these changes in order to survive. Previous investigators have studied various fungal species to define conserved pH-responsive signaling pathways. One of these pathways, known as the Pal/Rim pathway, is activated in response to alkaline pH signals, ultimately targeting the PacC/Rim101 transcription factor. Although the central signaling components are conserved among divergent filamentous and yeast-like fungi, there is some degree of signaling specificity between fungal species. This specificity exists primarily in the downstream transcriptional targets of this pathway, likely allowing differential adaptation to species-specific environmental niches. In this review, the role of the Pal/Rim pathway in fungal pH response is discussed. Also highlighted are functional differences present in this pathway among human fungal pathogens, differences that allow these specialized microorganisms to survive in the various micro-environments of the infected human host.

• Korean Journal of Computational Design and Engineering
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• v.19 no.4
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• pp.423-433
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• 2014

For the proper decision making and responsibility enhancement for an unexpected accident in large-scale facilities, it is important to train operators or first responders to minimize potential human errors and consequences resulted from them. Simulation technologies, including human-computer interaction and virtual reality, enables personnel to participate in simulated hazardous situations with a safe, interactive, repetitive way to perform these training activities. For the development of accident response training simulator, it is necessary to define components comprising the simulator and to integrate them for the given training purpose. In this paper, we analyze requirements of the training simulator, derive key components, and design the training simulator. Based on the design, we developed a prototype training simulator and verified the simulator through experiments.

• Journal of information and communication convergence engineering
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• v.21 no.1
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• pp.68-74
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• 2023

This study examines the response of users' feelings from a gender perspective toward interactive video mobile learning (IVML). An IVML prototype was developed for the Android platform allowing users to install and make use of the app for m-learning purposes. This study aims to measure the level of feelings toward the IVML prototype and examine the differences in gender perspectives, identify the most responsive feelings between male, and female users as prominent feelings and measure the correlation between user-friendly feeling traits as an independent variable in accordance with gender attributes. The feelings response could then be extracted from the user experience, user interface, and human-computer interaction based on gender perspectives using the Kansei engineering approach as the measurement method. The statistical results demonstrated the different emotional reactions from a male and female perspective toward the IVML prototype may or may not have a correlation with the user-friendly trait, perhaps having a similar emotional response from one to another.

• Journal of the Korean Society of Marine Environment & Safety
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• v.25 no.4
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• pp.413-422
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• 2019

Maritime accidents are always accompanied by human/property damages. If management level ship's of icers properly respond to emergency situation in a correct manner based on knowledge required by international conventions, when maritime accidents occur, it will be possible to minimize such human/property damages. To improve the ability to deal with maritime accidents, this study analyze maritime accident cases to identify which competencies ships' officers' were lacking, compared the emergency response competencies required by international conventions, analyzed various emergency management manuals of shipping companies and carried out questionnaire surveys to suggest improvements of emergency response capability for ship's master. Through the analysis of maritime accidents, it was identified that management level ship's officers lacked competencies regarding damage stability and intact stability, and that the training for emergency response required by international conventions had been insuf iciently carried out. In addition, even though emergency management manuals of ships were generally adequate, it has been identified that there were limitations in terms of practical use of emergency response manual. Therefore, based on the questionnaire, this study proposed the expansion of emergency response training required by international conventions based on use of simulators, and the development of guidelines or manuals for effective and efficient response in emergency situations.

• Korean Journal of Agricultural Science
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• v.48 no.2
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• pp.353-365
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• 2021

Previously, we reported that tissue factor (Tf) was included in the list of differentially expressed genes as an upregulated gene in a rejected porcine heart after xenotransplantation into monkey. In this study, we analyzed that expression of Tf in aortic endothelial cells (pAEC) isolated from alpha 1,3-galactosyltransferase knockout pig in response to allogeneic porcine serum and xenogeneic human serum. The consequence was significant upregulation of Tf expression by responding to human serum compared with porcine serum. To analyze the function of Tf gene as a promoter, we constructed reporter vectors for expression of luciferase linked to 1,246 and 787 base pairs of porcine Tf (pTF1246 and pTF787), and 535 base pairs of human TF (hTF535) sequences including putative promoter regions and AP-1 biding site at the 5' end. The reporter vectors were transfected into pAEC including cytomegalovirus enhancer/chicken β-actin (CAG)-luciferase vector as a control. Luciferase assay showed that all of the promoters were insufficient to express luciferase compared with CAG promoter in basic culture conditions. Notably, pTF1246, pTF787, and hTF535 led to a significant increase of luciferase expression in response to human serum compared with porcine serum while no change of CAG. pTF1246 and pTF787 showed higher expression than hTF535. Taken together, our findings suggest that pTF1246 and pTF787 promoters could mediate target gene expression specifically at xenogeneic stress condition.