• Proceedings of the Safety Management and Science Conference
• /
• 2011.11a
• /
• pp.123-133
• /
• 2011

This paper reviewed the relationship between job stress and human error, and the moderating effect of age and maintenance type on the relationship between job stress and human error in maintenance personnel. Based on the responses from 450 maintenance personnels, the results of multiple regression analysis showed that physiological and psychological stress responses have positively related with human error. In moderating effect test, age appeared to impact on the relationship between physiological/behavioral stress and human error.

• Proceedings of the Korean Society of Precision Engineering Conference
• /
• 2010.11a
• /
• pp.643-644
• /
• 2010

• Molecules and Cells
• /
• v.46 no.4
• /
• pp.191-199
• /
• 2023

The Golgi apparatus modifies and transports secretory and membrane proteins. In some instances, the production of secretory and membrane proteins exceeds the capacity of the Golgi apparatus, including vesicle trafficking and the post-translational modification of macromolecules. These proteins are not modified or delivered appropriately due to the insufficiency in the Golgi function. These conditions disturb Golgi homeostasis and induce a cellular condition known as Golgi stress, causing cells to activate the 'Golgi stress response,' which is a homeostatic process to increase the capacity of the Golgi based on cellular requirements. Since the Golgi functions are diverse, several response pathways involving TFE3, HSP47, CREB3, proteoglycan, mucin, MAPK/ETS, and PERK regulate the capacity of each Golgi function separately. Understanding the Golgi stress response is crucial for revealing the mechanisms underlying Golgi dynamics and its effect on human health because many signaling molecules are related to diseases, ranging from viral infections to fatal neurodegenerative diseases. Therefore, it is valuable to summarize and investigate the mechanisms underlying Golgi stress response in disease pathogenesis, as they may contribute to developing novel therapeutic strategies. In this review, we investigate the perturbations and stress signaling of the Golgi, as well as the therapeutic potentials of new strategies for treating Golgi stress-associated diseases.

• Proceedings of the Korea Water Resources Association Conference
• /
• 2005.09a
• /
• pp.456-457
• /
• 2005

• Journal of Environmental Health Sciences
• /
• v.38 no.1
• /
• pp.1-7
• /
• 2012

Carbon nanotubes (CNTs) stand at the frontier of nanotechnology and are destined to stimulate the next industrial revolution. Rapid increase in their production and use in the technology industry have led to concerns over the effects of CNT on human health and the environment. The prominent use of CNTs in biomedical applications also increases the possibility of human exposure, while properties such as their high aspect ratio (fiber-like shape) and large surface area raise safety concerns for human health if exposure does occur. It is crucial to develop viable alternatives to in vivo tests in order to evaluate the toxicity of engineered CNTs and develop validated experimental models capable of identifying CNTs' toxic effects and predicting their level of toxicity in the human respiratory system. Human lung epithelial cells serve as a barrier at the interface between the surrounding air and lung tissues in response to exogenous particles such as air-pollutants, including CNTs. Monolayer culture of the key individual cell types has provided abundant fundamental information on the response of these cells to external perturbations. However, such systems are limited by the absence of cell-cell interactions and their dynamic nature, which are both present in vivo. In this review, we suggested two viable alternatives to in vivo tests to evaluate the health risk of human exposure to CNTs.

• Clinical and Experimental Reproductive Medicine
• /
• v.14 no.2
• /
• pp.101-108
• /
• 1987

In order to evaluate the consistency of the serum estradiol pattern and response and to determine the influence of number of ovary on them in repeat cycles in the same patient, 57 cycles in 24 patients who underwent in Vitro Fertilization-Embryo Transfer or Gamete Intrafallopian Transfer in Seoul National University Hospital. The patients were stimulated by follicular stimulating hormone and human menopausal gonadotropin and classified as high(${\geqq}$400 pg/ml) and low(<400 pg/ml) response group according to preovulatory estradiol concentration and classified as three estradiol patterns (A,G.B) according to Jones criteria. Seventeen(89.5%) of 19 patients in when a high response to ovulation induction in their first cycle showed a high response. 40%(2/5) of the second ovulation induction cycle were low response in the patient whose first cycle resulted resulted in a low response. Serum estradiol pattern in the first ovulation induction cycle tended to be repeated in the second cycle. Women with high response tended to be more likely to have A and G patterns and less likely to have a cancellation than those with low response. One-ovary patients were at higher risk for inadequate ovulation induction response.

• The Korean Nurse
• /
• v.22 no.1 s.119
• /
• pp.26-29
• /
• 1983

• The Journal of the Korean Society for Microbiology
• /
• v.20 no.1
• /
• pp.45-53
• /
• 1985

This study was undertaken to assess the susceptibility of pigmented and nonpigmented strains of Serratia marcescens to antibiotics and human sera, and the effect of culture filtrates from pigmented and nonpigmented of Serratia marcescens on humoral and cellular immune responses in mice to thymus-dependent and indepependent antigens. Humoral immune response was measured by hemagglutinin (HA) and hemolysin (HE) to sheep red blood cell (SRBC), and Arthus or antibody response to polyvinylpyrrolidone (PVP). The cellular immune response was measured by delayed-type hypersensitivity (DTH) determined by footpad swelling reactin to SRBC. The resistance of pigmented strains of Serratia marcescens to the bactericidal action of heat inactivated human serum was insignificantly greater than that of nonpigmented strains. However, the pigmented strains were significantly more resistant to the bactericidal action of heat-untreated human serum than that of nonpigmented strains. The clinical isolates of Serratia marcestens was also tested for their resistance to several antibiotics. There was no difference between the pigmented and non-pigmented strains in the resistance to carbenicillin. However, nonpigmented strains were more resistant to gentamicin, kanamycin and tobramycin than the pigmented strains. The intraperitoneal administration of culture filtrates from the pigmented or nonpigmented strains into mice caused enhancemented of antibody response to SRBC or PVP, and of DTH to SRBC. Besides, their enhancement of immune responses was more prominent when culture filtrate from the pigmented strains was administered.

• International Journal of High-Rise Buildings
• /
• v.4 no.1
• /
• pp.1-8
• /
• 2015

A team of researchers and practitioners were recently assembled to prepare a monograph on "Wind-Induced Motion of Tall Buildings: Designing for Habitability". This monograph presents a state-of-the-art report of occupant response to wind-induced building motion and acceptability criteria for wind-excited tall buildings. It provides background information on a range of pertinent subjects, including: ${\bullet}$ Physiological, psychological and behavioural traits of occupant response to wind-induced building motion; ${\bullet}$ A summary of investigations and findings of human response to real and simulated building motions based on field studies and motion simulator experiments; ${\bullet}$ A review of serviceability criteria to assess the acceptability of wind-induced building motion adopted by international and country-based standards organizations; ${\bullet}$ General acceptance guidelines of occupant response to wind-induced building motion based on peak acceleration thresholds; and ${\bullet}$ Mitigation strategies to reduce wind-induced building motion through structural optimization, aerodynamic treatment and vibration dissipation/absorption. This monograph is to be published by the American Society of Civil Engineers (ASCE) and equips building owners and tall building design professionals with a better understanding of the complex nature of occupant response to and acceptability of wind-induced building motion. This paper is a brief summary of the works reported in the monograph.

• Transactions of the Korean Society for Noise and Vibration Engineering
• /
• v.21 no.1
• /
• pp.31-40
• /
• 2011

This paper examines the dynamic characteristics of a human carpal muscle through theoretical analysis and experiment. The carpal muscle was modeled as a 1-DOF vibration system and vibration response due to a ramp function force was calculated. The electromyogram signal corresponding to the muscle excitation force was measured, and the excitation force function of an envelope curve from the electromyogram signal was extracted. The ramp input function of electrical stimulation to the carpal muscle was applied by using a device for functional electrical stimulation, and the angular displacements corresponding to steady state response were measured. Theoretical calculations of the vibration response displacements were compared with the experimental results of the angular displacements, and have shown a good agreement with the result that is linearly proportional to the excitation force magnitude. As a result, the relationship between the input current of the electrical stimulation and the excitation force magnitude was inferred. The result was shown that it can be applied to develop rehabilitation training devices.