• 환경생물
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• 제23권2호
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• pp.152-156
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• 2005

Ionizing radiation is a well- known therapy factor for human carcinoma cells. Genotoxic stress mediates cell cycle control, transcription and cellular signaling. In this work, we have used a microarray hybridization approach to characterize the cell type-specific transcriptional response of human carcinoma MCF-7 and HeLa cell line to $\gamma-radiation$, such as 4Gy 4hr. We found that exposure to $\gamma-ray$ alters by at least a $log_2$ factor of 1.0 the expression of known genes. Of the 27 genes affected by irradiation, 11 are down- regulated in MCF-7 cells and 2 genes induced by radiation,15 are repressed in HeLa cells. Many genes were involved in known damage- response pathways for cell cycling, transcription factor and cellular signaling response. However, in MCF-7 cells, we observed gene expression pattern in chromatin, apoptosis, stress, differentiation, cytokine, metabolism, ribosome and calcium. In HeLa cells, it showed clearly the expression changes in adhesion and migration, lysosome, brain, genome instability and translation. These insights reveal new therapy directions for studying the human carcinoma cell response to radiation.

• 대한인간공학회지
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• 제29권3호
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• pp.365-373
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• 2010

Many studies on safety issues of human-machine interaction are being conducted, especially taking emergency situations into consideration. In light of this view, the importance of objective and reliable measurement of users' reactions under emergency situations is becoming more important than ever in reflecting such issues in the design of everyday things. However, despite the need to consider the human-machine interactions and human performances at the design stage, there were few studies which considered human performances and behaviors under emergency situations. This study is about an evaluation method and design guide to include such human performances under emergency situations during human-machine interactions. This is achieved through an experiment where operators are instructed to press the emergency button at an experimentally designed location under a random emergency situation. By analyzing the results in a human factors perspective, the response time and the accuracy of the operators' behaviors are explained. Analysis revealed that in designing the center fascia for automobiles, there is a tradeoff between response time and accuracy, and the optimal size of buttons differ in each part of the center fascia. This method is expected to be applicable to industrial situations to derive optimal position for emergency buttons.

• Asian Pacific Journal of Cancer Prevention
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• 제14권10호
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• pp.5747-5751
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• 2013

Golgi phosphoprotein 2 (GOLPH2) is a very important biomarker in a variety of diseases. Its biological function is not clear, particularly in gastric cancer. To investigate the role of GOLPH2 in human gastric cancer, and determine its effect on the Th1 lymphocyte response, its expression and that of IL-12A were measured by real-time PCR and immunohistochemistry. The relationship between GOLPH2 and IL-12A was analysed statistically. The effect of GOLPH2 on the Th1 lymphocyte response was investigated with an in vitro co-culture system. The results showed that in human gastric cancer, the expression of GOLPH2 was significantly higher and the expression of IL-12A was lower than in normal gastric mucosal tissues, and the expression levels of GOLPH2 and IL-12A were negatively correlated. In addition, obvious down-regulation of the Th1 response was observed when lymphocytes were co-cultured with gastric cancer SGC7901 cells over-expressing GOLPH2. GOLPH2 down-regulated the expression of IL-12A, and inhibited the expression of TNF-${\alpha}$ and IFN-${\gamma}$. The results indicated that GOLPH2 down-regulates the Th1 response via suppression of IL-12A in human gastric cancer, and this might provide a target for the prevention and treatment.

• 한국병원경영학회지
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• 제22권4호
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• pp.1-15
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• 2017

This study was designed to analyze the effect of servicescape and human service quality on patients' internal response and their behavioral intention in dental care organizations. Self-administered survey questionnaires with structured instruments were developed, and a total of 226 responses were used for statistical analyses using SPSS Windows version 18.0 program and AMOS 18.0 program. Major findings of the study are as follows. First, among other servicescape components, air condition environment was found to have a positive effect on patients' cognitive and physiological responses, while signals and symbols had a positive effect on cognitive and emotional responses. Second, the competence, among other factors of the human service quality, had positive influence on cognitive and emotional responses, while customer understanding affected positively on emotional response. Third, none of the servicescape components showed a direct effect on patients' behavioral intention, but their influence was mediated by internal responses. However, customer understanding, among other human service quality factors, had a direct effect on patients' behavioral intention. Fourth, emotional response, among other internal response factors, proved to have positive influence on behavioral intention. Results from this study suggest that dental care service providers can increase their competitiveness and customer satisfaction by understanding and improving the most important areas of servicescape and human service quality.

• 조명전기설비학회논문지
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• 제28권3호
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• pp.63-71
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• 2014

A single-inverted-pendulum model is presented to simulate and predict the passive response of human balance control. This simplified biomechanical model was comprised of a torsional spring and damper, and a lump mass. An estimation of frequency response function was conducted to parameterize the complexity. The frequency domain identification method is used to identify the parameters of the model. The equivalent viscoelastic parameters of standing body were obtained and there was good conformity between the simulation and experimental result.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2004년도 춘계학술대회논문집
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• pp.109-114
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• 2004

Measurement of noise is not only to know the information of acoustic pressure but to assess human response for noise. Provided that want to find human response for transportation noise, we will have to reproduce the measured noise. The method of reproduction is largely divided into monaural and binaural reproduction techniques. Human fundamentally hears sound through both ears, which is binaural hearing. And binaural technique includes the more information of physical phenomena like acoustical reflection and deflection. So, binaural reproduction is more suitable for assessment of the psychoacoustical and physiological response for transportation noise exposures.

• 한국콘텐츠학회논문지
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• 제10권9호
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• pp.432-437
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• 2010

본 연구의 목적은 축제의 서비스스케이프와 인적서비스가 참가자의 감정반응과 행동의도에 어떠한 영향을 미치는지를 소비자인 참가자의 관점에서 분석하였다. 축제의 서비스스케이프는 4개의 공통요인으로 추출되어 청결성, 편의성, 적합성, 매력성으로 명명하였다. 분석결과 축제의 서비스스케이프 변수 중에서 청결성과 편의성이 긍정감정에 정(+)의 영향을 미치며, 부정감정에는 청결성과 편의성 변수가 부(-)의 영향을 미치는 것으로 나타났다. 또한 인적서비스의 친절성, 신뢰성 그리고 전문성 변수 모두가 긍정감정에 정(+)의 영향을 미치는 것으로 분석되었다. 특히 인적서비스 변수 중 전문성은 긍정감정에는 정(+)의 영향을, 부정감정에는 부(-)의 영향을 많이 미치는 것으로 나타났다. 행동의도에 미치는 영향관계 결과는 축제의 서비스스케이프 편의성 요인과 인적서비스 전문성 요인이 영향을 많이 미치는 것으로 나타났다. 그러므로 성공적 축제를 운영하기 위해서는 축제의 서비스스케이프와 인적서비스 요인들을 고려하여 축제전략을 수립하고 운영할 필요가 있다 하겠다.

• 해양환경안전학회지
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• 제25권4호
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• pp.441-447
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• 2019

해사안전을 위한 비상대응훈련 및 해기교육기관의 안전교육은 정해진 시나리오와 교육내용을 기반으로 실시되기 때문에, 다양한 상황에 따른 인적오류 감소와 대응에는 한계가 있다. 이에 대한 개선 필요성이 요구되고 있으나, 기존 교육훈련에 대한 평가와 상황의 다양성 확보를 통한 대응능력 향상을 위한 방안은 부재하다. 본 연구는 비상대응훈련 개선을 위해 상황 다변성을 모델링할 수 있는 이론적 절차 분석기법을 제안한다. 선원과 시스템의 유기적 관계에 기반한 인적 및 시스템 이론적 절차 분석 모델(HSTPA)을 정의하고, 각 구성요소들이 발생시킬 수 있는 오류를 분석, 수직적 보고체계와 대응이 요구되는 화재대응 훈련 시나리오에 이를 적용하여 기존 훈련의 한계점을 식별하였다. 제안된 HSTPA 모델을 적용한 훈련 시나리오 고려요소의 세분화 및 점검은 비상대응훈련 및 교육에 있어 다양하고 현실적인 시나리오 생성과 피훈련자들의 상황판단 이해력 및 대응능력 향상에 도움이 될 것으로 판단된다.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2012년도 춘계학술대회 논문집
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• pp.455-460
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• 2012

Thirteen taxi drivers as the subject in the experiment were exposed to vertical vibration which is controlled on a rigid seat reflecting vibration on passenger vehicle. They were employed not only to get human response of objective measurement but also to make subjective evaluation of the vibration. The subjective evaluation was estimated using the absolute discomfort threshold of the controlled vibration, which was achieved with the three-down one-up method that is widely used in the field of psychophysics. As the result, apparent mass and apparent eccentric mass as objective human response tend to gradually decrease when frequency of the vibration increases. The absolute discomfort threshold was increased in case of increasing the frequency. Concludingly, the subjective discomfort evaluation is highly correlated with the objective human responses at the range of idle vibration on passenger vehicle.

• 한국소음진동공학회논문집
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• 제22권5호
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• pp.422-428
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• 2012

Thirteen taxi drivers as the subject in the experiment were exposed to vertical vibration which is controlled on a rigid seat reflecting vibration on passenger vehicle. They were employed not only to get human response of objective measurement but also to make subjective evaluation of the vibration. The subjective evaluation was estimated using the absolute discomfort threshold of the controlled vibration, which was achieved with the three-down one-up method that is widely used in the field of psychophysics. As the result, apparent mass and apparent eccentric mass as objective human response tend to gradually decrease when frequency of the vibration increases. The absolute discomfort threshold was increased in case of increasing the frequency. Concludingly, the subjective discomfort evaluation is highly correlated with the objective human responses at the range of idle vibration on passenger vehicle.