• Bulletin of the Korean Chemical Society
• /
• v.32 no.2
• /
• pp.719-721
• /
• 2011

• Journal of the Korean housing association
• /
• v.19 no.3
• /
• pp.71-81
• /
• 2008

A traditional Korean housing is a typical type which is contained life style, spatial organization and scape element of people who lived in Korea. In the hanok, people want to be live not only in human environment and traditional culture, but also modem urban housing as a high density. This article deals as follows: First, Hanok as urban housing would be composed in a housing lot, linear type layout, devide building, and cluster type. Second, Housing unit and configuration of Multi family housing can be used single story, second story, second story + single story, multi story and Hanok roofing. Thirds, structure of the building are traditional wooden, combined one of steel and wood or concrete and wood, and the building system in exterior and interior can be seperated into another system. Forth, Image of multi story Hanok A last, consistency of Hanok is not a repeat of an origin but application and creative aptitude of the origin, and multi family housing application of Hanok can be a trial creative.

• Proceedings of the Korean Society of Applied Pharmacology
• /
• 1998.11a
• /
• pp.183-183
• /
• 1998

Telomerase synthesizes telomeric DNA repeats onto chromosome ends de novo. Telomerase activation and telomere shortening in human somatic cells have been implicated in cell tumorigenesis and immortalization. In order to find the potential inhibitors against telomerase activitiy which can be used as potential anticancer agents, we screened about 100 kinds of natural products after partition into n-hexane, ethyl acetate and aqueous layers from methanol extracts. The inhibitory effects of these materials against telomerase enzyme activity were tested in 293T cell culture using telomeric repeat amplification protocol(TRAP). The incorporation of $\^$32/P-dGTP into amplified DNA was measured by adsorption to Whatman DE81 paper instead of using TRAP assay for screening the extracts of natural products. Strong effective compounds were not found in this study but DE81 filter spotting method may be a useful model for the screening. Some of the compounds which showed somewhat inhibitory effects had cytotoxic effects also.

• Proceedings of the Zoological Society Korea Conference
• /
• 2000.10a
• /
• pp.273.1-273
• /
• 2000

No Abstract, See Full Text

• ETRI Journal
• /
• v.33 no.3
• /
• pp.299-309
• /
• 2011

Energy consumption is a key issue in body sensor networks (BSNs) since energy-constrained sensors monitor the vital signs of human beings in healthcare applications. In this paper, packet size optimization for BSNs has been analyzed to improve the efficiency of energy consumption. Existing studies on packet size optimization in wireless sensor networks cannot be applied to BSNs because the different operational characteristics of nodes and the channel effects of in-body and on-body propagation cannot be captured. In this paper, automatic repeat request (ARQ), forward error correction (FEC) block codes, and FEC convolutional codes have been analyzed regarding their energy efficiency. The hop-length extension technique has been applied to improve this metric with FEC block codes. The theoretical analysis and the numerical evaluations reveal that exploiting FEC schemes improves the energy efficiency, increases the optimal payload packet size, and extends the hop length for all scenarios for in-body and on-body propagation.

• Genomics & Informatics
• /
• v.12 no.4
• /
• pp.261-267
• /
• 2014

MicroRNAs (miRNAs) are known for their role in mRNA silencing via interference pathways. Repetitive elements (REs) share several characteristics with endogenous precursor miRNAs. In this study, 406 previously identified and 1,494 novel RE-derived miRNAs were sorted from the GENCODE v.19 database using the RepeatMasker program. They were divided into six major types, based on their genomic structure. More novel RE-derived miRNAs were confirmed than identified as RE-derived miRNAs. In conclusion, many miRNAs have not yet been identified, most of which are derived from REs.

• Archives of Pharmacal Research
• /
• v.26 no.6
• /
• pp.482-486
• /
• 2003

Adult periodontitis is a multifactorial disease characterized by multple genetic and environmental factors. In view of the importance of interleukin-4 (IL-4) gene as a genetic factor for adult periodontitis, we investigated the relationship between two polymorphisms (-590 C $\rightarrow$ T polymorphism and 70 bp repeat polymorphism) of the human IL-4 gene and adult periodontitis in the Korean population. Genomic DNA was extracted from white blood cells of 32 adult periodontitis patients and 150 normal controls, respectively. There were no significant differences in the allele, genotype and haplotype distributions of two polymorph isms between normal controls and adult periodontitis group. Therefore, our results suggest that IL-4 gene locus contributes little to the interindividual susceptibility for adult periodontitis in Korean population.

• The Journal of Korea Robotics Society
• /
• v.16 no.3
• /
• pp.270-275
• /
• 2021

Most of the initial forms of cooperative robots were intended to repeat simple tasks in a given space. So, they showed no significant difference from industrial robots. However, research for improving worker's productivity and supplementing human's limited working hours is expanding. Also, there have been active attempts to use it as a service robot by applying AI technology. In line with these social changes, we produced a mobile manipulator that can improve the worker's efficiency and completely replace one person. First, we combined cooperative robot with mobile robot. Second, we applied speech recognition technology and deep learning based object detection. Finally, we integrated all the systems by ROS (robot operating system). This system can communicate with workers by voice and drive autonomously and perform the Pick & Place task.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.19 no.3
• /
• pp.722-728
• /
• 2005

The DNA topoismerase I inhibitor ${\beta}-lapachone$, the product of a lapacho tree (Tabebuia avellanedae) from South America, activates a novel apoptotic response in a number of cell lines. In the present report, we investigated the effects of ${\beta}-lapachone$ on the growth of human lung in human non-small-cell-lung-cancer A549 cells. Upon treatment with ${\beta}-lapachone$, a concentration-dependent inhibition of cell viability and cell proliferation was observed as measured by hemocytometer counts and MTT assay. The ${\beta}-lapachone-treated$ cells developed many of the hallmark features of apoptosis, including membrane shrinking, condensation of chromatin and DNA fragmentation. These apoptotic effects of ${\beta}-lapachone$ in A549 cells were associated with a marked induction of pro-apoptotic Bax expression, however the levels of anti-apoptotic Bcl-2 expression were decreased in a dose-dependent manner. Accordingly, elevated amount of cyclin-dependent kinase inhibitor p21 expression accompanied by up-regulation of tumor suppressor p53 was observed. By RT-PCR analyses, decrease in gene expression level of telomerase reverse transcriptase and telomeric repeat binding factor were also observed. Thus, these findings suggest that ${\beta}-lapachone$ may be a potential anti-cancer therapeutics for the control of human lung cancer cell model.

• Development and Reproduction
• /
• v.21 no.4
• /
• pp.425-434
• /
• 2017

Polyploidy is occurred by the process of endomitosis or cell fusion and usually represent terminally differentiated stage. Their effects on the developmental process were mainly investigated in the amphibian and fishes, and only observed in some rodents as mammalian model. Recently, we have established tetraploidy somatic cell nuclear transfer-derived human embryonic stem cells (SCNT-hESCs) and examined whether it could be available as a research model for the polyploidy cells existed in the human tissues. Two tetraploid hESC lines were artificially acquired by reintroduction of remained 1st polar body during the establishment of SCNT-hESC using MII oocytes obtained from female donors and dermal fibroblasts (DFB) from a 35-year-old adult male. These tetraploid SCNT-hESC lines (CHA-NT1 and CHA-NT3) were identified by the cytogenetic genotyping (91, XXXY,-6, t[2:6] / 92,XXXY,-12,+20) and have shown of indefinite proliferation, but slow speed when compared to euploid SCNT-hESCs. Using the eight Short Tendem Repeat (STR) markers, it was confirmed that both CHA-NT1 and CHA-NT3 lines contain both nuclear and oocyte donor genotypes. These hESCs expressed pluripotency markers and their embryoid bodies (EB) also expressed markers of the three embryonic germ layers and formed teratoma after transplantation into immune deficient mice. This study showed that tetraploidy does not affect the activities of proliferation and differentiation in SCNT-hESC. Therefore, tetraploid hESC lines established after SCNT procedure could be differentiated into various types of cells and could be an useful model for the study of the polyploidy cells in the tissues.