• 한국데이타베이스학회:학술대회논문집
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• 한국데이타베이스학회 2008년도 연합학회학술대회
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• pp.477-486
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• 2008

This paper examines the evolution issues of regional tourism resources in complicated and networked industry the perspective of co-evolution types and dualism. Regional tourism structure has been changing more and faster according to various attractions and internal and external environment; natural resources, facilities, festivals and events, drama and movies, and public resources, etc. This paper approaches Olikowski's dualism perspective as a theoretical view about the alliance network between region's attractions and tourism industry in Korea. Exploratory analysis was explained the dualism cases performed on the matrix between resource characteristics and alliance complexity on human resources based on regional tourism industry.

• Animal cells and systems
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• 제6권1호
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• pp.81-84
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• 2002

SINE-R retroposons have been derived from human endogenous retrovirus HERV-K family and found to be hominoid specific. Both SINE-R retroposons and HERV_K family are potentially capable of affecting the expression of closely located genes. Using the genomic DNA from patients with schizophrenia, we identified 26 SINE-R retroposons and analyzed them with the sequences derived from the hominoid primates. The SINE-R retroposons from schizophrenia showed 89.7-96.6％ sequence similarities with the sequence of the schizo-cDNA clone that derived from postmortem tissue from the frontal cortex of an individual suffering from schizophrenial. Phylogenetic analysis using the neighbor-joining method revealed that the new SINE-R retroposons in schizophrenia have proliferated independently during hominid evolution. Such retroposons have great relevance to genomic change connected to human diseases. The data suggest that new SINE-R retroposons identified in schizophrenia deserve further investigation as potential leads on the understanding of neuropsychiatric diseases.

• Genomics & Informatics
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• 제3권2호
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• pp.77-80
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• 2005

Targeting of complex system such as human cells rather than biochemically pure molecules will be a useful approach to massively identify ligands specific for the markers associated with human disease such as cancer and simultaneously discover the specific molecular markers. In this study, we developed in vitro selection method to identify nuclease-resistant nucleic acid ligands called RNA aptamers that are specific for human cancer cells. This method is based on the combination of the cell-based selection and subtractive systematic evolution of ligands by exponential enrichment (SELEX) method. These aptamers will be useful for cancer-specific ligands for proteomic research to identify cancer-specific molecular markers as well as tumor diagnosis and therapy.

• 한국실내디자인학회논문집
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• 제21권3호
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• pp.50-57
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• 2012

In Ubiquitous era. architecture is not the old building adapting ubiquitous technology. In order to take the role as new architectural paradigm in space, environment and technology, it has to develop technology continuously and experimental architecture at the same time. it must have co-evolution of architectural field and others through organic network. by that, the evolution of space will be in the way that combines space which is responded to human emotion and user-centric human-friendly. It will be the new paradigm of Ubiquitous digital space. Digital technology resulted in a change to a society as well as to the life of human and its way of thinking. Due to those changes, new terms or concepts come out and a new meaning is added to the conventional concepts. This aims to examine type of spatial contexts for interaction design experience. This study is performed through Literature research for theory by interactive space and case studies for construction elements to design. The range of case study is limited to interaction space in addition of interactive elements and user interface. And analysis conclusion is show the many type, First, Interactive space has special purpose for make a interaction by intelligent elements.(sensor, program, algorithm, New-technology) Second, Interactive space was cooperation with various professional for space purpose. Third. Interactive space is self-develop by algorithm, program, sensor network and that is harmonize with user. finally. Interaction space is show the temper elements about allness, metastatic, activeness, liquidity, relationship. That was written by ecological theory.

• 철학연구
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• 제143권
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• pp.87-118
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• 2017

이 논문에서 필자는 피터 싱어의 인간 개념에서 발견되는 몇 가지 이론적인 모순점들을 보여줄 것이다. 싱어는 인간을 한편으로는 자연에 종속된 존재로 간주하면서 다른 한편으로는 초월적인 존재로 간주한다. 이것이 그의 인간개념의 첫 번째 비일관성이다. 그의 두 번째 비일관성은 이성의 능력에 대한 그의 입장과 관련되어 있다. 그는 이성의 능력이 진화의 산물이라고 믿으면서 동시에 이성능력은 진화의 맹목성에 저항할 수 있는 능력이라고 믿기도 한다. 세 번째로, 인간의 도덕능력에 대한 평가에 있어서도 그는 모순적인 태도를 노출하고 있다. 이 세 가지 모순들을 고려한다면, 싱어는 인간과 동물 간에는 질적인 차이가 없다는 자신의 주장을 증명하지 못했다는 사실이 분명해진다. 싱어의 이론이 대중들의 호응을 얻고 있음에도 불구하고, 필자는 그의 동물해방론의 이론적 기초가 꽤나 허약하다고 생각한다. 필자가 싱어 이론의 약점을 드러내는 이유는 인간이 동물을 무자비하게 다루는 관행으로 로 되돌아가기 위함이 아니라, 동물복지의 미명하에서 인간의 존엄성을 파괴하는 것이 잘못임을 보이기 위함이다.

• 만화애니메이션 연구
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• 통권39호
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• pp.261-295
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• 2015

90년대 말에 등장한 사이버가수는 잠시 등장했다가 사라져 버렸고 2000년대 들어 몇 번의 시도는 있었지만 유의미한 성공사례를 보여주지 못하고 있다. 사이버가수는 대중음악계에서 아이돌 육성시스템의 등장과 IT산업의 기술발달에 힘입어 탄생하게 되었고 '아담'에서 시작해 보컬로이드 '시유'까지 개발되게 된다. 만화나 게임에 등장하는 일반적인 디지털캐릭터와 차별화되는 사이버가수는 음악을 매개로 하는 우상화의 대상이 될 수 있고 다수의 팬덤을 형성하는 특징을 가지고 있다. 따라서 실패를 거듭하고, 유행이 흘러간 컨텐츠로 간주될 수 있겠으나 보컬로이드 같은 새로운 매체를 활용해 지속적인 창작 시도를 하고 있어 진정한 사이버가수 탄생에 대한 기대가 존재한다고 볼 수 있다. 초창기 사이버가수는 인간의 외형만 닮아가려는 노력으로 진행되다가 사이아트와 시유에서 인간의 기능들을 닮아가는 것으로 진화되어 왔다. 본 논문은 과거 등장했다가 사라진 사이버가수가 단순히 실패사례로 끝나지 않고 나름의 인공생명체로 진화하려는 과정 속에서 기술을 발전시키고 기계이미지를 바라보는 대중의 인식변화를 조금씩 이끌었다는 점에서 의미 있는 시도였다고 본다. 더불어 그 진화의 방향성은 인간의 기능을 기계적으로 하나씩 획득하면서 인간과 상호 재미와 감정을 교류하면서 자신만의 외형과 기능을 갖춘 인공생명체로 진화하려는 모습을 갖추고 있다. 이런 논리를 뒷받침하기 위해 브루스 매즐리시의 인간과 기계의 공진화에 대한 연구를 참고했고 90년대 후반부터 등장했던 8개의 사이버가수들의 기획 및 디자인적인 캐릭터성과 가수로써 중요하게 평가되는 목소리(보컬)에 대한 발달과정을 브루스가 연구한 관점에서 사이버가수의 진화과정으로 분석했다. 기계는 인간과 함께 공진화하면서 진화해오고 있다. 사이버가수도 인간의 이데아적 욕망과 죽음에 대한 공포의 양가적 대상으로 인식되고 있지만 새로운 인공생명체가 되려는 개발노력은 지속되고 있다. 따라서 새로운 사이버생명체라면 시유 같은 스타일이 될 가능성이 높다. 왜냐하면 만화적 형태나 기계음 목소리가 인간이 실재 욕망하는 기표의 형태는 아닐 수 있으나 현시대의 대중이 원하는 욕망과 기술적 발달이 교차되는 지점에서 탄생할 수 있는 기표의 형태이기 때문이다.

• Journal of Mechanical Science and Technology
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• 제20권11호
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• pp.1863-1872
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• 2006

In FMS (Flexible Manufacturing System) and CIM (Computer Integrated Manufacturing), machine-tools have been the target of integration in the last three decades. The conventional concept of integration is being changed into the autonomous manufacturing device based on the knowledge evolution by applying advanced information technology in which an open architecture controller, high-speed network and internet technology are included. In the advanced environment, the machine-tools is not the target of integration anymore, but has been the key subject of cooperation. In the near future, machine-tools will be more improved in the form of a knowledge-evolutionary intelligent device. The final goal of this study is to develop an intelligent machine having knowledge-evolution capability and a management system based on internet operability. The knowledge-evolutionary intelligent machine-tools is expected to gather knowledge autonomically, by producing knowledge, understanding knowledge, reasoning knowledge, making a new decision, dialoguing with other machines, etc. The concept of the knowledge-evolutionary intelligent machine is originated from the machine control being operated by human experts' sense, dialogue and decision. The structure of knowledge evolution in M2M (Machine to Machine) and the scheme for a dialogue agent among agent-based modules such as a sensory agent, a dialogue agent and an expert system (decision support agent) are presented in this paper, with intent to develop the knowledge-evolutionary machine-tools. The dialogue agent functions as an interface for inter-machine cooperation. To design the dialogue agent module in an M2M environment, FIPA (Foundation of Intelligent Physical Agent) standard platform and the ping agent based on FIPA are analyzed in this study. In addition, the dialogue agent is designed and applied to recommend cutting conditions and thermal error compensation in a tapping machine. The knowledge-evolutionary machine-tools are expected easily implemented on the basis of this study and shows a good assistance to sensory and decision support agents.

• Molecules and Cells
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• 제44권12호
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• pp.861-878
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• 2021

The human genome contains many retroviral elements called human endogenous retroviruses (HERVs), resulting from the integration of retroviruses throughout evolution. HERVs once were considered inactive junk because they are not replication-competent, primarily localized in the heterochromatin, and silenced by methylation. But HERVs are now clearly shown to actively regulate gene expression in various physiological and pathological conditions such as developmental processes, immune regulation, cancers, autoimmune diseases, and neurological disorders. Recent studies report that HERVs are activated in patients suffering from coronavirus disease 2019 (COVID-19), the current pandemic caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection. In this review, we describe internal and external factors that influence HERV activities. We also present evidence showing the gene regulatory activity of HERV LTRs (long terminal repeats) in model organisms such as mice, rats, zebrafish, and invertebrate models of worms and flies. Finally, we discuss several molecular and cellular pathways involving various transcription factors and receptors, through which HERVs affect downstream cellular and physiological events such as epigenetic modifications, calcium influx, protein phosphorylation, and cytokine release. Understanding how HERVs participate in various physiological and pathological processes will help develop a strategy to generate effective therapeutic approaches targeting HERVs.

• Preventive Nutrition and Food Science
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• 제16권4호
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• pp.394-407
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• 2011

Better understanding of the complex factors leading to human diseases will be necessary for both long term prevention and for managing short and long-term health problems. The underlying causes, leading to a global health crisis in both acute and chronic diseases, include finite global health care resources for sustained healthy human survival, the population explosion, increased environmental pollution, decreased clean air, water, food distribution, diminishing opportunities for human self-esteem, increased median life span, and the interconnection of infectious and chronic diseases. The transition of our pre-human nutritional requirements for survival to our current culturally-shaped diet has created a biologically-mismatched human dietary experience. While individual genetic, gender, and developmental stage factors contribute to human diseases, various environmental and culturally-determined factors are now contributing to both acute and chronic diseases. The transition from the hunter-gatherer to an agricultural-dependent human being has brought about a global crisis in human health. Initially, early humans ate seasonally-dependent and calorically-restricted foods, during the day, in a "feast or famine" manner. Today, modern humans eat diets of caloric abundance, at all times of the day, with foods of all seasons and from all parts of the world, that have been processed and which have been contaminated by all kinds of factors. No longer can one view, as distinct, infectious agent-related human acute diseases from chronic diseases. Moreover, while dietary and environmental chemicals could, in principle, cause disease pathogenesis by mutagenic and cytotoxic mechanisms, the primary cause is via "epigenetic", or altered gene expression, modifications in the three types of cells (e.g., adult stem; progenitor and terminally-differentiated cells of each organ) during all stages of human development. Even more significantly, alteration in the quantity of adult stem cells during early development by epigenetic chemicals could either increase or decrease the risk to various stem cell-based diseases, such as cancer, later in life. A new concept, the Barker hypothesis, has emerged that indicates pre-natal maternal dietary exposures can now affect diseases later in life. Examples from the studies of the atomic bomb survivors should illustrate this insight.

• BMB Reports
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• 제51권11호
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• pp.584-589
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• 2018

Secondary prevention via earlier detection would afford the greatest chance for a cure in premalignant lesions. We investigated the exomic profiles of non-malignant and malignant changes in head and neck squamous cell carcinoma (HNSCC) and the genomic blueprint of human papillomavirus (HPV)-driven carcinogenesis in oropharyngeal squamous cell carcinoma (OPSCC). Whole-exome (WES) and whole-genome (WGS) sequencing were performed on peripheral blood and adjacent non-tumor and tumor specimens obtained from eight Korean HNSCC patients from 2013 to 2015. Next-generation sequencing yielded an average coverage of $94.3{\times}$ for WES and $35.3{\times}$ for WGS. In comparative genomic analysis of non-tumor and tumor tissue pairs, we were unable to identify common cancer-associated early mutations and copy number alterations (CNA) except in one pair. Interestingly, in this case, we observed that non-tumor tonsillar crypts adjacent to HPV-positive OPSCC appeared normal under a microscope; however, this tissue also showed weak p16 expression. WGS revealed the infection and integration of high-risk type HPV16 in this tissue as well as in the matched tumor. Furthermore, WES identified shared and tumor-specific genomic alterations for this pair. Clonal analysis enabled us to infer the process by which this transitional crypt epithelium (TrCE) evolved into a tumor; this evolution was accompanied by the subsequent accumulation of genomic alterations, including an ERBB3 mutation and large-scale CNAs, such as 3q27-qter amplification and 9p deletion. We suggest that HPV16-driven OPSCC carcinogenesis is a stepwise evolutionary process that is consistent with a multistep carcinogenesis model. Our results highlight the carcinogenic changes driven by HPV16 infection and provide a basis for the secondary prevention of OPSCC.