• 국제학술발표논문집
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• The 1th International Conference on Construction Engineering and Project Management
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• pp.1007-1012
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• 2005

Although the design-build (DB) delivery system has been taking great strides in the world and relevant researches have also been quite abundant, few studies have dealt with its potential impacts on the construction industry as a whole. This research first identified the potential entry barrier factors, which may hinder the market access, based on the theory of industrial economics and characteristics of DB project. Then through a nation-wide questionnaire survey involving 103 construction contractors and engineering consultants, the influences of each factor on company's competitiveness and corporate strategies were scrutinized, and consequently, the evolution of the construction industry was examined. It is found that as opposed to the traditional design-bid-build delivery system, the DB delivery system elevates competitive advantages of large organizations in terms of the financial capability, working experience, human resource, and administrative strength, and among them, the financial strength was concluded to be the most significant force in differentiating corporate strategies and widening the gap of competitiveness between companies. It is inferred if the government extensively adopts DB delivery system, large organizations that already possess the competitive advantage tend to obtain both design and construction abilities, and dominate the DB market. Small and medium sized companies will find little room to maneuver and be forced to become specialty sub-contractors.

• 한국수정란이식학회:학술대회논문집
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• 한국수정란이식학회 2002년도 국제심포지엄
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• pp.56-62
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• 2002

The International Union for Conservation of Nature and Natural Resources (IUCN) considers the western/lowland bongo Tragelaphus eurycerus eurycerus to be a threatened species, and the eastern/mountain bongo Tragelaphus eurycerus isaaci an endangered species［1］. Although extinction is considered by many biologists to be a natural process during evolution, the exponential growth of the human population has drastically and prematurely reduced the numbers and genetic diversity of many species［2］. Species have evolved to adapt to a specific habitat or environment that meet their survival needs. Alteration or destruction of their habitat results in a species becoming incapable of adapting and hence becoming threatened with extinction. A widespread scientific and public consensus has emerged suggesting that governments should assign high priority to the maintenance of biological diversity via habitat preservation and management far species conservation［3］. Unfortunately, the loss of biological diversity far surpasses the available conservation resources and species are lost forever on a daily basis［4］. Notwithstanding the focus on habitat preservation and wildlife management, conservation biologists have also become increasingly interested in using the technologies of reproductive and developmental biology to help manage or rescue endangered species［5］.

• Journal of Korean Neurosurgical Society
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• 제66권2호
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• pp.113-120
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• 2023

Artificial intelligence (AI) is a field of computer science that equips machines with human-like intelligence and enables them to learn, reason, and solve problems when presented with data in various formats. Neurosurgery is often at the forefront of innovative and disruptive technologies, which have similarly altered the course of acute and chronic diseases. In diagnostic imaging, such as X-rays, computed tomography, and magnetic resonance imaging, AI is used to analyze images. The use of robots in the field of neurosurgery is also increasing. In neurointensive care units, AI is used to analyze data and provide care to critically ill patients. Moreover, AI can be used to predict a patient's prognosis. Several AI applications have already been introduced in the field of neurosurgery, and many more are expected in the near future. Ultimately, it is our responsibility to keep pace with this evolution to provide meaningful outcomes and personalize each patient's care. Rather than blindly relying on AI in the future, neurosurgeons should gain a thorough understanding of it and use it to enhance their patient care.

• International Journal of Advanced Culture Technology
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• 제11권1호
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• pp.253-262
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• 2023

Chinese traditional patterns, which are part of our national precious heritage, have a long history. Tiger culture plays a very important role in folk art. In modern society, it is a symbol of human spirit and morality. The tiger pattern is also a unique traditional pattern in Chinese folklore. From the Spring and Autumn period to modern society, the tiger pattern has evolved in form through thousands of years of development. It is also a representative intangible cultural heritage in contemporary times. It plays a special role in the cultural exchange of different regions, resulting in the generation of the creation of folk art with great local characteristics. Therefore, traditional tiger patterns are an important part of traditional Chinese folk culture and art. In this study, by analyzing the development and evolution history of Chinese traditional tiger patterns, the application methods of Chinese traditional tiger patterns were summarized, the rich cultural connotation, artistic characteristics and application of traditional tiger pattern in modern fashion design were discussed. In contemporary design, the new and improved tiger pattern styles were explored, intangible cultural heritage was interpreted and inherited, and the cultural and artistic values contained therein were extracted. The author combined with modern fashion design, according to people's aesthetic taste and design principles, it is recreated,so that the traditional pattern has certain characteristics of The Times.But at the same time it retains its original character,and the traditional tiger pattern was inherited and the cultural connotation of clothing design was enriched.

• 센서학회지
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• 제32권6호
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• pp.340-351
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• 2023

Wearable sensors designed for strain, pressure, and temperature measurements are essential for monitoring human movements, health status, physiological data, and responses to external stimuli. Notably, recent research has led to the development of high-performance wearable sensors using innovative materials and device structures that exhibit ultra-high sensitivity compared with their commercial counterparts. However, the quest for accurate sensing has identified a critical challenge. Specifically, the mechanical flexibility of the substrates in wearable sensors can introduce interference signals, particularly when subjected to varying external stimuli and environmental conditions, potentially resulting in signal crosstalk and compromised data fidelity. Consequently, the pursuit of non-interference sensing technology is pivotal for enabling independent measurements of concurrent input signals related to strain, pressure, and temperature, ensuring precise signal acquisition. In this comprehensive review, we present an overview of the recent advances in noninterference sensing strategies. We explore various fabrication methods for sensing strain, pressure, and temperature, emphasizing the use of hybrid composite materials with distinct mechanical properties. This review contributes to the understanding of critical developments in wearable sensor technology that are vital for their ongoing application and evolution in numerous fields.

• BMB Reports
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• 제57권1호
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• pp.2-11
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• 2024

Advancements in gene and cell therapy have resulted in novel therapeutics for diseases previously considered incurable or challenging to treat. Among the various contributing technologies, genome editing stands out as one of the most crucial for the progress in gene and cell therapy. The discovery of CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and the subsequent evolution of genetic engineering technology have markedly expanded the field of target-specific gene editing. Originally studied in the immune systems of bacteria and archaea, the CRISPR system has demonstrated wide applicability to effective genome editing of various biological systems including human cells. The development of CRISPR-based base editing has enabled directional cytosine-to-thymine and adenine-to-guanine substitutions of select DNA bases at the target locus. Subsequent advances in prime editing further elevated the flexibility of the edit multiple consecutive bases to desired sequences. The recent CRISPR technologies also have been actively utilized for the development of in vivo and ex vivo gene and cell therapies. We anticipate that the medical applications of CRISPR will rapidly progress to provide unprecedented possibilities to develop novel therapeutics towards various diseases.

• Journal of Gastric Cancer
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• 제24권1호
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• pp.29-56
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• 2024

In recent years, remarkable progress has been made in the molecular profiling of gastric cancer. This progress has led to the development of various molecular classifications to uncover subtype-specific dependencies that can be targeted for therapeutic interventions. Human epidermal growth factor receptor 2 (HER2) is a crucial biomarker for advanced gastric cancer. The recent promising results of novel approaches, including combination therapies or newer potent agents such as antibody-drug conjugates, have once again brought attention to anti-HER2 targeted treatments. In HER2-negative diseases, the combination of cytotoxic chemotherapy and programmed cell death-1/programmed cell death ligand-1 (PD-1/PD-L1) inhibitors has become the established standard of care in first-line settings. In the context of gastric cancer, potential biomarkers such as PD-L1 expression, Epstein-Barr virus, microsatellite instability, and tumor mutational burden are being considered for immunotherapy. Recently, promising results have been reported in studies on anti-Claudin18.2 and fibroblast growth factor receptor 2 treatments. Currently, many ongoing trials are aimed at identifying potential targets using novel approaches. Further investigations will be conducted to enhance the progress of these therapies, addressing challenges such as primary and acquired resistance, tumor heterogeneity, and clonal evolution. We believe that these efforts will improve patient prognoses. Herein, we discuss the current evidence of potential targets for systemic treatment, clinical considerations, and future perspectives.

• 환경생물
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• 제38권4호
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• pp.650-657
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• 2020

본 연구는 동해유입하천(강릉 연곡천, 양양 남대천), 한강수계(섬강, 속사천), 낙동강수계(길안천)에 서식하는 참갈겨니(Zacco koreanus) 개체군을 대상으로 채집된 110개체로부터 미토콘드리아 DNA COI 유전자(mitochondrial DNA cytochrome oxidase I)를 분자마커로 이용하여 계통지리학적 분석을 수행하고, 추가적으로 강릉 연곡천 상·중·하류 개체군을 대상으로 집단유전학적 분석을 수행하였다. 계통지리학 분석 결과, 동해유입하천과 한강수계의 참갈겨니 개체군은 동일한 단일계통을 나타내었고, 낙동강수계의 개체군은 상이한 계통으로 분기됨을 나타내었으며, 다른 수계 계통과의 유전적 거리 수치 범위가 평균 4.0%(3.7~4.2%)로서 동일종 이상 수준을 보여 잠재종 가능성을 시사하였다. 참갈겨니가 서식하는 수계에 따른 형태학적 차이는 연구된 바 있으나 DNA 염기서열의 변이를 이용한 분자유전학적 연구는 부족한 실정이므로 본 연구 결과는 향후 낙동강수계 참갈겨니 개체군의 계통분류학적 연구에 기초자료로 활용될 수 있을 것으로 판단된다. 추후 집단유전체학 및 생태학적 분석을 통하여 관찰된 낙동강수계 계통이 다른 종, 잠재종 혹은 단순히 큰 수준의 종내 변이를 나타내는지에 대한 추가적인 연구가 필요하다. 강릉 연곡천 상·중·하류에 서식하는 개체군의 집단유전학 분석을 통해 중류의 개체군이 상대적으로 높은 다양성을 나타냈으며 상·중·하류 개체군 간의 유전적 차이는 나타나지 않았다. 이는 상·중·하류 개체군 간 유전자 확산이 원활하게 이루어지고 있음을 의미하며 하천의 개체군 간 연결성을 판단할 수 있는 지표로 활용될 수 있다. 하지만 생태학적 시간 스케일의 연구에 더 적합한 분자마커를 이용한 추후 연구가 필요할 것으로 사료된다.

• 한국철학논집
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• 제36호
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• pp.319-352
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• 2013

본 논문은 한국과 중국의 신문화운동 시기, 양수명과 이돈화의 근대화에 대한 견해 및 그 철학적 근거에 대해 비교, 검토함을 목적으로 한다. 이 시기 두 인물의 한중 양국 신문화운동에 대한 적극성은 달랐지만 서구적 근대화에 대한 태도 및 이 태도를 정당화하는 생명철학적 근거에는 많은 유사점이 있다. 양수명은 서구적 근대화에 찬동하면서 서구에서 과학과 민주가 발전할 수 있었던 정신적 동력의 문제에 대해 삶의 세 가지 근본문제, 그에 대한 인간의 세 가지 태도, 이로부터 유형화한 세 가지 문화 및 그것의 3단계 재현설 등을 통해 체계적으로 답변했고 생명의 자기중심성에 대한 주목에서 출발해 자기와 타자의 분리를 전제로 이성을 동원해 대상을 계산하고 개조하는 삶의 태도를 서양의 정신으로 규정함으로써 그것에 대한 문제의식의 첨예성을 드러냈다. 한편 이돈화는 서구적 근대화에 대해 기본적으로 찬동하면서도 처음부터 서구적 근대의 병폐를 지적하고 이를 천도교의 인내천(人乃天)주의로 극복하려 했다. 근대 과학을 수용하면서도 신비는 여전히 유효하다는 주장, 진화론을 수용하면서도 이것이 천도교 식 창조론과 모순되지 않는다는 주장, 서구의 생철학적 개념을 사용하면서도 동학의 교의에 입각해 생명의 타자 연관성, 협동성, 연대성을 강조하는 점 등이 그것이다. 이렇게 근대를 수용하면서도 근대를 넘어서려는 그의 태도는 양수명보다 한발 앞선 것 같지만, 아쉽게도 그에게는 서양의 정신에 대한 첨예한 문제의식이 보이지 않으며, 그로 인해 그의 서구 근대에 대한 비판은 양수명처럼 이성에 대한 비판으로까지 나아가지 못하고 있다.

• IMMUNE NETWORK
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• 제4권1호
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• pp.23-30
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• 2004

Background: A human orthologue of mouse S100A6-binding protein (CacyBP), Siah-1-interacting protein (SIP) had been shown to be a component of novel ubiquitinylation pathway regulating $\beta$-catenin degradation. The role of the protein seems to be important in cell proliferation and cancer evolution but the expression pattern of SIP in actively dividing cancer tissues has not been known. For the elucidation of the role of SIP protein in carcinogenesis, it is essential to produce monoclonal antibodies specific to the protein. Methods: cDNA sequence coding for ORF region of human SIP gene was amplified and cloned into an expression vector to produce His-tag fusion protein. Recombinant SIP protein and monoclonal antibody to the protein were produced. The N-terminal specificity of anti-SIP monoclonal antibody was conformed by immunoblot analysis and enzyme linked immunosorbent assay (ELISA). To study the relation between SIP and colon carcinogenesis, the presence of SIP protein in colon carcinoma tissues was visualized by immunostaining using the monoclonal antibody produced in this study. Results: His-tag-SIP (NSIP) recombinant protein was produced and purified. A monoclonal antibody (Korea patent pending; #2003-45296) to the protein was produced and employed to analyze the expression pattern of SIP in colon carcinoma tissues. Conclusion: The data suggested that anti-SIP monoclonal antibody produced here was valuable for the diagnosis of colon carcinoma and elucidation of the mechanism of colon carcinogenesis.