• Journal of Genetic Medicine
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• v.9 no.2
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• pp.67-72
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• 2012

The generation of induced pluripotent stem cells (iPSCs) derived from patients' somatic cells provides a new paradigm for studying human genetic diseases. Human iPSCs which have similar properties of human embryonic stem cells (hESCs) provide a powerful platform to recapitulate the disease-specific cell types by using various differentiation techniques. This promising technology has being realized the possibility to explore pathophysiology of many human genetic diseases at the molecular and cellular levels. Furthermore, disease-specific human iPSCs can also be used for patient-based drug screening and new drug discovery at the stage of the pre-clinical test in vitro. In this review, we summarized the concept and history of cellular reprogramming or iPSC generation and highlight recent progresses for disease modeling using patient-specific iPSCs.

• International Journal of Control, Automation, and Systems
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• v.4 no.2
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• pp.227-235
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• 2006

For a sophisticated humanoid that explores and learns its environment and interacts with humans, anthropomorphic physical behavior is much desired. The human vision system orients each eye with three-degree-of-freedom (3-DOF) in the directions of horizontal, vertical and torsional axes. Thus, in order to accurately replicate human vision system, it is imperative to have a simulator with 3-DOF end-effector. We present a 3-DOF anthropomorphic oculomotor system that reproduces realistic human eye movements for human-sized humanoid applications. The parallel link architecture of the oculomotor system is sized and designed to match the performance capabilities of the human vision. In this paper, a biologically-inspired mechanical design and the structural kinematics of the prototype are described in detail. The motility of the prototype in each axis of rotation was replicated through computer simulation, while performance tests comparable to human eye movements were recorded.

• 제어로봇시스템학회:학술대회논문집
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• 2005.06a
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• pp.1753-1758
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• 2005

Human Adaptive Mechatronics (HAM), which is a system concept to adapt human characteristics, has been proposed. As the HAM application, this paper addresses an information emphasis scheme to alert some hazards which are undetectable by a human operator. The emphasis scheme employs cognitive psychological approach to human discrimination characteristics because excess or deficient emphasis may disturb the operation. One of advantages of teleoperation system is able to include human valuable abilities as global environment recognition, planning, prediction and so on. To implement these abilities to mechanical system is difficult because of not enough intelligence. Proposed teleoperation system is designed to progress the human abilities, and moreover, to not disturb the abilities. In this paper, we consider that the discrimination characteristics depend on window positions on GUI display and operator's individuality. Finally, the efficiency of the alert scheme is verified by some experiments.

• Proceedings of the ESK Conference
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• 1996.10a
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• pp.125-140
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• 1996

Human Factors Engineering(HFE) program should be developed from the early stage of the design process for Nuclear Power Plant. The HFE program is conducted in accordance with the guidance in the Standard Review Plan(SRP) NUREG 0800, Chapter 18. The major purpose of this program is to reduce the incidence of human error during the operating life of the plants. A comprehensive human factors program is prepared by KOPEC to assure that key elements of human factors involvement are not inadvertently overlooked and the early, complete, and continuing inclusion of HFE in the design process. This paper is to introduce engineering steps of the HF activities to verify that the HF involvements on man-machine interface are adequate to support safe and efficient operation of nuclear power plant. If systems are developed without sufficient consideration on the HFE in the design, such systems may cost a high price due to the malfunction of the plant induced by the human errors.

• The Journal of the Acoustical Society of Korea
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• v.25 no.4E
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• pp.159-165
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• 2006

Human, horse and rat bloods in a cylindrical chamber where flow was controlled by a stirring magnet were used for studying red blood cell aggregation. Ultrasound backscattered powers from blood were obtained from the backscattered signals measured by a 5 MHz focused transducer in a pulse-echo setup. The experimental results showed the differences in red blood cell (RBC) aggregation tendency among the three mammalian species with an order of horse > human > rat. The ultrasound backscattered power decreased with stirring speed in human and horse blood, but no variations were observed in rat blood. Sudden flow stoppage led to the slow increase of the backscattered power for human and horse blood. There was no self-aggregation tendency in rat blood. The enveloped echo images showed the spatial and temporal variations of RBC aggregations in the cylindrical chamber. These observations from the different mammalian species may give a better understanding of the mechanism of RBC aggregation.

• Journal of the Korean Society of Safety
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• v.12 no.4
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• pp.201-208
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• 1997

In order to improve the safety of nuclear power plant, we performed a human factors review for the CFMS(Critical Function Monitoring system) design of nuclear power plant. Three works were performed in this study. In first work, we developed human factors engineering program plan(HFEPP) and human factors engineering verification and validation plan (HFE-V & V plan) to effectively perform CFMS design and review. In second work, we identified human engineering discrepancies(HEDs) for CFMS design through human factors design review and proposed those resolutions. In the third work, we developed the evaluation and management methodology for identified KEDs. Methodology developed in this study can be used in other complex system as well as in CFMS design review.

• Journal of Korea Multimedia Society
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• v.21 no.4
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• pp.478-484
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• 2018

The choice of the motion features influences the result of the human action recognition method directly. Many factors often influence the single feature differently, such as appearance of the human body, environment and video camera. So the accuracy of action recognition is restricted. On the bases of studying the representation and recognition of human actions, and giving fully consideration to the advantages and disadvantages of different features, the Dense Trajectories(DT) algorithm is a very classic algorithm in the field of behavior recognition feature extraction, but there are some defects in the use of optical flow images. In this paper, we will use the improved Dense Trajectories(iDT) algorithm to optimize and extract the optical flow features in the movement of human action, then we will combined with Support Vector Machine methods to identify human behavior, and use the image in the KTH database for training and testing.

• Journal of Institute of Control, Robotics and Systems
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• v.22 no.4
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• pp.288-292
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• 2016

In this paper, we propose an infrared image based human victim recognition method for a search and rescue robot in dark environments, like general disaster situations. For recognizing a human victim, an infrared camera on a RGB-D camera, Microsoft Kinect, is used. The contrast and brightness of the infrared image are first improved by histogram equalization, and the noise on the image is removed by morphological operation and Gaussian filtering. For recognizing a human victim, the binarization and blob labeling methods are applied to the improved image. Finally, for verifying the effectiveness and feasibility of the proposed method, an experiment for human victim recognition is carried out in a dark environment.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.24 no.10
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• pp.1390-1393
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• 2020

Recently, a hologram-like system and a virtual human to provide a realistic experience has been serviced in various places such as musical performance and museum exhibition. Also, the realistically responded virtual human in the hologram-like system need to be expressed in a way that matches the users' interaction. In this paper, to improve the feeling of being in the same space with a virtual human in the hologram-like system, user's gesture based interactive contents were presented, and the effectiveness of interaction was evaluated. Our approach was found that the gesture based interaction was provided a higher sense of co-presence for immersion with the virtual human.

• Journal of Biomedical Engineering Research
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• v.45 no.2
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• pp.57-65
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• 2024

Recently, several studies have been conducted to lower the cost of transport of human by adding external joint stiffness elements. However, it has not been clearly elucidated whether adaptation time is required for human subjects to adapt to the added external joint stiffness. In this study, carbon plates in the form of shoe midsoles were added to the metatarsophalangeal joint, and the lower limb joint torque and mechanical energy consumption were compared before and after a total of 5 sessions (2.5 weeks) of running. A total of 11 young healthy participants exhibited higher elastic energy storage in carbon plates in the fifth session compared to the first session, and lower power in the ankle joint. This suggests that a single training session may be insufficient to validate the efficiency effect of added joint stiffness, and the human body seems to increase the elastic energy stored in the assistive joint stiffness and its reutilization.