• Information Systems Review
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• v.4 no.2
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• pp.309-322
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• 2002

In this paper, we study changes in company revenue structure. For this, we introduce a new concept for an expanded e-business community - Supra Hub. Based on this concept, we analyze current problems with regard to revenue structure in industry-specific cases and propose advisable alternatives. These alternatives are derived from Burts research on Network and Organization. We conclude that new community is coming connecting industry-specific networks.

• Korean Management Science Review
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• v.18 no.2
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• pp.39-60
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• 2001

This Paper deals with a collaborative decision making procedure of web-based DSS for supply chain management (SCM). The seemingly autonomous DSS dedicated to each of mutually exclusive prob1em domains forms a communication network and cooperates each other for better SCM decision making. We a1so propose a hub-spoke information sharing model for the DSS network. In the hub-spoke model, an information hub at the center facilitates information exchange between DSS\\`s and controls the conversations defined by the series of XML messages between agents of DSS. A product ordering scenario where supply decision is triggered upon customer order is used to demonstrate the SCM decision procedure through a collaboration of the web-based DSS.

• Journal of KIISE:Computer Systems and Theory
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• v.34 no.5_6
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• pp.202-213
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• 2007

A network is an important model widely used in natural and social science as well as engineering. To analyze these networks easily it is necessary that we should layout the features of networks visually. These Graph-Layout researches have been performed recently according to the development of the computer technology. Among them, the Scale-free Network that stands out in these days is widely used in analyzing and understanding the complicated situations in various fields. The Scale-free Network is featured in two points. The first, the number of link(Degree) shows the Power-function distribution. The second, the network has the hub that has multiple links. Consequently, it is important for us to represent the hub visually in Scale-free Network but the existing Graph-layout algorithms only represent clusters for the present. Therefor in this thesis we suggest Graph-layout algorithm that effectively presents the Scale-free network. The Hubity(hub+ity) repulsive force between hubs in suggested algorithm in this thesis is in inverse proportion to the distance, and if the degree of hubs increases in a times the Hubity repulsive force between hubs is ${\alpha}^{\gamma}$ times (${\gamma}$??is a connection line index). Also, if the algorithm has the counter that controls the force in proportion to the total node number and the total link number, The Hubity repulsive force is independent of the scale of a network. The proposed algorithm is compared with Graph-layout algorithm through an experiment. The experimental process is as follows: First of all, make out the hub that exists in the network or not. Check out the connection line index to recognize the existence of hub, and then if the value of connection line index is between 2 and 3, then conclude the Scale-free network that has a hub. And then use the suggested algorithm. In result, We validated that the proposed Graph-layout algorithm showed the Scale-free network more effectively than the existing cluster-centered algorithms[Noack, etc.].

• Genomics & Informatics
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• v.19 no.4
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• pp.42.1-42.17
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• 2021

Salivary gland carcinoma (SGC) is rare cancer, constituting 6% of neoplasms in the head and neck area. The most responsible genes and pathways involved in the pathology of this disorder have not been fully understood. We aimed to identify differentially expressed genes (DEGs), the most critical hub genes, transcription factors, signaling pathways, and biological processes (BPs) associated with the pathogenesis of primary SGC. The mRNA dataset GSE153283 in the Gene Expression Omnibus database was re-analyzed for determining DEGs in cancer tissue of patients with primary SGC compared to the adjacent normal tissue (adjusted p-value < 0.001; |Log2 fold change| > 1). A protein interaction map (PIM) was built, and the main modules within the network were identified and focused on the different pathways and BP analyses. The hub genes of PIM were discovered, and their associated gene regulatory network was built to determine the master regulators involved in the pathogenesis of primary SGC. A total of 137 genes were found to be differentially expressed in primary SGC. The most significant pathways and BPs that were deregulated in the primary disease condition were associated with the cell cycle and fibroblast proliferation procedures. TP53, EGF, FN1, NOTCH1, EZH2, COL1A1, SPP1, CDKN2A, WNT5A, PDGFRB, CCNB1, and H2AFX were demonstrated to be the most critical genes linked with the primary SGC. SPIB, FOXM1, and POLR2A significantly regulate all the hub genes. This study illustrated several hub genes and their master regulators that might be appropriate targets for the therapeutic aims of primary SGC.

• The Korean Journal of Physiology and Pharmacology
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• v.28 no.1
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• pp.59-72
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• 2024

To investigate the mechanism of Wenshen Xuanbi Decoction (WSXB) in treating osteoarthritis (OA) via network pharmacology, bioinformatics analysis, and experimental verification. The active components and prediction targets of WSXB were obtained from the TCMSP database and Swiss Target Prediction website, respectively. OA-related genes were retrieved from GeneCards and OMIM databases. Protein-protein interaction and functional enrichment analyses were performed, resulting in the construction of the Herb-Component-Target network. In addition, differential genes of OA were obtained from the GEO database to verify the potential mechanism of WSXB in OA treatment. Subsequently, potential active components were subjected to molecular verification with the hub targets. Finally, we selected the most crucial hub targets and pathways for experimental verification in vitro. The active components in the study included quercetin, linolenic acid, methyl linoleate, isobergapten, and beta-sitosterol. AKT1, tumor necrosis factor (TNF), interleukin (IL)-6, GAPDH, and CTNNB1 were identified as the most crucial hub targets. Molecular docking revealed that the active components and hub targets exhibited strong binding energy. Experimental verification demonstrated that the mRNA and protein expression levels of IL-6, IL-17, and TNF in the WSXB group were lower than those in the KOA group (p < 0.05). WSXB exhibits a chondroprotective effect on OA and delays disease progression. The mechanism is potentially related to the suppression of IL-17 and TNF signaling pathways and the down-regulation of IL-6.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.39C no.12
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• pp.1250-1260
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• 2014

In this paper, a novel resource scheduling, which is used for hub network based long distance airborne tactical communication, is proposed. Recently, some countries of the world has concentrated on developing data rate and networking performance of CDL, striving to keep pace with modern warfare, which is changed into NCW. And our government has also developed the next generation high capacity CDL. In hub network, a typical communication structure of CDL, hybrid FDMA/TDMA can be considered to exchange high rate data among multiple UAVs simultaneously, within limited bandwidth. However, due to different RTT and traffic size of UAV, idle time resource and unnecessary packet transmission delay can occur. And these losses can reduce entire efficiency of hub network in long distance communication. Therefore, in this paper, we propose RTT and data traffic size based UAV scheduling, which selects time/frequency resource of UAVs by using iterative sorting algorithm. The simulation results verified that the proposed scheme improves data rate and packet delay performance in low complexity.

• Proceedings of the KSR Conference
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• 2010.06a
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• pp.1589-1595
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• 2010

China has experienced rapid economic growth and burgeoning trade since it began economic reforms and an opening policy. With this the amount of marine cargoes between Korea and China had been increased Recently this increasing rate of cargoes, the development of the Yellow Sea Sub-Region and the change of the Northeast Asian logistics network have acted as important factors of Korea's strategy to be the Northeast Asian logistics hub. This paper analyzes China's inland transport network to offer basic understanding on transport and logistics network in China. Therefore, the outcomes of this paper could be used as basic materials to further transport and logistics cooperation between China and Korea and to developing a more realistic plan to complete Korea's Northeast Asia logistics hub strategy.

• Journal of Korean Society of Transportation
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• v.28 no.6
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• pp.167-177
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• 2010

This study proposes a methodology for assessing the improvement of network connectivity of transport hubs. Extending a previously developed model that measures the connectivity of a node in transportation networks, we define two quantities called the supplied connectivity and the experienced connectivity. Using these quantities, we provide a systematic procedure for analyzing the network connectivity of a transport hub and also suggest criteria for determining whether a given project is effective in improving the network connectivity of the transport hub. The application of the methodology to a test site produces reasonable results, and as such it is expected that the methodology can be used for various transport hubs in the national road network. Once enough data from the application of the methodology are accumulated, a further study on the level of service in terms of network connectivity needs to be followed.

• Journal of the Korean Society for Precision Engineering
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• v.23 no.6 s.183
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• pp.44-51
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• 2006

This paper deals with the aspects of die design for the multistage fine tooth hub gear in the cold forging process. In order to manufacture the cold forged product for the precision hub gear used as the ARD 370 system of bicycle, it examines the influences of different designs on the metal flow through experiments and FE-simulation. To find the combination of design parameters which minimize the damage value, the low gear length, upper gear length and inner diameter as design parameters are considered. An orthogonal fraction factorial experiment is employed to study the influence of each parameter on the objective function or characteristics. The optimal punch shape of fine tooth hub gear is designed using the results of FE-simulation and the artificial neural network. To verify the optimal punch shape, the experiments of the cold forging of the hub gear are executed.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.10a
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• pp.769-772
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• 2005

This paper deals with the aspects of die design for the multistage fine tooth hub gear in the cold forging process. In order to manufacture the cold forged product fur the precision hub gear used as the ARD 370 system of bicycle, it examines the influences of different designs on the metal flow through experiments and FE-simulation. To find the combination of design parameters which minimize the damage value, the low gear length, upper gear length and inner diameter as design parameters are considered. An orthogonal fraction factorial experiment is employed to study the influence of each parameter on the objective function or characteristics. The optimal punch shape of fine tooth hub gear is designed using the results of FE-simulation and the artificial neural network. To verify the optimal punch shape, the experiments of the cold forging of the hub gear are executed.