• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.36 no.2
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• pp.60-75
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• 2023

Objectives : A bibliometric approach using network analysis was applied to explore the global trends of research on herbal medicine for atopic treatment. Methods : Articles related to herbal medicine on atopic treatment from 2003 to 2022 were retrieved from Web of Science Core Collection. Extracted records were analyzed according to the publication year, research area, journal title, country, organization, author and keyword. The VOSviewer program was used to visualize the trends and the research hotspots in herbal medicine for atopy. Results : Analysis of 406 articles indicated the consistent increase of using herbal medicine for atopic treatment over the last 20 years. The most productive country and research organization in issuing articles were South Korea and Kyunghee university. Many articles have been published in research areas such as 'integrative complementary medicine' and 'pharmacology pharmacy'. By evaluating the total link strength, the average publication year and the average citations of countries and authors, the influential countries and authors were identified. A network analysis based on the co-occurrence and the publication year of keywords revealed the relevant characteristics and trends of herbal medicine for atopy. The most up-to-date keywords were 'topical application', 'skin barrier' and 'care'. Conclusions : This bibliometric study examined the overall trends and the time-based development of herbal medicine for atopic treatment. The current study would be useful not only for grasping the global network hub of research on herbal medicine for atopic treatment, but also to explore the new directions for future research.

• Asia Marketing Journal
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• v.9 no.2
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• pp.97-129
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• 2007

The critical link between consumer-based internet ordering and the delivery of the product to the consumer is a key success factor in online shopping. Market areas of online shopping company implies the range of space where products ordered from online shopping can be physically delivered to customers distributed over space with reasonable shipping cost and lead time through the physical distribution network. The average rate of growth in online shopping is 36% per year in Korea for the last 5 years. But there are no maps available that describe sales/delivery density of online shopping, few researches are focused on the short-term/long-term adaptation to demand increase by online shopping. In this paper (1) Maps of trade area are described indicating the sales/delivery density around the nation. (2) Empirical researches suggested that short-term adaptation to demand increase resulted in price reduction and service in enhancement of service quality in local transportation. But the long-term adaptation on the parts of parcel delivery industry are to be investigated in future researches.

• Journal of Life Science
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• v.30 no.1
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• pp.45-57
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• 2020

The prenatal period in livestock animals is crucial for meat production because net increase in the number of muscle fibers is finished before birth. However, there is no study on the growth and development mechanism of muscles in Hanwoo during this period. Therefore, to find candidate genes involved in muscle growth and development during this period in Hanwoo, mRNA expression data of longissimus in Hanwoo at 6 and 9 months post-conceptional age (MPA) were analyzed. We independently identified differentially expressed genes (DEGs) using DESeq2 and edgeR which are R software packages, and considered the overlaps of the results as final-DEGs to use in downstream analysis. The DEGs were classified into several modules using WGCNA then the modules' functions were analyzed to identify modules which involved in myogenesis and adipogenesis. Finally, the hub genes which had the highest WGCNA module membership among the top 10% genes of the STRING network maximal clique centrality were identified. 913(6 MPA specific DEGs) and 233(9 MPA specific DEGs) DEGs were figured out, and these were classified into five and two modules, respectively. Two of the identified modules'(one was in 6, and another was in 9 MPA specific modules) functions was found to be related to myogenesis and adipogenesis. One of the hub genes belonging to the 6 MPA specific module was axin1 (AXIN1) which is known as an inhibitor of Wnt signaling pathway, another was succinate-CoA ligase ADP-forming beta subunit (SUCLA2) which is known as a crucial component of citrate cycle.

• Journal of Korea Society of Industrial Information Systems
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• v.12 no.5
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• pp.1-13
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• 2007

In this research, we found out that bridging nodes have great effect on the robustness of protein-protein interaction networks. Until now, many researchers have focused on node's degree as node's essentiality. Hub nodes in the scale-free network are very essential in the network robustness. Some researchers have tried to relate node's essentiality with node's betweenness centrality. These approaches with betweenness centrality are reasonable but there is a positive relation between node's degree and betweenness centrality value. So, there are no differences between two approaches. We first define a bridging node as the node with low connectivity and high betweenness value, we then verify that such a bridging node is a primary factor in the network robustness. For a biological network database from Internet, we demonstrate that the removal of bridging nodes defragment an entire network severally and the importance of the bridging nodes in the network robustness.

• Journal of the Korean Magnetic Resonance Society
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• v.21 no.1
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• pp.31-43
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• 2017

Together with radiotherapy, chemotherapy using cytotoxic agents is one of the most common therapies in cancer. Metabolic changes in cancer cells are drawing much attention recently, but the metabolic alterations by anticancer agents have not been much studied. Here, we investigated the effects of commonly used cytotoxic agents on lung normal cell MRC5 and lung cancer cell A549. We employed cis-plastin, doxorubicin, and 5-Fluorouracil and compared their effects on the viability and metabolism of the normal and cancer cell lines. We first established the concentration of the cytotoxic reagents that give differences in the viabilities of normal and cancer cell lines. In those conditions, the viability of A549 decreased significantly, whereas that of MRC5 remained unchanged. To study the metabolic alterations implicated in the viability differences, we obtained the metabolic profiles using $^1H$-NMR spectrometry. The $^1H$-NMR data showed that the metabolic changes of A549 cells are more remarkable than that of MRC5 cells and the effect of 5-FU on the A549 cells is the most distinct compared to other treatments. Heat map analysis showed that metabolic alterations under treatment of cytotoxic agents are totally different between normal and cancer cells. Multivariate analysis and weighted correlation network analysis (WGCNA) revealed a distinctive metabolite signature and hub metabolites. Two different analysis tools revealed that the changes of cell metabolism in response to cytotoxic agents were highly correlated with the Warburg effect and Reductive lipogenesis, two pathways having important effects on the cell survival. Taken together, our study addressed the correlation between the viability and metabolic profiles of MRC5 and A549 cells upon the treatment of cytotoxic anticancer agents.

• Journal of Navigation and Port Research
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• v.31 no.8
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• pp.733-739
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• 2007

Demand for Sea & Air intermodal transport has increased between north-China costal cities and Incheon since China's international airline network was not established completely. It will be big opportunity for Incheon to be logistics hub of Sea & Air intermodal transport in the north-east Asia, musing large sea-air cargoes to be transferred at the port of Incheon. Therefore, this study aims to propose competitive strategy on Sea & Air intermodal transport system of Incheon. In this analysis results, this paper shows that sea & air cargoes rather from china to U.S. than from China to Europe is very significant, considering geographically for Incheon and is also devote to not only providing high quality services but also activating RFS(Road Feeder Service) system, enlarging toward Shanghai, Weihai, and Yantai.

• Cartoon and Animation Studies
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• s.12
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• pp.56-72
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• 2007

The purpose of this study is to analyze the characteristics of animation cluster in Chuncheon. It has been over 10 years since Chuncheon was designated as the cluster raising the animation industry. The Chuncheon cluster is trying to differentiate through managing several unique strategies. In order to realize the micro-regionalism, it focuses on co-production not with domestic companies but with foreign companies. Especially, for establishing the whole concrete production pipe-line, it concerns to make co-production contracts dealing with not only for the main production part but also pre- and post-production parts. Based on these production experience, it is building the production complex in the name of ICT convergence cluster. The changed role of the policy-management organization(Gangwon Information & Multimedia Corporation, GIMC) enables these differentiated strategies by itself. The establishment of the Asian Animation Round(AAR) is recognized as the characteristic of macro-regionalism. Starting from the year of 2006, the AAR tries to place Chuncheon as the hub of animation production in Asia and focuses on constructing the network of animation production countries that have developed their production capabilities through sub-contracts. This type of production and market bloc has not been made before.

• Journal of Digital Convergence
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• v.16 no.3
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• pp.291-301
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• 2018

Supply chain in service sector has been established on the premise that firms need to manage their process uncertainties to satisfy customers in an efficient manner. Information sharing and synchronization play key roles in minimize uncertainties from their involved supply chain. The duality of customers being inputs providers as well as consumers, differentiates service supply chains from manufacturing and is a challenging issue to traditional supply chain management. The service supply chain is a structured network which should be managed with supply chain theory and principles. Various key operations need to be carried out through a highly integrated and collaborated service supply chain and supporting information hub. The purpose of this paper is to present the issues and key components in the service supply chain, where the repetitive service is provided along the value chain, such as tourism, restaurant, mega-sized hospital supply chain.

• Journal of the Korea Fashion and Costume Design Association
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• v.7 no.1
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• pp.101-112
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• 2005

21th is the century of culture. So each country create new culture from tradition, and at the hub, there is Rapid development of network which makes these things to be able. Also, Korea selected Han-Bok as a symbol of Korea culture, and also Han-Bok internationally. Han-Bok expresses our nation's emotion very well, and also, Han-Bok has universality that can stimulate on world's sensitivity. Consequently, this study will arrange and analyze the records of foreigners' feeling who visited in the period of the opening of a port as a target of our study. This study will offer materials for study in the period of the opening of a port. Also, this study will discover the significance and organization of our clothes. Way to wear it and the beauty of our clothes that we didn't even realize or not mentioned on the record because we were too accustomed to our beauty from the ancient time. So, we would like to be basic study that can make our clothes globally and appeal to world's sensitivity by finding the universality. The result of this study is as follows. First, the items of hat made us be called as a 'world of hat' so, Gat, Galmo(갈모), a women's winter hat(조바위), a fur-lined hood(남바위) and Ayam(아얌) will be obtained the world's focus. Secondly, we checked Belt, breast-tie, rainbow striped sleeves and Pocket which append vitality and movement arrested the foreigners' attention. Thirdly, foreigner's were interested with straw shoes and paper shoes.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.11
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• pp.6347-6350
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• 2013

Post-transplant lymphoproliferative disorder (PTLD) is a common complication of therapeutic immunosuppression after organ transplantation. Gene expression profile facilitates the identification of biological difference between Epstein-Barr virus (EBV) positive and negative PTLDs. Previous studies mainly implemented variance/regression analysis without considering unaccounted array specific factors. The aim of this study is to investigate the gene expression difference between EBV positive and negative PTLDs through partial least squares (PLS) based analysis. With a microarray data set from the Gene Expression Omnibus database, we performed PLS based analysis. We acquired 1188 differentially expressed genes. Pathway and Gene Ontology enrichment analysis identified significantly over-representation of dysregulated genes in immune response and cancer related biological processes. Network analysis identified three hub genes with degrees higher than 15, including CREBBP, ATXN1, and PML. Proteins encoded by CREBBP and PML have been reported to be interact with EBV before. Our findings shed light on expression distinction of EBV positive and negative PTLDs with the hope to offer theoretical support for future therapeutic study.