• Journal of Korean Society of Water and Wastewater
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• v.19 no.6
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• pp.749-757
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• 2005

The present study analyzed actual cases of designed flow estimation method and designed flow rate of sewage pipe lines. In order to examine the effects of peak-hour demand factor estimation with given daily highest peak loading, we analyzed its effects on designed flow rate with changing the peak-hour demand factor from 2.0 to 10.0. The results of this study are as follows. When reviewing the recent designs, we found that 59.4% of pipe line with 250mm and 300mm diameter, which fall under minimum allowable pipeline did not meet the minimum velocity which is specified as 0.6m/sec in design standards. The pipe line that have minimal access population or have very low slope did not satisfy the minimum velocity. In estimating the designed sewage flow, the applied daily highest peak loading and hourly highest peaking loading were the load factor for the entire population of the planned area, and for the peak loading of the initial pipes connected to a very small population, we applied the same factor as that applied to the entire area and, as a result, the hourly highest flow was underestimated. Because, in case of the initial pipes, the method of applying the same peak loading to all subject areas is highly possible to produce underestimated design flow, when estimating the designed flow of the initial pipes connected to a small population need to adopt a rational flow factor according to the size of population. For this, it is considered to investigate and analyze raw data on daily and hourly variation of sewage flow.

• Toxicological Research
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• v.26 no.1
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• pp.29-35
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• 2010

The present study was conducted to investigate the antimutagenic potential of the methanolic extract from the leaves of sweet potato (Ipomea batatas, IB) with the SOS chromotest (umu test) and Salmonella typhimurium TA 98 and TA 100. The anticarcinogenic effects were also studied by calculation of the $IC_{50}$ on human cancer cell lines and investigating the function of gap junction in rat liver epithelial cells. The IB extract inhibited dose-dependently the ${\beta}$-galactosidase activity induced spontaneously at concentration of more than 200 mg/ml in S. typhimurium TA 1535/pSK 1002, and decreased significantly (p < 0.01) the ${\beta}$-galactosidase activities induced by mutagen 6-chloro-9-[3-(2-chloroethylamino)proylamino]-2-methoxyacridine dihydrochloride (ICR) at dose of more than 0.4 mg/0.1 ml. The IB extract showed no effect on the spontaneous reversions of S. typhimurium TA 98 and 100 but benzo(${\alpha}$)pyrene (BaP)-stimulated reversions were decreased dose-dependently (p < 0.01) at the concentration of more than 100 mg/ml. The $IC_{50}$ value of stomach cancer cells was lower than that of normal rat liver epithelial cells, but the values of colon and uterine cancer cell lines were similar to those of normal rat liver epithelial cells. The transfer of dye through gap junctions was not affected by treatment of the IB extracts at any concentration during treatment periods. The simultaneously treatment of IB extract and 12-O-tetradecanoylphorbol-13-acetate (TPA) effectively prevented the inhibition of dye transfer induced by TPA 1 hour after treatment at all exposed concentrations. The number of gap junctions was significantly (p < 0.01) increased by the treatment with IB extract at concentrations of more than 40 ${\mu}g$/ml. The inhibition of the expression of gap junction proteins by TPA (0.01 ${\mu}g$/ml) was recovered dose dependently by the simultaneous treatment of IB extracts. Our data suggest that Ipomea batatas has antimutagenic and anticarcionogenic activity in vitro.

• Journal of Information Technology Services
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• v.19 no.2
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• pp.125-138
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• 2020

Currently, subway crowding is estimated by observing a specific point at specific hours once or twice every 1 or 2 years. Given the extensive subway network in Seoul Metropolitan Area covering 588 stations, 11 lines and 80 transfer stations as of 2017, implementing crowding mitigation policy may have its limitations due to data uncertainty. A proposal has recently been made to effectively use smart card data, which generates big data on the overall subway traffic related to an estimated 8 million passengers per day. To mitigate subway crowding, this study proposes two viable options based on data related to smart card used in Seoul Metropolitan Area. One is to create a subway passenger pattern model to accurately estimate subway crowding, while the other is to prove effectiveness of early bird policy to distribute subway demand that is concentrated at certain stations and certain time. A subway passenger pattern model was created to estimate the passenger routes based on subway terminal ID at the entrance and exit and data by hours. To that end, we propose assigning passengers at the routes similar to the shortest routes based on an assumption that passengers choose the fastest routes. In the model, passenger flow is simulated every minute, and subway crowding level by station and line at every hour is analyzed while station usage pattern is identified by depending on passenger paths. For early bird policy, highly crowded stations will be categorized based on congestion level extracted from subway passenger pattern model and viability of a policy which transfers certain traveling demands to early commuting hours in those stations will be reviewed. In particular, review will be conducted on the impact of policy implemented at certain stations on other stations and lines from subway network as a whole. Lastly, we proposed that smart card based subway passenger pattern model established through this study used in decision making process to ensure effective implementation of public transport policy.

• The Korean Journal of Zoology
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• v.38 no.4
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• pp.542-549
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• 1995

The effect of extraceflular matrix (ECM) protein on the neuronai differentiation of SI(-N-SH and IMR-32 human neuroblastoma cell lines was examined. When ceils were cultured on the laminin/collagen coated plate for 7 days, the extensive neurite outgrowth was observed In IMR-32. To address the reason why IMR-32 cell llne did not respond to ECM proteins, the ECM mediated early signalling mechanisms were analysed in both SK-N-SH and IMR-32. When cells were plated on the laminin/collagen coated plates, tyrosine phosphorylated proteins were Increased within an hour In both of these cells. Moreover, the foaal adhesion IlInase (FAK) was tyrosine phosphorylated in both of these two cell lines. These results suggest that the ECM mediated early signalling mechanism was normal in IMR-32 cell line. The expression of both NSE and Bcl-2 was increased by ECM treatment in SK-N-SH. However, these components were not changed by ECM In IMR 32 cells to ECM component Is likely due to the abnomality of the transcriptional regulation mechanism which Is responsible for the neuronal differentiation.

• Journal of Chest Surgery
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• v.30 no.6
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• pp.566-572
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• 1997

A major obstacles to evaluation of newly-developed treatment strategy for human lung cancer has been the lack of appropriate experimental animal models. We describe a new experimental model of orthotopically-developed non-small cell lung cancer in nude rat, involving inoculation of tumor cell suspension by thoracotomy. Over 40 direct implantation to the periphery of the lung has been performed to date, each requiring less than'1 hour for completion. This model has been used to perform a series of experiments to investigate whether the rat lung and surrounding structures trapped tumor cells with 2 different non-small cell lung cancer cell lines(NCI-H46O and NCI-H1299). Every animal showed development of tumor masses, which were loculated at the periphery of the lung karenchyma and identified also by radiography. After 3 weetu of the inoculation, tumor develop meat at the mediastinal strutures were identified. The life expectancies of the victims were different between the cell lines, but were approximately 5 weeks when NCI-H46O cell line was used. This new orthotopic lung cancer model may be facilitate future studies of the new therapeutics of localized non-small cell lung cancer .

• Proceedings of the KOR-KST Conference
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• 1998.09a
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• pp.3-16
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• 1998

The goal of the transportation policy of Seoul is to increase the ridership of the subway system by constructing the public transportation network, the subway system. To accomplish this goal, the city of Seoul has been constructing the Metropolitan Subway System. Currently, seven subway lines which connect major areas in Seoul are operating. However, the ridership of subway system was not increased as much as we expected, even though more subway lines have been implemented. It seems that although the length of the subway line was extended, the current way of the subway operation that trains stop at every station cannot satisfy the passenger's need. Thus, we should try to increase the demand by providing quicker services and diversifying the subway operations; changing the point of view is required. This paper introduces the distinctive features of the express subway system and the model for analysing the effects of that system. This paper also presents the results for the feasibility study of the express subway system on the 5th Subway Line and Kyong-Eue Railway Line. Based on the results of the case studies, We can conclude as : First, the express system reduces a total travel time by about $13\%$; in particular, the Kyong-Eue Line is more effective than the subway Line ${\sharp}5$. Second, the shorter headway of express trains increases the time saving effects on subway system although it requests more waiting time to low-speed train passengers. When the service frequency is increased from 5 to 7.5 times/hour, total saved time ratio is about $10\%$ in the Subway Line ${\sharp}5$ and about $18\%$ in the Kyong-Eue Line.

• Biomolecules & Therapeutics
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• v.27 no.1
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• pp.54-62
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• 2019

Cis-3-O-p-hydroxycinnamoyl ursolic acid (HCUA), a triterpenoid compound, was purified from Elaeagnus oldhamii Maxim. This traditional medicinal plant has been used for treating rheumatoid arthritis and lung disorders as well as for its anti-inflammation and anticancer activities. This study aimed to investigate the anti-proliferative and apoptotic-inducing activities of HCUA in oral cancer cells. HCUA exhibited anti-proliferative activity in oral cancer cell lines (Ca9-22 and SAS cells), but not in normal oral fibroblasts. The inhibitory concentration of HCUA that resulted in 50% viability was $24.0{\mu}M$ and $17.8{\mu}M$ for Ca9-22 and SAS cells, respectively. Moreover, HCUA increased the number of cells in the sub-G1 arrest phase and apoptosis in a concentration-dependent manner in both oral cancer cell lines, but not in normal oral fibroblasts. Importantly, HCUA induced p53-mediated transcriptional regulation of pro-apoptotic proteins (Bax, Bak, Bim, Noxa, and PUMA), which are associated with mitochondrial apoptosis in oral cancer cells via the loss of mitochondrial membrane potential. HCUA triggered the production of intracellular reactive oxygen species (ROS) that was ascertained to be involved in HCUA-induced apoptosis by the ROS inhibitors YCG063 and N-acetyl-L-cysteine. As a result, HCUA had potential antitumor activity to oral cancer cells through eliciting ROS-dependent and p53-mediated mitochondrial apoptosis. Overall, HCUA could be applicable for the development of anticancer agents against human oral cancer.

• Journal of Korean Society of Disaster and Security
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• v.12 no.2
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• pp.1-13
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• 2019

In this study, we propose rainfall frequency criteria for the development of early-warning system based on the evaluation of the highway debris flow that includes the contents of the rainfall recurrence cycle. The rainfall criterion was recommended based on the results of previous researches and the recommended rainfall criterion was 1 hour, 6 hours, and 3 days. At this time, the study subjects were located in Gangwon area and the probability rainfall of 8 stations in Gangwon area was collected. Also, the probabilistic distribution of the 1 hour, 6 hour, and 3 day rainfall criteria to be used for the early warning for the highway debris flow in Kangwon area was estimated through the probability analysis. In addition, we analyzed the correlation between 3 types of rainfall criteria selected from the rainfall data and the actual destructive damages of debris flow at 12 points in 7 lines of Gangwon highways. At this time, the rainfall criterion on the probability distribution was divided into an average value and a lower limit value. As a result of the review, it was found that the case of using the lower limit value of the rainfall according to the recurrence intervalwell simulates the situation of actual debris flow hazards.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.52 no.1
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• pp.12-16
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• 2007

To facilitate breeding of lines with either the Ppd-D1a or ppd-d1a, we screened 342 $F_2$ progenies from a cross between Laura (photoperiod insensitive, Ppd-D1a) spring wheat and SWP5304 (photoperiod sensitive, ppd-d1a) for their time to heading under 10 hour day length, and with a set of 37 microsatellite primers previously mapped to chromosome 2D. Bulk segregant analysis was used to identify tow linked microsatellite loci. The Ppd-D1a locus was flanked by Xgwm484 with 13.7 cM distance and Xgwm455 with 27 cM. These markers may be useful in selection of the desired photoperiod sensitivity in segregating populations grown in Northern latitude.

• Journal of the Optical Society of Korea
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• v.20 no.2
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• pp.251-256
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• 2016

The prediction of thermal effects in lithography projection objective plays a significant role in the real-time dynamic compensation of thermal aberrations. For the illuminated lithography projection objective, this paper applies finite element analysis to get the temperature distribution, surface deformation and stress data. To improve the efficiency, a temperature distribution function model is proposed to use for the simulation of thermal aberrations with the help of optical analysis software CODE V. SigFit is approved integrated optomechanical analysis software with the feature of calculating OPD effects due to temperature change, and it is utilized to prove the validation of the temperature distribution function. Results show that the impact of surface deformation and stress is negligible compared with the refractive index change; astigmatisms and 4-foil aberrations dominate in the thermal aberration, about 1.7 λ and 0.45 λ. The system takes about one hour to reach thermal equilibrium and the contrast of the imaging of dense lines get worse as time goes on.