• 제목/요약/키워드: host factors

검색결과 534건 처리시간 0.027초

DFT Study of p-tert-Butylcalix[6]aryl Ester Complexed with Alkylammonium Ions

  • Kim, Kwang-Ho;Choe, Jong-In
    • Bulletin of the Korean Chemical Society
    • /
    • 제30권3호
    • /
    • pp.589-594
    • /
    • 2009
  • We have performed DFT B3LYP/6-31G(d,p) calculations to investigate the complexation behaviors of the ethyl ester derivative of p-tert-butylcalix[6]arene (1) toward a variety of alkylammonium ions. We have studied the binding sites of these host-guest complexes focusing on the p-tert-butylcalix[6]arene pocket (endo) of 1. The smaller alkylammonium cations have the better complexation efficiency than the bulkier alkylammonium ions with the p-tert-butylcalix[6]aryl ester. The hydrogen-bonding of N-H$\ldots$O is one of the important factors for the complexation behavior of the p-tert-butylcalix[6]aryl ester, in addition to the NH-aromatic π, CH-aromatic π and electrostatic interactions, and the steric hindrance of alkylammonium cation. The hydrogen-bonded distances and angles of N-H$\ldots$O are reported for the complexes of the p-tert-butylcalix[6]aryl ester with various alkylammonium ions.

Identification of hemolysin as one of the important virulent factors in vibrio anguillarum V7

  • Choe, Young-Chool;Jeong, Gajin
    • Journal of Microbiology
    • /
    • 제33권4호
    • /
    • pp.283-288
    • /
    • 1995
  • We have identified hemolysin rendering virulency of Vibrio anguilarum grown at 23.deg.C which was evaluated on human RBCs. Hemolysin itself was separated as a single band on non-denaturing gel electrophoresis. Vibrio hemolysin was destroyed by trypsin and proteinase K and was heat labile. Optimal pH for activity was around pH 6 while pI of the molecule was recognized as 5.7, with relative distance (R$\sub$f/) on non-denaturing gel was 0.7. Addition of EDTA and FeCI$\sub$3/ drew the possibility that the production of hemolysin was mainly induced to overcome iron deficiency inside host animalsd infection.

  • PDF

강원풍력발전 CDM 사업 사례 연구 (Study on Gangwon Wind Park CDM project)

  • 박금주;정재수;이문구;김두훈
    • 한국신재생에너지학회:학술대회논문집
    • /
    • 한국신재생에너지학회 2006년도 춘계학술대회
    • /
    • pp.298-303
    • /
    • 2006
  • CDM(Clean Development Mechanism) is one of three Kyoto mechanisms. As a non-annex I party of UNFCCC, Korea can host CDM projects. Currently eight CDM projects are hosted in Korea under Kyoto protocol. Six of these CDM projects are related to renewable energy power generation. Renewable energy power plants assumes zero GHGs emission and has great potential to become CDM projects which is very environmental friendly energy Gangwon wind park CDM project is the first renewable CDM project in Korea. In this research, emission factors and additionality proving process are studied, which are important procedures of doing CDM project.

  • PDF

강원풍력발전 CDM 사업 사례 연구 (Study on Gangwon Wind Park CDM project)

  • 박금주;정재수;이문구;김두훈
    • 신재생에너지
    • /
    • 제2권1호
    • /
    • pp.66-71
    • /
    • 2006
  • CDM(Clean Development Mechanism) is one of three Kyoto mechanisms. As a non-annex I party of UNFCCC, Korea can host CDM projects. Currently eight CDM projects are hosted in Korea under Kyoto protocol. Six of these CDM projects are related to renewable energy power generation. Renewable energy power plants assumes zero GHGs emission and has great potential to become COM projects which is very environmental friendly energy. Gangwon wind park CDM project is the first renewable CDM project in Korea. In this research, emission factors and additionality proving process are studied, which are important procedures of doing CDM project.

  • PDF

Mechanism on the development of periapical lesion - Effect of whole-body diseases on the development of periradicular lesions in rats

  • Nakamura, Hiroshi
    • 대한치과보존학회:학술대회논문집
    • /
    • 대한치과보존학회 2003년도 제120회 추계학술대회 제 5차 한ㆍ일 치과보존학회 공동학술대회
    • /
    • pp.591-591
    • /
    • 2003
  • Apical periodontitis is inflammation of the periodontium caused by infection of the pulp canal system. Moreover, a dental periradicular lesion occurs as a periradicular tissue reaction to bacterial infection and consists of periradicular inflammation with alveolar bone destruction and root resorption, a consequence of the interaction between oral flora and the existing host defenses. Many investigations dealing with the pathogenesis and history of periradicular lesions have described histologically, immunologically, biochemically the development of the periradicular lesion;but none of these studies have shown any correlation between this lesion and several factors, the whole body disease in the worldwide.(omitted)

  • PDF

The Trend in the Development of Oncolytic Virus Therapy

  • Kwon, Sun-Il
    • 대한의생명과학회지
    • /
    • 제25권3호
    • /
    • pp.201-210
    • /
    • 2019
  • The oncolytic viruses selectively infect and destroy cancer cells, not harming normal cells. The cancer cell materials released by oncolysis, like tumor antigens, stimulate host antitumor immune responses, which is a long-lasting antitumor immunity removing cancer cells in remote parts of the body by a systemic response. Oncolytic viruses armed with transgenes such as cytokines or other immune stimulating factors enhance the immune responses. The first oncolytic virus approved by US-FDA is $Imlygic^{(R)}$ targeting for melanoma. The oncolytic virus is considered as a revolutionary immunotherapy for tumors together with immune checkpoint inhibitors. A variety of oncolytic viruses are under research in the treatment of kidney cancer, liver cancer, breast cancer, and many others solid tumors. Clinical trials have shown promising results in different types of cancers. Here, we present a brief introduction of various aspects of oncolytic virus, and a review of the current status of oncolytic virus therapy development.

Fibrous composite matrix of chitosan/PLGA for tissue regeneration

  • Shim, In-Kyong;Hwang, Jung-Hyo;Lee, Sang-Young;Cho, Hyun-Chul;Lee, Myung-Chul;Lee, Seung-Jin
    • 대한약학회:학술대회논문집
    • /
    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
    • /
    • pp.237.3-238
    • /
    • 2003
  • Tissue engineering may be adequately defined as the science of persuading the body to regenerate or repair tissue that fail to regenerate or heal spontaneously. In the various techniques of cartilage tissue engineering, the use of 3-dimensional polymeric scaffolds implanted at a tissue defect site is usually involved. These scaffolds provided a framework for cells to attach, proliferate, and form extracellular matrix(ECM). The scaffolds may also serve as carriers for cells and/or growth factors. In the ideal case, scaffold absorb at a predefined rate so that the 3-dimensional space occupied by the initial scaffold is replaced by regenerated host tissue. (omitted)

  • PDF

Anti-angiogenic activity of conjugated linoleic acid on the basic fibroblast growth factor-induced angiogenesis

  • Moon, Eun-Joung;Lee, You-Mie;Kim, Kyu-Won
    • 대한약학회:학술대회논문집
    • /
    • 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
    • /
    • pp.337.2-337.2
    • /
    • 2002
  • Conjugated linoleic acid (CLA) is a potent inhibitor of mammary carcinogenesis. Cancer cells produce various angiogenic factors which stimulate host vascular endothelial cell mitogenesis and chemotaxis for their growth and metastasis. Basic fibroblast growth factor (bFGF) is a potent angiogenic factor that is expressed in many tumors. In this study. we found that CLA decreased bFGF-induced endothelial cell proliferation and DNA synthesis in a dose-dependent manner. However, CLA did not inhibit endothelial cell migration. Furthermore CLA showed a potent inhibitory effect on embryonic vasculogenesis and bF GF-induced angiogenesis in vivo. Collectively. these results suggest that CLA selectively inhibis the active proliferating endothelial edll induced by bFGF. which may explain its anti-carcinogenix properties in vivo.

  • PDF

다국적기업 본사의 역지식이전 동기요인에 대한 탐색적 연구 (An Exploratory Research on MNC Parents' Motivation to Facilitate Reverse Knowledge Transfer)

  • 홍성진;양오석
    • 아태비즈니스연구
    • /
    • 제10권3호
    • /
    • pp.53-67
    • /
    • 2019
  • Reverse knowledge transfer has been an important research theme in the literature on multinational corporations (MNCs). This paper proposes major determinants of MNC headquarters' willingness to adopt and use marketing knowledge from their subsidiaries. We argue that the willingness will be jointly determined by both the headquarter's absorptive capacity and the focal subsidiary's transfer capacity and willingness to transfer. In addition, we argue that these capability and motivation effects are moderated by (1) institutional distance between home and the focal host country, (2) the need to unlearn existing routines, and (3) types of entry modes. This paper contributes to the reverse knowledge transfer literature by proposing the argument that both motivational and capability factors are likely to determine the MNC parents' willingness to adopt and use marketing knowledge from their subsidiaries.

Organizational Commitment of Five Working Groups of MNCs

  • Miao Wang;Jongwook Kwon;Junjian Li
    • 아태비즈니스연구
    • /
    • 제14권1호
    • /
    • pp.21-39
    • /
    • 2023
  • Purpose - The purpose of this study is to confirm that five different working positions show different Organizational Commitment (OC) and factors influencing OC levels in the Chinese MNCs. Design/methodology/approach - The study collected data of 326 employees in different positions in Chinese MNCs abroad and in domestic country. To test hypotheses, ANOVA analysis and linearity regression are used with SPSS 26 and AMOS 26 software on the collected data. Findings - Results shows that different working groups do not show significant difference of AC and CC level. However, there are significant difference of NC among the five groups in the Chinese MNCs. Employee's position and marital status are positively related to CC and NC. Tenure is positively related to AC. Research implications or Originality - Our research offers insight for further research direction on OC difference research. It provides implication for Chinese MNCs to consider more about strategies how to stimulate host country employee's normative commitment.