• Korean Journal of Veterinary Research
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• v.42 no.3
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• pp.419-423
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• 2002

Postoperative suture granuloma have rarely been reported in animals. Eight biopsy masses from testes areas of neutralized dogs were diagnosed as suture granuloma. The suture granuloma occurred at any time from several weeks to a few years after surgery and appeared to be testicular tumors by macroscopic examination. The granulomas were classified into three types based on the histopathological findings. The first type of pyogranuloma was mainly composed of neutrophils, macrophages, and suture fragments. The second type was chronic necrotizing granuloma which was well demarcated by fibrous connective tissues and was composed of a few suture fragments, macrophages and central fibrinoid necrosis. The third type of granuloma had a poorly defined margin with scarcely observed suture fragments and central necrosis in the tissue. These histopathological findings suggested that various types of suture granuloma may be caused by suture material and could even appear long after surgery.

• Korean Journal of Veterinary Research
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• v.34 no.3
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• pp.537-547
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• 1994

Ninety seven cases of histopathologically diagnosed spontaneous canine parvovirus enteritis(CPE) were studied gross pathologically, histopathologically, immunohistochemically, to investigate histopathological types of small intestinal lesions, and antigen distributions in each pattern related to the infected age. And also, reliability of histopathological method in diagnosis of CPE was inspected with immunohistochemistry. The results were as follows : 1. Age-related occurring ratio in histopathologically diagnosed CPE was 53.6% in 4-8 weeks, 26.8% in 9-15 weeks, 8.25 in 16-19 weeks and 11.3% in 20-45 weeks of the clog age. 2. In histopathologic classification based on patterns of villi/crypts lesions of small intestine(jejunum), the ratio of A type (initial phase of necrosis of crypt epithelia, desquamated epithelial cells in the dilated lumen of the crypt) was 20.6%; the ratio of B type(middle phase of atrophy and fission of the villi, collapse of the mucosa, loss of normal crypt structure) was 62.9%, and C type(regenerative phase of the crypt architecture) was 16.5%. 3. The ratio of A, B, C type in 4-8 weeks old, respectively, was 23.5%, 61.5%, 15.4%; in 9-15 weeks old was 19.2%, 65.4%, 15.3% in 16-19 weeks old was 25.0%, 75.0%, 0.0%; and in 20-45 weeks old was 9.0%, 54.5%, 36.4%. 4. The antigen distribution in the nuclei of the crypt epithelial cells was higher than of the cytoplasm and numerous desquamated epithelial cells in dialated crypts in A type; The antigen cytoplasm and numerous desquamated epithelial cells in dialated crypts in A type; The antigen distribution in the nuclei of the collapsed crypt epithelial cells was not higher than that of the cytoplasm, crypts were lined by and filled with released viral antigens from the destructed epithelial cells in B type; and its distribution was also higher than in the epithelial cells adjacent to the tips of the villi, but it was not reacted in the regenerative crypt epithelial cells in C type. 5. Immunohistochemically detected antigen ratio in the small intestine of histopathologically diagnosed CPE was 94.6%, and this result indicates that histopathological diagnosis is very reliable method in diagnosis of CPE.

• Biomolecules & Therapeutics
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• v.13 no.3
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• pp.133-137
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• 2005

Wogonin(5,7-dihydroxy-8-methoxyflavone), an anti-inflammatory plant flavonoid, was previously demonstrated to modulate the several parameters of animal skin inflammation. This compound inhibited edematic response as well as proinflammatory gene expression. In this investigation, the histopathological changes of the lesions from different types of experimental skin inflammation were compared and the potential therapeutic effect of topically applied wogonin was evaluated. From the results, it was found that multiple TPA treatment drastically increased ear edema accompanied with epidermal hyperplasia and inflammatory cell infiltration, while phenol treatment provoked only edematic response in the dermal area. Wogonin somewhat differently inhibited these animal models of skin inflammation.

• Journal of Veterinary Clinics
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• v.36 no.6
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• pp.349-352
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• 2019

A five-year-old female Yorkshire Terrier dog presented with a perianal mass. Fine needle aspiration revealed that the mass comprised two different types of cells: hepatoid epithelial cells and melanin-containing melanocytes. Histopathological examination confirmed perianal gland adenoma with malignant melanoma. Evidence of metastasis was found on thoracic radiography with soft-tissue densities observed within the pulmonary parenchyma. The dog survived for three months after diagnosis of malignant melanoma. This report describes the clinical findings, diagnostics used, cytological and histopathological findings, and the potential prognosis for a dog diagnosed with malignant anal sac melanoma.

• The Korean Journal of Nuclear Medicine
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• v.2 no.1
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• pp.1-7
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• 1968

Presented here are the results for clinical study on 65 cases of simple goiter the author treated during the period of 4 years and 10 months from Jan. 1963 through Oct. 1967 at the Seoul National University Hospital and Han-Il Hospital. It had been customary to classify simple goiter, according to the gross morphological characteristics of the thyroid gland, as diffuse and nodular type. This paper attempts to investigate the histopathological changes and treatment of simple goiter respectively. Sixty five cases of simple goiter were classified into 4 types; namely degenerative type was 20 cases (30.8%), proliferative type was 7 cases (10..8%), colloidal type was 24 cases (36.9%) and cyst formation with degeneration was 14 cases (21.5%), on the basis of histopathological findings. Thus, it is essential that simple goiter should be differentiated from thyroid tumors as soon as practicable. The effectiveness of medical treatment with desicated thyroid and autohemotherapy for certain simple goiter are also discussed.

• Journal of Gastric Cancer
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• v.24 no.1
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• pp.69-88
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• 2024

This review comprehensively examines the diverse spectrum of gastric cancers, focusing on unusual or uncommon histology that presents significant diagnostic and therapeutic challenges. While the predominant form, tubular adenocarcinoma, is well-characterized, this review focuses on lesser-known variants, including papillary adenocarcinoma, micropapillary carcinoma, adenosquamous carcinoma, squamous cell carcinoma (SCC), hepatoid adenocarcinoma, gastric choriocarcinoma, gastric carcinoma with lymphoid stroma, carcinosarcoma, gastroblastoma, parietal cell carcinoma, oncocytic adenocarcinoma, Paneth cell carcinoma, gastric adenocarcinoma of the fundic gland type, undifferentiated carcinoma, and extremely well-differentiated adenocarcinoma. Although these diseases have different nomenclatures characterized by distinct histopathological features, these phenotypes often overlap, making it difficult to draw clear boundaries. Furthermore, the number of cases was limited, and the unique histopathological nature and potential pathogenic mechanisms were not well defined. This review highlights the importance of understanding these rare variants for accurate diagnosis, effective treatment planning, and improving patient outcomes. This review emphasizes the need for ongoing research and case studies to enhance our knowledge of these uncommon forms of gastric cancer, which will ultimately contribute to more effective treatments and better prognostic assessments. This review aimed to broaden the pathological narrative by acknowledging and addressing the intricacies of all cancer types, regardless of their rarity, to advance patient care and improve prognosis.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.4
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• pp.2099-2103
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• 2016

Background: The gold standard diagnosis of H. pylori related gastritis is evidence of bacteria on histopathological examination of gastric mucosa. Our aim was to study the correlation between gastric mucosal morphology and histopathological severity of H. pylori related gastritis. Materials and Methods: Division was made on morphological features into:Type 1, showing regular arrangement of red dots; Type 2, showing cleft-like appearance; Type 3, with a mosaic appearance; and Type 4, having a mosaic appearance with focal or diffuse hyperemia. Results: Types 1 and 2 gastric mucosal morphologies were statistically significant in predicting an H. pylori negative status (137/145, p<0.01), while Types 3 and 4 were significant a positive status (139/155, p<0.01). The sensitivity, specificity, positive and negative predictive values of Type 3 and 4 morphologies for predicting H. pylori positive were 94.6%, 89.5%, 89.7% and 94.5%, respectively, with a good correlation with inflammation grading (p<0.01). Conclusions: Our study suggests that gastric mucosal morphology can be reliably identified using conventional white light source gastroscopy with good correlation between findings and inflammation grading.

• Korean Journal of Head & Neck Oncology
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• v.14 no.1
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• pp.76-80
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• 1998

Generally, the papillary carcinoma generally has a favorable prognosis, and several variants of pathologic heterogeneity are recognized. Variants that are regarded as more aggressive are tall cell, columnar cell, and diffuse sclerosing types. Seventeen cases of papillary thyroid carcinoma showing clinically aggressive behavior, invading extrathyroidal structures, were retrospectively reviewed to evaluate the morphological variants of the tumors. Six of them were found to be pure papillary and nine were mixed types regarded as non-aggressive variants. Four cases were found to be tall cell variants, two cases of non-extrathryoidal invasion and two of extrathyroidal invasion regarded as aggressive variants. Our findings suggest that the prognosis of papillary carcinoma not always be based on its morphological variant and more attention should be given to other clinical parameters.

• Korean Journal of Veterinary Research
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• v.39 no.1
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• pp.85-89
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• 1999

From 2,373 slaughtered pigs examined, 1,899 of them had visible evidence of pulmonary lesion. The lungs with pulmonary lesion were examined by grossly, histopathological technique to investigate the prevalence according to season, severity of pulmonary lesion, types of the pneumonia and relationship between rearing management and prevalence of pulmonary lesion. The results were as follows : 1. Prevalence of pneumonia according to season was 72.3% to 85.9% and the highest prevalence was in winter. 2. In the severity of pulmonary lesion, rates mild, moderate and severe lesions were 38.3%, 47.0% and 14.7%, respectively. Prevalence of mild lesion was the highest in autumn. Prevalence of moderate and severe lesions was the highest in winter. 3. In the type of pneumonia, rates of interstitial pneumonia and bronchopneumonia fibrinous pneumonia were 23.6%, 13.0%, and 3.4%, respectively. Prevalence of interstitial pneumonia was high in spring and autumn while that of broncho-pneumonia and fibrinous pneumonia was high in winter and summer, respectively. 4. In relationship of pulmonary lesions according to severity of pulmonary lesion and types of pneumonia, similarity was observed in prevalence of mild lesion and bronchopneumonia.

• The Journal of Internal Korean Medicine
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• v.31 no.3
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• pp.539-553
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• 2010

Objectives : The object of this study was to obtain accurate information (single oral dose toxicity) of Lonicerae Flos (LF; Dried flower bud parts of Lonicera japonica Thunb (Caprifoliaceae)), which has traditionally been used in Korean medicine for treating various inflammatory diseases. Methods : In order to observe the 50% lethal dose (LD 50), approximate lethal dosage (ALD) and target organs, test articles were once orally administered to female and male ICR mice at dose levels of 2,000, 1,000, 500 and 0 (control) mg/kg (body weight.). The mortality and changes on body weight, clinical signs and gross observation were monitored for 14 days after single oral treatment of LF aqueous extracts with organ weights and histopathological observations of 12 types of principle organs. Results : 1. After single oral treatment of LF aqueous extracts, we could not find any mortality and toxicological evidences up to 2,000 mg/kg treated group, the limited dosages in rodents at body and organ weights, clinical signs, gross and histopathological observations. 2. Slight diarrhea was detected in most mice treated with 2,000 mg/kg of LF aqueous extracts and male mice of LF aqueous extracts 1,000 mg/kg within 2 days after end of treatment, respectively. Conclusion : The results obtained in this study suggest that the LD 50 and ALD of LF aqueous extracts in both female and male mice after single oral treatment were considered as over 2,000 mg/kg because no mortalities were detected up to 2000 mg/kg, the highest dose recommended by KFDA and OECD. However, we also observed the possibility of digestive disorders like diarrhea when over 1,000 mg/kg of LF aqueous extracts were administered in the present study.