Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Histopathological Comparison of Animal Models of Skin Inflammation and Inhibition of the Inflammatory Responses by Plant Flavonoid, Wogonin

  • Kim, Hyun-Pyo (College of Pharmacy, Kangwon National University)
  • Published : 2005.09.01
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Abstract

Wogonin(5,7-dihydroxy-8-methoxyflavone), an anti-inflammatory plant flavonoid, was previously demonstrated to modulate the several parameters of animal skin inflammation. This compound inhibited edematic response as well as proinflammatory gene expression. In this investigation, the histopathological changes of the lesions from different types of experimental skin inflammation were compared and the potential therapeutic effect of topically applied wogonin was evaluated. From the results, it was found that multiple TPA treatment drastically increased ear edema accompanied with epidermal hyperplasia and inflammatory cell infiltration, while phenol treatment provoked only edematic response in the dermal area. Wogonin somewhat differently inhibited these animal models of skin inflammation.

Keywords

References

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