• The Journal of Internal Korean Medicine
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• v.38 no.6
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• pp.1049-1059
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• 2017

Objectives: The aim of this study was to evaluate the effect of Korean medicine on a patient with dizziness due to hippocampal sclerosis. Methods: A 51-year-old woman with dizziness, diagnosed with hippocampal sclerosis, was treated with herbal medication, acupuncture, and moxibustion. Her improvement was evaluated by a balance test, NRS, and the percentage of dizziness severity compared to that on her admission day. Results: Improvement in the balance test result and NRS, and a decrease of percentage of dizziness severity, were observed after treatment with Korean medicine. Conclusions: This study suggests that treatment with Korean medicine may be an effective therapy for dizziness due to hippocampal sclerosis.

• Investigative Magnetic Resonance Imaging
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• v.6 no.1
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• pp.47-54
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• 2002

Purpose : Hippocampal atrophy is one of the characteristic pathologic findings of hippocampal sclerosis, for which MR imaging of the hippocampus is essential in the evaluation of hippocampal sclerosis. The purpose of this study is to present the normal MR volumetric data of the hippocampus in normal adult Korean and to compare those with MR volumetric data of hippocampus in patients with hippocampal s-clerosis, providing the diagnostic volume criteria of the hippocampal atrophy. Materials and methods : MR volumetry was performed in 30 normal adults and 28 patients with temporal lobe epilepsy whose final diagnosis was hippocampal sclerosis. The volumetric data were compared between sexes, right and left sides, and normal and abnormal hippocampus, and the volume criteria for the diagnosis of hippocampal atrophy was determined. Results : The mean $volumes({\pm}standard$ deviation) of normal Korean adult were $2.20{\pm}0.73\textrm{cm}^3$ (right) and $2.17{\pm}0.72\textrm{cm}^3$ (left) in male and $2.27{\pm}0.47{\;}\textrm{cm}^3$ (right) and $2.23{\pm}0.48\textrm{cm}^3$ (left) in female. The mean right-left differences were $0.14{\pm}0.11\textrm{cm}^3$ and $0.19{\pm}0.13\textrm{cm}^3$ in male and female, respectively. The MR volumetry showed no significant statistical differences between sexes and between right and left. The mean volume and standard deviation of the hippocampus in hippocampal sclerosis patients was $1.46{\pm}0.60{\;}\textrm{cm}^3$, and the right-left difference was $0.51{\pm}0.41\textrm{cm}^3$, In comparison of two volume distributions between normal adult group and hippocampal sclerosis patients group, the reasonable diagnostic volume criteria was $0.4{\;}\textrm{cm}^3$ as right-left volume difference, in which the sensitivity and specificity are 0.61 and 0.90. In all patients with right-left volume difference more than $0.4{\;}\textrm{cm}^3$, visual determination of unilateral hippocampal atrophy was possible. Conclusion : The MR-based hippocampal volumetry is a useful add-on of visual MR diagnosis, only when visual diagnosis of hippocampal sclerosis is difficult.

• Proceedings of the KSMRM Conference
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• 2001.11a
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• pp.168-168
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• 2001

Purpose： Cerebral perfusion, as measured by interictal SPECT and PET, is known to be decreased in the affected hippocampus of the patients with hippocampal sclerosis. The purpose of th study is to evaluate the capability of perfusion MR imaging to demonstrate ipsilate hypopefusion in patients with hippocampal sclerosis.

• Korean Journal of Radiology
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• v.2 no.2
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• pp.63-67
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• 2001

Objective: Atrophy and a high T2 signal of the hippocampus are known to be the principal MR imaging findings of hippocampal sclerosis. The purpose of this study was to determine whether or not individual MRI findings correlate with surgical outcome in patients with this condition. Materials and Methods: Preoperative MR imaging findings in 57 consecutive patients with pathologically-proven hippocampal sclerosis who underwent anterior temporal lobectomy and were followed-up for 24 months or more were retrospectively reviewed, and the results were compared with the postsurgical outcome (Engel classification). The MR images included routine sagittal T1-weighted and axial T2-weighted spin-echo images, and oblique coronal T1-weighted 3D gradient-echo and T2-weighted 2D fast spin-echo images obtained on either a 1.5 T or 1.0 T unit. The images were visually evaluated by two neuroradiologists blinded to the outcome; their focus was the presence or absence of atrophy and a high T2 hippocampal signal. Results: Hippocampal atrophy was seen in 96% of cases (55/57) [100% (53/53) of the good outcome group (Engel class I and II), and 50% (2/4) of the poor outcome group (class III and IV)]. A high T2 hippocampal signal was seen in 61% of cases (35/57) [62% (33/53) of the good outcome group and 50% (2/4) of the poor outcome group]. All 35 patients with a high T2 signal had hippocampal atrophy. 'Normal' hippocampus, as revealed by MR imaging, occurred in 4% of patients (2/57), both of whom showed a poor outcome (Engel class III). The presence or absence of hippocampal atrophy correlated well with surgical outcome (p<0.01). High T2 signal intensity did not, however, significantly correlate with surgical outcome (p>0.05). Conclusion: Compared with a high T2 hippocampal signal, hippocampal atrophy is more common and correlates better with surgical outcome. For the prediction of this, it thus appears to be the more useful indicator.

• The Korean Journal of Applied Statistics
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• v.37 no.2
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• pp.139-155
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• 2024

This study performed a multi-classification task to classify mesial temporal lobe epilepsy with left hippocampal sclerosis patients (left mTLE), mesial temporal lobe epilepsy with right hippocampal sclerosis (right mTLE), and healthy controls (HC) using magnetoencephalography (MEG) data. We applied various artificial neural networks and compared the results. As a result of modeling with convolutional neural networks (CNN), recurrent neural networks (RNN), and graph neural networks (GNN), the average k-fold accuracy was excellent in the order of CNN-based model, GNN-based model, and RNN-based model. The wall time was excellent in the order of RNN-based model, GNN-based model, and CNN-based model. The graph neural network, which shows good figures in accuracy, performance, and time, and has excellent scalability of network data, is the most suitable model for brain research in the future.

• Proceedings of the KSMRM Conference
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• 1997.10a
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• pp.22-22
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• 1997

• Korean Journal of Radiology
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• v.1 no.1
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• pp.25-32
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• 2000

Objective: The purpose of our study was to determine the ability of H-1 MR spectroscopy (MRS) to lateralize the lesion in patients with hippocampal sclerosis. Materials and Methods: Twenty healthy volunteers and 25 patients with intractable temporal lobe epilepsy whose MR imaging diagnosis was unilateral hippocampal sclerosis were included. This diagnosis was based on the presence of unilateral atrophy and/or high T2 signal intensity of the hippocampus. Single-voxel H-1 MRS was carried out on a 1.5-T unit using PRESS sequence (TE, 136 msec). Spectra were obtained from hippocampal areas bilaterally with volumes of interest (VOIs) of 6.0 cm³ and 2.25 cm³ in healthy volunteers, and of either 6.0 cm³ (n = 14) or 2.25 cm³ (n = 11) in patients. Metabolite ratios of NAA/Cho and NAA/Cr were calculated from relative peak height measurements. The capability of MRS to lateralize the lesion and to detect bilateral abnormalities was compared with MR imaging diagnosis as a standard of reference. Results: In healthy volunteers, NAA/Cho and NAA/Cr ratios were greater than 0.8 and 1.0, respectively. In patients, the mean values of these ratios were significantly lower on the lesion side than on the contralateral side, and lower than those of healthy volunteers (p < .05). The overall correct lateralization rate of MRS was 72% (18/25); this rate was lower with a VOI of 6.0 cm³ than of 2.25 cm³ (64% versus 82%, p < .05). Bilateral abnormalities on MRS were found in 24% (6/25) of cases. Conclusion: Although its rate of correct lateralization is low, single-voxel H-1 MRS is a useful and promising diagnostic tool in the evaluation of hippocampal sclerosis, particularly for the detection of bilateral abnormalities. To improve the diagnostic accuracy of H-1 MRS, further investigation, including the use of a smaller VOI and measurement of the absolute amount of metabolites, are needed.

• Journal of Korean Neurosurgical Society
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• v.30 no.11
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• pp.1300-1307
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• 2001

Purposes : This study reports the possible causes of seizure recurrence in patients underwent previous epilepsy surgery, and surgical strategy for resection of the additional epileptogenic zone locating at the distant area to the site of first resection. Methods : A total of 10 patients with previous surgery due to intractable epilepsy were studied. Five of these underwent standard temporal lobectomy, four extratemporal resection, and one corticoamygdalectomy. Seizure outcome of these were class III-IV. Evaluation methods for reoperation included MRI, 3D-surface rendering of MRI, PET, prologned video-EEG recording with surface electrodes and subdural grid electrodes. Additional resection was done in the frontal lobe in two, in the temporal lobe in three, in the parietal lobe in two, and in the supplementary sensori-motor area in two. Tumor in the superior frontal gyrus in the left hemisphere was removed in one patient. Extent of resection was decided based on the results of ictal subdural grid EEGs and MRI findings. Awake anesthesia and electrocortical stimulation were performed in the two patients for defining the eloquent area. Results : Histopathologic findings revealed extratemporal cortical dysplasia in six, hippocampal sclerosis and cortical dysplasia of the temporal neocortex in one, neuronal gliosis in two, and meningioma in one. Previous pathology of the five patients with cortical dysplasia in the second operation was hippocampal sclerosis plus cortical dysplasia of the temporal neocortex. After reoperation, seizure outcomes were class I in six, class II in three, class III in one at the mean follow-up period of 17.5 months. Characteristically, patients in class II-III after reoperation showed histopathologic findings of hippocampal sclerosis plus temporal neocortical cortical dysplasia plus extratemporal cortical dysplasia. Conclusions : Seizure recurrence after epilepsy surgery was related with the presence of an additional epileptogenic zone distant to the site of first operation, and the majority of the histopathology of the surgical specimens was cortical dysplasia. In particular, hippocampal sclerosis plus temporal neocortical cortical dysplasia was highly related with seizure recurrence in patients with previous operation. In these patients, multimodal evaluation methods were necessary in defining the additional epileptogenic zone.

• Clinical and Experimental Pediatrics
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• v.53 no.1
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• pp.106-110
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• 2010

Hippocampal sclerosis (HS) is one of the most common features of intractable temporal lobe epilepsy. Generally it can be identified through brain magnetic resonance imaging (MRI) with high degree of sensitivity and specificity. Typical brain MRI findings of HS are hippocampal atrophy with hyperintense signal confined to the lesion. On the other hand cortical dysplasia exhibits blurring of the gray-white matter junction and abnormal white matter signal intensity. We present a case where preoperative brain MRI strongly suggested the presence of diffuse cortical dysplasia in the left temporal lobe but postoperative pathology revealed the temporal lesion to be unremarkable except for hippocampal sclerosis.

• Proceedings of the KSMRM Conference
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• 2000.11a
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• pp.16-17
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• 2000