• Journal of the Society of Cosmetic Scientists of Korea
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• v.49 no.2
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• pp.127-139
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• 2023

In this study, minoxidil, which is well known as a pharmaceutical raw material, and diaminopyrimidine oxide (DAO), which is a cosmetic raw material, were used as active ingredients to evaluate the physical properties of niosomes and compare the skin penetrations of artificial skin. To prepare niosomes of the size of nanoparticles, a high pressure homogenization method was used, and physical properties were evaluated with a zetasizer. The particle size of the noisome including the active ingredient was measured to be 99 to 123 nm according to HLB, and the zeta potential was measured in the range of -60 to -81 mV. Through DSC (differential scanning colorimetry), it was confirmed that minoxidil, a crystalline component, was uniformly dissolved in an amorphous state in niosomes. In order to confirm and compare skin penetration, it was measured by the in vitro Franz diffusion cell method, and the niosome formulation showed 3.4 times higher penetration for minoxidil and 11.1 times higher penetration for DAO than the control gel formulation. In addition, when comparing the skin penetration of minoxidil niosome and DAO niosome, a similar trend was shown, and the penetration amount of DAO was relatively high. The shapes of the niosome formulations with different HLB values were observed using Cryo-TEM, and it was confirmed that vesicles were formed in all of them and that they were intermediate between SUV (small unilamella vesicle) and LUV (large unilamella vesicle). Through this study, minoxidil, an effective drug for hair loss, and DAO, a cosmetic raw material, can be effectively delivered to the skin by encapsulating them in a noisome formulation.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.45 no.2
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• pp.139-150
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• 2019

This study is investigated sunscreen formulation that enhances UV absorption efficiency by UV light. Ethylhexyl methoxycinnamate (OMC) is one of the most common UV filters. Many studies have been conducted about photostability of OMC. It is well known that under the UV exposure, trans-OMC could turn to cis-OMC, or produce various photoproducts including its dimers. Those chemical structure changes were understood as the reason of a decrease in UV absorption efficiency upon UV exposure. However, it was found that OMC and isoamyl p-methoxycinnamate (IMC) could even enhance its UV absorption efficiency when it was exposed to UV light in an environment similar to actual use. In order to develop sunscreen formulation that enhances UV absorption efficiency by UV light, emollient with high polarity and compatibility should be avoided from the formular. Those emollient seemed to prevent OMC or IMC from producing photoproducts under UV light. Finally, a sunscreen formulation (UV sensing SPF boosting formular) enhancing UV absorption efficiency by UV was developed by the UV activated SPF boosting technology, and the effect of the sunscreen was evaluated. in vitro SPF of the sunscreen was increased from 50.69 to 72.33 when it was exposed to UV light and its in vivo SPF (53.7) was 56.10% higher than that of the control sunscreen (below 34.4).

• Earthquakes and Structures
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• v.14 no.2
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• pp.103-115
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• 2018

In this work, a simple but accurate hyperbolic plate theory for the free vibration analysis of functionally graded material (FGM) sandwich plates is developed. The significant feature of this formulation is that, in addition to including the shear deformation effect, it deals with only 3 unknowns as the classical plate theory (CPT), instead of 5 as in the well-known first shear deformation theory (FSDT) and higher-order shear deformation theory (HSDT). A shear correction factor is, therefore, not required. Two common types of FGM sandwich plates are considered, namely, the sandwich with the FGM face sheet and the homogeneous core and the sandwich with the homogeneous face sheet and the FGM core. The equation of motion for the FGM sandwich plates is obtained based on Hamilton's principle. The closed form solutions are obtained by using the Navier technique. The fundamental frequencies are found by solving the eigenvalue problems. Numerical results of the present theory are compared with the CPT, FSDT, order shear deformation theories (HSDTs), and 3D solutions. Verification studies show that the proposed theory is not only accurate and simple in solving the free vibration behaviour of FGM sandwich plates, but also comparable with the higher-order shear deformation theories which contain more number of unknowns.

• Korean journal of food and cookery science
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• v.20 no.6 s.84
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• pp.658-666
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• 2004

In order to develop and commercialize high quality frozen soy yogurt, the effects of industrial proteases and commercial mixed cultures were examined on the functional properties and the sensory attributes of frozen soy yogurt. For quality improvement, soy protein isolates were primarily hydrolyzed by either Flavourzyme or Neurtrase, industrial Proteases, to reduce the beany flavor and increase the functional properties of the protein. The viable cell count of lactic acid bacteria was higher in the soy protein hydrolysates than whenuntreated. ABT-5 (L. acidophilus, Bifidobacterium lactis, and S. thermophilus) resulted in higher acid tolerance, bile acid tolerance and melt-down percent values than those with YC-X11 (Lactobacillus bulgaricus and Streptococci thermophilus). The overrun of frozen soy yogurt was improved by both Flavourzyme $(193.3\%)$ and Neurtrase $(156.7\%)$ treatments. With regard to thesensory characteristics, Flavourzyme improved the beany flavor, astringency taste, mouth feel and overall quality of frozen soy yogurts fermented with ABT-5. Further studies onproduct formulation will be needed to commercialize the frozen soy yogurt for the market.

• Korean journal of food and cookery science
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• v.24 no.4
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• pp.412-418
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• 2008

In this study, Sulgidduk samples were prepared with substitutions of 1, 2, 3, and 4% tomato powder, along with a control, and were then analyzed for quality characteristics such as moisture content, water activity, color, textural characteristics, and sensory qualities, in order to determine the optimal ratio of tomato powder in the formulation. According to the results, moisture content and water activity were not significantly different among the Sulgidduk samples. In terms of color, as the level of tomato powder content increased, lightness decreased, while the a-value (+redness/-greenness), and yellowness increased. For the textural characteristics, the samples showed significant differences for hardness, adhesiveness, and gumminess, while fracturability was not significantly different. In addition, the samples containing tomato powder presented significantly higher springiness, cohesiveness(except the 1% substitution level), chewiness, and resilience than the control group. In the sensory evaluation, the control group had significantly higher scores for color and flavor as compared to the tomato powder samples. Furthermore, flavor and overall acceptability decreased, while tomato flavor, sourness, and off-flavor increased with increasing tomato powder content. Sweetness and after-taste were not significantly different among the samples. In conclusion, the results indicate that substituting 2${\sim}$3% tomato powder in Sulgidduk is optimal for quality, and provides a product with reasonably high overall acceptability.

• Steel and Composite Structures
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• v.34 no.2
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• pp.241-260
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• 2020

This article presented a comprehensive model to study static buckling stability and associated mode-shapes of higher shear deformation theories of sandwich laminated composite beam under the compression of varying axial load function. Four higher order shear deformation beam theories are considered in formulation and analysis. So, the model can consider the influence of both thick and thin beams without needing to shear correction factor. The compression force can be described through axial direction by uniform constant, linear and parabolic distribution functions. The Hamilton's principle is exploited to derive equilibrium governing equations of unified sandwich laminated beams. The governing equilibrium differential equations are transformed to algebraic system of equations by using numerical differential quadrature method (DQM). The system of equations is solved as an eigenvalue problem to get critical buckling loads and their corresponding mode-shapes. The stability of DQM in determining of buckling loads of sandwich structure is performed. The validation studies are achieved and the obtained results are matched with those. Parametric studies are presented to figure out effects of in-plane load type, sandwich thickness, fiber orientation and boundary conditions on buckling loads and mode-shapes. The present model is important in designing process of aircraft, naval structural components, and naval structural when non-uniform in-plane compressive loading is dominated.

• Structural Engineering and Mechanics
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• v.51 no.4
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• pp.531-546
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• 2014

In this paper the extension of a recently established energy-based pushover procedure in order to include the higher mode contributions to the seismic response of structures is presented and preliminary evaluated. The steps of the proposed methodology in its new formulation are quite similar to those of the well-known Modal Pushover Analysis. However, the determination of the properties of the 'modal' equivalent single-degree-of-freedom systems is achieved by a rationally founded energy-based concept. Firstly, the theoretical background and the assumptions of the proposed methodology are presented and briefly discussed. Secondly, the sequence of steps to be followed for its implementation along with the necessary equations is systematically presented. The accuracy of the methodology is evaluated by an extensive parametric study which shows that, in general, it provides better results compared to those produced by other similar procedures. In addition, the main shortcoming of the initial version of the methodology now seems to be mitigated to a large extent.

• Journal of Pharmaceutical Investigation
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• v.25 no.1
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• pp.47-54
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• 1995

Transdermal patch formulations of estradiol to treat post-menopausal symptoms and prevent osteoporosis in women were developed and evaluated for the permeation characteristics through the excised hairless mouse abdorminal skin and the uterotropic effect on the ovariectomized rabbits. The design of patch formulations was optimized by varying several formulation parameters, such as type of enhancers, amount of enhancers, amount of drug loading and coating thickness. Compared to a commercially available transdermal product, several patch formulations showed the similar skin permeation profiles (following zero-order kinetics), but their skin permeation rates were lasted for the longer period (a week). In one-week uterotropic efficacy test in the ovariectimized rabbits, the selected patch formulations showed the positive effect in atrophy of the urogenital epithelium. The mean values of uterus weight in rabbits after application of patches containing estradiol were much higher than those in control group (containing no drug).

• Advances in Computational Design
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• v.2 no.3
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• pp.165-194
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• 2017

The present work proposes the thermo mechanically induced statistics of nonlinear transverse central deflection of elastically supported functionally graded (FG) plate subjected to static loadings with random system properties. The FG plate is supported on two parameters Pasternak foundation with Winkler cubic nonlinearity. The random system properties such as material properties of FG material, external loading and foundation parameters are assumed as uncorrelated random variables. The material properties are assumed as non-uniform temperature distribution with temperature dependent (TD) material properties. The basic formulation for static is based on higher order shear deformation theory (HSDT) with von-Karman nonlinear strain kinematics through Newton-Raphson method. A second order perturbation technique (SOPT) and direct Monte Carlo simulation (MCS) are used to compute the nonlinear governing equation. The effects of load parameters, plate thickness ratios, aspect ratios, volume fraction, exponent, foundation parameters, and boundary conditions with random system properties are examined through parametric studies. The results of present approaches are compared with those results available in the literature and by employing direct Monte Carlo simulation (MCS).

• Structural Engineering and Mechanics
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• v.57 no.1
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• pp.127-140
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• 2016

In this paper, a new first shear deformation plate theory based on neutral surface position is developed for the static and the free vibration analysis of functionally graded plates (FGPs). Moreover, the number of unknowns of this theory is the least one comparing with the traditional first-order and the other higher order shear deformation theories. The neutral surface position for a functionally graded plate which its material properties vary in the thickness direction is determined. The mechanical properties of the plate are assumed to vary continuously in the thickness direction by a simple power-law distribution in terms of the volume fractions of the constituents. Based on the present shear deformation plate theory and the neutral surface concept, the governing equations are derived from the principle of Hamilton. There is no stretching-bending coupling effect in the neutral surface based formulation. Numerical illustrations concern flexural and dynamic behavior of FG plates with Metal-Ceramic composition. Parametric studies are performed for varying ceramic volume fraction, length to thickness ratios. The accuracy of the present solutions is verified by comparing the obtained results with the existing solutions.