• Korean Journal of Clinical Pharmacy
• /
• v.11 no.1
• /
• pp.1-6
• /
• 2001

This research is conducted to evaluate the clinical and economic benefits from therapeutic drug monitoring(TDM) service on vancomycin in a tertiary general hospital. Total 99 pairs of steady state peak and trough concentrations of vancomycin were obtained from 73 patients. To see the clinical benefits, the appropriateness of vancomycin dosing before TDM was evaluated. In 72 pairs of vancomycin blood concentrations obtained prior to TDM consultation, $47.2\%$ of the cases had reached within therapeutic range. Serum vancomycin levels in patients with $40{\leq}CLcr<60$ (ml/min) were higher and than the levels in patients with 40>CLcr and $60{\leq}CLcr$ (ml/min). Dose reduction rate in patients with creatinine clearance $40{\leq}CLcr<60$ (ml/min) were also significantly higher than those of compared groups ($61.5\%$, p=0.0138). Serum vancomycin concentrations were re-obtained from 21 patients who received modified dose through TDM service. Ninety percent (19/21cases) of them were within the target therapeutic range. For the evaluation of economic benefits from TDM consultation, estimated cost savings were calculated in those patients. The total drug saving were 586 vials in 21 patients. The calculated mean cost saving from the drugs was 314,570 won (range: $11,273\sim473,466)$ per patient. The study revealed that TDM service for vancomycin is necessary because empirical dosing is not effective for obtaining therapeutic drug level, especially patients with mild renal insufficiencies. The cost saving from TDM is also beneficial for the patients.

• Phonetics and Speech Sciences
• /
• v.5 no.4
• /
• pp.99-107
• /
• 2013

The purpose of this study is to examine the relative distances among English front vowels in a message produced by 47 Korean and American speakers in order to better instruct pronunciation skills of English vowels for Korean English learners. A Praat script was developed to collect the first and second formant values(F1 and F2) of eight words in each sound file which was recorded from an internet speech archive. Then, the Euclidean distances were measured between the three vowel pairs: [i-ɛ], [i-ɪ], and [ɛ-æ]. The first vowel pair [i-ɛ] was set as the reference from which the relative distances of the other two vowel pairs were measured in percent in order to compare the vowel sounds among speakers of different vocal tract lengths. Results show that F1 values of the front vowels produced by the Korean and American speakers increased from the high front vowel to the low front vowel wih differences among the groups. The Korean speakers generally produced the front vowels with smaller jaw openings than the American speakers did. Secondly, the relative distance of the high front vowel pair [i-ɪ] showed a significant difference between the Korean and American speakers while that of the low front vowel pair [ɛ-æ] showed a non-significant difference. Finally, the Korean speakers in the higher proficiency level produced front vowels with higher F1 values than those in the lower proficiency level. The author concluded that Korean speakers should produce the front high vowels distinctively by securing sufficient relative distance of the formant values. Further studies would be desirable to examine how strong the Korean speakers' English proficiency correlate with the relative distance of target words of comparable productions.

• Journal of the Korean Chemical Society
• /
• v.38 no.9
• /
• pp.660-666
• /
• 1994

The effects of temperature and flow rate of eluent on the separation of adjacent lighter lanthanide pairs (La : Ce, Ce : Pr, Pr: Nd) have been studied with displacement chromatography. Two serial columns packed with Amberlite 120 cation exchange resin are used for loading and separation. The retaining ion is $H^+$ ion and the eluent is 0.012M and 0.015M of EDTA solution. The columns and the eluent are maintained at the temperature of 90$^{\circ}C$ and pressurized to reduce vaporizing in the ion-exchange resin column. The eluated solution is analyzed directly with ICP-AES. The separation factors of the lanthanide pairs, La: Ce, Ce :Pr, and Pr: Nd, are 4.6, 2.8, and 1.9, respectively and are higher than that from theoretical calculation at 25$^{\circ}C$. When the flow rate is reduced from 2.5 ml/min to 1.5 ml/min, the HETP is reduced from 1.60 cm to 0.88 cm. The separation efficency can be improved at lower flow rate of eluent and higher operating temperature. The recoveries of pure lanthanides than 99.9% are 49∼77% from this separation.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• v.15 no.11
• /
• pp.4084-4104
• /
• 2021

Visual place recognition (VPR) is a fundamental yet challenging task of mobile robot navigation and localization. The existing VPR methods are usually based on some pairwise similarity of image descriptors, so they are sensitive to visual appearance change and also computationally expensive. This paper proposes a simple yet effective four-step method that achieves adaptive convolutional neural network (CNN) landmark matching for VPR. First, based on the features extracted from existing CNN models, the regions with higher significance scores are selected as landmarks. Then, according to the coordinate positions of potential landmarks, landmark matching is improved by removing mismatched landmark pairs. Finally, considering the significance scores obtained in the first step, robust image retrieval is performed based on adaptive landmark matching, and it gives more weight to the landmark matching pairs with higher significance scores. To verify the efficiency and robustness of the proposed method, evaluations are conducted on standard benchmark datasets. The experimental results indicate that the proposed method reduces the feature representation space of place images by more than 75% with negligible loss in recognition precision. Also, it achieves a fast matching speed in similarity calculation, satisfying the real-time requirement.

• Earthquakes and Structures
• /
• v.24 no.3
• /
• pp.217-235
• /
• 2023

Orthogonal pairs of rollers on concave beds (OPRCB) are a low-cost, low-tech rolling-based isolating system, whose high efficiency has been shown in a previous study. However, seismic performance of OPRCB isolators has only been studied in the two-dimensional (2D) state so far. This is while their performance in the three-dimensional (3D) state differs from that of the 2D state, mainly since the vertical accelerations due to rollers' motion in their beds, simultaneously in two orthogonal horizontal directions, are added up and resulting in bigger vertical inertia forces and higher rolling resistance. In this study, first, Lagrange equations were used to derive the governing equations of motion of the OPRCB-isolated buildings in 3D. Then, some regular shear-type OPRCB-isolated buildings were considered subjected to three-component excitations of far- and near-source earthquakes, and their responses were compared to those of their fixed-base counterparts. Finally, the effects of more realistic modeling and analysis were examined by comparing the responses of isolated buildings in 2D and 3D states. Response histories were obtained by the fourth-order Runge-Kutta-Nystrom method, considering the geometrical nonlinearity of isolators. Results reveal that utilizing the OPRCB isolators effectively reduces the acceleration response, however, depending on the system specifications and earthquake characteristics, the maximum responses of isolated buildings in the 3D state can be up to 40% higher than those in the 2D state.

• The korean journal of orthodontics
• /
• v.49 no.1
• /
• pp.3-11
• /
• 2019

Objective: The purpose of this study was to investigate the influence of heritability on the craniofacial soft tissue cephalometric characteristics of monozygotic (MZ) twins, dizygotic (DZ) twins, and their siblings (SIB). Methods: The samples comprised Korean adult twins and their siblings (mean age, 39.8 years; MZ group, n = 36 pairs; DZ group, n = 13 pairs of the same gender; and SIB group, n = 26 pairs of the same gender). Thirty cephalometric variables were measured to characterize facial profile, facial height, soft-tissue thickness, and projection of nose and lip. Falconer's method was used to calculate heritability (low heritability, $h^2$ < 0.2; high heritability, $h^2$ > 0.9). After principal components analysis (PCA) was performed to extract the models, we calculated the intraclass correlation coefficient (ICC) value and heritability of each component. Results: The MZ group exhibited higher ICC values for all cephalometric variables than DZ and SIB groups. Among cephalometric variables, the highest ${h^2}_{(MZ-DZ)}$ and ${h^2}_{(MZ-SIB)}$ values were observed for the nasolabial angle (NLA, 1.544 and 2.036), chin angle (1.342 and 1.112), soft tissue chin thickness (2.872 and 1.226), and upper lip thickness ratio (1.592 and 1.026). PCA derived eight components with 84.5% of a cumulative explanation. The components that exhibited higher values of ${h^2}_{(MZ-DZ)}$ and ${h^2}_{(MZ-SIB)}$ were PCA2, which includes facial convexity, NLA, and nose projection (1.026 and 0.972), and PCA7, which includes chin angle and soft tissue chin thickness (2.107 and 1.169). Conclusions: The nose and soft tissue chin were more influenced by genetic factors than other soft tissues.

• Korean Journal of Environmental Agriculture
• /
• v.19 no.5
• /
• pp.382-393
• /
• 2000

The principal indicators contributing to water qualities was screened by factor analyses, based on the monitored chemical parameters of water quality for various water resources from 1995 to 1999 in the small agricultural catchments of the Han River Basin. Water samples of streams, groundwaters, and reservoirs were taken four times a year from upper (Daegwanryong), middle (Dunnae and Chunchon) and lower (Guri) reaches of Han River Basin. In these areas, the respective type of farming practiced was alpine agriculture and livestocks raising, typical upland and paddy cultivation, and intensive cropping in the plastic film house. Water quality was monitored for twenty-one water quality parameters, including pH, EC, SS, T-N, T-P, COD, cations, anions, and heavy metals. pH, EC and COD of the stream waters were suitable for the Korea irrigation water quality guidelines. However, T-N and T-P concentrations of water samples in four catchments far exceeded the irrigation water guideline. Concentrations of canons and heavy metals in Wangsuk stream in Guri area were higher than those in streams in other areas. Factor analysis revealed that significant correlation was observed for 81 pairs out of 231 water quality indicators of stream water among the $21\;{\times}\;21$ cross correlation matrix of stream water quality indicators. The first factor accounted for 27.01% of the total variation in stream water quality indicators, and high positive factor loadings were shown on EC, K, Na, $NH_4\;^+-N$, $PO_4\;^{3-}$, $SO_4\;^{2-}$, and COD. Fifty-three water quality indicator pairs were significant out of 190 ground water quality parameters. The first factor accounted for 28.54% of the total variation in ground water quality indicators, and high loadings were revealed on EC, Ca, Mg, K, Na, $NH_4\;^+-N$, and $SO_4$. Twenty-nine pairs of reservoir water quality indicators were significant out of 66 pairs. The first factor accounted for 37.06% of the total variation in reservoir water quality indicators, and high loadings were shown on EC, Mg, K, Na, SS, T-P, Cl, and COD. These results demonstrate that EC was the first factor contributing to water quality.

• Korean Institute of Interior Design Journal
• /
• no.17
• /
• pp.60-64
• /
• 1998

The results of simulation on greenery ratio using CG are as follows: arrangement type of optimal condition and greenery ratio were summarized as below as dispersion type and 5% ratio greenery for 20 pairs of assessment items and these assessment items were classified into 5 factors as a result of factor analysis,. These factors were Harmony Animation Atmosphere texture Peculiarity. Verification results of factors differences according to each condition can be. there was no apparent difference among factors in accordance with gender, In case of arrangement type dispersion type was higher than concentration type in all factors. Based on the above results dispersion type was assessed higher than concentration type the most suitable condition of Harmony Factor was 5% dispersion type Animation Factor was 5% dispersion type Animation Factor was 7% dispersion type Atmosphere Factor was 10% dispersion type Texture Factor was 5% concentration type and $\ulcorner$Peculiarity Factor$\lrcorner$was 7% concentration type.

• The Korean Journal of Malacology
• /
• v.10 no.1
• /
• pp.9-18
• /
• 1994

This study was conducted to compare the genital organs of 14 land snail species belonging to family Bradybaenidae in Korea. The species used for present experiment were characterized by well developed dart sac, accessory sacs and two mucous glands between accessory sacs. No flagellum in the snails of three species employed(Acusta despecta sieboldiana, Koreanohadra kurodana, K. koreana) was observed in this study. The similarity value between Koreanohadra kurodana and Koreanohadra koreana (S=0.834) was more higher than the other species pairs. The higher value followed was recorded between Aegista gottschei and Aegista pyramidata (S=0.761). The clustering type by anatomical genital organs was similar to that analysed by the shell morphologies.

• Asian-Australasian Journal of Animal Sciences
• /
• v.14 no.7
• /
• pp.1014-1018
• /
• 2001

Pigs respond to extreme temperature (very cold or hot) by physiological and nutritional adjustments. Yet little is known about the effects of different environmental temperature (thermoneutral in the highland area, and hot temperature in the coastal area) where pigs are maintained on the performance of the pigs. Ten pigs each (10 pairs of littermates) were assigned to two treatments (2 locations): highland area (control=CA) or coastal area (hot/heat stress=HS). Experimental design was Paired 't' test. HS pigs had higher average daily water intake (p<0.05) compared to CA pigs (6,05 vs 3.89 kg/d), CA pigs had higher feed intake compared to HS pigs (2.9 vs 1.95 kg/d, p<0,05). CA pigs had higher daily gain compared to HS pigs (0.72 vs 0.58 kg/d, p<0.05). Feed conversion was not significantly different between CA pigs and HS pigs. The digestibility of dry matter, N, Na, K, Mg, CI, Ca and P was not significantly affected by the treatments. High environmental temperature in the coastal area (heat stress) increased water intake, decreased voluntary feed intake and daily gain of the pigs. The results demonstrate that different environmental temperature in the coastal area (heat stress) and highland area (control) had no pronounced effect on digestibility of nutrients.