• Journal of Microbiology and Biotechnology
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• v.16 no.11
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• pp.1713-1719
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• 2006

A method for the simple, rapid, specific, and accurate detection of Bacillus anthracis spores was developed by employing specific capture peptides conjugated with fluorescent quantum dots (QDs). It was possible to distinguish B. anthracis spores from the spores of B. thuringiensis and B. cereus using these peptide-QD conjugates by flow cytometric and confocal laser scanning microscopic analyses. For more convenient high-throughput detection of B. anthracis spores, spectrofluorometric analysis of spore-peptide-QD conjugates was performed. B. anthracis spores could be detected in less than 1 h using this method. In order to avoid any minor yet false-positive signal caused by the presence of B. thuringiensis spores, the B-Negative peptide, which can only bind to B. thuringiensis, conjugated with another type of QD that fluoresces at different wavelength was also developed. In the presence of mixed B. anthracis and B. thuringiensis spores, the BABA peptide conjugated with QD525 and the B-Negative peptide conjugated with QD585 were able to bind to the former and the latter, specifically and respectively, thus allowing the clear detection of B. anthracis spores against B. thuringiensis spores by using two QD-labeling systems. This capture peptide-conjugated QD system should be useful for the detection of B. anthracis spores.

• Journal of KIISE:Information Networking
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• v.28 no.4
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• pp.517-526
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• 2001

In order to reduce the increasing packet loss rates caused by an exponential increase in network traffic, the IETF(Internet Engineering Task Force) is considering the deployment of active queue management techniques such as RED(Random Early Detection). While active queue management in routers and gateways can potentially reduce total packet loss rates in the Internet, this paper has demonstrated the inherent weakness of current techniques and shows that they are ineffective in preventing high loss rates. The inherent problem with these queue management algorithms is that they all use queue lengths as the indicator of the severity of congestion. In this paper, in order to solve this problem, a new active queue management algorithm called MRED(Modified Random Early Detection) is proposed. MRED computes the packet drop probability based on our heuristic method rather than the simple method used in RED. Using simulation, MRED is shown to perform better than existing queue management schemes. To analyze the performance, we also measure throughput of traffics under the FIFO control, and compared the performance with that of this MRED system.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.35 no.2B
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• pp.345-351
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• 2010

It has been growing interests that convergence services of broadcasting and telecommunication services such as DMB 2.0 and Mobile IPTV etc. Unicast type is difficult to service broadcasting due to limits of capacity and poor receiving environments, WiBro supports broadcast service with MBS. MBS is transmission method that base stations belong to same the MBS zone transmit the all users who request broadcasting service. Terminals are received resources from all base station in the MBS zone and SINR can be improved because of macro diversity. If terminals are located at edge of the MBS zone, complement algorithm are needed beacause received SINR is very low. In this paper, MIMO STBC, Relay and FFR are introduced to improve the throughputs using high MCS. The basic simulation environment is assumed to be SISO. Transparent relay and FFR applicable on MBS are divided by SISO and MIMO STBC environment and evaluate the performance.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.33 no.9B
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• pp.760-766
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• 2008

As a backbone network, wireless mesh network (WMN) aims to provide reliable high throughput network connectivity to wireless users. Recent research has focused on routing and channel allocation to increase the capacity of wireless mesh backbones. Wireless mesh networking is an attractive solution for home, community, and enterprise networks as it is a self-configuring, instantly deployable, and lowcost networking system. In this paper, we empirically evaluate and analyze charateristic of WMN to establish WMN testbed by measurement. We use laptops and net4826 Soekris board widely used. Soekris boards are equipped with one network interface card (NIC) or above in our measurements. We also use paket generator, routing demon tools and so on. Throughout this measurements, we show limitation of Soekris board and software we use, and suggest guideline to establish WMN.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.30 no.4 s.48
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• pp.479-483
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• 2004

An attempt was made to develop a proteinchip for screening of MITF (microphthalmia transcription factor) inhibitor. Binding of MITF to E-box causes transcription of several pigmenting genes including tyrosinase gene. We investigated binding of MITF and its DNA binding site (E-box) using a protein-DNA chip with various detection methods including flurorescence (Cyt3). SPR (surface plasmon resonance) and SPRi (surface plasmon resonance imaging). A fusion protein (MITF-Maltose Binding Protein) was attached on the glass plate by chemical modification. An inhibitory synthetic DNA oligomer, artificially designed based on the E-box sequence, inhibited the binding of MITF and E-box. These results showed the potentials of flurorescence-based MITF protein chip as a microarray for high throughput screening (HTS) system of depigmenting agents.

• Korean Journal of Materials Research
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• v.23 no.8
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• pp.405-422
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• 2013

Atomic layer deposition(ALD) is a promising deposition method and has been studied and used in many different areas, such as displays, semiconductors, batteries, and solar cells. This method, which is based on a self-limiting growth mechanism, facilitates precise control of film thickness at an atomic level and enables deposition on large and three dimensionally complex surfaces. For instance, ALD technology is very useful for 3D and high aspect ratio structures such as dynamic random access memory(DRAM) and other non-volatile memories(NVMs). In addition, a variety of materials can be deposited using ALD, oxides, nitrides, sulfides, metals, and so on. In conventional ALD, the source and reactant are pulsed into the reaction chamber alternately, one at a time, separated by purging or evacuation periods. Thermal ALD and metal organic ALD are also used, but these have their own advantages and disadvantages. Furthermore, plasma-enhanced ALD has come into the spotlight because it has more freedom in processing conditions; it uses highly reactive radicals and ions and for a wider range of material properties than the conventional thermal ALD, which uses $H_2O$ and $O_3$ as an oxygen reactant. However, the throughput is still a challenge for a current time divided ALD system. Therefore, a new concept of ALD, fast ALD or spatial ALD, which separate half-reactions spatially, has been extensively under development. In this paper, we reviewed these various kinds of ALD equipment, possible materials using ALD, and recent ALD research applications mainly focused on materials required in microelectronics.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.40 no.12
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• pp.46-58
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• 2003

The recent Internet is changing from its best-effort service and needs the network structure and traffic engineering, which can support various applications requiring differentiated traffic processing and high quality of service. The extension of the Internet from wired to wireless system generating location-dependent and burst errors make more difficult to support a good service with the existing packet scheduling algorithm. In this paper, we propose a wireless diffserv packet scheduling (WDSPS) algorithm that can provide reliable service in the differentiated wireless internet service network. The proposed scheduling algorithm solves the HOL(head of line) blocking problems of class queue occurred in wireless network, supports the differentiated service for each class which is defined in differentiated service networks and makes possible the gradual and efficient service compensation not only among classes but also among flows to prevent the monopoly of one class or one flow. Through simulations, we show that our proposed WDSPS scheduling algorithm can provide the required QoS differentiation between classes and enhance the service throughput in various wireless network conditions.

• The KIPS Transactions:PartD
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• v.10D no.2
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• pp.195-210
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• 2003

In this paper, we propose an enhanced concurrency control algorithm that maximizes the concurrency of multi-dimensional index structures. The factors that deteriorate the concurrency of index structures are node splits and minimum bounding region (MBR) updates in multi-dimensional index structures. The proposed concurrency control algorithm introduces PLC(Partial Lock Coupling) technique to avoid lock coupling during MBR updates. Also, a new MBR update method that allows searchers to access nodes where MBR updates are being performed is proposed. To reduce the performance degradation by node splits the proposed algorithm holds exclusive latches not during whole split time but only during physical node split time that occupies the small part of a whole split process. For performance evaluation, we implement the proposed concurrency control algorithm and one of the existing link technique-based algorithms on MIDAS-3 that is a storage system of a BADA-4 DBMS. We show through various experiments that our proposed algorithm outperforms the existing algorithm in terms of throughput and response time. Also, we propose a recovery protocol for our proposed concurrency control algorithm. The recovery protocol is designed to assure high concurrency and fast recovery.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.34 no.3B
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• pp.264-273
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• 2009

For IEEE 802.15.3 HR-WPAN, we propose the DABL algorithm that PNC can allocate the channel times to the DEV in super frame in order that system frame throughput is increased and the delay is decreased. In detail, the DABL algorithm allows to dynamically allocate channel time as well as to adaptively apply the modulation and coding scheme based on the link quality of the DEV. In addition, due to the facts that QoS is quite different depending on service types, we provide the DABL algorithm taking into account RT(Real Time) traffic and Non-RT traffic respectively. Finally, we show simulation results of the DABL algorithm compared to the conventional algorithm that the PNC equally allocates channel times to the DEV regardless of the link quality of the DEV.

• Journal of Genetic Medicine
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• v.12 no.2
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• pp.79-84
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• 2015

Purpose: We developed and validated a fetal trisomy detection method for use as a noninvasive prenatal test (NIPT) including a Clinical Laboratory Improvement Amendments (CLIA)-certified bioinformatics pipeline on a cloud-based computing system using both Illumina and Life Technology sequencing platforms for 221 Korean clinical samples. We determined the necessary proportions of the fetal fraction in the cell-free DNA (cfDNA) sample for NIPT of trisomies 13, 18, and 21 through a limit of quantification (LOQ) test. Materials and Methods: Next-generation sequencing libraries from 221 clinical samples and three positive controls were generated using Illumina and Life Technology chemistries. Sequencing results were uploaded to a cloud and mapped on the human reference genome (GRCh37/hg19) using bioinformatics tools. Based on Z-scores calculated by normalization of the mapped read counts, final aneuploidy reports were automatically generated for fetal aneuploidy determination. Results: We identified in total 29 aneuploid samples, and additional analytical methods performed to confirm the results showed that one of these was a false-positive. The LOQ test showed that the proportion of fetal fraction in the cfDNA sample would affect the interpretation of the aneuploidy results. Conclusion: Noninvasive chromosome examination (NICE), a CLIA-certified NIPT with a cloud-based bioinformatics platform, showed unambiguous success in fetus aneuploidy detection.