• 한국지역지리학회지
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• 제20권4호
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• pp.444-453
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• 2014

환경위험의 피해가 환경불평등과 사회불평등의 상호작용으로 인해 환경약자가 더 많이 피해를 받게 되는 환경 피해 불평등이 심화될 것으로 전망되고 있다. 본 연구는 서울시를 대상으로 미국 캘리포니아 환경보호청에서 개발한 환경보건 스크리닝 툴을 적용하여 통합적인 지역 규모의 누적영향을 평가하였다. 환경보건 취약지역을 스크리닝하기 위하여 환경노출과 건강영향의 환경부담, 민감집단과 사회경제적 요인의 인구특성에 따라 10개 지표를 선정하였다. 환경보건 스크리닝 툴을 통하여 2009~2011년 서울시 누적영향평가를 실시한 결과, 서울의 강서와 강남지역에서 위험요인이 높게 나타났며 강서지역은 환경부담과 인구특성 모두에서 위험요인이 높았고, 강남지역은 환경부담요인이 높은 것으로 나타났다. 연구결과는 민감 취약계층 등 환경약자를 고려한, 공정하고 효율적인 환경정책을 추진하기 위한 과학적인 근거를 제공할 수 있다.

• 한국가스학회지
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• 제28권1호
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• pp.85-99
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• 2024

수소전기차의 보급 확대가 빠르게 이루어지며 수소충전소의 모델 또한 다양화되고 있다. 이에 따라 종류별 수소 충전소의 안전에 대한 이슈가 대두되고 있다. 본 연구에서는 승용·버스·트럭 등 다차종 동시 수소충전이 가능한 수소 스테이션의 정량적 위험성평가를 진행하였다. 정량적 위험성평가에 범용적으로 사용되는 Gexcon 사(社)의 Effects&Riskcurves Software를 활용하여 수소 누출에 따른 화재, 폭발 등의 시나리오를 부여하였다. 이를 통해 복사 열, 폭발 과압에 의한 피해 영향 거리를 계산해냈으며, 주변 건물 및 인구에 미치는 위험도를 측정하였다. 피해 영향 거리가 가장 크게 나타난 것은 충전설비 및 고압 압축가스 설비의 화재 및 폭발이었으며 개인적 및 사회적 위험도에 가장 크게 기여한 설비는 고압 압축가스 설비로 나타났다. 이에 따라 충전설비 및 압축가스 설비에 대한 안전거리를 보수적으로 책정하며 적절한 방호조치를 설치한다면 수소 누출 사고 발생 시 인적·물적 피해 최소화에 기여할 수 있을 것으로 검토된다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.2039-2043
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• 2012

Objectives: Depression is common in cancer patients. However, only limited evidence is available for Asian populations. The authors therefore examine the prevalence of depression in Thai patients with cancer. In addition, associated factors were determined. Methods: This cross-sectional study was conducted in cancer patients admitted to a university hospital during December 2006 - December 2007. The Patient Health Questionnaire (PHQ-9) was used to assess all cancer patients. Suicidal risk was assessed by using the Mini-International Neuropsychiatric Interview (MINI) in the module of suicidal risk assessment. Results: Of 108 cancer patients, 29.6 % were diagnosed with a depressive disorder (mild, 14.8 %; moderate, 5.6 %; severe, 9.3 %). However, only 25.0 % of these were recognized as being depressed by the primary physician. According to the MINI., 28.1 % of these depressed cancer patients had a moderate to severe level of suicidal risk. In addition, the findings suggest that increased risk of depression is significantly associated with increased pain score, lower number of cancer treatments (< 2 methods), increased educational duration (>13 years), increased age (> 50 years old) and being female. Conclusions: The prevalence of depression is high in Thai cancer patients. However, depressive disorder in those patients is frequently undiagnosed. It is associated with several factors including pain, a number of cancer treatments, education duration, age and sex. To improve quality of life, increase compliance with treatments and prevent of suicide, screening for depressive disorders in this patient group is strongly recommended.

• Asian Pacific Journal of Cancer Prevention
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• 제15권13호
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• pp.5207-5214
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• 2014

Background: To study the relationship of susceptibility to lung cancer with the gene polymorphisms of CYP1A1, GSTM1, GSTM3, GSTT1, GSTP1 and smoking status in Han and Mongolian populations of Inner Mongolia, an autonomous region of China. Materials and Methods: PCR-RFLP, allele-specific and multiplex PCR were employed to identify the genotypes of CYP1A1, GSTM1, GSTM3, GSTT1 and GSTP1 in a case-control study of 322 lung cancer patients diagnosed by bronchoscopy and 456 controls free of malignancy. Results: There is a significant difference in genotypic frequency of GSTT1 of healthy Mongolian and Han subjects. A statistically prominent association was found between CYP1A1 Msp1 (vt/vt) (OR=4.055, 95%CI:2.107-7.578, p=0.000), GSTM1 (-) (OR=2.290, 95%CI:1.467-3.573, p=0.000) and lung cancer in Mongolians. Similarly, in the Han population, CYP1A1 Msp1 (vt/vt) (OR=3.194, 95%CI:1.893-5.390, p=0.000) and GSTM1 (-) (OR=1.884, 95%CI:1.284-2.762, p=0.001) carriers also had an elevated risk of lung cancer. The smokers were more susceptible to lung cancer 2.144 fold and 1.631 fold than non-smokers in Mongolian and Han populations, respectively. The smokers who carried with CYP1A1 Msp1 (wt/vt+vt/vt), exon7 (Val/Val+Ile /Val), GSTM1 (-), GSTM3 (AB+BB), and GSTT1 (-) respectively were found all to have a high risk of lung cancer. Conclusions: CYP1A1 Msp1 (vt/vt) and GSTM1 (-) are risk factors of lung cancer in Han and Mongolian population in the Inner Mongolia region. The smokers with CYP1A1 Msp1 (wt/vt+vt/vt), CYP1A1 exon7 (Val/Val+Ile /Val), GSTM1 (-), GSTM3 (AB+BB), and GSTT1 (-) genotypes, respectively, are at elevated risk of lung cancer.

• Journal of Community Nutrition
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• 제7권1호
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• pp.29-35
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• 2005

It has been suggested that dietary fat increases the risk of breast cancer by elevating serum estrogen concentrations. However, studies on a relationship between fat intake and breast cancer risk have shown contradictory results, possibly because the levels of fat intake in study populations were too high to observe differences. Also, the effect of other dietary factors may present. The present study was performed to investigate the relationship between diet and estrogen metabolism in premenopausal women whose usual fat intake is relatively low compared to their western counterparts. Twenty lacto-ovo vegetarians (LOV) and twenty omnivores participated in the study. Three day food records including a Saturday or a Sunday were used to estimate nutrient intake. Serum lipids, estradiol, sex-hormone binding globulin, and urinary estradiol were measured. Study results showed $24.8\%$ and $20.9\%$ of energy intake were provided from fat in omnivorous and LOV subjects, respectively. Serum and urinary levels of estradiol were two times higher in omnivores. Fat intake was not related to either serum estradiol nor urinary estradiol when the Spearman correlation coefficient analysis was performed. Carbohydrate, total dietary fiber and soluble dietary fiber intakes were negatively related to serum estradiol concentration. Legumes, vegetables and fruit consumption showed significantly negative relationships with both serum and urinary estradiol concentrations. These results indicate lower estrogen availability may be associated with plant food­based diets in premenopausal women whose usual diets contain less than $25\%$ of energy as fat.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제22권6호
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• pp.501-510
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• 2019

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in children. The global prevalence of pediatric NAFLD from general populations is 7.6%. In obese children, the prevalence is higher in Asia. NAFLD has a strong heritable component based on ethnic difference in the prevalence and clustering within families. Genetic polymorphisms of patatin-like phospholipase domain-containing protein 3 (PNPLA3), transmembrane 6 superfamily member 2, and glucokinase regulatory protein (GCKR) are associated with the risk of NAFLD in children. Variants of PNPLA3 and GCKR are more common in Asians. Alterations of the gut microbiome might contribute to the pathogenesis of NAFLD. High fructose intake increases the risk of NAFLD. Liver fibrosis is a poor prognostic factor for disease progression to cirrhosis. Magnetic resonance spectroscopy and magnetic resonance proton density fat fraction are more accurate for steatosis quantification than ultrasound. Noninvasive imaging methods to assess liver fibrosis, such as transient elastography, shear-wave elastography, and magnetic resonance elastography are useful in predicting advanced fibrosis, but they need further validation. Longitudinal follow-up studies into adulthood are needed to better understand the natural history of pediatric NAFLD.

• The Korean Journal of Medicine
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• 제93권6호
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• pp.509-517
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• 2018

A small number of viable tuberculosis bacilli can reside in an individual with latent tuberculosis infection (LTBI) without obvious clinical symptoms or abnormal chest radiographs. Diagnosis and treatment of LTBI are important for tuberculosis (TB) control in public and private healthcare facilities, particularly in high-risk populations. The updated 2017 Korean guidelines for TB recommend that tuberculin skin tests, interferon-gamma release assays, or a combination of them can be used for the diagnosis of LTBI, depending on the age and immune status of the patient as well as their TB contact history. For diagnosis of LTBI, exclusion of active TB is essential, and the possibility of healed TB in those without a history of treatment for TB but at risk of its development must be considered. The treatment options for LTBI include isoniazid, rifampicin, isoniazid/rifampicin, and isoniazid/rifapentine. The benefits and risks of these agents based on the age of the patient and their hepatotoxicity must be considered when selecting the appropriate drug. Standardized diagnosis and treatment of LTBI based on the updated 2017 guidelines will contribute to the control of TB in Korea as well as to further revisions of the guidelines.

• Parasites, Hosts and Diseases
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• 제59권6호
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• pp.595-605
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• 2021

An understanding of the knowledges, attitudes and perceptions of different populations is key for public health policy makers. Here, a survey was performed on knowledge, attitudes, and perceptions about malaria diagnosis, prevention, control, and treatment. The 407 survey participants included both uninfected inhabitants and patients from 2 cities (Gimpo- and Paju-si) of Northern Gyeonggi-do, known as high-risk areas for vivax malaria. We used community-based study design and non-probability sampling method using the primary data. Association between variables were tested using χ²-tests. In general, the information on malaria reported by the participants in this study was unsystematic and included inaccurate details. The knowledge of malaria symptoms, identified as headache, chills and fever, was high, but the surveyed community lacks knowledge of the specific medications used for malaria treatment, with a large number of respondents having no knowledge of any form of medication. Survey questions with high correct answer rates included questions about easy treatment of malaria in Korea, the high daytime activity of malaria-borne mosquitoes, and the infection risk posed by outdoor activities. However, a large portion of the respondents was unable to provide simple medical and biological information about the disease. This study aimed to comprehensively evaluate the knowledge, attitude, and practical behavior of the surveyed community with respect to malaria and the implications reported here could be applicable to other malaria endemic areas in Korea.

• 보건교육건강증진학회지
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• 제21권2호
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• pp.147-165
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• 2004

Injury is a leading cause of death in the children and adolescent populations. In particular, more than 80％ of unintentional injury was related to risk-taking behaviors involved in diverse accidents around school and home. Therefore, educational approaches should be provided for children and adolescent populations, and schools are the essential and appropriate sites to conduct safety education. This study was conducted to identify injury prevalence and safety education at schools among middle and high school students in Korea. About 1,034 middle and high students in 28 schools participated in a self-administered survey. The target schools were selected from the stratified random sampling method throughout schools of seven metropolitan cities in Korea. The questionnaires were delivered to the vice-principals by ground mailing service and the vice-principals administered survey data collection. The questionnaire asked about safety education provided in schools, injury experience in the last year, needs for injury prevention class in school, and demographics. All survey responses were entered into SPSS worksheet. Multivariate analysis of variance (MANOVA) and descriptive discriminant analysis (DDA) were used in statistical analysis with SPSS software 11.1. Multivariate analysis of variance was conducted as a preliminary analysis of DDA. According to the result of multivariate analysis of variance, gender (man), grade (poor), living with both parents, and displaying injury prevention messages on school news board were significantly different between the injured student group and the uninjured student group (p＝ .00). These four factors also had significant effects on students' injury experience in DDA, although correlation of the four factors with injury experience was weak overall based on their canonical function coefficients. All structure coefficients of the four factors were greater than .30, which means the four factors have discriminant effects on injury prevalence. The sizes of the discriminant effects, in order, were largly from gender, grade, living with both parents, and safety message display on school news boards.

• Journal of Korean Biological Nursing Science
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• 제19권3호
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• pp.131-140
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• 2017

Purpose: Dyslipidemia was a known risk factor for cardiovascular disease and was a leading cause of mortality in worldwide. This study aimed to determine the factors associated with prevalence and medication treatment of dyslipidemia in Korean adult population. Methods: In this study, based on the criteria set by the Korean Society of Lipidology and Atherosclerosis, the factors associated with prevalence and medication treatment of dyslipidemia was evaluated in a population of 12,506 people ($age{\geq}20$), who participated in the Korean National Health and Nutrition Examination Survey (2013-2015). The findings were tested by using multivariate logistic regression. Results: Dyslipidemia prevalence rate was 36.5%. Among populations with dyslipidemia, 17.5% were treated with lipid-lowering drugs. In the multivariate logistic regression model, male, increase in age, lower education level, non-drinker, current smoking, less physical activity, increase of body mass index, hypertension, and diabetes were associated with an increased odd of dyslipidemia. Female, increase in age, higher income, excess fat intake, hypertension, diabetes, myocardial infarction, and angina were associated with an increased odd of medication treat. Conclusion: The results of this study could be used to screen patients at the high risk for dyslipidemia or to predict medication adherence.