• Asian Pacific Journal of Cancer Prevention
• /
• 제16권5호
• /
• pp.1897-1900
• /
• 2015

Purpose: To evaluate acute toxicity in nasopharyngeal cancer (NPC) patients treated with intensity modulated radiotherapy (IMRT)/volumetric modulated arc therapy (VMAT) with or without cisplatin-based chemotherapy. Materials and Methods: A total of 45 newly diagnosed, histologically proven non-metastatic NPC patients treated with IMRT between May 2010 and December 2012, were evaluated retrospectively, 37 planned with Eclipse and 8 with Prowess Panther treatment planning system. The doses to the planning target volumes of primary tumor and involved lymph nodes, high risk region, and uninvolved regional nodal areas were 70 Gy, 60 Gy, and 54 Gy respectively and delivered simultaneously over 33 fractions to 39 patients. Another 6 patients irradiated with sequential boost technique. Some 84.4% of patients received chemotherapy. Acute toxicities were graded according to the Radiation Therapy Oncology Group scoring criteria and Common Terminology Criteria for Adverse Events (CTCAE) for chemotherapy side effects. Results: Median age was 43 years (14-79) and all patients were WHO type II. Grade 1 mucositis and dysphagia were observed in 17 (37.8%), and 10 (22.2%) patients, respectively. The incidence of acute grade 2 mucositis and dysphagia was 55.6% and 68.9%, respectively. The most common chemoradiotherapy related acute toxicities were nausea, leucopenia and thrombocytopenia. Grade 3 toxicity was detected in 13 (28.8%) cases. No grade 4 toxicity was occurred. Mean weight loss was 9%. None of the patients required the insertion of percutaneous endoscopic gastrostomy for nutritional support. Radiation therapy was completed without interruption in all patients. Conclusions: IMRT is a safe and effective treatment modality, and well tolerated by patients in the treatment of nasopharyngeal carcinoma. No unexpected side effects were observed.

• 대한소아치과학회지
• /
• 제45권3호
• /
• pp.378-385
• /
• 2018

하악의 골절은 아이들의 악안면 영역 골절 중 높은 빈도로 발생하며, 성장기의 환자에서 악골의 골절은 성인의 골절과 구별된 처치가 필요하다. 골편의 변위가 심하지 않다면 비관혈적 정복술과 추가적인 악간 고정을 시행할 수 있으며 악관절 강직을 예방하기 위한 기능적 운동이 필요하다. 하악의 골절 이후 여러 합병증이 발생할 수 있다. 특히 과두 골절의 경우, 골절 이환 측에서 성장장애를 일으켜 부정교합과 안면비대칭을 야기할 수 있다. 하악의 골절 이후 성장 장애가 발생한 경우, 환자에 따라 catch-up growth가 일어날 수 있으므로 주기적인 관찰이 필요하다. 성장장애가 지속되는 경우엔 안면 비대칭이 심해지는 것을 방지하기 위해 기능성 장치의 사용을 고려할 수 있다. 본 증례에서는 하악의 골절 이후 안면비대칭을 보이는 2명의 환자를 장기적으로 관찰하고 의미 있는 결과를 나타내고 있기에 이를 보고하는 바이다.

• Journal of Mechanical Science and Technology
• /
• 제16권12호
• /
• pp.1702-1709
• /
• 2002

This paper analyzes heterogeneous distribution of branch-like structure at the downstream region of the spray. The liquid and vapor phase of the spray are obtained using a 35㎜ still camera and CCD camera in order to investigate spray structure of evaporating diesel spray. There have been many studies conducted on diesel spray structure but have yet only focused on the analyses of 2-D structure. There are a few information which is concerned with 3-D structure analysis of evaporating spray. The heterogeneous distribution of droplets in inner spray affects the mixture formation of diesel spray and the combustion characteristics of the diesel engines. In this study, the laser beam of 2-D plane was used in order to investigate 3-D structure of evaporating spray The incident laser beam was offset on the central axis of the spray. From the analysis of images taken by offset laser beam, we will examine the formation mechanism of heterogeneous distribution of the diesel spray by vortex flow at the downstream of the spray. The images of liquid and vapor phase of free spray are simultaneously taken through an exciplex fluorescence method. Through this, the branch-like structure consisting of heterogeneous distribution of the droplets forms high concentrated vapor phase at the periphery of droplets and at the spray tip.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권4호
• /
• pp.1547-1551
• /
• 2012

Background: Lung cancer is the leading cause of cancer morbidity and mortality. Its management has a significant economic impact on society. Despite a high incidence of cancer, so far, there is no national register for this disease in Morocco. The main goal of this report was to estimate the medical costs of lung cancer in our country. Methods: We first estimated the number of annual new cases according to stage of the disease on the basis of the Grand-Casablanca-Region Cancer Registry data. For each sub-group, the protocol of treatment was described taking into account the international guidelines, and an evaluation of individual costs during the first year following diagnosis was made. Extrapolation of the results to the whole country was used to calculate the total annual cost of treatments for lung cancer in Morocco. Results: Overall approximately 3,500 new cases of lung cancer occur each year in the country. Stages I and II account for only 4% of cases, while 96% are diagnosed at locally advanced or metastatic stages III and IV. The total medical cost of lung cancer in Morocco is estimated to be around USD 12 million. This cost represents approximately 1% of the global budget of the Health Department. According to AROME Guidelines, about 86% of the newly diagnosed lung cancer cases needed palliative treatment while 14% required curative intent therapy. The total cost of early and advanced stages lung cancer management during the first year were estimated to be 4,600 and 3,420 USD, respectively. Conclusion: This study provides health decision-makers with a first estimate of costs and the opportunity to achieve the optimal use of available data to estimate the needs of health facilities in Morocco. A substantial proportion of the burden of lung cancer could be prevented through the application of existing cancer control knowledge and by implementing tobacco control programs.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권4호
• /
• pp.1261-1266
• /
• 2012

Introduction: HPV has been found repeatedly in esophageal squamous cell carcinoma (ESCC) tissues. However, reported detection rates of HPV DNA in these tumors have varied markedly. Differences in detection methods, sample types, and geographic regions of sample origin have been suggested as potential causes of variation. We have reported that infection of HPV DNA in ESCC tumors depends on anatomical sites of esophagus of the patients from Mazandaran, north of Iran. Materials and Methods: HPV DNA was examined in 46 upper, 69 middle and 62 lower third anatomical sites of esophageal squamous cell carcinoma specimens collected from Mazandaran province in north Iran, near the Caspian Littoral as a region with high incidence of ESCC. HPV L1 DNA was detected using Qualitative Real time PCR and MY09/MY11 primers. Results: 28.3% of upper, 29% of middle and 25.8% of lower third of ESCC samples were positive for HPV DNA. 13.6% for males and 14.1% for females were HPV positive in all samples. Conclusions: HPV infection is about one third of ESCC in this area. Findings in this study increase the possibility that HPV is involved in esophageal carcinogenesis. Further investigation with a larger sample size is necessary.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• 제21권3호
• /
• pp.176-183
• /
• 2018

Purpose: Acute gastroenteritis (AGE) is a major cause of morbidity and remains a major cause of hospitalization. Following the Syrian refugee crisis and insufficient clean water in the region, this study reviews the etiological and epidemiological data in Lebanon. Methods: We prospectively analyzed demographic, clinical and routine laboratory data of 198 children from the age of 1 month to 10 years old who were admitted with the diagnosis of AGE to a private tertiary care hospital located in the district of Nabatieh in south Lebanon. Results: Males had a higher incidence of AGE (57.1%). Pathogens were detected in 57.6% (n=114) of admitted patients, among them single pathogens were found in 51.0% (n=101) of cases that consisted of: Entamoeba histolytica 26.3% (n=52), rotavirus 18.7% (n=37), adenovirus 6.1% (n=12) and mixed co-pathogens found in 6.6% (n=13). Breast-fed children were significantly less prone to rotavirus (p=0.041). Moreover, children who had received the rotavirus vaccine were significantly less prone to rotavirus (p=0.032). Conclusion: Our findings highlight the high prevalence of E. histolytica infection as the major cause of pediatric gastroenteritis in hospitalized children, during the summer period likely reflecting the insanitary water supplies and lack of hygiene. Moreover the 42.4% of unidentified causative pathogens should prompt us to widen our diagnostic laboratory arsenal by adopting new diagnostic technologies.

• Asian Pacific Journal of Cancer Prevention
• /
• 제17권1호
• /
• pp.73-80
• /
• 2016

Colorectal cancer is a very prevalent diagnosed cancer. The current study was performed in order to examine the role of BRAE (Basella rubra aqueous extract) in regulating aberrant crypt foci (ACF) formation, cell proliferation and inhibition of apoptosis in a colon carcinogenesis model in male Wistar rats. Rats were randomly allocated into six groups. Group I served as control, and group II acted as a drug control administered BRAE (250mg/kg b.w.) orally for 30 weeks. Rats in group III-VI were given subcutaneous injections of DMH (25mg/kg b.w. weekly) for 15 weeks to initiate colon carcinogenesis. Those in group IV and VI were administered BRAE along with DMH injections. Rats in group V were administered with BRAE after cessation of DMH injection. After 30 weeks of experimental period colons were obtained from experimental groups and analyzed for ACF incidence, argyrophilic nucleolar organizing region-associated proteins (AgNOR) count, histopathological and immunohistochemical changes. Only in DMH exposed groups were ACF and AgNOR numbers increased. Administration of BRAE appreciably decreased the numbers of ACF and AgNOR in BRAE treated groups. Histopathological findings revealed a high level of dysplastic changes with decreased number of goblet cells found only in only DMH injected rats. Administration of BRAE in treated group rats reversed these changes. Expression markers for cell proliferation (PCNA and Ki67) were elevated in DMH treated rats, but reduced with BRAE treatement. This expression was reversed with apoptosis markers (p53 and Caspase-3). Thus the results results of the present study were found to be significant and confirmed the potential efficacy of BRAE against colon carcinogenesis.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권5호
• /
• pp.1727-1735
• /
• 2012

Regardless of advances in treatment modalities with the invention of newer therapies, breast cancer remains a major health problem with respect to its diagnosis, treatment and management. This female malignancy with its tremendous heterogeneous nature is linked to high incidence and mortality rates, especially in developing region of the world. It is the malignancy composed of distinct biological subtypes with diverse clinical, pathological, molecular and genetic features as well as different therapeutic responsiveness and outcomes. This inconsistency can be partially overcome by finding novel molecular markers with biological significance. In recent years, newer technologies help us to indentify distinct biomarkers and increase our understanding of the molecular basis of breast cancer. However, certain issues need to be resolved that limit the application of gene expression profiling to current clinical practice. Despite the complex nature of gene expression patterns of cDNAs in microarrays, there are some innovative regulatory molecules and functional pathways that allow us to predict breast cancer behavior in the clinic and provide new targets for breast cancer treatment. This review describes the landscape of different molecular markers with particular spotlight on vitamin D signaling pathway and apoptotic specific protein of p53 (ASPP) family members in breast cancer.

• Journal of Chest Surgery
• /
• 제29권2호
• /
• pp.244-247
• /
• 1996

다발성 대칭성 지방종증은 경부, 견갑부, 흉부, 복부 및 서혜부에 대칭적으로 피하지방종을 형성하는 드문 질환으로 최근에는 지각 및 자율신경계의 이상동반이 보고되 기도 하나, 현재까지는 원인이 화실하게 밝혀지지 않고 있다. 본 증례는 기관압박을 동반하는 종격동을 침범한 다발성 대칭성 지방종에 대한 증례이다. 환자는 55세 남자로 호흡곤란과 약 10년전부터 서서히 성장하는 경부, 견갑부, 흉부, 복부 및 서혜부의 종괴를 주소로 내원하였으며, 수십년의 심한 음주력이 있었다. 경부와 기관주위를 포함하는 종격동의 지방종괴는 transverse cervical incision을 통해 제거하였다. 그러나 기관주위의 불완전한 지방종괴의 제거로 인한 기관압박의 완화를 위해 술후 15일만에 재수술을 시행하였다. 술후 환자는 종격동기흥 및 피하기종이 심하여 2일 후 응급기관절개술을 시행받은 후, 영구기관절개술후 퇴원하였다.

• 한국균학회지
• /
• 제46권2호
• /
• pp.200-204
• /
• 2018

2016년 4월에 한국 구례지역에서 재배하는 쑥부쟁이 줄기에 균핵병이 발생하였다. 그 병징은 주로 줄기에 발생하여 물러 썩어서 심하면 식물체가 마른다. 흰색 균사가 감염된 식물체 줄기와 땅 표면에 퍼져있으며, 병든 줄기 내와 병 발생 부위에 작은 흑색 균핵을 형성하였다. 균핵병은 쑥부쟁이 재배 포장에서 20~80% 높게 발생하였다. 분리균의 형태적 특성 및 유전자 분석에 의하여 이 균은 Sclerotinia minor로 동정하였다. 한국에서 쑥부쟁이에서 분리한 Sclerotinia minor에 의한 균핵병 발생을 처음으로 보고한다.