• 셀메드
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• 제2권3호
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• pp.24.1-24.5
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• 2012

Obesity is psychological and socioeconomic problems as well as health problems related to physical disease and disorder. The obesity epidemic, including a marked increase in the prevalence of obesity among pregnant women, represents a critical public health problem throughout the world. Gung-Gui-Tang (GGT), a prescription of traditional Korean medicine, has been used to treat dizziness due to loss of blood as well as static blood after childbirth. However, the therapeutic potential of GGT on postpartum obesity has not been fully elucidated in an experimental model. In our research, GGT inhibited the increases of body weight and adipose tissues in postpartum mice fed a high-fat diet. GGT also inhibited the elevations of plasma lipid profiles such as triglyceride, low-density lipoprotein cholesterol, total cholesterol, and glutamate pyruvate transaminase. Overall, these results provide evidence that GGT can help to inhibit postpartum obesity and open new perspective to recover the shape of mother into the moment of conception.

• Food Science and Biotechnology
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• 제27권6호
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• pp.1771-1779
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• 2018

Chrysanthemum zawadskii (CZ) is a perennial herb belonging to the Asteraceae family. CZ is used medicinally to treat inflammatory and uterine diseases in Asia. CZ was extracted with 50% ethanol and CZ extract (CZE; at 125, 250, and 500 mg/kg body weight) was administered orally every day for 5 or 6 weeks to investigate the anti-diabetic effects in streptozotocin (STZ)-induced rats and STZ + high-fat diet (HFD)-fed mice. CZE significantly decreased fasting blood glucose levels in STZ- and STZ + HFD-induced diabetic models. In addition, glucose tolerance and insulin tolerance were improved in the STZ + HFD + CZE group by increasing insulin levels and decreasing hemoglobin A1c (HbA1c) levels in serum. Furthermore, CZE supplements decreased components of the serum lipid profile such as triglyceride, total cholesterol, and low-density lipoprotein cholesterol levels. These results suggest that CZE may be a potential candidate for controlling hyperglycemia.

• 생명과학회지
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• 제31권1호
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• pp.37-46
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• 2021

생마늘 및 흑마늘 열수 추출물 각각을 동결건조하여 SD계 수컷 흰쥐를 정상식이 섭취군(NG), 고지방 콜레스테롤 섭취 대조군(CG), 고지방 콜레스테롤 식이에 1% 생마늘 열수추출 분말 혼합 급이군(FGEG), 고지방 콜레스테롤 식이에 1% 흑마늘 열수추출 분말 혼합 급이군(BGEG)으로 나누어 4주간 실험급이한 후 지질개선 효능을 조사하였다. 식이에 혼합한 생마늘 열수추출 분말(FGE) 및 흑마늘 열수추출 분말(BGE)의 총 페놀화합물 함량은 1319.99±10.46 mg/100 g이었고 S-allyl-cysteine (SAC) 함량은 FGE에 비해 16.3% 더 높았다. 혈청 총 지질, 총 콜레스테롤 및 중성지질 함량은 FGEG 및 BGEG에서 CG 보다 유의적으로 더 낮았다. HDL-콜레스테롤 함량은 CG 보다 FGEG 및 BGEG에서 유의적으로 더 높았고, LDL 및 VLDL-콜레스테롤 함량은 FGEG 및 BGEG가 더 낮았다. 혈청 ALT 및 AST 활성은 CG 보다 유의적으로 낮았으며, 특히 BGEG에서 더 낮았다. 간 조직의 총 지질 및 중성지질 함량은 BGEG에서 152.26 mg/g 및 64.59 mg/g으로 CG 보다 각각 36% 및 14.3% 더 낮았다. 혈청 및 간 조직에서의 TBARS 농도는 CG에 비해 유의적으로 낮았으며, FGEG와 BGEG 간에는 차이가 없었다. 이상의 결과로부터 마늘 추출분말의 지속적인 급이는 생체 내에서 지질농도의 감소, 과산화물질 생성억제 활성 및 항산화 활성은 증가하였으며 생마늘 보다는 흑마늘 열수추출 분말 급이군에서 더 효과적이었는데, 이러한 효과는 생마늘 보다 흑마늘에 총 페놀화합물이나 갈별물질 등 항산화 활성을 가지는 물질의 함량이 더 높기 때문으로 생각된다.

• 동의생리병리학회지
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• 제20권5호
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• pp.1337-1345
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• 2006

Hypercholesterolemia is a pivotal pathogenic factor for the development and maintenance of atherosclerosis. The present study was designed to evaluate whether the methanol extract of Sorbus commixta cortex (MSC) restores vascular dysfunction in association with the aortic expressions of proinflarnmatory and adhesion molecules in high cholesterol (HC) diet-rats. Chronic treatment with low (100 mg/kg/day) or high doses (200 mg/kg/day) of MSC lowered the increase in plasma levels of triglyceride (TG) and low-density lipoprotein (LDL) cholesterol induced by a cholesterol-enriched diet without affecting on the plasma level of high density lipoprotein (HDL)-cholesterol. Vascular tone attenuated in the HC-diet rats was restored by administration with MSC. Treatment with MSC also suppressed the HC-induced increase in the monocyte chemoattractant protein-1 (MCP-1) and nuclear factor-$_K$B (NF-$_K$B) p65 expressions as well as expressions levels of adhesion molecules including intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (ICAM-1), and E-selectin in aorta. The present study also showed that MSC inhibited the HC-mediated induction of ET-1 and ACE expression. In histopathological examination, aortic segments in the HC-diet rat revealed thickening intima and media, which were blocked by administration with MSC. Taken together, MSC could suppress the development of atherosclerosis in the HC-diet rat model through the inhibition of the aortic expression levels of pro-inflammatory and adhesion molecules.

• The Korean Journal of Physiology and Pharmacology
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• 제18권6호
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• pp.469-474
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• 2014

DWP208 is a sodium succinate form of ZYM-201 which is a triterpenoid glycoside isolated from Sanguisorba officinalis, a medicinal plant prescribed for various diseases, such as duodenal ulcers and bleeding in East Asian counties. We demonstrated that this compound is able to normalize the altered lipid metabolism induced by hyperglycemia and a high fat diet. In this study, we determined whether hyperlipidemic conditions induced with chronically treated alcohol can also be restored by DWP208. Similar to our previous results, orally administered DWP208 (1 to 10 mg/kg) also ameliorated the hyperlipidemia that was induced by alcohol. This compound reversed the alcohol-induced hyperlipidemia including (i) up-regulated hyperlipidemic parameters such as low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), atherosclerotic index (AI), triglyceride, and total cholesterol, and (ii) down-regulated hyperlipidemic parameters such as absolute body weight, superoxide dismutase (SOD) activity, and high-density lipoprotein (HDL) in serum and liver. According to our data, the ameliorative activity of DWP208 is due to its indirect anti-oxidative activity as a result of which lipid peroxide and hydroxyl radical levels were reduced and the activity of SOD was enhanced. Therefore, our data strongly suggest that DWP208 can be used as a remedy against alcohol-induced hyperlipidemia.

• 생명과학회지
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• 제26권12호
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• pp.1415-1421
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• 2016

본 연구는 발효 무궁화 추출물과 비발효 무궁화 추출물로 나누어 발효하였을 때, 무궁화 추출물의 항산화 활성과 혈액순환 개선에 미치는 효과가 비발효 무궁화 추출물보다 더 높은지 조사하려고 진행되었다. In vitro 실험에서 항산화 활성을 분석하기 위해서 항산화의 생리활성 물질인 polyphenol과 flavonoid의 함량을 비롯한 DPPH radical 소거효능을 측정한 결과 발효 무궁화 추출물과 비발효 무궁화 추출물 모두에서 polyphenol과 flavonoid의 함량이 농도 의존적으로 높았으며 DPPH radical 소거효능도 역시 농도 의존적으로 높게 나타났다. In vivo 생쥐 실험에서는 보통식이군(NOR), 고지방식이군(CON), 고지방식이+발효 무궁화 추출물 섭취군(FHS), 고지방식이+비발효 무궁화 추출물 섭취군(NFHS)으로 나누어 총콜레스테롤(total cholesterol), 중성지질(triglyceride), 고밀도 지질단백질(HDL cholesterol), 저밀도 지질단백질(LDL cholesterol)을 측정한 결과 발효 무궁화 추출물과 비발효 무궁화 추출물은 총콜레스테롤, 저밀도 지질단백질, 중성지질을 저하시키는 효과가 있는 반면 고밀도 지질단백질을 상승시키는 효과가 있었다. 결론적으로 발효 무궁화는 항산화 생리활성 물질을 많이 함유하고 있어 항산화 효과가 있고 혈액순환을 개선하는데 상당한 효과가 있는 것으로 확인되었다.

• 한방비만학회지
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• 제15권2호
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• pp.75-92
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• 2015

Objectives: This study was designed to investigate the effect of Gami-cheongpyesagan-tang extract (GCST) on high fat diet-induced obesity in rats. Methods: The mice were divided into six groups; normal diet control, high fat diet control (HFD), HFD+GCST administrated group (100, 200, and 400 mg/kg) and olistat-admistrated group. Obesity was induced by high fat diet (45%) for 7 weeks in mice, and GCST was administrated orally every day for 7 weeks. The body weight, food intake, and serological markers such as total cholesterol, triglyceride, lipid contents, leptin, adiponectin and glutamic oxaloacetic transaminase/glutamic pyruvic transaminase were measured in mice. The mRNA expression of obese-associating genes such as sterol regulatory element-binding protein (SREBP)-1c, fatty acid synthase (FAS), stearoyl-CaP desaturase (SCD-1), peroxisome proliferator-activated receptor $(PPAR)-{\alpha}$, COA oxidase (ACO), and carnitine palmitoyltransferase ($CPT-1{\alpha}$) was analyzed by reverse transcription polymerase chain reaction. Results: The administration of GCST at 400 mg/kg, significantly reduced the increase of body weight and food intake as well as food efficiency compared to HFD group. GCST decreased the serum levels of triglyceride, total cholesterol, low-density lipoprotein-cholesterol, leptin in HFD control group and inhibited lipid accumulation in liver and adipose tissues, but did not increase high-density lipoprotein-cholesterol. In the liver tissues of GCST administrated HFD group, the mRNA levels of SREBP-1c, FAS and SCD-1 were decreased and the mRNA levels of $PPAR-{\alpha}$, ACO, and $CPT-1{\alpha}$ were increased. Conclusions: These results indicate that GCST could improve high fat diet induced obesity through inhibiting the hyperlipidemia in fatty Liver. It suggest that GCST may be used clinically for declining the accumultion of body fat with hyperlipidemia.

• 한국식품영양학회지
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• 제22권4호
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• pp.554-559
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• 2009

The purpose of this study was to determine changes in body composition and blood lipids and to analyze the effects of Danhak exercise for 3 months in older women. For this study, 35 female subjects 60 to 70 years of age were recruited and administered 90 min of Danhak exercise, five times per week for three months by a professional coach. The results of this study were as follows: At baseline, the mean BMI(body mass index) and body fat(%) were 23.9 kg/$(m)^2$ and 32.4$\pm$4.9(%), respectively. The mean WHR(waist-hip ratio) was 0.91$\pm$0.04 and all subjects were determined to be abdominally obese. A significantly lower body fat was observed after 3 months of Danhak exercise(p<0.05). However, there were no significant differences in BMI, WHR or body weight before and after exercise. Danhak exercise also resulted in a decrease in total cholesterol and an increase in HDL(high density lipoprotein, and these differences were significant. Taken together, the results of this study indicate that the effects of Danhak exercise were similar to those of aerobic exercise with respect to improve body fat(%) and blood lipid profiles, which suggests that Danhak is a profitable exercise for individuals aged 60 and over.

• Journal of Korean Biological Nursing Science
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• 제4권2호
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• pp.51-58
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• 2002

The purpose of this study was to identify clinical characteristics of type 2 diabetic patients with hypertension. The subjects were 209 type 2 diabetic patients who visited at the endocrine center at Kangnam St. Mary's Hospital of Catholic University in Seoul from beginning of March through the end of April in 2001. The patient's clinical laboratory data were assessed at medical record review. The data were analyzed using for t-test, $x^2$ test. The results were as follows: 1) There were no significant differences in age, body mass index, sex, family history of diabetes and oral hypoglycemic agents between hypertensive group and normotensive group, However, percentage of patients receiving insulin treatment was higher significantly in the hypertensive group. 2) Creatinine and microalbuminuria levels were higher significantly in the hypertensive group. However, fasting blood glucose levels were lower significantly in the hypertensive group. There were no significant differences in $HbA_1c$, 2-hour postprandial blood glucose, total cholesterol, triglyceride, high density lipoprotein cholesterol, lipoprotein(a) and blood urea nitrogen between two groups. Our present study supports that Creatinine and microalbuminuria levels were higher significantly in the hypertensive group.

• 한국보건간호학회지
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• 제16권2호
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• pp.346-353
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• 2002

The purpose of this study was to identify clinical characteristics of type 2 diabetic patients with microalbuminuria. The subjects were 390 out type 2 diabetic patients from beginning of March through the end of April in 2001, who visited at the endocrine center at Kangnam St. Mary's Hospital of Catholic University in Seoul. The patients' clinical laboratory data were assessed at medical record review. The data were analyzed using for t-test and $\chi^2$ test. The results were as follows : 1. There were no significant differences in age, body mass index, family history of diabetes and hypoglycemic agents between normoalbuminuria group and microalbuminuria group. 2. The level of systolic blood pressure and creatinine of microalbuminuria group were higher than those of normoalbuminuria group. There were no significant differences in HbAlc, fasting blood glucose, 2-hour postprandial blood glucose, diastolic blood pressure, total cholesterol, triglyceride, high density lipoprotein cholesterol, lipoprotein(a) and blood urea nitrogen between normoalbuminuria group and microalbuminuria group.