• Clinical and Experimental Reproductive Medicine
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• v.29 no.4
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• pp.251-258
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• 2002

Objective : The aim of this study was to evaluate the outcomes of the GnRH antagonist (Cetrotide) minimal stimulation protocol comparing with GnRH agonist combined long step down stimulation protocol in PCOS patients. Materials and Method: From Apr 2001 to May 2002, 22 patients (22 cycles) were performed in controlled ovarian hyperstimulation using by GnRH antagonist and GnRH agonist for PCOS patients. GnRH antagonist (Cetrotide) combined minimal stimulation protocol was administered in 10 patients (10 cycles, Study Group) and GnRH agonist long step down stimulation protocol was administered in 12 patients (12 cycles, Control Group). We compared the pregnancy rate/cycle, total FSH (A)/cycle, Retrieved oocyte/cycle, the incidence of ovarian hyperstimulation syndrome, multiple pregnancy rate between the two groups. Student-t test were used to determine statistical significance. Statistical significance was defined as p<0.05. Results: Group of GnRH antagonist (Cetrorelix) minimal stimulation protocol produced fewer oocytes (6.4 versus 16.3 oocytes/cycle) using a lower dose of FSH (22.2 versus 36.1 Ample/cycle) and none developed OHSS and multiple pregnancy. Although the trends were in favour of the GnRH antagonist (Cetrorelix) protocol, the differences did not reach statistical significance. This was probably due to small sample size. Conclusion: The use of GnRH antagonist reduce the risk of ovarian hyperstimulation and multiple pregnancy. We suggest that GnRH antagonist might be alternative controlled ovarian hyperstimulation method, especially in PCOS patients who will be ovarian high response.

• Clinical and Experimental Pediatrics
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• v.53 no.9
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• pp.830-833
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• 2010

Crohn's disease is characterized by chronic inflammation involving any portion of the gastrointestinal tract. Treating Crohn's disease is a major challenge for clinicians, as no curative therapy currently exists. Pediatric Crohn's disease is characterized by frequent relapses, a wide extent of disease, a high prevalence of extraintestinal manifestations, and a severe clinical course. The classic therapeutic approach is known as the 'step-up' strategy, and follows a progressive course of treatment intensification as disease severity increases. Although this approach is usually effective for symptom control, many patients become either resistant to or dependent on corticosteroids. The efficacy of infliximab suggests that, rather than a progressive course of treatment, early intense induction may reduce complications associated with conventional treatment and improve quality of life. Intensive early therapy with infliximab is known as the 'top-down' strategy. Such therapy offers the potential for altering the natural history of Crohn's disease, and is changing treatment paradigms. However, the relatively new concept of an early aggressive or 'top-down' treatment approach is not yet widely accepted, especially in pediatric patients. The results of our current study demonstrate that early and intensive treatment of pediatric Crohn's disease patients with infliximab, at initial diagnosis, was more effective for maintaining remission and reducing flares.

• Nuclear Engineering and Technology
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• v.46 no.3
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• pp.387-394
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• 2014

A Slowing Down Time Spectrometer (SDTS) system is a highly efficient technique for isotopic nuclear material content analysis. SDTS technology has been used to analyze spent nuclear fuel and the pyro-processing of spent fuel. SDTS requires an external neutron source to induce the isotopic fissile fission. A high intensity neutron source is required to ensure a high for a good fissile fission. The electron linear accelerator system was selected to generate proper source neutrons efficiently. As a first step, the electron generator of an 80-keV electron gun was manufactured. In order to produce the high beam power from electron linear accelerator, a proper beam current is required form the electron generator. In this study, the beam current was measured by evaluating the performance of the electron generator. The beam current was determined by five parameters: high voltage at the electron gun, cathode voltage, pulse width, pulse amplitude, and bias voltage at the grid. From the experimental results under optimal conditions, the high voltage was determined to be 80 kV, the pulse width was 500 ns, and the cathode voltage was from 4.2 V to 4.6 V. The beam current was measured as 1.9 A at maximum. These results satisfy the beam current required for the operation of an electron linear accelerator.

• Proceedings of the IEEK Conference
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• 2004.08c
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• pp.486-490
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• 2004

Programmable logic controller (PLC) is widely used in manufacturing system or process control. This paper presents the design of a 32-bit microprocessor for a sequence control using an Application Specification Integrated Circuit (ASIC). The 32-bit microprocessor was designed by a VHDL with top down method; the program memory was separated from the data memory for high speed execution of 274 specified sequence instructions. Therefore it was possible that sequence instructions could be operated at the same time during the instruction fetch cycle. And in order to reduce the instruction decoding time and the interface time of the data memory interface, an instruction code size was implemented by 32-bits. And the real time debugging as single step run, break point run was implemented. Pulse instruction, step controller, master controllers, BIN and BCD type arithmetic instructions, barrel shit instructions were implemented for many used in PLC system. The designed microprocessor was synthesized by the S1L50000 series which contains 70,000 gates with 0.65um technology of SEIKO EPSON. Finally, the benchmark was performed to show that designed 32-bit microprocessor has better performance than Q4A PLC of Mitsubishi Corporation.

• The KSFM Journal of Fluid Machinery
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• v.4 no.3 s.12
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• pp.53-61
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• 2001

Vortex type Fluidic Device(FD) which is installed at the bottom of Safety Injection Tank(SIT) controls the discharge flow rate from the tank. In case of loss of coolant accident the injection water flows into primary system in two steps; initial high flow rate for certain period of time and subsequent low flow rate. By two-step control of the discharge flow rate, FD can ensure the effective use of water in the tank. A small-scale FD has been tested to obtain a required flow characteristics maintaining full pressure and height of prototype, which are the major contributing parameters. Through the testing of many different arrangements of internal geometry of FD, most appropriate one was selected and its performance data was obtained. As characteristics of FD, time dependent Euler number, flow rate and pressure are presented and discussed. Also a method to predict the full size FD is presented.

• Journal of Power Electronics
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• v.15 no.1
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• pp.31-38
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• 2015

In this paper, a buck-boost type battery charger is developed for charging battery set with a lower voltage. This battery charger is configured by a rectifier circuit, an integrated boost/buck power converter and a switched capacitors circuit. A boost power converter and a buck power converter sharing a common power electronic switch are integrated to form the integrated boost/buck power converter. By controlling the common power electronic switch, the battery charger performs a hybrid constant-current/constant-voltage charging method and gets a high input power factor. Accordingly, both the power circuit and the control circuit of the developed battery charger are simplified. The switched capacitors circuit is applied to be the output of the boost converter and the input of the buck converter. The switched capacitors circuit can change its voltage according to the utility voltage so as to reduce the step-up voltage gain of the boost converter when the utility voltage is small. Hence, the power efficiency of a buck-boost type battery charger can be improved. Moreover, the step-down voltage gain of the buck power converter is reduced to increase the controllable range of the duty ratio for the common power electronic switch. A prototype is developed and tested to verify the performance of the proposed battery charger.

• Journal of Korean Institute of Industrial Engineers
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• v.16 no.2
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• pp.135-147
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• 1990

A nuclear power plant can be viewed as a large complex man-machine system where high system reliability is obtained by ensuring that sub-systems are designed to operate at a very high level of performance. The chance of severe accident involving at least partial core-melt is very low but once it happens the consequence is very catastrophic. The prediction of risk in low probability, high-risk incidents must be examined in the contest of general engineering knowledge and operational experience. Engineering knowledge forms part of the prior information that must be quantified and then updated by statistical evidence gathered from operational experience. Recently, Bayesian procedures have been used to estimate rate of accident and to predict future risks. The Bayesian procedure has advantages in that it efficiently incorporates experts opinions and, if properly applied, it adaptively updates the model parameters such as the rate or probability of accidents. But at the same time it has the disadvantages of computational complexity. The predictive distribution for the time to next incident can not always be expected to end up with a nice closed form even with conjugate priors. Thus we often encounter a numerical integration problem with high dimensions to obtain a predictive distribution, which is practically unsolvable for a model that involves many parameters. In order to circumvent this difficulty, we propose a method of approximation that essentially breaks down a problem involving many integrations into several repetitive steps so that each step involves only a small number of integrations.

• Journal of IKEEE
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• v.14 no.3
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• pp.250-255
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• 2010

The interleaved power management IC(PMIC) with DTMOS(Dynamic Threshold voltage MOSFET) switching device is proposed in this paper. The buck-boost converter used to provide the high output voltage and low output voltage for portable applications. Also we used the PWM(Pulse Width Modulation) control method for high power efficiency at high current level. DTMOS with low on-resistance is designed to decrease conduction loss. The interleaved PMIC to reduce output ripple. And step-down DC-DC converter in stand-by mode below 1mA is designed with LDO in order to achive high efficiency.

• Proceedings of the Korean Vacuum Society Conference
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• 1999.07a
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• pp.163-163
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• 1999

MOSFET, MESFET 그리고 MODFET는 Logic ULSIs, high speed ICs, RF MMICs 등에서 중요한 역할을 하고 있으며, 그것의 gate electrode, contact, interconnect 등의 물질로는 refractory metal을 이용한 CoSi2, MoSi2, TaSi2, PtSi2, TiSi2 등의 효과를 얻어내고 있다. 그중 TiSi2는 비저항이 가장 낮고, 열적 안정도가 좋으며 SAG process가 가능하므로 simpler alignment process, higher transconductance, lower source resistance 등의 장점을 동시에 만족시키고 있다. 최근 소자차원이 scale down 됨에 따라 TiSi2의 silicidation 과정에서 C49 TiSi2 phase(high resistivity, thermally unstable phase, larger grain size, base centered orthorhombic structure)의 출현과 그것을 제거하기 위한 노력이 큰 issue로 떠오르고 있다. 여러 연구 결과에 따르면 PAI(Pre-amorphization zimplantation), HTS(High Temperature Sputtering) process, Mo(Molybedenum) implasntation 등이 C49를 bypass시키고 C54 TiSi2 phase(lowest resistivity, thermally stable phase, smaller grain size, face centered orthorhombic structure)로의 transformation temperature를 줄일 수 있는 가장 효과적인 방법으로 제안되고 있지만, 아직 그 문제가 완전히 해결되지 않은 상태이며 C54 nucleation에 대한 physical mechanism을 밝히진 못하고 있다. 본 연구에서는 증착 시 기판온도의 변화(400~75$0^{\circ}C$)에 따라 silicon 위에 DC/RF magnetron sputtering 방식으로 Ti/Si film을 각각 제작하였다. 제작된 시료는 N2 분위기에서 30~120초 동안 500~85$0^{\circ}C$의 온도변화에 따라 RTA법으로 각각 one step annealing 하였다. 또한 Al을 cosputtering함으로써 Al impurity의 존재에 따른 영향을 동시에 고려해 보았다. 제작된 시료의 분석을 위해 phase transformation을 XRD로, microstructure를 TEM으로, surface topography는 SEM으로, surface microroughness는 AFM으로 측정하였으며 sheet resistance는 4-point probe로 측정하였다. 분석된 결과를 보면, 고온에서 제작된 박막에서의 C54 phase transformation temperature가 감소하는 것이 관측되었으며, Al impuritydmlwhswork 낮은온도에서의 C54 TiSi2 형성을 돕는다는 것을 알 수 있었다. 본 연구에서는 결론적으로, 고온에서 증착된 박막으로부터 열적으로 안정된 phase의 낮은 resistivity를 갖는 C54 TiSi2 형성을 보다 낮은 온도에서 one-step RTA를 통해 얻을 수 있다는 결과와 Al impurity가 존재함으로써 얻어지는 thermal budget의 효과, 그리고 그로부터 기대할 수 있는 여러 장점들을 보고하고자 한다.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.24 no.3
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• pp.337-342
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• 2011

Medical lift column controlling the vertical position while supporting heavy eccentric load should have the high fatigue strength as well as the extremely low structural deflection and vibration in order to maintain the positioning accuracy. The lift column driven by a induction motor is generally in a three-step sliding boom structure and exhibits the time-varying stress distribution according to the up-and-down motion. This study is concerned with the numerical prediction of the fatigue strength of the lift column subject to the time-varying stress caused by the up-and-down motion. The stress variation during a motion cycle is obtained by finite element analysis and the fatigue life is predicted making use of Palmgren-miner's rule and S-N curves. In order to secure the numerical analysis reliability, a 3-D FEM, model in which the detailed lift column structure and the fitting parts are fully considered, is generated and the interfaces between lift column and pads are treated by the contact condition.