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Design of MAHA Supercomputing System for Human Genome Analysis (대용량 유전체 분석을 위한 고성능 컴퓨팅 시스템 MAHA)

  • Kim, Young Woo;Kim, Hong-Yeon;Bae, Seungjo;Kim, Hag-Young;Woo, Young-Choon;Park, Soo-Jun;Choi, Wan
    • KIPS Transactions on Software and Data Engineering
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    • v.2 no.2
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    • pp.81-90
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    • 2013
  • During the past decade, many changes and attempts have been tried and are continued developing new technologies in the computing area. The brick wall in computing area, especially power wall, changes computing paradigm from computing hardwares including processor and system architecture to programming environment and application usage. The high performance computing (HPC) area, especially, has been experienced catastrophic changes, and it is now considered as a key to the national competitiveness. In the late 2000's, many leading countries rushed to develop Exascale supercomputing systems, and as a results tens of PetaFLOPS system are prevalent now. In Korea, ICT is well developed and Korea is considered as a one of leading countries in the world, but not for supercomputing area. In this paper, we describe architecture design of MAHA supercomputing system which is aimed to develop 300 TeraFLOPS system for bio-informatics applications like human genome analysis and protein-protein docking. MAHA supercomputing system is consists of four major parts - computing hardware, file system, system software and bio-applications. MAHA supercomputing system is designed to utilize heterogeneous computing accelerators (co-processors like GPGPUs and MICs) to get more performance/$, performance/area, and performance/power. To provide high speed data movement and large capacity, MAHA file system is designed to have asymmetric cluster architecture, and consists of metadata server, data server, and client file system on top of SSD and MAID storage servers. MAHA system softwares are designed to provide user-friendliness and easy-to-use based on integrated system management component - like Bio Workflow management, Integrated Cluster management and Heterogeneous Resource management. MAHA supercomputing system was first installed in Dec., 2011. The theoretical performance of MAHA system was 50 TeraFLOPS and measured performance of 30.3 TeraFLOPS with 32 computing nodes. MAHA system will be upgraded to have 100 TeraFLOPS performance at Jan., 2013.

Integrated Rotary Genetic Analysis Microsystem for Influenza A Virus Detection

  • Jung, Jae Hwan;Park, Byung Hyun;Choi, Seok Jin;Seo, Tae Seok
    • Proceedings of the Korean Vacuum Society Conference
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    • 2013.08a
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    • pp.88-89
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    • 2013
  • A variety of influenza A viruses from animal hosts are continuously prevalent throughout the world which cause human epidemics resulting millions of human infections and enormous industrial and economic damages. Thus, early diagnosis of such pathogen is of paramount importance for biomedical examination and public healthcare screening. To approach this issue, here we propose a fully integrated Rotary genetic analysis system, called Rotary Genetic Analyzer, for on-site detection of influenza A viruses with high speed. The Rotary Genetic Analyzer is made up of four parts including a disposable microchip, a servo motor for precise and high rate spinning of the chip, thermal blocks for temperature control, and a miniaturized optical fluorescence detector as shown Fig. 1. A thermal block made from duralumin is integrated with a film heater at the bottom and a resistance temperature detector (RTD) in the middle. For the efficient performance of RT-PCR, three thermal blocks are placed on the Rotary stage and the temperature of each block is corresponded to the thermal cycling, namely $95^{\circ}C$ (denature), $58^{\circ}C$ (annealing), and $72^{\circ}C$ (extension). Rotary RT-PCR was performed to amplify the target gene which was monitored by an optical fluorescent detector above the extension block. A disposable microdevice (10 cm diameter) consists of a solid-phase extraction based sample pretreatment unit, bead chamber, and 4 ${\mu}L$ of the PCR chamber as shown Fig. 2. The microchip is fabricated using a patterned polycarbonate (PC) sheet with 1 mm thickness and a PC film with 130 ${\mu}m$ thickness, which layers are thermally bonded at $138^{\circ}C$ using acetone vapour. Silicatreated microglass beads with 150~212 ${\mu}L$ diameter are introduced into the sample pretreatment chambers and held in place by weir structure for construction of solid-phase extraction system. Fig. 3 shows strobed images of sequential loading of three samples. Three samples were loaded into the reservoir simultaneously (Fig. 3A), then the influenza A H3N2 viral RNA sample was loaded at 5000 RPM for 10 sec (Fig. 3B). Washing buffer was followed at 5000 RPM for 5 min (Fig. 3C), and angular frequency was decreased to 100 RPM for siphon priming of PCR cocktail to the channel as shown in Figure 3D. Finally the PCR cocktail was loaded to the bead chamber at 2000 RPM for 10 sec, and then RPM was increased up to 5000 RPM for 1 min to obtain the as much as PCR cocktail containing the RNA template (Fig. 3E). In this system, the wastes from RNA samples and washing buffer were transported to the waste chamber, which is fully filled to the chamber with precise optimization. Then, the PCR cocktail was able to transport to the PCR chamber. Fig. 3F shows the final image of the sample pretreatment. PCR cocktail containing RNA template is successfully isolated from waste. To detect the influenza A H3N2 virus, the purified RNA with PCR cocktail in the PCR chamber was amplified by using performed the RNA capture on the proposed microdevice. The fluorescence images were described in Figure 4A at the 0, 40 cycles. The fluorescence signal (40 cycle) was drastically increased confirming the influenza A H3N2 virus. The real-time profiles were successfully obtained using the optical fluorescence detector as shown in Figure 4B. The Rotary PCR and off-chip PCR were compared with same amount of influenza A H3N2 virus. The Ct value of Rotary PCR was smaller than the off-chip PCR without contamination. The whole process of the sample pretreatment and RT-PCR could be accomplished in 30 min on the fully integrated Rotary Genetic Analyzer system. We have demonstrated a fully integrated and portable Rotary Genetic Analyzer for detection of the gene expression of influenza A virus, which has 'Sample-in-answer-out' capability including sample pretreatment, rotary amplification, and optical detection. Target gene amplification was real-time monitored using the integrated Rotary Genetic Analyzer system.

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Family Selection on Height Growth in Open-Pollinated Progeny Trials of Pinus densiflora Using Relative Height Growth Rate (상대수고생장속도를 이용한 소나무 우수가계 선발)

  • Oh, Chang-Young;Han, Sang-Urk;Lee, Kyung-Joon;Kim, Chang-Soo;Oh, Chan-Jin;Ji, Dong-Hyun
    • Korean Journal of Breeding Science
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    • v.41 no.3
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    • pp.220-227
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    • 2009
  • This study was conducted to select superior families based on the open-pollinated (OP) progeny tests of P. densiflora. A total of 232 OP families were analyzed for relative height growth. The OP progeny test trials were established at 1 to 4 sites from 1975 to 1987. To minimize temporal and spatial variation, we applied the standardization method for family selection. In each progeny test, superior and inferior families were selected at ages of 10, 20 and 30. Relative height growth rate (RHGR), growth speed at a given time unit, was comparatively high at age of 10 with range from 0.1 to 0.6 and showed a large variation among families. However, after age 15, the RHGR was low (average 0.04) and also the variation was not significantly different among families. To reduce selection errors due to age differences (from age 23 to 35) of tests, we made the family selection after age 15 when the values of RHGR were stable. Height growth at each age was transformed to be height growth at age 35 based on the RHGR. As the results, family CB2, CB3, KW99 and KW2 were selected as superior families and KW158, KW22, KB40 and GG1 were considered as inferior ones, respectively. Rank correlations (r) between test ages and selection age 35 were high and statistically significant; r = 0.881 between age 30 and 35, 0.653 between age 20 and 35, and -0.222 between age 10 and 35.

Features of International Marriage of Vietnamese Immigrant Women and Plans for Institutional Improvement (베트남결혼이주여성의 혼인의 특징과 국제결혼의 제도적 개선 방안)

  • Moon, Heung-Ahn
    • Journal of Legislation Research
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    • no.44
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    • pp.757-799
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    • 2013
  • Ever since Korea and Vietnam reestablished diplomatic relations, the two countries'bond has become stronger than ever, augmenting the range of exchange between them in almost every possible field including politics, economy, society, and culture at such a high speed. Among many, an increase in number of Vietnamese immigrant women in international marriage is worthy of close attention. Since 2010, Vietnamese has topped the proportion of total foreign women married to Korean men, having surpassed Chinese. Nonetheless, the quick international marriage between Korean men and Vietnamese women, which usually happens without sufficient time to get to know about different cultures and languages, has not only raised problems for people concerned, but numerous social issues as well. Recognizing these problems, a number of government departments have provided various support on policies and legal issues toprotect multicultural families as a means of social integration and settlement support. Nevertheless, the support policies until now have been generalizing all of the immigrant women in international marriage as people subject to protection. Thus, considering every immigrant women as people in need, and trying to help them with various social issues have caused the government a high cost and low efficiency. This thesis emphasizes the point that through the cases of Vietnamese immigrant women in international marriage, there should be a specific support plan for specific people in need, reflecting various traits of different cultures and societies, in order to ease their settlement in Korea. Moreover, it suggests detailed plans for improvements on legal and institutional problems. Although the Vietnamese government forbids commercial agents for international marriage, many of agencies are still active and to help the immigrant women, who desire to return and resettle in Vietnam in case of divorce, this thesis suggests legal and institutional remedies for Korean and Vietnamese government. The composition of the thesis follows below: Part II on social and cultural traits of international marriage between Korean men and Vietnamese women. Part III on institutional problems and plans for improvements regarding settlement of immigrant women in international marriage. Part IV on legal and institutional problems and plans for improvements regarding divorced immigrant women and their return to Vietnam. Part V on conclusion. Divorce is not a flaw anymore nowadays, but in case of Vietnamese immigrant women ininternational marriage, an inadequate legal system hampers their resettlement process. Cases of not being ableto remove their own names from the family register due to poor financial and legal abilities are often identified and it is both the Vietnamese and Korean governments'duty to acquit their ethical responsibilities by seeking ways to institutionally and financially support them.

Characteristics of Beach Change and Sediment Transport by Field Survey in Sinji-Myeongsasimni Beach (신지명사십리 해수욕장에서 현장조사에 의한 해빈변화와 퇴적물이동 특성)

  • Jeong, Seung Myong;Park, Il Heum
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.27 no.5
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    • pp.594-604
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    • 2021
  • To evaluate the causes of beach erosion in Sinji-Myeongsasimni Beach, external forces, such as tides, tidal currents, and waves, were observed seasonally from March 2019 to March 2020, and the surface sediments were analyzed for this period. In addition, the shoreline positions and beach elevations were regularly surveyed with a VRS GPS and fixed-wing drone. From these field data, the speed of the tidal currents was noted to be insufficient, but the waves were observed to af ect the deformation of the beach. As the beach is open to the southern direction, waves of heights over 1 m were received in the S-SE direction during the spring, summer, and fall seasons. Large waves with heights over 2 m were observed during typhoons in summer and fall. Because of the absence of typhoons for the previous two years from July 2018, the beach area over datum level (DL) as of July 2018 was greater by 30,138m2 compared with that of March 2019, and the beach area as of March 2020 decreased by 61,210m2 compared with that of March 2019 because of four typhoon attacks after July 2018. The beach volume as of March 2019 decreased by 5.4% compared with that of July 2018 owing to two typhoons, and the beach volume as of September 2019 decreased by 7.3% because of two typhoons during the observation year. However, the volume recovered slightly by about 3% during fall and winter, when there were no high waves. According to the sediment transport vectors by GSTA, the sediments were weakly influxed from small streams located at the center of the beach; the movement vectors were not noticeable at the west beach site, but the westward sediment transport under the water and seaward vectors from the foreshore beach were prominently observed at the east beach site. These patterns of westward sediment vectors could be explained by the angle between the annual mean incident wave direction and beach opening direction. This angle was inclined 24° counterclockwise with the west-east direction. Therefore, the westward wave-induced currents developed strongly during the large-wave seasons. Hence, the sand content is high in the west-side beach but the east-side beach has been eroded seriously, where the pebbles are exposed and sand dune has decreased because of the lack of sand sources except for the soiled dunes. Therefore, it is proposed that efforts for creating new sediment sources, such as beach nourishment and reducing wave heights via submerged breakwaters, be undertaken for the eastside of the beach.

An Exploratory Study on Domestic Mobile Games and In-app Payment Fees (국내 모바일 게임 및 인앱 결제 수수료 적정성에 대한 탐색적 연구)

  • Lee, Taehee;Jeon, Seongmin
    • The Journal of Society for e-Business Studies
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    • v.26 no.3
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    • pp.55-66
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    • 2021
  • The mobile application (APP) market is growing at an unprecedented speed. Amid such growth, the global platform providers are mandating exclusive in-app payments and charging 30% for platform commission fees. A serious tension has arisen between mobile global platform providers and local content providers. The present study attempts to analyze the domestic mobile game market and in-app payment commission fees. This study estimates the size of the domestic mobile game market and platform commission fees by directly using publicly available financial statements and footnote information of some representative listed mobile game firms. Also, the study analyzes the cost structures of the same sample firms and attempts to draw some implications on sustainable growths of the mobile game ecosystem. We estimated that, in 2019, the domestic mobile game market is around 4.9 trillion Won and the ensuing in-app payment commission fees market was 1.5 trillion Won. High market share firms display a proportional increase in in-app payment commission fees in relation to sales growth. This, in turn, makes the in-app payment commission fees a primary cost item far exceeding employee salaries and R&D expenses. During the same period, low market share firms generated a mere profit or experienced net loss. Analysis of the cost structure reveals that these firms are even more liable to higher in-app payment commission fee cost structure than high market share. Most constituents of the mobile game ecosystem are small business entrepreneurs. By employing a micro-level analysis, the study estimates that, in 2019, a representative median firm generates 530 million Won in sales. At the same time, it spends 190 million Won in employee salaries, 50 Won million in R&D and 190 million Won in in-app payment commission fees, respectively. In the absence of other cost items, these three cost items alone account for 73.8% of sales revenue. The results imply that a sustainable growth of the local mobile game market heavily depends upon the cost structure of such representative median firm, the in-app payment commission fees being the primary cost item of such firm.

Analysis and Management Strategies of the Cold Air Characteristics in Hannamgeumbuk-Jeongmaek and Geumbuk-Jeongmaek (한남금북·금북정맥 일대의 찬공기 특성 분석을 통한 청주시 찬공기 관리방안)

  • SON, Jeong-Min;EUM, Jeong-Hee
    • Journal of the Korean Association of Geographic Information Studies
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    • v.22 no.2
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    • pp.152-171
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    • 2019
  • In this study, we analyzed the characteristics of the cold air generated in Hannamgeumbuk and Geumbuk-Jeongmaek and proposed their management strategies. We also suggested management strategies after analyzing detailed cold airflows for Cheongju located Hannamgeumbuk-Jeongmaek and we compared the degree of nighttime temperature reduction of the Jeongmaek by using data obtained from observatories located on Cheongju. We used KALM(Kaltluftabflussmodell), a cold air simulation model developed in Germanay and identified both cold airflows and altitude of cold air layers generated during 360minutes at night. As a result, the cold airflow generated in the Jeongmaek became strong and the cold air was appeared clearly in the western part of the Hannamgeumbuk-Jeongamek and in the northern part of the Geumbuk-Jeongmaek. The average velocity of cold airflow was recorded at 0.45m/s, and the maximum speed of cold airflow was recorded at 2.70m/s. The average height of the cold air layer was 104.27m/s and the maximum thickness was 255.0m. The average velocity of cold airflows in Cheongju was 0.51m/s and the average height of cold air layer was 48.87m high. The highest degree of nighttime temperature reduction appeared in the Cheongnamdae observatory($-3.8^{\circ}C$), where the altitude of the cold air layer is high. The results showed that cooling effect of Jeongmaek actually affected the temperature reduction during nighttime. Based on the results, we designated the main mountain area of the Jeongmaek with active cold air generation as "cold air conservation areas" and proposed the current forest and topography conservation. We also proposed to designate areas that facilitate the cold airflows as "cold air management areas" and to complement the function of Jeongmaek. This study could support the establishment of systematic management plans of the Jeongmaek. In addition, it is expected that the results can be applied as basic data for ventilation paths of Cheongju.

Detection of flash drought using evaporative stress index in South Korea (증발스트레스지수를 활용한 국내 돌발가뭄 감지)

  • Lee, Hee-Jin;Nam, Won-Ho;Yoon, Dong-Hyun;Mark, D. Svoboda;Brian, D. Wardlow
    • Journal of Korea Water Resources Association
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    • v.54 no.8
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    • pp.577-587
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    • 2021
  • Drought is generally considered to be a natural disaster caused by accumulated water shortages over a long period of time, taking months or years and slowly occurring. However, climate change has led to rapid changes in weather and environmental factors that directly affect agriculture, and extreme weather conditions have led to an increase in the frequency of rapidly developing droughts within weeks to months. This phenomenon is defined as 'Flash Drought', which is caused by an increase in surface temperature over a relatively short period of time and abnormally low and rapidly decreasing soil moisture. The detection and analysis of flash drought is essential because it has a significant impact on agriculture and natural ecosystems, and its impacts are associated with agricultural drought impacts. In South Korea, there is no clear definition of flash drought, so the purpose of this study is to identify and analyze its characteristics. In this study, flash drought detection condition was presented based on the satellite-derived drought index Evaporative Stress Index (ESI) from 2014 to 2018. ESI is used as an early warning indicator for rapidly-occurring flash drought a short period of time due to its similar relationship with reduced soil moisture content, lack of precipitation, increased evaporative demand due to low humidity, high temperature, and strong winds. The flash droughts were analyzed using hydrometeorological characteristics by comparing Standardized Precipitation Index (SPI), soil moisture, maximum temperature, relative humidity, wind speed, and precipitation. The correlation was analyzed based on the 8 weeks prior to the occurrence of the flash drought, and in most cases, a high correlation of 0.8(-0.8) or higher(lower) was expressed for ESI and SPI, soil moisture, and maximum temperature.

Grapevine Growth and Berry Development under the Agrivoltaic Solar Panels in the Vineyards (영농형 태양광 시설 설치에 따른 포도나무 생육 및 과실 특성 변화 비교)

  • Ahn, Soon Young;Lee, Dan Bi;Lee, Hae In;Myint, Zar Le;Min, Sang Yoon;Kim, Bo Myung;Oh, Wook;Jung, Jae Hak;Yun, Hae Keun
    • Journal of Bio-Environment Control
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    • v.31 no.4
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    • pp.356-365
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    • 2022
  • Agrivoltaic systems, also called solar sharing, stated from an idea that utilizes sunlight above the light saturation point of crops for power generation using solar panels. The agrivoltaic systems are expected to reduce the incident solar radiation, the consequent surface cooling effect, and evapotranspiration, and bring additional income to farms through solar power generation by combining crops with solar photovoltaics. In this study, to evaluate if agrivoltaic systems are suitable for viticulture, we investigated the microclimatic change, the growth of vines and the characteristics of grape grown under solar panels set by planting lines compared with ones in open vineyards. There was high reduction of wind speed during over-wintering season, and low soil temperature under solar panel compared to those in the open field. There was not significant difference in total carbohydrates and bud burst in bearing mother branches between plots. Despite high content of chlorophyll in vines grown under panels, there is no significant difference in shoot growth of vines, berry weight, cluster weight, total soluble solid content and acidity of berries, and anthocyanin content of berry skins in harvested grapes in vineyards under panels and open vineyards. It was observed that harvesting season was delayed by 7-10 days due to late skin coloration in grapes grown in vineyards under panels compared to ones grown in open vineyards. The results from this study would be used as data required in development of viticulture system under panel in the future and further study for evaluating the influence of agrivoltaic system on production of crops including grapes.

Analysis of Thermal Environment Modification Effects of Street Trees Depending on Planting Types and Street Directions in Summertime Using ENVI-Met Simulation (ENVI-Met 시뮬레이션을 통한 도로 방향별 가로수 식재 형태에 따른 여름철 열환경 개선 효과 분석)

  • Lim, Hyeonwoo;Jo, Sangman;Park, Sookuk
    • Journal of the Korean Institute of Landscape Architecture
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    • v.50 no.2
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    • pp.1-22
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    • 2022
  • The modification effects of street trees on outdoor thermal comfort in summertime according to tree planting types and road direction were analyzed using a computer simulation program, ENVI-met. With trees, the air temperature and wind speed decreased, and the relative humidity increased. In the case of mean radiant temperature (Tmrt) and human thermal sensation, physiological equivalent temperature (PET) and universal thermal climate index (UTCI), there was a decrease during the daytime. The greatest change among the meteorological factors by trees happened in Tmrt, and PET and UTCI showed similar patterns with Tmrt·The most effective tree planting type on thermal comfort modification was low tree height, wide tree crown, high leaf area index, and narrow planting interval (LWDN). Tmrt, PET and UTCI showed a large difference depending on shadow patterns of buildings and trees according to solar altitude and azimuth angles, and building locations. When the building shade areas increased, the thermal modification effect by trees decreased. In particular, results on the east and west sidewalks showed a large deviation over time. When applying the LWDN, the northwest, west and southwest sidewalks showed a significant reduction of 8.6-12.3℃ PET and 4.2-4.5℃ UTCI at 10:00, and the northeast, east and southeast sidewalks showed 8.1-11.8℃ PET and 4.4-5.0℃ UTCI at 16:00. On the other hand, when the least effective type (high tree height, narrow tree crown, low leaf area index, and wide planting interval) was applied, the maximum reduction was up to 1.8℃ PET and 0.9℃ UTCI on the eastern sidewalks, and up to 3.0℃ PET and 0.9℃ UTCI on the western ones. In addition, the difference in modification effects on Tmrt, PET and UTCI between the tree planting types was not significant when the tree effects were reduced by the effects of buildings. These results can be used as basic data to make the most appropriate street tree planting model for thermal comfort improvement in urban areas in summer.