• Journal of the Korean Society of Food Science and Nutrition
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• v.26 no.1
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• pp.116-122
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• 1997

Rats were adapted to diets containing 10% cellulose,10% sodium alginate and fiber-free diet for 5 weeks. Following a 14 hour fasting, rats were fed 5g of a test meal that provided 50% energy from fat, then killed at 4 hour postprandially. Plasma and lipoprotein fraction-cholesterol levels were lower in sodium alginate-fed animals than in rats fed other diets. Plasma TG did not differ among diet treatments. Increase in TG content of HDL fraction occurred in dietary fiber groups. Intestinal apolipoprotein B level and lipase activity were lower in sodium alginate-fed group than in other dietary groups. These results suggest that chronic consumption of sodium alginate affects plasma cholesterol level as in the case of fiber supplemetation, but is less likely to modify the acute Plasma TG response to high fat meal than if a fiber supplement is incorporated into the meal.

• The Journal of Internal Korean Medicine
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• v.27 no.3
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• pp.561-571
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• 2006

Objectives : This study was aimed at examining significant curative effects of Pyungjingunbitanggagam-bang on CVA(Cerebral Vascular Accident) patients with hyperlipidemia. Methods : The subjects in this study were sixteen patients admitted to Dong-Eui University Oriental Hospital who broke out with CVA from November 2004 through August 2005, with high total cholesterol (240mg/ dl above) or high TG (200mg/dl above). Before prescription. they were tested for total cholesterol, ALT. AST. BUN. and creatinine with fasting and were then prescribed the herbs(Pyungjingnnbitanggagam-bang) for 2 weeks. after which they were retested for total cholesterol. ALT. AST. BUN. and creatinine every 2 weeks. Conclusions : In the whole treatment group, hypertension & DM group. and cerebral infarction group.statistical significance of total cholesterol changes was recognized before and after the treatment.. Pyungjingunbitanggagam-bang decreased total cholesterol in HT. DM. and cerebral infarction groups. In the whole treatment. HT. and DM groups. statistical significance of TG changes was not recognized before and after the treatment. Hepatotoxicity and nephrotoxicity did not appeared when a stroke patient was given Pyungjingunbitanggagam-bang.

• Journal of Nutrition and Health
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• v.24 no.5
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• pp.420-430
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• 1991

To compare the hypolipidemic effects of n6 linoleic acid. n3 $\alpha$-linolenic acid and n3 eicosapentaenoic acid in rats fed high carbohydrate(70% Cal) diet. male Sprague Dawley rats were fed different experimental diets for 6 weeks. which were different only in fatty acid composition. The dietary fats were beer tallow(BT) as a source of saturated fatty acid (SFA), corn oil(CO) for n6 linoleic acid(LA), perilla oil(PO) for n3 $\alpha$-linolenic acid(LL) and fish oil(FO) for n3 eicosapentaenoic acid(EPA) and docosahexaenoic acid (DHA) Plasma total cholesterol(Chol) level was increased by n6 LA but decreased by n3 LL and n3 EPA and most effectively reduced by n3 EPA. HDL-Chol level was raised by n6 LA, but there was no significant change in HDL-Chol levels by n3 LL and was lowered by n3 EPA. Plasma TG level was reduced by n6 LA, but lipogenesis in liver was not affected by n6 LA. However, plasma TG level was lowered by n3 LL and EPA. Both lipogenic enzyme activity and liver TC level were also decreased by n3 PUFA. The relative proportions of TG in VLDL was significantly lowered by n3 EPA. but the proportions of Apo B in VLDL was not changed by n3 EPA. Overall. the hypolipidemic effect was in the order of EPA+ DHA(n3) >LL(n3) >LA(n6) and fish oil and perilla oil rich in n3 PUFA may have important nutritional applications in the prevention and treatment of hypertriglyceridemia.

• The Korea Journal of Herbology
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• v.33 no.2
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• pp.59-67
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• 2018

Objective : Plantago asiatica L. has been used for many years in Korea, China, and Japan for the treatment of many diseases such as anti-inflammatory, anti-asthma and diuretic. But the anti-obesity effect of Plantaginis asiaticae Folium has not been studied yet. Thus, this study aimed to demonstrate the anti-obesity efficacy of Plantaginis asiaticae Folium water extract (PAF) in high fat diet-induced obesity animal model. Method : Male, five-weeks old C57BL/6 mice were divided into 5 groups; ND (normal diet + 0.9% saline), HFD (high-fat diet + 0.9% saline), PC (high-fat diet + Garcinia cambogia 500 mg/kg), PAF 100, 300 (high-fat diet + PAF 100, 300 mg/kg. Treatments were performed daily for 6 weeks per os. We evaluated the changes of body weight, white adipose tissues weight, hepatic and fecal lipids level, pancreatic lipase activity and lipid profiles in plasma. Result : Body weights, adipose tissue weights and FER were significantly lower in mice fed the high-fat diet with PAF treatment than in mice fed the high-fat diet alone. In plasma, TG, TC, LDL-C, ATS and ALT levels significantly decreased in PAF groups compared with HFD group. Also, hepatic triglyceride (TG) levels decreased and fecal TG increased in PAF groups compared to HFD group. In addition, the activity of pancreatic lipase was decreased in the PAF groups compared to that of HFD group. Conclusion: These results suggest PAF extract is effective in preventing and improvement obesity, so it might be a potential and safe material for anti-obesity agent of weight control or functional supplements.

• Biomolecules & Therapeutics
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• v.13 no.4
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• pp.232-239
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• 2005

An aqueous extract of oriental herbal composition named Onchengyeum and curcumin, an antioxidant isolated from turmeric (Curcuma Zonga L.) reduced hepatotoxicity induced by carbon tetrachloride ($CCI_4$). Improved liver function was observed by measuring the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), blood urea nitrogen (BUN), creatinine (CRE), total cholesterol (T-CHO), triglyceride (TG), low density lipoprotein cholesterol (LDL-CHO), high density lipoprotein cholesterol (HDL-CHO), total protein (TP), albumin (ALB) and total bilirubin (BIL) in serum. Hepatic parameters monitored were levels of cholesterol (CHO), triglyceride (TG), and malondialdehyde (MDA) and activities of cytochrome P450 (CYP), NADPH-CYP reductase, superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), glutathione S-transferase (GST), glutathione reductase (GR), and glutathione peroxidase (GPx). The histopathological examination showed that the treatment of Onchengyeum and curcumin relieved the ballooning degeneration of hepatocytes which had been generated by $CCI_4$. The results suggested that hepatoprotective effects of Onchengyeum and curcumin possibly are due to their promising antioxidative activity.

• Journal of Nutrition and Health
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• v.31 no.2
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• pp.135-142
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• 1998

This study was undertaken to determine whether dehulled defatted flour has an effect on postprandial plasma lipoprotein composition, hepatic lipid composition, enzyme and hormone levels in rats. Control(casein) and experimental (dehulled defatted soy flour)diets were fed to rats for 7 weeks. all animals (S. D. rats, male) were sacrificed 2 hrs after the feeding of 5g of each diet. Defatted soy flour feeding significantly lowered postprandial plasma total cholesterol, chylomicron/VLDL-cholesterol, hepatic cholesterol and triglyceride(TG) as compared with casein feeding, whereas no significant effect on plasma TG was observed. Intestinal kipase activity was elevated , whereas trypsin activity was suppressed in the dehulled defatted soy flour group. Plasma glucagon, thyroid hormone and hepatic HMG-coA reductase levels were not affected by diet treatment. These results hypothesize that dehulled defatted soy flour affects cholesterol digestion and absorption in guts, thus delaying the appearance of chylomicron cholesterol in plasma or affecting the disappearance of chylomicron remnant to high-density-lipoprotein(HDL).

• The Korea Journal of Herbology
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• v.20 no.2
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• pp.149-157
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• 2005

Objectives : Each 2 types of Bangkeehwangkeetang(BHT) and Bangkeebok-ryeongtang(BBT) was prescribed to examined the therapeutic effects on hyperlipidemia. BHT-1 and BBT-1 were composed of Bunbangkee(粉防己, Stephaniae Radix) for Bangkee with other drugs, but BHT-2 and BBT-2 were composed of Cheongpungdeung(淸風藤, Sinomenii acuti Lignum). Methods : Four decoctions prepared from the prescriptions were respectively administrated to animal models in rats such as hyperlipidemic model induced by high cholesterol diet. Results : On the hyperlipidemic model, BHT-2 and BBT-2 would decrease the levels of total cholesterol(Tc) and triglyceride(TG) in blood, on the other hand, BHT-1 and BBT-1, despite little change of Tc, decrease TG but also HDL-cholesterol(HDLc). Conclusion : BBT, especially composed of Cheongpungdeung(Sinomenii acuti Lignum) for Bangkee, could be used more effectively than the others(Stephaniae Radix) on hyperlipidemia.

• YAKHAK HOEJI
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• v.53 no.6
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• pp.357-367
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• 2009

A meta-analysis of 63 randomized controlled trials of Pioglitazone and Rosiglitazone in patients with type 2 diabetes was conducted. Pioglitazone significantly lowered fasting plasma glucose and triglyceride (TG) level and increased high-density lipoprotein cholesterol (HDL) level. Rosiglitazone significantly lowered hemoglobin A1C level and fasting plasma glucose, whereas it increased all kinds of lipids (HDL, LDL (low-density lipoprotein cholesterol), TG, total cholesterol). In comparison, glucose lowering effect was higher in Rosiglitazone, and Pioglitazone produced a more favorable lipid profile.

• The Korean Journal of Ecology
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• v.15 no.3
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• pp.257-265
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• 1992

The effects of insecticide dimilin including the technical grade(tg) and wettable power(wp-25), inhibiting the synthesis of chitin in the cuticle of insect larvae, and herbicides alachlor and atrazine on the development of shrimp caridina denticulata denticulata were investigated in various concentrations. This species is abundant in the freshwater such as river and pond. The shrimp larvae were reared at dimilin solutions(tg and wp 2), alachlor solutions, and atrazin solutions. the concentrations of dimiline were 0, 1, 5, 10 and 25 ppb dimilin solutions, and those of alachlor and atrazin were 0, 1, 5, 10 and 25ppm, respectively.mortality was high at 10 ppb when the larvae were exposed to dimilin and at 25ppm in the case of alachlor and atranzine solutions. If lethal concentration is defined as a concentration in which less than 10% of larvae to the post larval stage from hatching it can be concluded that the lethal concentration of dimilin is 5ppb, and that of alachlor and atrazin is 25 ppm.

• Journal of Communications and Networks
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• v.8 no.3
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• pp.297-305
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• 2006

High-rate wireless personal area network (HR-WPAN) has been standardized by the IEEE 802.15.3 task group (TG). To support multimedia services, the IEEE 802.15.3 TG adopts a time-slotted medium access control (MAC) protocol controlled by a central device. In the time division multiple access (TDMA)-based wireless packet networks, the packet scheduling algorithm plays a key role in quality of service (QoS) provisioning for multimedia services. In this paper, we propose an adaptive cross-layer packet scheduling method for the TDMA-based HR-WPAN. Physical channel conditions, MAC protocol, link layer status, random traffic arrival, and QoS requirement are taken into consideration by the proposed packet scheduling method. Performance evaluations are carried out through extensive simulations and significant performance enhancements are observed. Furthermore, the performance of the proposed scheme remains stable regardless of the variable system parameters such as the number of devices (DEVs) and delay bound.