• Structural Engineering and Mechanics
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• v.30 no.5
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• pp.619-645
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• 2008

This study presents the efficiency of simulating structural systems using a method that combines a simplified component model (SCM) and rigorous component model (RCM). To achieve a realistic simulation of structural systems, a numerical model must be adequately capturing the detailed behaviors of real systems at various scales. However, capturing all details represented within an entire structural system by very fine meshes is practically impossible due to technological limitations on computational engineering. Therefore, this research develops an approach to simulate large-scale structural systems that combines a simplified global model with multiple detailed component models adjusted to various scales. Each correlated multi-scale simulation model is linked to others using a multi-level hierarchical modeling simulation method. Simulations are performed using nonlinear finite element analysis. The proposed method is applied in an analysis of a simple reinforced concrete structure and the Reuipu Elementary School (an existing structure), with analysis results then compared to actual onsite observations. The proposed method obtained results very close to onsite observations, indicating the efficiency of the proposed model in simulating structural system behavior.

• Genomics & Informatics
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• v.18 no.1
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• pp.11.1-11.3
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• 2020

In genome-wide association studies, pathway-based analysis has been widely performed to enhance interpretation of single-nucleotide polymorphism association results. We proposed a novel method of hierarchical structural component model (HisCoM) for pathway analysis of common variants (HisCoM for pathway analysis of common variants [HisCoM-PCA]) which was used to identify pathways associated with traits. HisCoM-PCA is based on principal component analysis (PCA) for dimensional reduction of single nucleotide polymorphisms in each gene, and the HisCoM for pathway analysis. In this study, we developed a HisCoM-PCA software for the hierarchical pathway analysis of common variants. HisCoM-PCA software has several features. Various principle component scores selection criteria in PCA step can be specified by users who want to summarize common variants at each gene-level by different threshold values. In addition, multiple public pathway databases and customized pathway information can be used to perform pathway analysis. We expect that HisCoM-PCA software will be useful for users to perform powerful pathway analysis.

• Genomics & Informatics
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• v.17 no.4
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• pp.45.1-45.3
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• 2019

To identify pathways associated with survival phenotypes using gene expression data, we recently proposed the hierarchical structural component model for pathway analysis of gene expression data (HisCoM-PAGE) method. The HisCoM-PAGE software can consider hierarchical structural relationships between genes and pathways and analyze multiple pathways simultaneously. It can be applied to various types of gene expression data, such as microarray data or RNA sequencing data. We expect that the HisCoM-PAGE software will make our method more easily accessible to researchers who want to perform pathway analysis for survival times.

• Communications for Statistical Applications and Methods
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• v.17 no.4
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• pp.551-560
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• 2010

This paper considers a Bayesian approach to modeling a flexible regression function under structural measurement error model. The regression function is modeled based on semiparametric regression with penalized splines. Model fitting and parameter estimation are carried out in a hierarchical Bayesian framework using Markov chain Monte Carlo methodology. Their performances are compared with those of the estimators under structural measurement error model without a semiparametric component.

• Genomics & Informatics
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• v.16 no.4
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• pp.38.1-38.3
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• 2018

Gene-gene interaction (GGI) analysis is known to play an important role in explaining missing heritability. Many previous studies have already proposed software to analyze GGI, but most methods focus on a binary phenotype in a case-control design. In this study, we developed "Hierarchical structural CoMponent analysis of Gene-Gene Interactions" (HisCoM-GGI) software for GGI analysis with a continuous phenotype. The HisCoM-GGI method considers hierarchical structural relationships between genes and single nucleotide polymorphisms (SNPs), enabling both gene-level and SNP-level interaction analysis in a single model. Furthermore, this software accepts various types of genomic data and supports data management and multithreading to improve the efficiency of genome-wide association study data analysis. We expect that HisCoM-GGI software will provide advanced accessibility to researchers in genetic interaction studies and a more effective way to understand biological mechanisms of complex diseases.

• International Journal of Aeronautical and Space Sciences
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• v.16 no.3
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• pp.394-406
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• 2015

In this work, an efficient aircraft landing simulation strategy is proposed to develop an efficient and reliable hard-landing monitoring procedure. Landing stage is the most dangerous moment during operation cycle of aircraft and it may cause structural damage when hard-landing occurs. Therefore, the occurrence of hard-landing should be reported accurately to guarantee the structural integrity of aircraft. In order to accurately determine whether hard-landing occurs or not from given landing conditions, full nonlinear structural dynamic simulation can be performed, but this approach is highly time-consuming. Thus, a more efficient approach for aircraft landing simulation which uses a hierarchical aircraft landing model and an extended inertia relief technique is proposed. The proposed aircraft landing model is composed of a multi-body dynamics model equipped with landing gear and tire models to extract the impact force and inertia force at touch-down and a linear dynamic structural model with an extended inertia relief method to analyze the structural response subject to the prescribed rigid body motion and the forces extracted from the multi-body dynamics model. The numerical examples show the efficiency and practical advantages of the proposed landing model as an essential component of aircraft hard-landing monitoring procedure.

• Smart Structures and Systems
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• v.31 no.4
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• pp.325-334
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• 2023

Computer vision-based damage detection enables non-contact, efficient and low-cost bridge health monitoring, which reduces the need for labor-intensive manual inspection or that for a large number of on-site sensing instruments. By leveraging recent semantic segmentation approaches, we can detect regions of critical structural components and identify damages at pixel level on images. However, existing methods perform poorly when detecting small and thin damages (e.g., cracks); the problem is exacerbated by imbalanced samples. To this end, we incorporate domain knowledge to introduce a hierarchical semantic segmentation framework that imposes a hierarchical semantic relationship between component categories and damage types. For instance, certain types of concrete cracks are only present on bridge columns, and therefore the noncolumn region may be masked out when detecting such damages. In this way, the damage detection model focuses on extracting features from relevant structural components and avoid those from irrelevant regions. We also utilize multi-scale augmentation to preserve contextual information of each image, without losing the ability to handle small and/or thin damages. In addition, our framework employs an importance sampling, where images with rare components are sampled more often, to address sample imbalance. We evaluated our framework on a public synthetic dataset that consists of 2,000 railway bridges. Our framework achieves a 0.836 mean intersection over union (IoU) for structural component segmentation and a 0.483 mean IoU for damage segmentation. Our results have in total 5% and 18% improvements for the structural component segmentation and damage segmentation tasks, respectively, compared to the best-performing baseline model.

• Genomics & Informatics
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• v.17 no.1
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• pp.10.1-10.3
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• 2019

To identify miRNA-mRNA interaction pairs associated with binary phenotypes, we propose a hierarchical structural component model for miRNA-mRNA integration (HisCoM-mimi). Information on known mRNA targets provided by TargetScan is used to perform HisCoM-mimi. However, multiple databases can be used to find miRNA-mRNA signatures with known biological information through different algorithms. To take these additional databases into account, we present our advanced application software for HisCoM-mimi for binary phenotypes. The proposed HisCoM-mimi supports both TargetScan and miRTarBase, which provides manually-verified information initially gathered by text-mining the literature. By integrating information from miRTarBase into HisCoM-mimi, a broad range of target information derived from the research literature can be analyzed. Another improvement of the new HisCoM-mimi approach is the inclusion of updated algorithms to provide the lasso and elastic-net penalties for users who want to fit a model with a smaller number of selected miRNAs and mRNAs. We expect that our HisCoM-mimi software will make advanced methods accessible to researchers who want to identify miRNA-mRNA interaction pairs related with binary phenotypes.

• Structural Engineering and Mechanics
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• v.37 no.1
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• pp.17-37
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• 2011

This paper presents a new Internet-based computational framework for the realistic simulation of multi-scale response of structural systems. Two levels of parallel processing are involved in this frame work: multiple local distributed computing environments connected by the Internet to form a cluster-to-cluster distributed computing environment. To utilize such a computing environment for a realistic simulation, the simulation task of a structural system has been separated into a simulation of a simplified global model in association with several detailed component models using various scales. These related multi-scale simulation tasks are distributed amongst clusters and connected to form a multi-level hierarchy. The Internet is used to coordinate geographically distributed simulation tasks. This paper also presents the development of a software framework that can support the multi-level hierarchical simulation approach, in a cluster-to-cluster distributed computing environment. The architectural design of the program also allows the integration of several multi-scale models to be clients and servers under a single platform. Such integration can combine geographically distributed computing resources to produce realistic simulations of structural systems.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1995.04b
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• pp.457-462
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• 1995

This paper describes diagnosis strategy of the Flexible Multiple Fault Diagnosis Module for forecasting faults in system and deciding current machine state form sensor information. Most studydeal with diagnosis control stategy about single fault in a system, this studies deal with multiple fault diagnosis. This strategy is consist of diagnosis control module such as backward tracking expert system shell, various neural network, numerical model to predict machine state and communication module for information exchange and cooperate between each model. This models are used to describe structure, function and behavior of subsystem, complex component and total system. Hierarchical structure is very efficient to represent structural, functional and behavioral knowledge. FT(Fault Tree). ST(Symptom Tree), FCD(Fault Consequence Diagrapy), SGM(State Graph Model) and FFM(Functional Flow Model) are used to represent hierachical structure. In this study, IA(Intelligent Agent) concept is introduced to match FT component and event symbol in diagnosed system and to transfer message between each event process. Proposed diagnosis control module is made of IPC(Inter Process Communication) method under UNIX operating system.