• The Korean Journal of Food And Nutrition
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• v.24 no.3
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• pp.442-450
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• 2011

Numerous studies have suggested that dietary flavonoids contribute to prevent cardiovascular disease. Onion contains many functional phytochemicals such as quercetin. The aim of this study was to examine whether onion peel extracts supplementation affect blood lipid profiles and blood coagulation in animal model. Total 48 Sprague-Dawley male rats at 5 weeks old were divided into 6 groups with different diets(C: control, HF: high fat diet, HFOE 0.01%: high fat+onion peel extract 0.01% diet, HFOE 0.02%, HFOE 0.05%, HFOE 0.1%) for 8 weeks. Onion peel extract supplementation significantly decreased serum levels of LDL-cholesterol and increased HDL-cholesterol, while total cholesterol and triglyceride levels were not affected. Hematological parameters(hematocrit, white blood cell, red blood cell, and platelet count) and blood coagulation parameters(prothrombin time, activated partial thromboplastin time, thrombin time, and fibrinogen) were not significantly different among 6 groups. However, activated partial thromboplastin time of HFOE 0.05% group was significantly longer than that of HF group. These results indicate that onion peel extract supplementation displays hypocholestrolemic effects but does not seem to have anti-coagulation effects in high fat fed SD rats.

• Journal of the Korean Society of Food Science and Nutrition
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• v.35 no.2
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• pp.164-170
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• 2006

The purpose of this study was to compare the nutrient intakes, blood pressure, and biochemical values and lipid profile in blood according to smoking status. Subjects were recruited from Korean adult men, which included non-smoker (n=47), smoker (n=58), and ex- smoker (n=44) . Anthropometrical measurement, blood pressure measurement, dietary intake assessment using 24-hour recall method, and blood collection and analysis were conducted. The average age, height, weight, and BMI of the subject were 54.7 years, 165.8 cm, 67.3 kg, and $24.5\;kg/m^2 $, respectively. There was no significant difference in general characteristics among three groups. The mean daily intakes of energy and protein were 1740.9 kcal and 69.6 g. The daily folate intake of the smoker was significantly lower than that of the non- smoker or ex-smoker. However, cholesterol intake of the smoker was significantly higher than two groups. The daily total food intake was 1250.0 g for non-smoker, 1180.1 g for smoker, and 1237.5 g for ex-smoker. The mushrooms intake in the smoker was significantly lower than that in the ex - smoker. However, eggs intake of the smoker was significantly higher than two groups. The RBC count and serum GOT/GPT of the subjects were $4598.2\times1000/mm^3$ and 27.3/27.3 U/L. The WBC count, hematocrit and hemoglobin of the smoker were significantly higher than those of the non-smoker and ex-smoker. Blood pressure and serum lipids of the subjects were 128.3/75.5 mmHg for SBP/DBP, 180.2 mg/dL for total cholesterol, 160.8 mg/dL for triglyceride, 41.5 mg/dL for HDL-cholesterol, 106.5 mg/dL for LDL-cholesterol, and 3.5 for atherogenic index. Especially serum triglyceride of smoker was significantly higher than that of non-smoker. The above results revealed that some nutrient intakes, such as folate and cholesterol, and hematological findings, and serum triglyceride of the smoker were different from non-smoker. However, these differences were recovered to non-smoking status by prohibition of smoking. Therefore, in order to stop smoking, the effect of smoking on nutritional and health status should be informed to smoker and more systematic study should be conducted.

• Reproductive and Developmental Biology
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• v.39 no.1
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• pp.13-21
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• 2015

The importance of genetic resource preservation has been highlighted in the literature as a means of maintaining genetic diversity. Investigations for hematologic values and the differential count of white blood cell count (WBC) for Korean indigenous cattle (KIC) and endangered indigenous cattle (EIC) are rarely performed. Therefore, the objective of this study was to investigate the hematologic values of total 40 EIC (White, Black, Mini cattle) and 35 KIC as control by analysis of hematologic characteristics. As a result, the mean values of RBC and platelet of EIC were significantly decreased by age (p<0.05). The mean values of RBC, HCT, MCV and MCHC between EIC and KIC of the same age (2~3 years) showed the statistical significance (p<0.05). Also, in the WBC of EIC, the mean values were decreased according to the age from $13.9{\times}10^3/{\mu}L{\sim}12.7{\times}10^3/{\mu}L$ under 1 year to $9.1{\times}10^3/{\mu}L{\sim}11.5{\times}10^3/{\mu}L$ over 2 years respectively. In the differential count of WBC of EIC (White, Black, Mini cattle), it showed generally the rates of 40.2%, 52.2%, 49.0% lymphocyte and 27.2%, 33.9%, 32.0% segmented neutrophil from 2~3 years respectively. Result of this study will be used for establishing reference range for blood analysis in EIC such as white, black and mini cattle. This study reported hematological values which could serve as baseline information for comparison in conditions of nutrient deficiency, physiological and health status of endangered Korean native cattle. In addition, this study provides a valuable resource for further investigations of the preservation of rare genetic stocks underlying traits of interest in cattle.

• The Korean Journal of Mycology
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• v.34 no.1
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• pp.7-14
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• 2006

Entomopathogenic fungus Cordyceps militaris is famous for its medicinal efficacies. It has been reported to have various pharmacological activities such as anti-tumour, insecticidal, antibacterial, immunomodulatory and antioxidant. In this study, we investigated the effect of the extract of C. militaris (MPUN8501), which was identified by the analysis of the nucleotide sequences of 5.8S ribosomal RNA, on the function of liver. C. militaris powder was extracted using hot water extracts method as time, volume and temperature and using method as differential polarity of organic solvent. Each fraction was tested for the improvement of hepatic enzyme alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) activity. The BuOH extracts (CME) had highest activity which was used for the test of toxicity and efficacy of C. militaris. The enhancing effect of CME on the activity of ADH and ALDH was much more than medicine, drink, natural tea etc. Thus CME promoted the resolution of alcohol and acetaldehyde in rats, inducing recovery to normal condition rapidly. Furthermore, oral administration of CME effectively protected the carbon tetrachloride-induced acute hepatic injury as revealed by the hematological parameters (levels of sGOT and sGPT) and histological observation. CME was ascertained to be safe by regulatory toxicity studies of single dose toxicity and genotoxicity. These results suggest that CME would be useful for the maintaining normal hepatic activity as a functional health food.

• Journal of agricultural medicine and community health
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• v.2 no.1
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• pp.36-42
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• 1977

A study on blood pressure and hematocrit values of 1,559 people in 19 Korean rural areas was carried out in 1974 and the results were analyzed statistically. Obtained as follows: 1. The blood pressure according to sex and age groups (from the twenties to the seventies) was as follows: 1) The blood pressure of male by age group il) In the twenties, M (mean) was 125. 85/74, 15mm/Hg, a (standard deviation) was 15.9/10.2, and ill (standard error) was 1.55/0.99. (2) In the thirties, ${\delta}$ was 123.93/77.19 mm/Hg, a was 14.4/10.8, and m was 1.24/0.93. (3) In the forties, M was 128.44/81.15 mm/Hg, a was 23.9/14.7, and m was 2.16/1.33. (4) In the fifties, M was 128.48/181.24 mm/Hg, a was 24.7/13.9, and m was 2.05/1.16. (5) In the sixties, M was 135.80/81.70 mm/Hg, a was 27.4/18.8, and ${\delta}$ was 2.74/1.88. (6) In the seventies, M was 146.84/83. 16mm/Hg, ${\delta}$ was 24.5/10.0, and m was 5.62/2.30. 2) The blood pressure of female by age group (1) In the twenties, M was 117.89/73.33 mm/Hg, ${\delta}$ was 15.7/12.1, and m was 1.42/1.09. (2) In the thirties, M was 118.04/75.71 mm/Hg, ${\delta}$ was 16.9/13.0, and m was 1.13/0.87. (3) In the forties, M was 120.92/78.17 mm/Hg, ${\delta}$ was 20.9/12.9, and m was 1.42/0.87. (4) In the fifties, M was 122.14/79.55 mm/Hg, ${\delta}$ was 24.2/15.9, and m was 1.63/1.07. (5) In the sixties, M was 131.57/84.29 mm/Hg, ${\delta}$ was 28.4/16.9, and m was 2.58/1.53. (6) In the seven ties, M was 139.62/86, 54 mm/Hg, ${\delta}$ was 22.4/15.7, and m was 4.38/3.09. And the range of systolic blood pressure in male was 70~230 mm/Hg and in female was 80-230 mm/Hg. The range of distolic blood pressure in male was 50~160 mm/Hg and in female was 40~140 mm/Hg. 2. The hematocrit value according to sex and age groups was as follows: 1) The hematocrit values of male by age group (1) In the twenties, M was 42.72%, ${\delta}$ was 3.05, and m was 0.30. (2) In the thirties, M was 41.77%, ${\delta}$ was 3.29, and m was 0.28. (3) In the forties, M was 41.39, ${\delta}$ was 3.86, and m was 0.35. (4) In the fifties, M was 40.12%, ${\delta}$ was 3.65, and m was 0.30. (5) In the sixties, M was 39.88%, ${\delta}$ was 3.81. and m was 0.38. (6) In the seventies, M was 38.47%, ${\delta}$ was 2.27, and m was 0.52. 2) The hematocrit values of female by age group (1) In the twenties, M was 35.40%, ${\delta}$ was 3.37, and m was 0.30. (2) In the thirties, M was 35.50%, ${\delta}$ was 3. 35, and m was 0.22. (3) In the forties, M was 35.75%, ${\delta}$ was 3. 18, and m was 0.22. (4) In the fifties, M was 35.84%, ${\delta}$ was 3.30, and m was 0.22. (5) In the sixties, M was 35.70%, ${\delta}$ was 3.35, and m was 0.30. (6) In the seventies, M was 35.08%, ${\delta}$ was 3.08, and m was 0.60. The range of hematocrit values in male was 23~50% and in female was 18~50% (un associated with age groups). 3. In comparison with the blood pressure and the value of hematocrit of study groups showed that the blood pressure raised higher but the value of hematocrit got lowered on the contrary as the groups are getting older. 4. Total number of patients with hypertension was 165(10.6%) which were consisted with 71 male (11.3%) and 94 female (10.1%). But only two cases of the male patient and one case of the female patient were associated with protein uria. 5. The incidence of anemia by hematocrit values was as follows: 1) The incidence of male anemia patients based on$\leqq$41% ($\leqq$39%). (1) In the twenties, incidence was 43.90% (16.98%). (2) In the thirties, 41.48% (25.93%). (3) In the forties, 42.62% (25.41%). (4) In the fifties, 62.76% (40.69%). (5) In the sixties, 70% (38%). (6) In the seventies, 84.21% (73.68%). 2) The incidence of female anemia patients bailed on $\leqq$35% ($\leqq$34%). (1) In the twenties, incidence was 43.90% (37.39%). (2) In the thirties, 48.21 % (33.93%). (3) In the forties, 43.58% (32.57%). (4) In the fifties, 45.91 % (34.09%). (5) In the sixties, 47.11% (37.19%). (6) In the seventies, 50% (46.15%) 6. The incidence rate of anemia patients with hypertension was highest in the age group 51~60 in male and 31~40 in female.