• 한국식품영양과학회지
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• 제28권3호
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• pp.710-721
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• 1999

This study was conducted to investigate the hematological characteristics and risk factors of hypercholesterolemia(HC) in Korean. 344 adult men who took the annual health check ups at D or J hospitals were participated in this cross sectional study. The subjects were grouped by plasma total cholesterol level into three groups: normal cholesterolemic(n=139), borderline hypercholesterolemic (n=93) and hypercholesterolemic(n=112) groups. The data of systolic and diastolic blood pressure (SBP/DBP), hemoglobin, plasma glucose, albumin and cholesterol levels were collected from medical records. The levels of plasma triglyceride(TG), HDL C, phospholipid, insulin, apo A and apo B were measured. The levels of plasma LDL C, VLDL C and atherogenic index(AI) were calculated. The subjects with HC had significantly higher SBP and DBP, albumin, TG, phospholipid, HDL C, LDL C, VLDL C and apo B level than those of the normal subjects. The relative and attributable risks on HC were 1.59 and 0.18 for hypertension(SBP/DBP$\geq$160/95), 2.08 and 0.35 for hypertriglyceridemia (TG $\geq$400mg/dl). Plasma total cholesterol level was positively correlated with several hematologic parameters: age(r=0.1242, p<0.05), DBP(r=0.1194, p<0.05), albumin(r=0.2029, p<0.001), plasma TG(r= 0.3829, p<0.001), phospholipid(r=0.6036, p<0.001), LDL C(r=0.8572, p<0.001), HDL C(r=0.2399, p< 0.001), AI(r=0.3116, p<0.001), apo B(r=0.2602, p<0.05) and Lp(a)(r=0.1372, p<0.05). However, plasma total cholesterol level was negatively correlated with the levels of Apo A1(r= 0.2922, p<0.001), and ABR(r= 0.3598, p<0.001).

• Advances in environmental research
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• 제11권1호
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• pp.31-38
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• 2022

The current observational epidemiological study analyzed blood lead levels (BLLs) in occupationally exposed workers from Riyadh region, Saudi Arabia and correlated them with the alterations in the differential cell populations of the WBC panel (lymphocytes [Lym %], mixed [Mid %] cells, and neutrophils [Neu %]). In addition, we examined the effect of confounding factors and their relation to BLLs. BLLs were estimated using the LeadCare II analyzer and hematological parameters using the ADVIA 120 analyser. An inferential analysis was conducted to detect association between the observations and the subjects' clinical characateristics. A total of 132 male subjects were included in the final analyses. Based on CDC guidelines, the subjects were categorized as Group I (BLL <10 ㎍/dL; n=118) or Group II (BLL >10 ㎍/dL; n=14) with average BLLs of 4.4 ㎍/dL and 18.1 ㎍/dL, respectively (p <0.0001). The percentages of Mid cells (p <0.0001) and neutrophils (p=0.048), were significantly altered in subjects with High BLL. A regression analysis indicated that subjects > 50 years of age had significantly higher BLLs (53.2 ㎍/dL) than younger age sub-groups (p <0.0001). Age, education, and profession were significant predictors for lead toxicity. Pb exposure is a major public health issue in Saudi Arabia and calls for further investigations on the cellular and molecular effects on hematological system.

• 대한예방한의학회지
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• 제10권2호
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• pp.31-49
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• 2006

This study was undertaken to investigate the effects of Gyoaesamultang in pregnant rats and their fetuses. Female Sprague-Dawley rats were orally administered with the Gyoaesamultang at dose of 5mg/kg/day for 20 days. Pregnant rats were sacrificed at 20th day of gestation, and observed internal and reproductive organs. Approximately, live fetuses in the 20th day of gestation were randomly selected and fixed in 95% ethanol. To observe skeletal malformations, fetuses were stained with alcian blue and alizarin red S. Maternal body weight of Gyoaesamultang treated group has a tendency to increase compared to that of control group. There were no significant difference in internal and reproductive organs. There were no significant changes between two groups in blood chemistry and hematological values. There were no significant changes in number of corpus luteum, implantation, live fetuses and implantation rate, delivery rate, late resorption rate and sex ratio. But Gyoaesamultang administered group showed lower early resorption rate than the control group. Neonatal body weight and number of fetus of Gyoaesamultang group were increased to that of control group. The fetuses of dams treated with Gyoaesamultang didn't showed external malformation. Vertebral and sternal variations were observed in Gyoaesamultang group but, compared to the control, those variations were insignificant. The number of ribs, cervical, thoracic, and lumber were normal. The number of sacral and caudal vertebrae were increased. Fetuses treated with Gyoaesamultang showed significant difference in the number of caudal vertebra(P<0.01). From these results, it can be concluded that Gyoaesamultang showed no toxicity effects on maternal body weight, early resorption rate, and number of live fetuses. There were no significant changes in organ weight, hematological data, reproductive organs. Although skeletal variations were showed in vertebrate and sternum, Gyoaesamultang were shown insignificant changes in bone malformation.

• 한국식품영양과학회지
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• 제39권1호
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• pp.78-84
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• 2010

본 연구는 부산시 해운대구 보건소에서 과체중 이상인 30세 이상 중년여성을 대상으로 스스로 평생 자기 건강관리를 할 수 있는 능력을 키울 수 있는 건강 체중조절 프로그램을 개발하여 운영하고, 효과적인 영양교육의 필요성과 체계적이고 지속적인 체중조절 프로그램의 운영방안을 마련하고자 하였다. 상반기, 하반기로 2차례에 걸쳐서 과체중 이상인 해운대구 거주 주민 여자 53명을 선착순 모집하여 프로그램을 운영하였다. 프로그램 시작 전후에 건강검진, 체력측정, 체성분측정, 설문조사를 하고, 건강상태와 비만도에 따른 결과를 개인상담으로 실시하였으며, 영양교육은 비만 특강(1시간)을 시작으로, 소그룹별로 4주간 매주 1회 실시한 결과는 다음과 같다. 영양교육과 운동프로그램 전후의 대상자의 체중, BMI는 유의적으로 감소(p<0.001)하였으며 체격 및 체력검사결과 허리둘레, 엉덩이둘레, 상완배부, 견갑하연부는 유의적으로 감소하였으며(p<0.001), 배근력(p<0.001), 악력(p<0.01)은 유의적으로 증가하였다. 또한 영양교육과 운동프로그램 실시 후에 공복 시 혈당(p<0.001), 중성지방(p<0.01)의 농도는 유의적으로 감소하였다(p<0.01). 건강 상태에 대한 평가 결과, 스스로의 건강상태에 대해 긍정적으로 변화되었고, 프로그램 실시 후에 건강관리를 위해서 운동을 중요시하는 양상을 보였다. 영양소 섭취 상태 조사 결과 비타민 D의 섭취량은 유의적으로 증가하였으며(p<0.05). 식습관 조사와 영양지식평가 결과, 평균점수가 유의적인 증가를 보였다(p<0.001). 4주간의 영양교육과 운동프로그램 실시 후 대상자의 식습관과 비만도, 혈액수치에 있어서 긍정적인 영향을 미쳤다고 사료되며, 교육효과를 더 증진시키기 위한 보다 체계적이고 지속적인 영양교육 프로그램의 개발이 필요하며 잘못된 식습관으로 인한 영양불균형이 성인병 등을 유발하지 않도록 평소 균형된 식생활이 이루어지도록 하여야 할 것이다.

• 대한의생명과학회지
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• 제12권4호
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• pp.375-383
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• 2006

The physiological responses following stress are different in individual or personality. We performed this study to clarify gender differences in influences of noise stress on physiological factors. 70 healthy subjects, which was divided man (n=30) and woman (n=40) groups, were exposed to 85 decibels of excavator noise for 15 minutes. Cardiac factors such as heart rate (HR), systolic and diastolic blood pressures (SBP and DBP, respectively), and heart rate-systolic pressure product (RPP) were determined. Transcranial Doppler ultrasound (TCD) was used to measure mean blood flow velocity (Vm), pulsatility index (PI), and resistance index (RI) in the middle, anterior and posterior cerebral arteries (MCA, ACA and PCA, respectively) before and during noise exposure. Cortisol level and hematological variables were also measured before (baseline) and immediately after the end of noise exposure. In the both groups HR, SBP, and RPP significantly decreased during noise exposure (P<0.05) but not significantly different between two groups (P>0.05). Vms of three cerebral arteries in man group decreased, whereas Vm of PCA in woman group fell during noise exposure (P<0.05). Vm, PI and RI in MCA and ACA during noise exposure were low in man group compared with woman group (P<0.05). Vm of PCA was low, whereas PI and RI of PCA were high in man group compared with woman group during noise exposure (P<0.05). Total leukocyte and red blood cell (RBC) counts slightly decreased during noise exposure but not significant (P>0.05). Levels in hematological variables decreased but not significant changed following noise exposure. Decreased rate of total leukocyte in man group was higher (P<0.05). Cortisol levels in the both groups decreased immediately after the end of noise exposure, while the decreased rate in man group was greater than that in woman group (p<0.05). These findings indicate that a transient exposure to experimental excavator noise may cause decreased changes in cardiac factors, cerebral hemodynamics and cortisol levels and the changes may be greater in men than in women.

• Journal of Nutrition and Health
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• 제13권2호
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• pp.82-91
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• 1980

The aim of this study was to define the range of the menstrual blood loss(MBL), and the upper limit of the MBL associated with iron deficiency anemia in Korean women, For this purpose, healthy unmarried women between the age of 15 to 26 years were selected from July to September, 1979 and results obtained were used for determining baseline MBL and its relationship to iron nutriture. One houndred forteen women were tested for their MBL and hematological and biochemical data such as hemoglobin(Hb) concentration, hematocrit, mean corpuscular hemoglobin concentration(MCHC), and serum iron and ferritin concentration. This study was partly supported by World Health Organization. The results of this study are summarized as follows: 1) The mean values and standard error of mean of MBL were $30.7{\pm}2.19ml$ for total subjects, $30.4{\pm}3.14ml$ for sutjects below 20 years of age and $30.3{\pm}2.49ml$ for subjects aged more than 20 years. No significant variation was noted for amount of MBL between two age groups. 2) The median value and 95th percentile value of MBL were 26.5ml and 69.0ml respectively for total subjects. Maximum number (24.6%) of the subjects fell in group with 10-20ml of MBL while 10.5% showed MBL above 50m1. 3) Mean value of the duration of menstruation for total subjects was 4.34 days. 4) It was observed that mean values of Hb concentration, hematocrit and MCHC were decreased slightly in subjects showing MBL more than 40m1. Serum iron and ferritin levels were markedly decreased in women with MBL above 40m1 and 20-30ml, respectively. 5) In subject population showing MBL above 50ml, the frequency of subjects with hematological and biochemical data below anemia criteria were remarkably increased. 6) Although the number of subjects tested was small and the subject selection was not done by random stratified sampling from a population group, this study suggested that the upper normal limit of MBL of Korean women seems to be in the range of 40-50ml.

• 한국임상수의학회지
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• 제24권1호
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• pp.1-4
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• 2007

고도병(High altitude disease)의 위험에도 불구하고, 고냉지에서 한우를 사육할 경우, 감염이나 스트레스 위험이 낮아서 한우의 육질을 개선하는데 도움이 된다고 한다. 하지만 어떤 고도가 고도병의 위험성이 없이 최적의 사육환경을 제공하는지에 대한 연구가 부족한 실정이다. 따라서 본 연구에서는 3가지 다른 고도(200m, 400m and 800m)에서 사육되고 있는 한우를 대상으로 혈액 검사, 혈청 생화학 검사 및 스트레스와 관련된 호르몬 검사를 실시하였다. 본 연구에서 적혈구 수치와 혈색소의 농도는 800m고지에서 사육된 한우에서 가장 높았고, 200m고지에서 사육된 한우에서 가장 낮게 나타났다. 이러한 결과는 저산소증에 따른 골수와 적혈구 신생 자극 반응에 기인한 것으로 보인다. 혈중의 AST, BUN과 cortisol농도는 800m고지에서 사육된 한우에서 가장 낮게 측정되었으며, 전반적인 건강상태도 200m지대에서 사육된 한우보다 800m지대에 사육된 한우 집단이 건강 상태가 양호한 것으로 나타났다. 이 결과는 한우의 건강에 영향을 주는 스트레스 요인이 800m고지에서 최소로 나타남을 의미하는 것 같다.

• Asian-Australasian Journal of Animal Sciences
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• 제32권8호
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• pp.1137-1144
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• 2019

Objective: This experiment was designed to evaluate the effects of Agave tequilana inulin and Lactobacillus casei (L. casei) on growth performace, hematological variables, serum metabolites, and total coliforms in nursing lambs. Methods: The experimental design was completely randomized; treatments were T1, control (pre-starter concentrate, PC), T2: T1+2% inulin, and T3: T1+2% inulin+L. casei; treatments were compared with Tukey test ($p{\leq}0.05$); and 45 new born $Kathadin{\times}Dorset lambs$ ($4.8{\pm}0.8kg$ birth weight) were the experimental units (15 per treatment). The variables were daily weight gain (DWG), dry matter intake and diarrheas incidence (%) during 56 d. Twenty-four hours after birth and at the end of the experiment, blood samples were collected to evaluate hematological variables and serum metabolites. Besides, the populations of total coliforms and lactobacilli were estimated in fecal samples. Results: Addition of agave inulin and L. casei increased ($p{\leq}0.05$) DWG 356, 384, and 415 g/d, weaning weight 24.92, 26.18, and 28.07 kg, as well as lactobacilli population 5.79, 6.32, and $6.48Log_{10}cfu/g$, for T1, T2, and T3, respectively. Lambs fed L. casei had decreased ($p{\leq}0.05$) populations of total coliforms (T1 = 6.18, T2 = 5.77, and $T3=5.07Log_{10}cfu/g$), diarrheas incidence (T1 = 11.67%, T2 = 8.33%, and T3 = 5.0%), and serum cholesterol concentration (11% in T2 and 13% in T3, compared to control). Conclusion: The combination of Agave tequilana inulin and L. casei increases weight gain and improves intestinal health by reducing coliforms and diarrheas incidence in $Katahdin{\times}Dorset$ lambs during the pre-weaning period.

• 대한임상검사과학회지
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• 제41권1호
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• pp.11-23
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• 2009

Chromosomal rearrangements are major pathology in hematological malignancies. The detection of minimal residual disease (MRD) for these gene rearrangements helps in monitoring treatment outcomes and predicting prognosis of patients. Recently, quantification of these gene transcripts based on real-time quantitative polymerase chain reaction (RQ-PCR) has been used as MRD detection. The purpose of this study is to ensure the usefulness of the RQ-PCR technique for detecting MRD in hamatological malignancy patients. The patients had been diagnosed to AML1-ETO positive AML, PML-RARa positive AML and BCR-ABL positive MPN at Chonnam National University Hwasun Hospital from Jan. 2006 to Aug. 2008. The fusion transcript was quntified by RQ-PCR and analyzed in comparison to conventional cytogenetics, FISH and RT-PCR. The fusion gene transcript was quantified by RQ-PCR in 57 samples from 14 patients with AML1-ETO positive AML, 79 samples from 27 patients with PML-RARa positive AML and 108 samples from 36 patients with CML. At diagnosis, the quantitative fusion transcripts for AM1-ETO, PML-RARa and BCR-ABL showed the range of 0.485552651~10.82233683 (mean 3.782217131, SD 2.998052348), 0.005300395~0.29267494 (mean 0.056901315, SD 0.080131381) and 0.1293929~12.94826849 (mean 1.701935665, SD 2.200913158). The increase of AML1-ETO fusion gene transcripts preceded morphologic relapse in two patients. Quantification of fusion gene transcripts by RQ-PCR could detected MRD in samples which were negative by in cytogenetic analysis or FISH. Our findings indicated that quantitative analysis of AML1-ETO, PML-RARa and BCR-ABL transcripts by RQ-PCR might be a useful tool for the monitoring of minimal residual disease in hematological malignancies.

• Journal of Nutrition and Health
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• 제40권5호
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• pp.428-434
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• 2007

본 연구에서는 무철분식이로 철분결핍성 빈혈 유발을 시킨 흰쥐에게 3주간 무철분식이를 섭취시키면서 saline, 참당귀 추출물 및 철분보충제를 투여한 후, 무철분식이를 일반식이로 대체하여 다시 3주간 같은 처리를 한 후 혈액학적 빈혈지표를 조사하여 결과를 요약하면 다음과 같다. 1) 실험동물의 체중은 무철분식이군에서 일반식이군에서 보다 유의적으로 낮게 나타났다. 무철분식이로 인한 저체중은 참당귀 추출물과 철분 보충제에 의해서 회복되지 않았다. 2) 혈액분석 결과 무철분식이는 모든 혈액 빈혈지표를 저하시켰으며, 철분보충제의 투여는 헤모글빈, 헤마토크릿, 평균 혈구 부피, 평균 혈구혈색소, 평균 혈구혈색소 농도, 총철결합능력이 유의적으로 회복시켰다. 무철분식이와 함께 투여한 참당귀 추출물은 혈액지표를 개선시키지 못하였다. 한편, 일반식이와 함께 섭취하였을 경우, 헤모글로빈, 헤마토크릿, 평균 혈구부피, 평균 혈구혈색소, 평균 혈구혈색소 농도, 총철결합능력 모두 유의적인 회복효과를 보였으나 일반식이만을 섭취한 군에서도 같은 회복효과를 보였다. 결론적으로, 장기간에 걸쳐 철분 섭취가 불량할 경우, 체중증가가 지연되며 후에 철분을 보충할 경우에도 체중의 회복은 개선되지 않았다. 철분결핍으로 인한 저체중의 경우, 철분보충제의 복용은 체중을 만회시키지 못하였으나 혈액학적 빈혈 지표들은 회복시키는 것으로 나타났다. 철분결핍 빈혈에서 식이철분이 부족할 경우, 참당귀의 회복효과는 미비한 것으로 나타났다. 향후 철분결핍 빈혈의 치료를 위한 생약제의 다양한 작용을 밝히기 위하여서는 영양학적인 관점에서 체내 이용률에 관한 심도 깊은 연구가 이루어져야 할 것으로 사료된다.