• Title/Summary/Keyword: heavy tail

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Evaluation of DNA Damage by Mercury Chloride (II) and Ionizing Radiation in HeLa Cells (이온화 방사선 및 염화수은(II)에 의한 자궁경부암 세포의 DNA 손상 평가)

  • Woo Hyun-Jung;Kim Ji-Hyang;Antonina Cebulska-Wasilewska;Kim Jin-Kyu
    • Korean Journal of Environmental Biology
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    • v.24 no.1 s.61
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    • pp.46-52
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    • 2006
  • The mercury is among the most highly bioconcentrated toxic trace metals. Many national and international agencies and organisations have targeted mercury for the possible emission control. The mercury toxicity depends on its chemical form, among which alkylmercury compounds are the most toxic. A human cervix uterus cancer cell line HeLa cells was employed to investigate the effect of the toxic heavy metal mercury (Hg) and ionizing radiation. In the in vitro comet assays for the genotoxicity in the HeLa cells, the group of Hg treatment after irradiation showed higher DNA breakage than the other groups. The tail extent moment and olive tail moment of the control group were $4.88{\pm}1.00\;and\;3.50{\pm}0.52$ while the values of the only Hg treatment group were $26.90{\pm}2.67\;and\;13.16{\pm}1.82$, respectively. The tail extent moment and olive tail moment of the only 0.001, 0.005, 0.01 Hg group were $12.24{\pm}1.82,\;8.20{\pm}2.15,\;20.30{\pm}1.30,\;12.26{\pm}0.52,\;40.65{\pm}2.94\;and \;20.38{\pm}1.49$, respectively. In the case of Hg treatment after irradiation, the tail extent moment and olive tail moment of the 0.001, 0.005, 0.01 Hg group were $56.50{\pm}3.93,\;32.69{\pm}2.48,\;62.03{\pm}5.14,\;31.56{\pm}1.97,\;72.73{\pm}3.70\;and \;39.44{\pm}3.23$, respectively. The results showed that Hg induced DNA single-strand breaks or alkali labile sites as assessed by the Comet assay. It is in good agreement with the reported results. The mercury inhibits the repair of DNA. The bacterial formamidopyrimidine-DNA glycosylase (Epg protein) recognizes and removes some oxidative DNA base modifications. Enzyme inactivation by Hg (II) may therefore be due either to interactions with rysteine residues outside the metal binding domain or to very high-affinity binding of Hg (II) which readily removes Zn (II) from the zinc finger.

Dynamic Analyis of Long Distance Belt Conveyor During Starting and Stopping (장거리 벨트 컨베이어의 기동 및 정지시의 동적거동 해석)

  • Kim, Won-Jin;Park, Tae-Geon;Lee, Shin-Sup
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.20 no.2
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    • pp.585-593
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    • 1996
  • According to the considerable increase of the length of belt conveyors, the dynamic analysis of systme becomes necessary to consider the variation of tensions and transient motion of components during starting and stopping of conveyor. The mathematical model of system is derived using the lumped parameter method. The input driving force is represented with two functions of time and pulley speed to count the characteristics of motor and fluid coupling. An example system was studied with 14 km in the distance of carrying. At head, it has two drivers and one gravity take-up and at tail ond driver and one power winch take-up. In the example, the transient tensions and responses, calculated using two cases of driving force, are mutually compared in starting mode. Also, the position of maximum tension and the braking force of take-up are obtained in stopping mode.

Evaluation of Authentication Signaling Load in 3GPP LTE/SAE Networks (3GPP LTE/SAE 네트워크에서의 인증 시그널링 부하에 대한 평가)

  • Kang, Seong-Yong;Han, Chan-Kyu;Choi, Hyoung-Kee
    • Journal of the Korea Institute of Information Security & Cryptology
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    • v.22 no.2
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    • pp.213-224
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    • 2012
  • The integrated core network architecture and various mobile subscriber behavior can result in a significant increase of signaling load inside the evolved packet core network proposed by 3GPP in Release 8. Consequently, an authentication signaling analysis can provide insights into reducing the authentication signaling loads and latency, satisfying the quality-of-experience. In this paper, we evaluate the signaling loads in the EPS architecture via analytical modeling based on the renewal process theory. The renewal process theory works well, irrespective of a specific random process (i.e. Poisson). This paper considers various subscribers patterns in terms of call arrival rate, mobility, subscriber's preference and operational policy. Numerical results are illustrated to show the interactions between the parameters and the performance metrics. The sensitivity of vertical handover performance and the effects of heavy-tail process are also discussed.

Multi-objective Optimal Design for the Low Drag Tail Shape of the MIRA model with the Lift Effect taken into account (양력 효과를 고려한 MIRA model 후미의 저저항 다목적 최적설계)

  • Lee Juhee;Lee Kyunghuhn;Kim Joonbae
    • Proceedings of the KSME Conference
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    • 2002.08a
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    • pp.565-568
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    • 2002
  • In the flow analysis around a bluffbody such as road vehicles, drag reduction has been of the primary concern mainly due to the effect on fuel economy. To reduce the drag, which is mostly due to the pressure difference caused by the flow separation, the location of the separation and eddy sizes are controlled. However, less attention has been given to the effect of the lift. The effect of lift may cause the driving stability problem of the vehicle at high speed white heavy downward effect of lift together with the vehicle weight may require more power to drive the vehicle forward. It is considered worthwhile to pursue the optimal design of the low drag tail shape of the MIRA model while taking the lift effect into account, even though it is considered as a reference. To this end, a commercial multi-objective optimization code, FRONTIER, Is used together with the CFD code, STAR-CD. It is hoped that the results will provide more insight into the flow field around the bluffbody as transportation means.

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An Estimation of Springing Responses for Recent Ships

  • Park, In-Kyu;Kim, Jong-Jin
    • Journal of Ocean Engineering and Technology
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    • v.19 no.6 s.67
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    • pp.58-63
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    • 2005
  • The estimation of springing responses for recent ships is carried out, and application to a ship design is described. To this aim, springing effects on hull girder were re-evaluated, including non-linear wave excitations and torsional vibrations of the hull. The Timoshenko beam model was used to calculate stress distribution on the hull girder, using the superposition method. The quadratic strip method was employed to calculate the hydrodynamic forces and moments on the hull. In order to remove the irregular frequencies, we adopted 'rigid lid' on the hull free surface level, and addedasymptotic interpolation along the high frequency range. Several applications were carried out on the following existing ships: The Bishop and Price's container ship, S-175 container ship, large container, VLCC, and ore carrier. One of them is compared with the ship measurement result, while another with that of the model test. The comparison between the analytical solution and the numerical solution for a homogeneous beam-type artificial ship shows good agreement. It is found that Most springing energy comesfrom high frequency waves for the ships having low natural frequency and North Atlantic route etc. Therefore, the high frequency tail of the wave spectrum should be increased by $\omega$$\^{-3}$ instead of $\omega$$\^{-4}$ or $\omega$$\^{-5}$ for the springing calculation.

Nano Particle Emission Charataristics of Biodiesel (바이오디젤의 미세입자 배출특성)

  • Song, Hoyoung;Lee, Minho;Kim, Jaigueon;Jung, Choongsub
    • 한국신재생에너지학회:학술대회논문집
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    • 2010.11a
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    • pp.199.2-199.2
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    • 2010
  • Biodiesels are well-known as alternative fuels. also we know that biodiesels increase NOx and reduce PM(Particulate Matter) by previous many studies. But PM in most these studies was considered about the mass. In this study, We have performed experimental test for PM and exhaust emission by mixed ratio of biodiesel in heavy duty diesel engine. PM was investigated by The nano particle number and the mass. The mass of PM was evaluated by using the standard gravimetric method, The number of PM was evaluated by using the EEPS(Engine Exhaust Particle Sizer), on the ESC(European Steady Cycle) mode. Sampled gas through dilutor was directly extracted from tail pipe and EEPS measured diluted exhaust gas. Biodiesel is made up of used cooking oil. Diesel as base fuel was sold on market and contains 2% biodiesel. The mass of PM was reduced 10% and the nano particle number was increased 5%. The particle number less than 40nm was increased, but the particle number more than 40nm is decreased.

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Estimation of VaR and Expected Shortfall for Stock Returns (주식수익률의 VaR와 ES 추정: GARCH 모형과 GPD를 이용한 방법을 중심으로)

  • Kim, Ji-Hyun;Park, Hwa-Young
    • The Korean Journal of Applied Statistics
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    • v.23 no.4
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    • pp.651-668
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    • 2010
  • Various estimators of two risk measures of a specific financial portfolio, Value-at-Risk and Expected Shortfall, are compared for each case of 1-day and 10-day horizons. We use the Korea Composite Stock Price Index data of 20-year period including the year 2008 of the global financial crisis. Indexes of five foreign stock markets are also used for the empirical comparison study. The estimator considering both the heavy tail of loss distribution and the conditional heteroscedasticity of time series is of main concern, while other standard and new estimators are considered too. We investigate which estimator is best for the Korean stock market and which one shows the best overall performance.

A Study on the Characteristics of Smoke Emissions from Heavy Duty Diesel Vehicles Using a Chassis Dynamometer (차대동력계를 이용한 대형 디젤 차량의 매연 배출 특성 연구)

  • Jin, Kwang-Suk;Lee, Choong-Hoon
    • Journal of the Korean Society of Safety
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    • v.24 no.4
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    • pp.1-10
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    • 2009
  • The characteristics of smoke emissions from diesel heavy duty vehicles which weigh over 5.5 tons was investigated by driving the vehicles with both the Lugdown 3 modes in the chassis dynamometer and tree accelerating mode under no load. The vehicles include commercial vehicles such as bus, microbus, trucks and specialized vehicles, etc. The total numbers of the vehicles tested were 200. The light extinction method was used to measure the smoke emissions from the vehicles tail pipe. The values of the smoke emissions in the tree accelerating mode showed $0{\sim}20%$ band nearly independent of both the mileage and year of production of the tested vehicles, while those in the Lugdown 3 modes showed $0{\sim}99%$ of wide band. The correlation coefficients between the values of the smoke emissions with both the Lugdown 3 modes and the free acceleration mode were 0.12, 0.08, 0.12, respectively. The inspection with Lugdown 3 modes is better one than that with tree acceleration from the point of exact inspection of the diesel vehicles' smoke emission.

VaR and ES as Tail-Related Risk Measures for Heteroscedastic Financial Series (이분산성 및 두꺼운 꼬리분포를 가진 금융시계열의 위험추정 : VaR와 ES를 중심으로)

  • Moon, Seong-Ju;Yang, Sung-Kuk
    • The Korean Journal of Financial Management
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    • v.23 no.2
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    • pp.189-208
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    • 2006
  • In this paper we are concerned with estimation of tail related risk measures for heteroscedastic financial time series and VaR limits that VaR tells us nothing about the potential size of the loss given. So we use GARCH-EVT model describing the tail of the conditional distribution for heteroscedastic financial series and adopt Expected Shortfall to overcome VaR limits. The main results can be summarized as follows. First, the distribution of stock return series is not normal but fat tail and heteroscedastic. When we calculate VaR under normal distribution we can ignore the heavy tails of the innovations or the stochastic nature of the volatility. Second, GARCH-EVT model is vindicated by the very satisfying overall performance in various backtesting experiments. Third, we founded the expected shortfall as an alternative risk measures.

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Enzymatic Properties of Protease from the Hepatopancreas of Shrimp, Penaeus japonicus

  • Kim Hyeung-Rak
    • Fisheries and Aquatic Sciences
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    • v.3 no.3_4
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    • pp.188-194
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    • 2000
  • A protease purified from hepatopancreas of shrimp, Penaeus japonicus, had maximum activity at $70^{\circ}C$ and in neutral and alkaline pH ranges. Specific activity at optimum reaction condition of the protease was estimated to be approximately 12 U/mg/min. The protease was stable in neutral and alkaline pH ranges and activity was retained after heat treatment at $50^{\circ}C$ for 30 min. Apparent $K_m$ and $V_{max}$ value against casein substrate were estimated to be $0.29\%$ and $7.8see^{-1}$, respectively, and those against N-CBZ-L-tyrosine p-nitropheny1 ester (CBZ­Tyr-NE) were 0.38 mM and $2,400 see^{-1}$, respectively. The N-termina1 sequence of the protease showed high homology to the trypsin from same species and the proteases from shrimp. Myosin heavy chain (MHC) from shrimp tail meat was the most susceptible to the protease and actin/tropomyosin were degraded progressively during 4 hr incubation, but to a lesser degree than MHC.

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