• Journal of Life Science
• /
• v.32 no.8
• /
• pp.611-621
• /
• 2022

Dimethyl sulfoxide (DMSO) is commonly used as control or vehicle solvent in preclinical research of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) due to its ability to dissolve lipophilic compounds and cross the blood brain barrier. However, the biochemical effects of DMSO on the outcomes of preclinical research are often overlooked. In the present study, we investigated whether the long-term oral administration of 5% DMSO affects the neurological, functional, and histological disease phenotype of the copper/zinc superoxide dismutase glycine 93 to alanine mutation (SOD1-G93A) mouse model of amyotrophic lateral sclerosis. SOD1-G93A transgenic mice showed shortened survival time and reduced motor function. We found that administration with DMSO led to increased mean survival time, reduced neurological scores, and improved motor performance tested using the rotarod and grip strength tests. On the other hand, DMSO treatment did not attenuate motor neuron loss in the spinal cord and denervation of neuromuscular junctions in the skeletal muscle. These results suggest that DMSO administration could improve the quality of life of the SOD1-G93A mouse model of ALS without affecting motor neuron denervation. In conclusion, the use of DMSO as control or vehicle solvent in preclinical research may affect the behavioral outcomes in the SOD1-G93A mouse model. The effect of the vehicle should be thoroughly considered when interpreting therapeutic efficacy of candidate drugs in preclinical research.

• Korean Journal of Forensic Psychology
• /
• v.11 no.2
• /
• pp.173-190
• /
• 2020

The purpose of this study is to verify whether it is possible for participants to discriminate between innocent and guilty suspects when they are exposed to criminal information utilizing an autobiographical implicit association test (aIAT). A total of 49 college students were randomly assigned to guilty group, innocent-aware group, or innocent-unaware group. Participants performed an aIAT to detect suspects after performing either mock crime or control task. It was verified that innocent suspect and guilty suspect exposed with crime information could be distinguished through D-score and reaction time, converted to symbolize strength of the association between guilty sentences, innocent sentences, and truth sentences. As a result of the analysis, guilty group showed significantly higher D-score than both innocent-aware group and innocent-unaware group. guilty group also showed faster response time in true-guilty condition than true-innocent condition. This shows that the association of true-guilty conditions is stronger than that of true-innocent conditions. On the other hand, the innocent-aware group showed a faster response time in the true-innocent condition than the true-guilty condition, and innocent-unaware group showed no significant difference between the two conditions. Through this, it was confirmed that innocent suspects exposed to criminal information can be discriminated according to the aIAT pattern, which has a faster reaction rate to the truth and innocence union than the guilty group. This study confirmed that suspects exposed to criminal information can be effectively discriminated using aIAT, and further suggests the usefulness and potential of aIAT in the field of lie detection.

• Economic and Environmental Geology
• /
• v.55 no.6
• /
• pp.571-582
• /
• 2022

In this study, the raw material and tempers of bricks used in three brick tombs built in Gongju, during the Ungjin period of Baekje were investigated. The royal tomb of King Muryeong, the 6th tomb in the royal tombs, and Kyochonri brick tomb remained in Gongju and the bricks of each site had different shape and physical properties despite their similarity in raw materials. As the results of the mineralogical and microstructural analysis, the bricks of the royal tombs were made of refined raw materials, and were infrequently added crushed bricks(grogs) as a tempering material. On the other hand, thick and elongated pores of bricks from the Kyochonri brick tomb were frequently found, and the remains of plant carbonization are observed in their microstructures. Since the pores are mainly distributed in a thickness of 0.3 to 1 mm, it is estimated that bricks were produced by adding a certain size of the plant to refined soil, and grogs also were added as a tempering material. In particular, it was found that adding plants and grogs in raw materials of bricks caused thick pores or cracks in the internal structure. Since the bricks of the Kyochonri brick tomb have internal cracks and low firing temperature, the ultrasonic velocity of the bricks was lower than that of the royal tomb bricks. It means that the mechanical strength of these bricks were relatively low. Accordingly, it is estimated that the tempering materials, firing temperature, and internal structures of bricks can affect durability of the brick, and it can be thought as a difference in the manufacturing technology of brick making.

• Journal of the Korean Geotechnical Society
• /
• v.24 no.11
• /
• pp.61-70
• /
• 2008

Load settlement behaviors and load transfer characteristics of rock-socketed pile subjected bi-directional load at pile tip were investigated using bi-directional pile load tests (BD PLT) performed on ten large-diameter drilled shafts at four sites. Based on test results, additional pile-toe displacement ($w_{bs}$) by coupled soil resistance was analyzed, and thus equivalent top loaded load-settlement curve of pile subjected bi-directional load was proposed by taking into account the coupled soil resistance. Through comparisons with field case studies, it is found that for test piles there exists effect of coupled soil resistance, which is represented by wbs, and thus an equivalent curve obtained by existing uncoupled methods can overestimate bearing capacity of piles by BD PLT. On the other hand, the analysis by the proposed method with soil coupling effect has a considerably larger settlement when compared with the results by uncoupled load transfer method and estimates reasonable load-settlement behaviors of test piles. In case of pile socketed in high strength rocks, however, effects of coupled soil resistance can be neglected.

• Journal of the Korean Society for information Management
• /
• v.40 no.2
• /
• pp.183-209
• /
• 2023

The purpose of this study is to evaluate the Dublin Core metadata generated by ChatGPT using book covers, title pages, and colophons from a collection of books. To achieve this, we collected book covers, title pages, and colophons from 90 books and inputted them into ChatGPT to generate Dublin Core metadata. The performance was evaluated in terms of completeness and accuracy. The overall results showed a satisfactory level of completeness at 0.87 and accuracy at 0.71. Among the individual elements, Title, Creator, Publisher, Date, Identifier, Rights, and Language exhibited higher performance. Subject and Description elements showed relatively lower performance in terms of completeness and accuracy, but it confirmed the generation capability known as the inherent strength of ChatGPT. On the other hand, books in the sections of social sciences and technology of DDC showed slightly lower accuracy in the Contributor element. This was attributed to ChatGPT's attribution extraction errors, omissions in the original bibliographic description contents for metadata, and the language composition of the training data used by ChatGPT.

• Journal of the Korean Recycled Construction Resources Institute
• /
• v.11 no.4
• /
• pp.400-406
• /
• 2023

In this study, the relationship between the material properties and air permeability characteristics was examined, an experimental method to analyze the air permeability characteristics was presented, and experimental results were derived. The effects of compressive strength and apparent density of hardened concrete on air permeability characteristics were evaluated experimentally. Focusing on the mix proportions used in nuclear power plant concrete structures, concrete test specimens were manufactured and air permeability characteristics were measured according to changes in binder, maximum aggregate size, and water-binder ratio. The apparent density was over 2,400 kg/m³ for the OPC mix and the FA-35 mix, and the air permeability for both mixes were low, in the range of 0.1-0.2 L/min. On the other hand, in the case of the combination of FA-40, FA-45, and FA-M, the apparent density was measured to be less than 2,400 kg/m³ and the air permeability was measured to be more than 0.3 L/min, experimentally verifying that the apparent density is an important factor in air permeability characteristics.

• Steel and Composite Structures
• /
• v.49 no.2
• /
• pp.245-255
• /
• 2023

The present paper summarizes the results of an experimental program on the influence of using waste lathe scraps in the concrete mixture on the shear behavior of RC beams with different amounts of shear reinforcement. Three different volumetric ratios (1, 2 and %3) for the scraps and three different stirrup spacings (160, 200 and 270 mm) were adopted in the tests. The shear span-to-depth ratios of the beams were 2.67 and the stirrup spacing exceeded the maximum spacing limit in the building codes to unfold the contribution of lathe scraps to the shear resistances of shear-deficient beams, subject to shear-dominated failure (shear-tension). The experiments depicted that the lathe scraps have a pronounced contribution to the shear strength and load-deflection behavior of RC beams with widely-spaced stirrups. Namely, with the addition of 1%, 2% and 3% waste lathe scraps, the load-bearing capacity escalated by 9.1%, 21.8% and 32.8%, respectively, compared to the reference beam. On the other hand, the contribution of the lathe scraps to the load capacity decreases with decreasing stirrup spacing, since the closely-spaced stirrups bear the shear stresses and render the contribution of the scraps to shear resistance insignificant. The load capacity, deformation ductility index (DDI) and modulus of toughness (MOT) values of the beams were shown to increase with the volumetric fraction of scraps if the stirrups are spaced at about two times the beam depth. For the specimens with a stirrup spacing of about the beam depth, the scraps were found to have no considerable contribution to the load capacity and the deformation capacity beyond the ultimate load. In other words, for lathe scrap contents of 1-3%, the DDI values increased by 5-23% and the MOT values by 63.5-165% with respect to the reference beam with a stirrup spacing of 270 mm. The influence of the lathe scraps to the DDI and MOT values were rather limited and even sometimes negative for the stirrup spacing values of 160 and 200 mm.

• Tunnel and Underground Space
• /
• v.33 no.6
• /
• pp.519-533
• /
• 2023

In this study, the linear cutting tests of pick cutters were carried out on a granitic rock with the average compressive strength over 100 MPa. From the tests, the correlation between the cutter acting force and the temperature measured by infrared thermal imaging camera during rock cutting was analyzed. In every experimental condition, the maximum temperature was measured at the rock surface where the chipping occurred, and the temperature generated in the rock was closely correlated with the cutter acting force. On the other hand, the temperature of a pick cutter increased up to only 36℃ above the ambient temperature, and the correlation with the cutter force was not obvious. This can be attributed to the short cutting distance under laboratory conditions and the high thermal conductivity of the tungsten carbide inserts. However, the relatively high temperature of the tungsten carbide inserts was found to be maintained. Therefore, it is recommended that a reinforcement between the insert and the head of a pick cutter or the quality improvement of silvering brazing in the production of a cutter is necessary to maintain the high cutting performance of a pick cutter.

• Computers and Concrete
• /
• v.33 no.5
• /
• pp.497-507
• /
• 2024

In squat reinforced concrete walls, the displacement capacity for lateral deformation is low and the ability to resist the axial load can quickly be lost, generating collapse. This work consists of testing two squat reinforced concrete walls. One of the specimens is built with conventional detailing of reinforced concrete walls, while the second specimen is built applying an alternative design, including stirrups along the diagonal of the wall to improve its ductility. This solution differs from the detailing of beams or coupling elements that suggest building elements equivalent to columns located diagonally in the element. The dimensions of both specimens correspond to a wall with a low aspect ratio (1:1), where the height and length of the specimen are 1.4 m, with a thickness of 120 mm. The alternative wall included stirrups placed diagonally covering approximately 25% of the diagonal strut of the wall with alternative detailing. The walls were tested under a constant axial load of 0.1f'cAg and a cyclic lateral displacement was applied in the upper part of the wall. The results indicate that the lateral strength is almost identical between both specimens. On the other hand, the lateral displacement capacity increased by 25% with the alternative detailing, but it was also able to maintain the 3 complete hysteretic cycles up to a drift of 2.5%, reaching longitudinal reinforcement fracture, while the base specimen only reached the first cycle of 2% with rapid degradation due to failure of the diagonal compression strut. The alternative design also allows 46% more energy dissipation than the conventional design. A model was used to capture the global response, correctly representing the observed behavior. A parametric study with the model, varying the reinforcement amount and aspect ratio, was performed, indicating that the effectiveness of the alternative detailing can double de drift capacity for the case with a low aspect ratio (1.1) and a large longitudinal steel amount (1% in the web, 5% in the boundary), which decreases with lower amounts of longitudinal reinforcement and with the increment of aspect ratio, indicating that the alternative detailing approach is reasonable for walls with an aspect ratio up to 2, especially if the amount of longitudinal reinforcement is high.

• Asia pacific journal of information systems
• /
• v.24 no.4
• /
• pp.493-513
• /
• 2014

With the development of related technologies, Location-Based Services (LBS) are growing fast and being used in many ways. Past LBS studies have focused on adoption of LBS because of the fact that LBS users have privacy concerns regarding revealing their location information. Meanwhile, the number of LBS users and revenues from LBS are growing rapidly because users can get some benefits by revealing their location information. Little research has been done on how LBS affects consumers' information search behavior in product purchase. The purpose of this paper is examining the effect of LBS information filtering on buyers' uncertainty and their information search behavior. When consumers purchase a product, they try to reduce uncertainty by searching information. Generally, there are two types of uncertainties - knowledge uncertainty and choice uncertainty. Knowledge uncertainty refers to the lack of information on what kinds of alternatives are available in the market and/or their important attributes. Therefore, consumers having knowledge uncertainty will have difficulties in identifying what alternatives exist in the market to fulfil their needs. Choice uncertainty refers to the lack of information about consumers' own preferences and which alternative will fit in their needs. Therefore, consumers with choice uncertainty have difficulties selecting best product among available alternatives.. According to economics of information theory, consumers narrow the scope of information search when knowledge uncertainty is high. It is because consumers' information search cost is high when their knowledge uncertainty is high. If people do not know available alternatives and their attributes, it takes time and cognitive efforts for them to acquire information about available alternatives. Therefore, they will reduce search breadth. For people with high knowledge uncertainty, the information about products and their attributes is new and of high value for them. Therefore, they will conduct searches more in-depth because they have incentive to acquire more information. When people have high choice uncertainty, people tend to search information about more alternatives. It is because increased search breadth will improve their chances to find better alternative for them. On the other hand, since human's cognitive capacity is limited, the increased search breadth (more alternatives) will reduce the depth of information search for each alternative. Consumers with high choice uncertainty will spend less time and effort for each alternative because considering more alternatives will increase their utility. LBS provides users with the capability to screen alternatives based on the distance from them, which reduces information search costs. Therefore, it is expected that LBS will help users consider more alternatives even when they have high knowledge uncertainty. LBS provides distance information, which helps users choose alternatives appropriate for them. Therefore, users will perceive lower choice uncertainty when they use LBS. In order to test the hypotheses, we selected 80 students and assigned them to one of the two experiment groups. One group was asked to use LBS to search surrounding restaurants and the other group was asked to not use LBS to search nearby restaurants. The experimental tasks and measures items were validated in a pilot experiment. The final measurement items are shown in Appendix A. Each subject was asked to read one of the two scenarios - with or without LBS - and use a smartphone application to pick a restaurant. All behaviors on smartphone were recorded using a recording application. Search breadth was measured by the number of restaurants clicked by each subject. Search depths was measured by two metrics - the average number of sub-level pages each subject visited and the average time spent on each restaurant. The hypotheses were tested using SPSS and PLS. The results show that knowledge uncertainty reduces search breadth (H1a). However, there was no significant correlation between knowledge uncertainty and search depth (H1b). Choice uncertainty significantly reduces search depth (H2b), but no significant relationship was found between choice uncertainty and search breadth (H2a). LBS information filtering significantly reduces the buyers' choice uncertainty (H4) and reduces the negative relationship between knowledge uncertainty and search breadth (H3). This research provides some important implications for service providers. Service providers should use different strategies based on their service properties. For those service providers who are not well-known to consumers (high knowledge uncertainty) should encourage their customers to use LBS. This is because LBS would increase buyers' consideration sets when the knowledge uncertainty is high. Therefore, less known services have chances to be included in consumers' consideration sets with LBS. On the other hand, LBS information filtering decrease choice uncertainty and the near service providers are more likely to be selected than without LBS. Hence, service providers should analyze geographically approximate competitors' strength and try to reduce the gap so that they can have chances to be included in the consideration set.