• 문화기술의 융합
• /
• 제4권3호
• /
• pp.253-259
• /
• 2018

떫은감 자원은 전통적으로 다방면의 여러 조직학적 질병을 치료하고 모발 성장을 비롯한 다양한 생물학적 활성에 매우 높은 효과가 있음이 알려져 왔다. 본 연구는 대머리 패턴의 검은 쥐 모델에 유전적으로 입증된 떫은감 추출물에 대한 발모 및 탈모방지 효능을 알아보고자 하였다. 표준화된 제형을 사용하여 대조군, 떫은감 추출물(10 mg/mouse/day)과 양성대조군인 미녹시딜(2 %)을 매일 두번씩 모발이 성장할 때까지 매일 등 피부에 일정량씩 도포 투여하여 조사하였다. C57BL/ 6 Black 쥐에서 모발 성장 세대를 통해 모발 성장의 변화 패턴이 관찰되었다. 모발 존재 면적과 모발의 길이는 처리 대조군 마우스 보다 떫은감 처리 마우스 처리구에서 유의하게 증가 하였다 (P>0.001). 또한 조직학적 평가에서도 대조군과 비교하여 떫은감 추출물의 처리구에서 모낭세포의 숫자가 현저하게 증가하였다. 따라서 본 실험 결과를 통하여 떫은감 추출물을 피부 도포시 누드 마우스의 모발 성장을 촉진하고 모발의 존재 영역을 확장시키고 모발 길이를 증가시켜 장기 모발 성장기의 지표가 될 수 있음을 알 수 있었다.

• Archives of Plastic Surgery
• /
• 제43권6호
• /
• pp.498-505
• /
• 2016

Background Algae have traditionally been used for promotion of hair growth. Use of hair regrowth drugs, such as minoxidil, is limited due to side effects. The aim of this study was to examine a mixture of Saccharina japonica and Undaria pinnatifida (L-U mixture) on hair growth and to compare the promoting effect of hair growth by a 3% minoxidil and a L-U mixture. Methods To evaluate the hair growth-promoting activity, saline, 50% ethanol, 3% minoxidil, and the L-U mixture were applied 2 times a day for a total of 14 days on the dorsal skin of C57BL/6 mice after depilation. Analysis was determined by using a high-resolution hair analysis system, real-time polymerase chain reaction, and H&E staining. Results On day 14, the hair growth effect of the L-U mixture was the same as that of the 3% minoxidil treatment. The L-U mixture significantly (P<0.05) stimulated hair growth-promoting genes, as vascular endothelial growth factor (VEGF) and insulin-like growth factor -1. Increase of VEGF was observed in the L-U mixture group compared with minoxidil and the negative control. In contrast, the L-U mixture suppressed the expression of transforming growth factor-${\beta}1$, which is the hair loss-related gene. In histological examination in the L-U mixture and minoxidil groups, the induction of an anagen stage of hair follicles was faster than that of control groups. Conclusions This study provides evidence that the L-U mixture can promote hair growth in mice, similar to the effect from minoxidil, and suggests that there is potential application for hair loss treatments.

• 동의생리병리학회지
• /
• 제31권6호
• /
• pp.374-379
• /
• 2017

Hair loss affects interpersonal relationships and causes psychological stress. In this study, we investigated the antioxidant activity of Cynanchi Wilfordii Radix (CWR) and its effects on dermal papilla (DP) cells. Antioxidant efficacy was examined by ABTS assay. To confirm the effect on cell activity, MTS assay was performed and cell count was directly measured by hemocytometer. The mRNA expression of genes involved in hair formation and hair loss formation was confirmed by quantitative RT-PCR. CWR has a strong antioxidant activity. Cell viability of DP cells was increased to 118.5% by treatment of 0.5 mg/ml CWR for 24 hours, but the effect on the cell number was insignificant. These results suggest that CWR increases mitochondrial activity without promoting cell proliferation. Treatment of DP cells with 0.5 mg/ml CWR resulted in 48.5% reduction of mRNA expression of type 2 $5{\alpha}$-reductase, a major cause of male hair loss. In addition, mRNA expression of bone morphogenetic pretein (BMP), fibroblast growth factor (FGF)7, and FGF10, which are closely related to hair growth, was also decreased. Reactive oxygen species (ROS) acts as a cause of hair loss. The excellent antioxidant efficacy of CWR is thought to be able to effectively remove ROS. The dihydrotestosterone produced by type 2 $5{\alpha}$-reductase in DP cells is a potent inducer of male pattern hair loss. The inhibitory effect of type 2 $5{\alpha}$-reductase mRNA on DP cells induced by CWR may induce a positive therapeutic effect of male pattern hair loss.

• 한국패션뷰티학회지
• /
• 제4권3호
• /
• pp.18-24
• /
• 2006

Hair is the part of body which expresses man into more manlike. When we create some artworks, we need the most suitable material for the artworks. Similarity, the healthy scalp hair condition and treatment are required to keep our hair clean and healthy. And the improper condition of scalp hair prohibits our hair from normal growing, proceeds the alopecia(loss of hair) and double our physical and mental stresses. The necessity of health treatment of scalp hair which was damaged by frequent permanent hair wave and hair coloring is on the rise. This study will present how to control and treat the scalp hair and will check how we feel about the necessity of scalp hair treatment. This study finally shows that people think their scalp hair conditions are not normal and chemically treated hair in spite of their natural hair. However, most people think that the scalp hair treatment is very useful to their hair and this result enables us to predict the future market of the scalp hair treatment business will be growing day by day. We need to study further not only scalp hair treatment but also prevention stage in order to keep the healthy hair and will check how we feel about the necessity of scalp hair treatment.

• 지능정보연구
• /
• 제28권1호
• /
• pp.217-242
• /
• 2022

AI 기술이 결합된 지능형 제품은 기술적 차별화를 실현하며 시장 경쟁력을 높일 수 있는 잠재성을 지닌다. 하지만 시장 수용도를 극대화 할 수 있는 AI 기반의 신제품 개발 방법론은 부재하다. 본 연구는 AI 기반의 지능형 제품 개발에 대한 방법론으로서 KANO-QFD 통합 모델을 제안한다. 실증적인 분석을 위한 구체적 사례로 탈모 예측 및 치료 기기에 대한 소비자 요구조건(Customer Requirements)의 유형을 분류하고, 이를 구현하기 위한 기술적 요구사항(Engineering Characteristics)의 상대적 중요도 및 우선순위를 도출하여 지능형 메디컬 신제품 개발의 방향을 제시하였다. 소비자 130명을 대상으로 실시한 설문조사 분석 결과, KANO 카테고리 중 매력적 품질(Attractive Quality) 요소로 미래 탈모 진행 상황에 대한 정확한 예측, 미래 탈모 모습 및 치료 후 개선된 미래 모습을 실물화하여 스마트폰으로 보고, 세련된 디자인, 레이저와 LED 빛 복합 에너지를 이용한 치료 등이 도출되었다. QFD의 품질의 집(House of Quality)을 기반으로 분석한 결과, 탈모 진단 및 예측을 위한 학습 데이터, 두피 스캔용 Micro 카메라 해상도, 탈모 유형 분류 모델, 맞춤화를 위한 개인별 계정 관리, 탈모 진행상황 진단 모델 순으로 상대적 중요도 및 우선순위가 도출되었다. 본 연구는 기존에 선행되지 않았던 AI 기반의 지능형 메디컬 제품 개발에 대한 방향을 제시하였다는 면에서 의의를 지닌다.

• 생약학회지
• /
• 제48권3호
• /
• pp.195-201
• /
• 2017

To develop new therapy for prevention and treatment of hair loss is very important according to increase of the number of hair loss people. The aim of this study was to investigate the hair growth promoting effects of pectin lyase-modified red ginseng extract (GS-E3D). We examined antioxidant and anti-inflammatory effects, human hair dermal papilla cells (HHDPC) proliferation, and testoterone-induced $5{\alpha}$-reductase inhibitory effects. GS-E3D show not only 1,1-diphenyl-2-picryhydrazyl (DPPH) radical scavenging activity and xanthine oxidase inhibitory effects as an anti-oxidant property, but also lip-oxygenase and hyaluronidase inhibitory effects as an anti-inflammatory property. Human hair dermal papilla cells proliferation by GS-E3D was higher than those of minoxidil or finasteride, using the positive controls. Moreover, GS-E3D exhibited $5{\alpha}$-reductase inhibitory activities after stimulating by testoterone. The present results indicate that GS-E3D has a potential to be as an hair growth promoting agent for cosmetic materials.

• Preventive Nutrition and Food Science
• /
• 제5권1호
• /
• pp.42-47
• /
• 2000

For the development of functional food for hair-growth stimulation, this study has tried an in vivo and clinical test. As an in vivo test male Sprague Dawley rats and as a clinical test 27 baldheaded or loosehaired men were recruited. Before the experiment, the total hair count in 6 $\textrm{mm}^2$ of the designated area was 46.5. In four weeks and eight weeks of the functional food feeding it increased to 61.8 and 75.3, respectively. Hence the net increase was totaled at 62% in eight weeks. Also, depilation was decreased by 28%. Before the experiment, average hair loss was 65.7. In four weeks and eight weeks of the functional food feeding it decreased to 55.2 and 47.3, respectively. LDL and phospholipids were decreased by 42% and 36%, respectively during that period. However, HDL was increased by 21%. Forty percent of the subjects responded that itching of head skin was reduced and 34% responded to have reduced dandruff. No side-effects among the subjects were examined and no other blood pa-rameters were significantly affected by the diet. The results in this study suggest that biotin-rich functional food may stimulate cholesterol and lipid metabolism and blood flow leading to the growth of new hair and prevention of hair loss.

• Archives of Plastic Surgery
• /
• 제46권2호
• /
• pp.147-151
• /
• 2019

Background Successful aesthetic plastic surgery is devoid of both unsightly scarring and postoperative disfigurement. Patients undergoing midface-lifting surgery are very often disconcerted by an altered side hairline, including sideburns, despite considerable amelioration of facial wrinkles. This study was conducted to identify an effective means of approaching an altered hairline and the unavoidable scarring arising from midface-lifting surgery. Methods A total of 37 patients who underwent corrective surgery with hair transplantation for hair loss or scar deformity arising from midface-lifting surgery from June 2014 to June 2017, and were observed for more than 6 months thereafter, were enrolled in the study. Prior to corrective surgery, the patients were administered a multiple-choice survey regarding their dissatisfaction arising from midface-lifting surgery. Among the 37 patients, 24, 12, and one underwent donor harvesting by the strip method, non-shaven follicular unit extraction, and partial shaving follicular unit extraction, respectively. Additionally, 33 of the 37 patients underwent hair transplantation in the frontotemporal recess area along with hairline correction surgery. The average number of transplanted grafts was 1,025. Results Surgery resulted in a natural and satisfactory appearance in all patients. The average patient and physician subjective satisfaction scores were 4.6 and 4.8, respectively. No adverse events such as folliculitis occurred. Conclusions Side-hairline correction surgery by hair transplantation can be considered an effective method of realigning an altered hairline accompanied by scars following midface-lifting surgery.

• 동의생리병리학회지
• /
• 제31권6호
• /
• pp.356-361
• /
• 2017

Houttuyniae Herba is widely used as a cosmetic for enhancing hair growth, and study on promoting mouse hair growth has also been reported. However, studies on the effects of the Houttuyniae Herba on dermal papilla (DP) cells, which play an important role in hair growth, are not well known. For this reason, we studied the effect of Houttuyniae Herba on DP cells. The strong antioxidant activity of Houttuyniae Herba was confirmed by ABTS assay. In the MTS assay, cell viability was reduced to 94.5% in DP cells by treatment of 2 mg/ml concentration of Houttuyniae Herb and cytotoxicity was not observed at 1 mg/ml concentration. The mRNA expression levels of Bone morphogenetic pretein (BMP6), fibroblast growth factor 7 (FGF7), FGF10, and ${\beta}$-galactosidase genes, which are involved in hair growth cycle and hair loss induction, were measured by quantitative RT-PCR after Houttuyniae Herbtreatment. Houttuyniae Herb did not significantly affect mRNA expression of BMP6, FGF7, FGF10, and ${\beta}$-catenin, which are important factors for regulating the hair cycle, including type 1 $5{\alpha}$-reductase. However, mRNA expression of type 2 $5{\alpha}$-reductase, the major cause of male hair loss, was significantly reduced to 56.1% by treatment of Houttuyniae Herbtreatment. Taken together, these results suggest that the Houttuyniae Herbtreatment can help to treat lair loss through removing free radicals and suppression of the expression level of type 2 $5{\alpha}$-reductase in DP cells.

• 분석과학
• /
• 제32권2호
• /
• pp.56-64
• /
• 2019

Recently, a number of adulterated products, which are advertised as hair-growth enhancer have been emerged among those who suffer hair loss disease. For continuous control of illegal products, in this study, a rapid and sensitive method for simultaneous screening of 12 compounds that enhance hair-growth was established to protect public health by ultrahigh-performance liquid chromatography coupled to quadrupole-orbitrap mass spectrometry (UHPLC-Q-Orbitrap-MS). Fragmentation pathways of them were proposed based on $MS^2$ spectral data obtained using the established method. In this analysis, the LODs and LOQs ranged from 0.05 to 50 ng/mL and from 0.17 to 167 ng/mL, respectively. The square of the linear correlation coefficient ($R^2$) was determined as more than 0.995. The intra- and inter-assay accuracies were respective 88-112 % and 88-115 %. Their precision values were measured within 5 % (intra-day) and 10 % (inter-day). Mean recoveries of target compounds in adulterated products ranged from 84 to 115%. The relative standard deviation of stability was less than 12 % at $4^{\circ}C$ for 48 h. The method was employed to screen 14 dietary supplements advertised to be effective for the treatment of hair loss. Some of the products (~21 %) were proven to contain synthetic drugs that promote hair growth such as triaminodil, minoxidil, and finasteride.