• Asian Pacific Journal of Cancer Prevention
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• 제13권4호
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• pp.1145-1149
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• 2012

Aim: To clarify any association between the hOGG1 Ser326Cys polymorphism and susceptibility to gastric cancer. Methods: A meta-analysis based on 11 eligible case-control studies involving 5,107 subjects was carried out to summarize the data on the association between hOGG1 Ser326Cys polymorphism and gastric cancer risk. Results: No association was found between hOGG1 Ser326Cys polymorphism and gastric cancer risk (dominant model: OR = 0.95, 95% CI: 0.83-1.09, p = 0.486, ph (p values for heterogeneity) = 0.419; additive model: OR = 1.02, 95% CI: 0.81-1.30, p = 0.850, ph = 0.181; recessive model: OR = 1.09, 95% CI: 0.80-1.48, p = 0.586, ph = 0.053). Subgroup analysis based on ethnicity (Asian and Caucasian) and smoking status (ever smoker and never smoker) did did notpresent any significant association. Sensitivity analysis did not perturb the results. Conclusions: This study strongly suggested there might be no association between the hOGG1 Ser326Cys polymorphism and gastric cancer risk. However, larger scale studies are needed for confirmation.

• Tuberculosis and Respiratory Diseases
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• 제52권1호
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• pp.5-13
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• 2002

연구배경 : 폐암의 80-90 %는 흡연과 관계가 있으나 흡연자의 일부에서만 폐암이 발생하는 현상은 개체의 유전적 소인이 폐암발생을 결정하는 주요 요인임을 시사한다. 저자들은 한국인에서 DNA 회복 유전자인 hOGG1 유전자의 codon 326 다형성과 폐암의 위험도를 조사 하였다. 방 법 : 1998년 1월부터 1998년 12월까지 경북대학교병원 내과에서 병리학적으로 폐암으로 확진된 환자를 대상으로 하였으며 악성종양으로 진단받은 과거력이 있는 사람은 제외하였다. 대조군은 1998년 1월부터 1999년 12월까지 경북대학교병원 건강검진센터를 방문한 40세 이상의 검진자들을 대상으로 하였으며 호흡기질환이나 악성종양이 있는 경우는 제외하였다. 대상인의 나이, 성, 홉연력, 과거력 등은 면접이나 병력지를 통해 얻었으며, 시료는 전혈 5cc에서 DNA를 추출하고 PCR 과 RFLP 법을 통해 hOGG1 유전자 다형성을 조사하였다. 결 과 : hOGG1 Ser326Cys 유전자형은 폐암군의 경우 Ser/Ser, Ser/Cys, Cys/Cys 형이 각각 23.4%, 51.8%, 24.8%였고 대조군은 각각 22.6%, 52.1%, 25.3% 로 두 군 사이에 유의한 차이가 없었으며, Ser/Ser 형에 비해 Ser/Cys 형과 Cys/Cys 형의 OR는 1.00 (95 % CI, 0.63-1.60)와 0.94(95% CI, 0.56-1.61)으로 통계적으로 유의한 의미가 없었다. Ser/Ser형 + Ser/Cys 형에 대한 Cys/Cys 형의 폐암의 위험도는 연령, 성별, 흡연력 등으로 구분한 경우에도 유의한 차이가 없었다. 폐암의 조직형을 구분하여 비교한 경우에도 hOGG1 유전자형과 폐암의 위험도는 유의한 관계가 없었다. 결 론 : 한국인에서 hOGG1 codon 326 유전자형은 폐암의 위험도를 결정하는 주요 인자는 아닌 것으로 생각된다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.1803-1808
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• 2012

This study aimed to investigate the effects of Ser/Cys polymorphism in hOGG1 gene, Arg/Pro polymorphism in p53 gene, smoking and their interactions on the development of lung cancer. Ser/Cys polymorphism in hOGG1 and Arg/Pro polymorphism in p53 among 124 patients with lung cancer and 128 normal people were detected using PCR-RFLP. At the same time, smoking status was investigated between the two groups. Logistic regression was used to estimate the effects of Ser/Cys polymorphism and Arg/Pro polymorphisms, smoking and their interactions on the development of lung cancer. ORs (95% CI) of smoking, hOGG1 Cys/Cys and p53 Pro/Pro genotypes were 2.34 (1.41-3.88), 2.12 (1.03-4.39), and 2.12 (1.15-3.94), respectively. The interaction model of smoking and Cys/Cys was super-multiplicative or multiplicative, and the OR (95% CI) for their interaction item was 1.67 (0.36 -7.78). The interaction model of smoking and Pro/Pro was super-multiplicative with an OR (95%CI) of their interaction item of 5.03 (1.26-20.1). The interaction model of Pro/Pro and Cys/Cys was multiplicative and the OR (95%CI) of their interaction item was 0.99 (0.19-5.28). Smoking, hOGG1 Cys/Cys, p53 Pro/Pro and their interactions may be the important factors leading to the development of lung cancer.

• Journal of Preventive Medicine and Public Health
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• 제39권2호
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• pp.130-134
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• 2006

Objectives : Oxidative DNA damage is a known risk factor of lung cancer. The glutathione peroxidase (GPX) antioxidant enzyme that reduces hydrogen peroxide and lipid peroxides plays a significant role in protecting cells from the oxidative stress induced by reactive oxygen species. The aim of this case-control study was to investigate effects of oxidative stress and genetic polymorphisms of the GPX1 genes and the interaction between them in the carcinogenesis of lung cancer. Methods : Two hundreds patients with lung cancer and 200 age- and sex-matched controls were enrolled in this study. Every subject was asked to complete a questionnaire concerning their smoking habits and their environmental exposure to PAHs. The genotypes of the GPX1 and 8-oxoguanine glycosylase 1 (hOGG1) genes were examined and the concentrations of urinary hydroxypyrene (1-OHP), 2-naphthol and 8-hydroxydeoxyguanosine (8-OH-dG) were measured. Results : Cigarette smoking was a significant risk factor for lung cancer. The levels of urinary 8-OH-dG were higher in the patients (p<0.001), whereas the urinary 1-OHP and 2-naphthol levels were higher in the controls. The GPX1 codon 198 polymorphism was associated with an increased risk of lung cancer. Individuals carrying the Pro/Leu or Leu/Leu genotype of GPX1 were at a higher risk for lung cancer (adjusted OR=2.29). In addition, these individuals were shown to have high urinary 8-OH-dG concentrations compared to the individuals with the GPX1 Pro/Pro genotype. On the other hand, the polymorphism of the hOGG1 gene did not affect the lung cancer risk and the oxidative DNA damage. Conclusions : These results lead to a conclusion that individuals with the GPX1 Pro/Leu or Leu/Leu genotype would be more susceptible to the lung cancer induced by oxidative stress than those individuals with the Pro/Pro genotype.

• 대한예방의학회:학술대회논문집
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• 대한예방의학회 2005년도 제57차 추계 학술대회 연제집
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• pp.491-491
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• 2005

• The Korean Journal of Physiology
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• 제4권1호
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• pp.55-57
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• 1970

Erythropoietic activity in anemic Plasma of chronic posthemorrhagic anemic men was studied in rats after subcutaneous injection of anemic plasma. Anemic plasma was obtained from blood donors who sold their blood once or twice a week for one or two years to blood bank. Hemoglobin concentrations of 8 blood donors ranged between 4.6 and 8.4 gm/100 ml. Pooled plasma was treated by acidification-boiling method and adjusted to pH 7.5 by adding 0.1 N NaOH. 7ml/kg and 15ml/kg of anemic plasma filtrate was injected to 2 groups of rats respectively for 7 and 8 days. Hemoglobin concentrations, red blood cell counts and reticulocyte counts were observed before and after injection of anemic plasma and no change was induced by the injection. Subsequently, it was concluded that there was no erythropoietin of high titer in the plasma of chronic post-hemorrhagic anemic men.

• 한국정보통신설비학회:학술대회논문집
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• 한국정보통신설비학회 2005년도 하계학술대회
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• pp.329-332
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• 2005

In this paper, we describe implementation of personal media gateway (PMG) for applications over BcN networks. PMG is a TV based set-top terminal, which enables transmission of Full D1 high quality video and audio at the speed of maximum 2Mbps. It supports SIP protocol and QoS for the BcN networks. The hardware of the PMG consists of host module, audio/video codec processing module, DTMF module, and remote control I/O module. H.263 and MPEG4 software are implemented in DSP as codec for hi-directional communication and streaming, respectively. G.711 and Ogg-Vorbis are implemented as audio codec. We examined the quality of video using the Video Quality Test Equpment, which was developed by KT Convergence Lab. The experimental results show the video quality of MOS 4.1 and audio quality of MOS 4.3. We expect that PMG will be prospective business models, and create new customer value.

• Journal of Oral Medicine and Pain
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• 제30권3호
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• pp.287-300
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• 2005

두경부에서 발생하는 편평세포암종은 같은 조직학적 분류, 조직학적 단계 및 임상 단계에 있다하더라도 항암제 투여에 따른 감수성은 환자마다 다양하게 나타난다. 따라서, 본 연구의 목적은 기존에 가장 많이 사용하는 항암제인 5-FU 와 Cisplatin의 감수성을 예측할 수 있는 생물학적 표지자를 찾아 환자에게 맞는 항암제를 선택하기 위해서이다. 5종의 구강 편평암세포암주를 이용하였으며, 5-FU 와 Cisplatin의 항암제 감수성을 측정하기 위해 MTT assay를 시행하였다. 각 세포 주의 전 RNA를 추출하였으며 이어서 cDNA를 합성하였다. 다양한 유전자를 1) 돌연변이 2) 염증(COX pathway) 3) 세포주기 4) 노화 5) 세포외기질 과 관련되게 분류하였고 RT-PCR을 시행하여 유전자의 발현량을 살펴보았다. 결과물은 Scion image 프로그램을 통해 분석하였고, Sigma plot을 이용해 표시하였다. 5-FU의 감수성과 비례하는 유전자들은 XPA, XPC, OGG, APEX, COX-2, PPAR, Cyclin E, Cyclin B1, CDC2, hTERT, hTR, TIMP-3, TIMP-4 및 HSP47이었으며, Cisplatin의 감수성과 비례하는 유전자들은 COX-1, iNOS, eNOS, PCNA, Col-1 및 MMP-9 으로 알 수 있었다. 위 결과는 암환자에게 알맞은 항암제를 선택 시 항암제의 감수성과 관련한 유전자들의 발현 정도를 파악한다면 올바른 항암제를 선택하는데 도움이 되리라 사료된다.