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http://dx.doi.org/10.7314/APJCP.2012.13.5.1803

hOGG1, p53 Genes, and Smoking Interactions are Associated with the Development of Lung Cancer  

Cheng, Zhe (Department of Respiratory Medicine, the First Affiliated Hospital of Zhengzhou University, Institute of Clinical Medical Research of Henan Universities)
Wang, Wei (Department of Respiratory Medicine, the First Affiliated Hospital of Zhengzhou University, Institute of Clinical Medical Research of Henan Universities)
Song, Yong-Na (Department of Respiratory Medicine, the First Affiliated Hospital of Zhengzhou University, Institute of Clinical Medical Research of Henan Universities)
Kang, Yan (Department of Respiratory Medicine, the First Affiliated Hospital of Zhengzhou University, Institute of Clinical Medical Research of Henan Universities)
Xia, Jie (Department of Respiratory Medicine, the First Affiliated Hospital of Zhengzhou University, Institute of Clinical Medical Research of Henan Universities)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.5, 2012 , pp. 1803-1808 More about this Journal
Abstract
This study aimed to investigate the effects of Ser/Cys polymorphism in hOGG1 gene, Arg/Pro polymorphism in p53 gene, smoking and their interactions on the development of lung cancer. Ser/Cys polymorphism in hOGG1 and Arg/Pro polymorphism in p53 among 124 patients with lung cancer and 128 normal people were detected using PCR-RFLP. At the same time, smoking status was investigated between the two groups. Logistic regression was used to estimate the effects of Ser/Cys polymorphism and Arg/Pro polymorphisms, smoking and their interactions on the development of lung cancer. ORs (95% CI) of smoking, hOGG1 Cys/Cys and p53 Pro/Pro genotypes were 2.34 (1.41-3.88), 2.12 (1.03-4.39), and 2.12 (1.15-3.94), respectively. The interaction model of smoking and Cys/Cys was super-multiplicative or multiplicative, and the OR (95% CI) for their interaction item was 1.67 (0.36 -7.78). The interaction model of smoking and Pro/Pro was super-multiplicative with an OR (95%CI) of their interaction item of 5.03 (1.26-20.1). The interaction model of Pro/Pro and Cys/Cys was multiplicative and the OR (95%CI) of their interaction item was 0.99 (0.19-5.28). Smoking, hOGG1 Cys/Cys, p53 Pro/Pro and their interactions may be the important factors leading to the development of lung cancer.
Keywords
hOGG1 gene; lung cancer; smoking; gene polymorphism; genetic susceptibility;
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1 Papadakis ED, Soulitzis N, Spandidos DA (2002). Association of p53 codon 72 polymorphism with advanced lung cancer: the Arg allele is preferentially retained in tumours arising in Arg/Pro germline heterozygotes. Br J Cancer, 87, 1013-8.   DOI   ScienceOn
2 Park J, Chen L, Tockman MS, Elahi A, Lazarus P (2004). The human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) DNA repair enzyme and its association with lung cancer risk. Pharmacogenetics, 14, 103-9.   DOI
3 Paz-Elizur T, Krupsky M, Blumenstein S, et al (2003). DNA repair activity for oxidative damage and risk of lung cancer. J Natl Cancer Inst, 95, 1312-9.   DOI
4 Sunaga N, Kohno T, Yanagitani N, et al (2002). Contribution of the NQO1 and GSTT1 polymorphisms to lung adenocarcinoma susceptibility. Cancer Epidemiol Biomarkers Prev, 11, 730-8.
5 Vogel U, Nexø BA, Wallin H, et al (2004). No association between base excision repair gene polymorphisms and risk of lung cancer. Biochem Genet, 42, 453-60.   DOI
6 Zhang JH, Li Y, Wang R, et al (2003). p53 gene polymorphism with susceptibility to esophageal cancer and lung cancer in Chinese population. Zhonghua Zhong Liu Za Zhi, 25, 365-7.
7 Canas M, Morán Y, Camargo ME, et al (2009). [TP53 codon 72 polymorphism and gastric cancer risk: a case-control study in individuals from the central-western region of Venezuela]. Invest Clin, 50, 153-61 [Article in Spanish].
8 Chang CH, Hsiao CF, Chang GC, et al (2009). Interactive effect of cigarette smoking with human 8-oxoguanine DNA N-glycosylase 1(hOGG1) polymorphisms on the risk of lung cancer: a case-control study in Taiwan. Am J Epidemiol, 170, 695-702.   DOI
9 El-Zein RA, Monroy CM, Cortes A, et al (2010). Rapid method for determination of DNA repair capacity in human peripheral blood lymphocytes amongst smokers. BMC Cancer, 10, 439.   DOI
10 Guan P, Huang D, Yin Z, Zhou B (2011). Association of the hOGG1 Ser326Cys polymorphism with increased lung cancer susceptibility in Asians: a meta-analysis of 18 studies including 7592 cases and 8129 controls. Asian Pac J Cancer Prev, 12, 1067-72.
11 Ito H, Hamajima N, Takezaki T, et al (2002). A limited association of OGG1 Ser326Cys polymorphism for adenocarcinoma of the lung. J Epidemiol, 12, 258-65.   DOI
12 Kim SR, Matsui K, Yamada M, et al (2004). Suppression of chemically induced and spontaneously occurring oxidative mutagenesis by three alleles of human OGG1 gene encoding 8-hydroxyguanine DNA glycosylase. Mutat Res, 554, 365-74.   DOI
13 Kiyohara C, Horiuchi T, Miyake Y, Takayama K, Nakanishi Y (2010). Cigarette smoking, TP53 Arg72Pro, TP53BP1 Asp353Glu and the risk of lung cancer in a Japanese population. Oncol Rep, 23, 1361-8.
14 Klinchid J, Chewaskulyoung B, Saeteng S, et al (2009). Effect of combined genetic polymorphisms on lung cancer risk in northern Thai women. Cancer Genet Cytogenet, 195, 143-9.   DOI
15 Le Marchand L, Donlon T, Lum-Jones A, Seifried A, Wilkens LR (2002). Association of the hOGG1 Ser326Cys polymorphism with lung cancer risk. Cancer Epidemiol Biomarkers Prev, 11, 409-12.
16 Liu CJ, Hsia TC, Tsai RY, et al (2010). The joint effect of hOGG1 single nucleotide polymorphism and smoking habit on lung cancer in Taiwan. Anticancer Res, 30, 4141-5.
17 Miller DP, Liu G, De Vivo I, et al (2002). Combinations of the variant genotypes of GSTP1, GSTM1, and p53 are associated with an increased lung cancer risk. Cancer Res, 62, 2819-23.
18 Okasaka T, Matsuo K, Suzuki T, et al (2009). hOGG1 Ser326Cys polymorphism and risk of lung cancer by histological type. J Hum Genet, 54, 739-45.   DOI