• Asian-Australasian Journal of Animal Sciences
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• 제21권4호
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• pp.478-483
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• 2008

Records of a Northeastern Thai indigenous cattle line population were used to estimate genetic parameters and annual trends for calf weights. The data set comprised records of 1,922 and 1,489 animals for birth and weaning weight, respectively born from 1993 to 2004. A bivariate analysis was carried out for variance and covariance components estimations using average information restricted maximum likelihood procedure. Average estimated breeding value and maternal breeding value of the animals born in 1993 were set to zero as a base group. Genetic trends of each trait were calculated by regressing average estimated breeding values and maternal breeding values on birth year of calves. Phenotypic trends for each trait were calculated by regressing the yearly adjusted weight on birth year of calves. The results revealed that the estimate of direct heritability, maternal heritability and maternal permanent environmental variance as a proportion of phenotypic variance for birth and weaning weight was 0.40, 0.14 and 0.04; 0.27, 0.05 and 0.23, respectively. Direct heritability was moderately heritable and genetic improvement through selection can be achieved. The estimate of phenotypic, direct genetic, maternal genetic and maternal permanent environmental correlation between birth and weaning weight was 0.48, 0.65, 0.98 and 0.73, respectively. The phenotypic trend, genetic trends of estimated breeding value and maternal breeding value for birth weight was 0.18, 0.04 and 0.01 kg/year, respectively. The phenotypic trend, genetic trends of estimated breeding value and maternal breeding value for weaning weight was -1.36, 0.32 and 0.03 kg/year, respectively. As maternal genetic effect was considerably less important than direct genetic effect, selection for improved weaning weight of this Northeastern Thai indigenous cattle line can place more emphasis on the direct genetic effect.

• Journal of Ecology and Environment
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• 제42권3호
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• pp.111-119
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• 2018

Background: Juniperus chinensis L. populations are distributed locally on several areas including coastal cliffs which are difficult to access in the central eastern Korea. Wild populations inhabit relatively barren environments such as rocky areas and cliffs, which are very sensitive to even minor environmental disturbances including artificial interventions and natural disturbances, and thus demonstrate great fluctuations in the population size and density. This study aims to analyze the genetic diversity, differentiation, and genetic structure of each population in order to provide useful data required to establish a substantial conservation strategy of J. chinensis. Results: The genetic diversity of J. chinensis at the population level (P = 78.7%, h = 0.282, S.I. = 0.420) was somewhat higher compared with those measured in the same genus, Juniperus. The genetic differentiation degree among nine populations established naturally in central eastern Korea was 11.50% and that among sub-populations within the same area was 5.52%. On the other hand, genetic variation of individuals within the populations was 82.93%. But frequency of the main allele was different among loci. In particular, fixation of allele frequency and occurrence of rare allele in the highly isolated population suggest a likelihood that genetic drift would occur in populations of this plant. As the result of analysis on the genetic structure of nine populations, nearby populations and isolated populations tended to form separate clusters from each other as the hypothetical number of clusters (K) increase. Conclusions: This result implies that if the population size of J. chinensis is reduced due to environmental change and artificial and/or natural disturbances in the future, it could affect negatively on the genetic diversity of the plant species. In order to maintain and conserve genetic diversity of J. chinensis, ecological network, which can help genetic exchange among the local populations, should be prepared, and conservation strategies in situ as well as ex situ are also required with continuous monitoring.

• Molecules and Cells
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• 제23권1호
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• pp.39-48
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• 2007

Charcot-Marie-Tooth (CMT) disease and hereditary neuropathy with liability to pressure palsies (HNPP) are frequent forms of genetically heterogeneous peripheral neuropathies. Reciprocal unequal crossover between flanking CMT1A-REPs on chromosome 17p11.2-p12 is a major cause of CMT type 1A (CMT1A) and HNPP. The importance of a sensitive and rapid method for identifying the CMT1A duplication and HNPP deletion is being emphasized. In the present study, we established a molecular diagnostic method for the CMT1A duplication and HNPP deletion based on hexaplex PCR of 6 microsatellite markers (D17S921, D17S9B, D17S9A, D17S918, D17S4A and D17S2230). The method is highly time-, cost- and sample-saving because the six markers are amplified by a single PCR reaction and resolved with a single capillary in 3 h. Several statistical and forensic estimates indicated that most of these markers are likely to be useful for diagnosing the peripheral neuropathies. Reproducibility, as determined by concordance between independent tests, was estimated to be 100%. The likelihood that genotypes of all six markers are homozygous in randomly selected individuals was calculated to be $1.6{\times}10^{-4}$, which indicates that the statistical error rate for this diagnosis of HNPP deletion is only 0.016%.

• 한국토양비료학회지
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• 제45권6호
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• pp.867-876
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• 2012

The concentration of veterinary antibiotics in aqueous and sediment matrices was measured in agricultural irrigation ditches bordering several animal-feeding operations (AFOs) and then compared to its concentration in the watershed. Analytical determination in aqueous samples was based on solid phase extraction (SPE) and appropriate buffer solutions were used to extract residuals in sediment samples. Separation and detection of extracted veterinary antibiotics were performed with high performance liquid chromatograph tandem mass spectrometry (HPLC/MS/MS). In general, higher concentrations of antibiotic were observed in the aqueous phase of irrigation ditches, with the highest concentration of erythromycin hydrochloride (ETM-$H_2O$) of $0.53{\mu}g\;L^{-1}$, than in aqueous watershed samples. In contrast, higher concentrations were measured in river sediment than in irrigation ditch sediment with the highest concentration of oxytetracycline of $110.9{\mu}g\;kg^{-1}$. There was a high calculated correlation ( > 0.95) between precipitation and measured concentration in aqueous samples from the irrigation ditches for five of the ten targeted veterinary antibiotics, indicating that surface runoff could be an important transport mechanism of veterinary antibiotics from field to environment. Further, environmental loading calculation based on measured concentrations in aqueous samples and flow information clearly showed that irrigation ditches were 18 times greater than river. This result suggests the likelihood that veterinary antibiotics can be transported via irrigation ditches to the watershed. The transport via surface runoff and likely environmental loading via irrigation ditches examined in this study helps identify the pathway of veterinary antibiotics residuals in the environment.

• 응용통계연구
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• 제21권5호
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• pp.813-823
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• 2008

비동질적 포아송과정(NHPP) 모형은 신뢰성 공학에서 소프트웨어 내에 남아있는 결함발견현상을 설명하는데 자주 사용된다. 이때 결함발견율은 연속적이며 단조함수를 가정하였으나 현실적으로 소프트웨어 시험환경, 전략 및 자원할당 등으로 인해 결함발견율이 변하는 경우가 있다. 본 논문은 결함발견율이 변화하는 변화점 문제를 고려한 소프트웨어 신뢰도 성장모형(SRGM)을 고려하여 모수를 추정하는데 목적이 있다. 이를 위해 자료를 모의 생성한 후 평균값 함수의 각 모수를 최우추정법과 최소제곱법을 이용하여 추정하며, 결함발견구간이 일정하게 증가하는 경우와 일정하게 증가하지 않는 경우를 각각 고려한다. 이때 각 모수의 적합도 비교 평가를 통하여 변화점을 고려한 SRGM에서의 최적 추정법을 수치적 방법으로 판단한다.

• 한국전자파학회논문지
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• 제7권1호
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• pp.61-70
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• 1996

M-ary DPSK는 대역 효율이 우수한 디지탈 변조 기법이고, 최큰에는 이용 가능한 무선 대역폭이 제한된 이동 위성통신 시스댐 분야의 응용에서 관심이 모아지고 있다. 동기 검파 방식은 잡음 환경에서 우수한 오류 성능을 제공하지만 페이딩 환경에서는 낀 포착 시간을 필요로 한다.본 논문에서는 라이시안 페이딩과 쉐도우 라이시안 페이딩 채널에서 다중 차동 궤환 검파 기법을 사용한 M-ary DPSK 신호의 오류 성능을 분석하였다. 다중 차동 궤환 검파 기법은 일반적인 차동 수신기의 복잡도를 증가시켜서 차동 수신과 동기 수선 사이의 성능 차이를 줄일 수 있는 효율적인 기법이다. 다중 심볼 최대 우도 검파 기법과 비교할 때 다중 차동 궤환 검파 기법은 H/W 구현상에서 매우 간단한 구조를 갖는다. 특히 이 기법은 잡음과 빠른 페이딩 채널 사이에서 시간과 공간에서 변할 수 있는 육상 이동위성 채널에 적용할 수 있다.

• 농촌계획
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• 제26권1호
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• pp.137-147
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• 2020

Rural Development Administration (RDA) has developed a manufacturing technology which can increase the amount of platycodin D in Platycodon grandiflorum. A study is needed to estimate the value of this new technology and predict the market demand for a new product. This study estimates additional amount of willingness to pay (WTP) using contingent valuation method (CVM) for a new product with the technology that RDA has developed. The survey was created under virtual health functional foods market of Platycodon grandiflorums. It was conducted with 1,000 adult males and females aged between 19 and 59 years old in 17 major cities and provinces nationwide from December 4 to December 7, 2018. The amount of WTP for the health functional Platycodon grandiflorum was drawn using maxinum likelihood estimation method. The estimated average and median WTP values are 21,933.85 won per person and 10,000 won per person, respectively. The independent factors, including the ratio of monthly average health function food consumption to income, the average monthly income level of a household, and existence of family members or relatives engaged in food and nutrition-related professions in a household, have been shown to have a statistically significant influence on the WTP. This study presents the potential magnitude of health functional food market and the value of the new technology based on health functional food market.

• 재활복지공학회논문지
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• 제1권1호
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• pp.21-28
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• 2007

대부분의 보청기에서는 난청인의 청력 손실을 보상하기 위해 음성 증폭 알고리즘과 잡음 및 피드백을 제거하기 위한 알고리즘 등을 사용하고 있고, 음성의 인지율을 높이기 위해서 음성의 대비를 강조하는 알고리즘을 사용한다. 음성 대비 강조 알고리즘 사용 시 과도한 대비증폭에 의해서 포먼트(formant) 사이에서 마스킹 현상이 발생할 수 있다. 마스킹 현상을 확인하기 위해서 6가지의 주관적인 평가와 1가지의 객관적인 평가를 수행하였다. 주관적인 평가로는 순음 검사, 어음 청취 역치 검사, 낱말 분별력 검사, 순음 마스킹 검사, 포먼트 순음 마스킹 검사, 어음 마스킹 검사로 이루어져있고 객관적인 평가를 위해서 LLR(log likelihood ratio)을 도입하였다. 정상 청각 피험자와 난청 피험자의 결과로 미루어 볼 때, 난청 피험자가 마스킹이 잘 일어난다는 것을 볼 수 있었고, 어음을 이용한 마스킹 검사에서는 마스킹에 의해서 난청 피험자에서 어음에 대한 인지율이 떨어지는 결과를 볼 수 있다. 이러한 현상은 포먼트 향상에 의한 왜곡 때문이 아닌 마스킹 때문이다. 그러므로 마스킹 효과의 특성을 조사하여, 보청기 적합 시, 이러한 마스킹 특성을 고려하는 것이 필요하다.

• Structural Engineering and Mechanics
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• 제20권1호
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• pp.85-110
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• 2005

This paper aims at formulating various statistical models for the study of a ten year Weigh-in-Motion (WIM) data collected from various WIM stations in Hong Kong. In order to study the bridge live load model it is important to determine the mathematical distributions of different load affecting parameters such as gross vehicle weights, axle weights, axle spacings, average daily number of trucks etc. Each of the above parameters is analyzed by various stochastic processes in order to obtain the mathematical distributions and the Maximum Likelihood Estimation (MLE) method is adopted to calculate the statistical parameters, expected values and standard deviations from the given samples of data. The Kolmogorov-Smirnov (K-S) method of approach is used to check the suitability of the statistical model selected for the particular parameter and the Monte Carlo method is used to simulate the distributions of maximum value stochastic processes of a series of given stochastic processes. Using the statistical analysis approach the maximum value of gross vehicle weight and axle weight in bridge design life has been determined and the distribution functions of these parameters are obtained under both free-flowing traffic and dense traffic status. The maximum value of bending moments and shears for wide range of simple spans are obtained by extrapolation. It has been observed that the obtained maximum values of the gross vehicle weight and axle weight from this study are very close to their legal limitations of Hong Kong which are 42 tonnes for gross weight and 10 tonnes for axle weight.

• Journal of Preventive Medicine and Public Health
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• 제52권3호
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• pp.179-187
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• 2019

Objectives: In the USA, certain races and ethnicities have a disproportionately higher gastric cancer burden. Selective screening might allow for earlier detection and curative resection. Among a USA-based multiracial and ethnic cohort diagnosed with non-cardia gastric cancer (NCGC), we aimed to identify factors associated with curable stage disease at diagnosis. Methods: We retrospectively identified endoscopically diagnosed and histologically confirmed cases of NCGC at Mount Sinai Hospital in New York City. Demographic, clinical, endoscopic and histologic factors, as well as grade/stage of NCGC at diagnosis were documented. The primary outcome was the frequency of curable-stage NCGC (stage 0-1a) at diagnosis in patients with versus without an endoscopy negative for malignancy prior to their index exam diagnosing NCGC. Additional factors associated with curable-stage disease at diagnosis were determined. Results: A total of 103 racially and ethnically diverse patients were included. Nearly 38% of NCGC were stage 0-Ia, 34% stage Ib-III, and 20.3% stage IV at diagnosis. A significantly higher frequency of NCGC was diagnosed in curable stages among patients who had undergone an endoscopy that was negative for malignancy prior to their index endoscopy that diagnosed NCGC, compared to patients without a negative endoscopy prior to their index exam (69.6% vs. 28.6%, p=0.003). A prior negative endoscopy was associated with 94.0% higher likelihood of diagnosing curable-stage NCGC (p=0.003). No other factors analyzed were associated with curablestage NCGC at diagnosis. Conclusions: Endoscopic screening and surveillance in select high-risk populations might increase diagnoses of curable-stage NCGC. These findings warrant confirmation in larger, prospective studies.