• Archives of Pharmacal Research
• /
• v.21 no.5
• /
• pp.487-495
• /
• 1998

Gorwth factors such as TGF-beta, PDGF and FGF are thought to play important roles in wound healing. However, thier biological activity and signal transduction during wound repair remain poorly understood. Growth factors are often ligands for receptor tyrosine kinase and receptor serine/threonine kinases. With recent advances in signal transduction by receptor kinases, we are beginning to understand the underlying mechanism of how growth factors may regulate cutaneous wound repair. In this paper, we will describe the pharmacological effects of growth factors on wound healing, and dscuss the potential underlying signaing mechanisms. thus, we hope to provide the basis for designing more specific therapeutics for wound healing in the near future.

• Transactions of Materials Processing
• /
• v.9 no.2
• /
• pp.128-139
• /
• 2000

Wrinkling is one of the major defects in sheet metal products and may be also attributable to the wear of the tool. The initiation and growth of wrinkles are influenced by many factors such as stress state, mechanical properties of the sheet material, geometry of the body, and contact condition. It is difficult to analyze the wrinkling initiation and growth considering the factors because the effects of the factors are very complex and the wrinkling behavior may show a wide variation for small deviations of the factors. In this study, the bifurcation theory is introduced for the finite element analysis of wrinkling initiation and growth. All the above mentioned factors are conveniently considered by the finite element method. The finite element formulation is based on the incremental deformation theory and elastic-plastic elements considering the planar anisotropy of the sheet metal. The proposed method is verified by employing a column buckling problem. And then, the initiation and growth of wrinkling in deep drawing of cylindrical cup are analyzed.

• The Journal of Pediatrics of Korean Medicine
• /
• v.24 no.3
• /
• pp.138-149
• /
• 2010

Objectives: The purpose of this study is to estimate genetic and environmental factors which can effect growth, and predict final height using this factors. Methods: Correlation analysis and regression analysis were conducted between measurements of height and Genetic & environmental factors through survey from 1352 child & adolescent patients. Results: Factors which have correlation with height percentile are MPH(Mid-Parental Height), NBW(Neonatal body weight), anorexia, dyspepsia, atopic dermatitis, frequency of breakfast and quality of sleeping time. MPH has moderate relation, NBW and anorexia have fair relation, and other factors have linear but poor relation. Regression equation from factors which have correlation and height percentile has 26.9% of predictive power. Regression equation considering only genetic factor has 20.4%. MPH has the most effect on height percentile. Anorexia has more effect than NBW. Other factors also have small and similar effect. Conclusions: Height of parents has the most effect on growth, anorexia, dyspepsia, atopic dermatitis, frequency of breakfast and quality of sleeping time also has effect.

• The Journal of Fisheries Business Administration
• /
• v.16 no.1
• /
• pp.31-54
• /
• 1985

The mutual credit of Fisheries Cooperatives is reciprocal financing bring overs and shorts to settlement themselves by filling each other's needs among feeble fishermen economically. The spread of mutual credit through Fisheries Cooperatives reduces private loan dependence and private loan interest rate at fishery village, and that fills up policy financing being restricted by working scale. And seeing movement side of Fisheries Cooperatives, it has done an under board to settle self-supporting foundation of primary fisheries cooperatives early. The mutual credit deposit shows about 53 times increase past an interval of a ten years. This increase rate is an epoch-making record being unparalleled in other banking facilities except Fisheries Cooperatives. Then being unparalleled increase rate, time and savings deposits increase has been contributed a great deal than demand deposits. Thinking important function factors as mutual credit growth, we can classify interior and exterior factors. The exterior factor is income of fishery household in some measure, interior factors are the high deposits interest rate and the enlargement of facilities organization. As these, they have been in a better factors, also have been a restriction factors. The restriction factors are conflict cancellation between mutual credit and them bring into existence a village vault, mutual savings and finance companies, private finance. For the sake of continuance growth rate in mutual credit as past, we should eliminate restricted factors in growth. On the other hand the better factors in growth should be act upon affirmation side continually. Consequently under circumstances not to an amicable settlement bring the fisheries fund demand as policy financing, we should do continuous and sound development of fisheries financing by means of putting in good order of fisheries cooperatives mutual credit. Surveying a problem from these viewpoints, when we study more deep and a full into a subject about growth project of mutual credit, we think to expect continuous growth in mutual credit of Fisheries Cooperatives.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.25 no.4
• /
• pp.674-682
• /
• 2011

The present study was undertaken to investigate the effect of acupuncture & moxibustion therapy on the hair follicle growth of skin 5 days and 10 days by macroscopic, microscopic and immunohistochemical methods. The results were as follows : Macroscopic hair follicle growth of plum-blossom needle treated group and strong moxibustion treated group was more increase than that of control group. Microscopic hair follicle growth of plum-blossom needle treated group and strong moxibustion treated group was hair growing cycle, anagen phase VI and that of control group and weak moxibustion treated group was hair growing cycle, anagen phase IV. Immunohistochemical observations on the expression of various growth factors, enzyme and receptor in hair follicle cycle after local treatment of acupuncture & moxibustion therapy are as follows: Expression of fibroblast growth factor was more intense in epidermis in plum-blossom needle treated group, epidermis and secondary hair germ cells in strong moxibustion treated group than control group. Expression of epidermal growth factor was more intense in epidermis in all experimental groups, and secondary hair germ cells in moxibustion treated group than control group. Expression of c-kit receptor was more intense in epidermis, secondary hair germ cells, outer root sheath in all experimental groups than control group. Expression of protein kinase C-${\alpha}$ was more intense in epidermis, secondary hair germ cells, outer root sheath in all experimental groups than control group. Expression of vascular endothelial growth factor was more intense in epidermis, bulge, secondary hair germ cells, outer root sheath in plum-blossom needle treated group and strong moxibustion treated group than control group. We concluded that acupuncture & moxibustion therapy related to the expression of various growth factors, enzymes and receptor on the hair growth cycle for hair growth.

• Korean Journal of Environmental Biology
• /
• v.29 no.4
• /
• pp.379-387
• /
• 2011

Copepod nauplii plays an important role as a linker between the microbial food web and classical food chain in marine ecosystem and is an essential food source for early stage of many larval fishes. Study on the influencing factors on the growth of copepod naupliar stages has been rarely carried out in despite of these ecological significances. Many studies have shown that food availability and temperature are major factors to influence copepod growth. However, due to the complicated environment parameters in coastal ecosystem, the relationships between growth of copepods and influencing factors are still unclear under the natural condition. Growth rates of the copepod $Acartia$ $hongi$ nauplii were measured in Kyeonggi Bay from February to December 2001. $Acartia$ $hongi$ is numerically abundant and widespread predominant species in the coastal regions of the Yellow Sea and occurs continuously throughout the year, with a maximum peak in late spring. The naupliar growth rates of $Acartia$ $hongi$ by the artificial cohort method varied from 0.03 to 0.18 $day^{-1}$, with a mean of 0.09 $day^{-1}$. The overall naupliar growth rates showed a significantly positive relationship with the variation in water temperature. However, Previous study reported that the growth rates of adult $Acartia$ $hongi$ were primarily influenced by the variation in chlorophyll-$a$. Therefore, these differences demonstrated that the influencing factors of growth did not correspond with the developmental stages. The results of this study suggest that the dissimilarity of growth between nauplius and adult female resulted from the size-dependant difference in food availability and the growth of older developmental stages containing adults are more food-dependent than juveniles.

• Mycobiology
• /
• v.31 no.1
• /
• pp.36-41
• /
• 2003

Influence of physiological and environmental factors on an antagonistic strain of Trichoderma viride RSR7 were studied optimize its biocontrol potential. The growth and sporulation of T. viride was greatly influenced by various carbon and nitrogen sources, and the environmental factors such as pH and temperature. The best growth and sporulation of T. viride was observed when sucrose, peptone and trehalose were supplemented in the medium as sole carbon sources. Rhamnose, pyruvic acid and sorbitol also supported a good growth. However, with these carbon sources the sporulation was poor. Growth and sporulation was also affected by various nitrogen sources. Growth and sporulation both were favoured by ammonium forms of nitrogen compared to nitrite or nitrate forms. Urea did not support either growth or sporulation. Among amino acids, glutamic acid, asparagine, leucine, aspartic acid, glutamic acid and alanine supported good growth as well as sporulation. T. viride was able to utilize large number of amino acids as sole nitrogen source. Proline was good for growth, but not for sporulation. Maximum growth and sporulation of T. viride was between pH 4.5 to 5.5. Temperatures between $20^{\circ}C\;and\;37^{\circ}C$ were good for both growth and sporulation of T. viride. At lower temperatures(i.e. below $20^{\circ}C$) growth and sporulation were inhibited. Based on the present study it may be concluded that T. viride RSR7 is capable of growing and sporulating with varied nutritional and environmental conditions and, therefore, this strain of T. viride may be useful as a biocontrol agent under diverse physiological and environmental conditions.

• Agribusiness and Information Management
• /
• v.6 no.1
• /
• pp.1-11
• /
• 2014

The purpose of this study is to develop the growth prediction model that can predict growth and development information influencing on the production of citrus fruits. The growth model was developed to predict the floral leaf ratio, number of fruit sets, fruit width, and overweight fruits depending on the main period of growth and development by considering the weather factors because the fruit production is influenced by weather depending on the growth and development period. To predict the outdoor-grown citrus fruit production, the investigation result for the standard farms is used as the basic data; in this study, we also understood that the influence of weather factors on the citrus fruit production based on the data from 2004 to 2013 of the outdoor-grown citrus fruit observation report in which the standard farms were targeted by the Agricultural Research Service and suggested the growth and development information prediction model with the weather information as an independent variable to build the observation model. The growth and development model for outdoor-grown citrus fruits was assumed by using the Ordinary Least Square method (OLS), and the developed growth prediction model can make a prediction in advance with the weather factors prior to the observation investigation for the citrus fruit production. To predict the growth and development information of the production of citrus fruits having a great ripple effect as a representative crop in Jeju agriculture, the prediction result regarding the production applying the weather factors depending on growth and development period could be applied usefully.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
• /
• v.23 no.1
• /
• pp.28-32
• /
• 2012

Vocal fold scar disrupts structure of lamina propria and causes significant change in vocal fold tissue biomechanics, resulting in a range of voice problems that often significantly compromise patient quality of life. Although several therapeutic management have been offered in an attempt to improve vocal fold scar, the ideal treatment has not yet been found. Recently, several tissue engineering technique for vocal fold scar using growth factors, several cells, and scaffolds have been described in tissue culture and animal models. Several growth factors such as hepatocyte growth factor, basic fibroblast growth factor, and transforming growth factor beta 3 for therapy and prevention of vocal fold scar have been studied. Cell types to regenerate vocal folds in scarring tissue have been introduced autologous or scarred vocal fold fibroblast and adult mesenchymal stem cells. Decellularized organ matrix and several hyaluronic acid materials have used as scaffolds for vocal fold scar.

• Journal of Distribution Science
• /
• v.17 no.12
• /
• pp.23-32
• /
• 2019

Purpose As consumer awareness grows, the importance of CSR becomes even more important for long-term growth. In response to this current trend, the purpose of this study is to analyze the effect of CSR activities on business performance for logistics companies. Research design, data, and methodology - Between CSR activities and growth, there was a generally positive(+) relationships between activities such as donation and volunteerism and the growth of the enterprise. In terms of the relationship between environmental factors and growth, negative results were expressed. In case of profitability, improved welfare for workers has had a positive impact on corporate profitability. Results - With respect to stability, a high proportion of equity capital is not considered to be more active in SCR activities. Significant negative results were given between the minimum factors for entry, transportation, and noise generation factors and the ratio of liabilities, which are representative friction factors in the community. Conclusions - With respect to stability, a high proportion of equity capital is not considered to be more active in SCR activities. Significant negative results were given between the minimum factors for entry, transportation, and noise generation factors and the ratio of liabilities, which are representative friction factors in the community.