• Journal of the Korean Regional Science Association
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• v.38 no.1
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• pp.3-20
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• 2022

The purpose of this study is to exploratory analyze the transition pattern of establishments and workers in new growth industries in the metropolitan area from 2010 to 2019 and to identify regional factors affecting the inflow and outflow of new growth industry start-ups. As for the analysis, the original data of the Census on Establishments were used, and spatial data at the sigungu level were constructed based on the inflow and outflow data of the number of new growth industry businesses and workers. For the analysis, the degree centrality of connection to outflow inflow by region was calculated, and an empirical analysis was conducted on regional-level factors affecting the inflow and outflow of new growth industries by applying a negative binomial regression model. According to the results, the new growth industry manufacturing sector was actively relocated in southern Gyeonggi Province, and the new growth industry service sector in Gangnam and Guro-Geumcheon-gu, and the impact of regional-level factors on the inflow and outflow of new growth industry start-ups varies depending on the industry. This study presented implications for regional industrial policies to improve the competitiveness of the local economy by attracting new industries by identifying spatial transition patterns for new growth industries and conducting empirical analysis to identify influencing factors.

• Journal of Environmental Science International
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• v.26 no.5
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• pp.585-590
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• 2017

The Diameter at Breast Height (DBH) provides information about the volume growth of a tree. In this study, we estimated the relative growth rates of Castanea crenata and Pinus rigida as 4.07% and 3.73%, respectively. Although the difference was low, we demonstrated that the growth rate of C. crenata is slightly faster than that of P. rigida. After calculating the relative growth rate for each section, we found that the relative growth of C. crenata decreased with time. However, the relative growth rate of P. rigida showed an overall increase. The gap widths of both species showed an increasing trend. However, the gradient of the two species was different. The gradient of C. crenata was approximately 12.0, but that of P. rigida was approximately 4.7. This means that the volume growth of C. crenata was faster than that of P. rigida during 4 years. However, this was relatively a short period for measuring the volume growth pattern, and we believe that additional useful information can be obtained by conducting long-term ecological monitoring. Results of canonical correspondence analysis showed that among the climate variables, temperature was significantly related to the gap widths for both species.

• Journal of Urban Science
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• v.9 no.1
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• pp.41-49
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• 2020

This study analyzed the factors affecting economic growth using multiple regression model and Geographically Weighted Regression in consideration of population, industry and employment, housing and political characteristics on economic growth by region. The analysis results are summarized as follows. First, the total employment growth rate, manufacturing employment growth rate, local election turnout and the level of party consensus between the central and local governments are having a positive impact on regional economic growth. Second, according to the GWR analysis, the population has a positive impact on economic growth in the southern region of Korea, and the increase in the total number of employees has a positive impact on the southern region of Gyeonggi Province, Gangwon Province, North Chungcheong Province and North Gyeongsang Province. Finally, the voter turnout of urbanites is positively affecting economic growth in South Chungcheong Province, Gangwon Province and the southern coast, while North Jeolla and South Jeolla provinces have a positive impact on economic growth as the parties of the central and local governments are equal. The results of this study may suggest the role of local government for regional economic development.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.15 no.1
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• pp.96-126
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• 2002

In the course of screening natural extracts for hair growth, we found that the extract of dried root of Sophora flavescens has the prominent hair growth promoting effect. After topical application of Sophora flavescens extract to the back of C57BL/6 mice, the earlier conversion of telogen-to-anagen phase was induced. In addition, the Sophora flavescens extract revealed to possess potent inhibitory effect on $5{\alpha}$-reductase Ⅰ and Ⅱ activity. The growth of dermal papilla cells and mouse vibrissae hair follicle cultured in vitro, however, was not affected by Sophora flavescens extract treatment. RT-PCR analysis showed that Sophora flavescens extract induced mRNA levels of growth factors such as insulin-like growth factor-Ⅰ and keratinocyte growth factor in dermal papilla cells, suggesting hair growth promoting effect of Sophora flavescens extract is mediated through inhibition of $5{\alpha}$-reductase type Ⅱ activity and the regulation of growth factors in dermal papilla cells. Furthermore, Sophora flavescens extract also showed anti-bacterial effect on Propionibacterium acnes. These results suggest that Sophora flavescens can be used as a potent treatment agent for helping hair growth stimulation and acne inhibition.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.4
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• pp.1081-1091
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• 2012

Myelodysplastic syndromes (MDS) represent a heterogeneous group of clonal hematologic neoplasms characterized by morphologic dysplasia, aberrant hematopoiesis and peripheral blood refractory cytopenias. MDS is recognized to be associated with an increased risk of symptomatic anemia, infectious complications and bleeding diathesis, as well as a risk of progression to acute myeloid leukemia, particularly in patients with a high IPSS score. The advent of use of hematopoietic growth factors such as granulocyte colony-stimulating factor (G-CSF) and recombinant erythropoietin (EPO) has improved symptoms in MDS patients in addition to some data that suggest there might be an improvement in survival. G-CSF is an effective therapeutic option in MDS patients, and it should be considered for the management of refractory symptomatic cytopenias. G-CSF and EPO in combination can improve outcomes in appropriate MDS patients such as those with lower-risk MDS and refractory anemia with ring sideroblasts (RARS). This article reviews use of growth factors for lower-risk MDS patients, and examines the data for G-CSF, EPO and thrombopietic growth factors (TPO) that are available or being developed as therapeutic modalities for this challenging disease.

• Transactions of Materials Processing
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• v.9 no.6
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• pp.653-662
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• 2000

Wrinkling is one of the major defects in sheet metal products together with tearing, springback and other geometric and surface defects. The initiation and growth of wrinkles are influenced by many factors such as stress ratios, mechanical properties of the sheet material, geometry of the workpiece, contact condition, etc. It is difficult to analyze the wrinkling initiation and growth considering all the factors because the effects of the factors are very complex and the wrinkling behavior may show a wide scatter of data even for small deviations of factors. The finite element analyses of the wrinkling initiation and growth in the sheet metal forming process provide the detailed information about the wrinkling behavior of sheet metal. The direct analyses of the wrinkling initiation and growth, however, bring about a little difficulty in complex industrial problems because it needs large memory size and long computation time. In the present study, therefore, a global-local analysis technique is introduced for the computational efficiency. Through the analysis of wrinkling in the door inner stamping process, the efficiency of the global-local analysis technique is investigated.

• Journal of the Korean Society of Food Science and Nutrition
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• v.24 no.4
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• pp.493-501
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• 1995

To investigate an effect of dietary sodium and potassium on blood pressure, 418 adolescents living in Kangwha area were studied. Two measurements were taken on each blood pressure(diastolic, systolic) and the average of the two readings was used in the analysis. Sodium and potassium intake were estimated by the determination of those electrolytes in 24hr urine. Not only dietary factors but also physical growth factors such as weight, height, arm-circumference and skinfold-thickness were induced in the stepwise multiple regression analysis to indentify the relative importance between the factors. The variation of blood pressure both in systolic and diastolic in both sexes was inconsistent with the levels of sodium and potassium intake. The results of multiple regression analysis showed that the physical growth were more influential than nutrient factor. It suggested that hypertension risk factors observed form the adults, may not be identical with that of the growing aged population. After control of the physical growth, there was no significant variation observed by the level of sodium and potassium intake on blood pressure. In summary, the results indicate that growth has been more influential than dietary factor on blood pressure for growing aged population.

• Journal of Yeungnam Medical Science
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• v.23 no.1
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• pp.10-18
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• 2006

Epithelial to mesenchymal transition (EMT) is an important etiologic factor for the development of peritoneal fibrosis in CAPD patients. Mesothelial cells are main source of trans-differentiated fibroblasts under stress from the bioincompatible peritoneal dialysate. In our study there was no difference in dialysate TGF-${\beta}$ and VEGF between the low and high GDP groups during an initial 12 months. However, after adjusting with D-CA125, the low GDPs group showed a significantly lower D-TGF-${\beta}$/D-CA125 and D-VEGF/CA125 during the initial 12 months. Among the adjusted peritoneal growth factors for CA125, VEGF/CA125 and TGF-b/CA125 were factors significantly associated with greater EMT in this study. Adjustment of the peritoneal growth factor for effluent CA125 (surrogate for mass of HPMCs) revealed significant association with EMT suggesting that the fibroblastoid transition from HPMCs could be affected by the amount of intraperitoneal growth factors (TGF-b, VEGF) per unit mass of HPMCs. There was significant improvement in both cell score and D-CA125 at the sixth and 12th months after switching from a high GDPs solution to a low GDPs solution. Use of icodextrin solution in patients who had average peritoneal transport showed not only better systemic effects such as decreased glucose absorption via dialysate but also preservation of the peritoneum, including less EMT and high mesothelial bulk mass. In conclusion, Therapy with low GDP solution including icodextrin may positively impact preservation of the peritoneal membrane integrity and prevention of peritoneal fibrosis with time on PD.

• Journal of the Architectural Institute of Korea Planning & Design
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• v.36 no.1
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• pp.3-14
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• 2020

Dormitories of Korean university are planned to pursue qualitative growth after a period of quantitative growth in the 1970s. However, since the 1990s, the physical plan for qualitative growth has not changed significantly and the effects of these changes on dormitory residents has not been verified. The purpose of this study is to identify the environmental factors influencing dormitory life adaptation and to provide a basis for qualitative growth of university dormitories to help dormitory residents adapt to the environment. The research was conducted in three stages. First, the elements of the residential environment of the dormitory complex, which is an independent variable, were derived. The dormitory life adaptation scale was developed to measure the dependent variable. Secondly, a questionnaire survey was conducted to obtain the environmental factors of current dormitory and previous residence and three elements of dormitory life adaptation; 'acceptance of change', 'familiarity', and 'anxiety'. Third, statistical analysis was conducted to determine whether each factor influenced dormitory life adaptation.

• Journal of Korean Neurosurgical Society
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• v.29 no.12
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• pp.1584-1591
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• 2000

Objective : Until now, it has been little known about the biological mechanisms associated with the genesis, growth, and rupture of intracranial aneurysm. This study was performed to investigate and understand a part of these mechanisms. Materials and Methods : Immunohistochemical stains for angiogenesis growth factors(basic fibroblast growth factor (bFGF) and vascular endothelial growth factor(VEGF)) and selected vascular wall matrix proteins(alpha smooth muscle actin(${\alpha}SMA$) and collagen Type IV) were performed in fixed sections from a normal circle of Willis artery which was taken from the autopsy specimen as a control vessel and 17 aneurysmal wall specimens which was taken during surgical clipping of aneurysms. The staining intensity and distribution of immunoreactivity to angiogenesis growth factors and selected wall matrix proteins in control vessel and aneurysmal wall were examined and compared with each other. The difference of staining intensity according to the size of aneurysm was also investigated. Results : There was no immunoreactivity to bFGF and VEGF in the control vessel. bFGF immunoreactivity was exhibited in 15 of 17 aneurysm specimens around smooth muscle cells within the media of aneurysm. VEGF immunoreactivity was also exhibited in all aneurysm specimens in patches or diffusely affecting all layers of the aneurysmal wall. The degrees of intensity of bFGF and VEGF immunoexpression were proportionate roughly to the size of aneurysm. Strong immunoexpression of both factors were noticed in large aneurysm. A regularly arranged and defined band of immunoreactivity of ${\alpha}SMA$ was noticed in the media of the control vessel, whereas diffuse, faint, irregularly arranged ${\alpha}SMA$ was noticed in the aneurysmal wall. A regularly defined band of collagen Type IV immunoreactivity was also noticed in the subendothelium of the control vessel, whereas diffuse disorganized immunoreactivity of collagen Type IV was noticed in the entire wall of the aneurysm. Conclusion : These results indicate substantial evidences of abnormal expression of angiogenesis factors and changes of selected vascular wall matrix proteins in the wall of intracranial aneurysm. The unbalanced changes of angiogenesis factors and vascular wall matrix proteins in the wall of aneurysm may be one of the biological mechanisms for the growth and rupture of aneurysm.