• Maxillofacial Plastic and Reconstructive Surgery
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• v.30 no.4
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• pp.333-344
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• 2008

The objectives of this study was to explore the growth pattern of the oral squamous cell carcinoma when overexpressed COX was inhibited, explore the pathway that COX inhibitors suppressed the proliferation of cancer cells, and then hereafter investigate the potential of COX as chemopreventive target for oral squamous cell carcinoma. For confirming the COX-dependent effect and mechanisms on growth of the oral cancer cells, we treated the nonselective NSAID, Mefenamic acid and COX-2 selective inhibitor, Celecoxib in HN4 cell line. And then the cell line was evaluated with MTT assay and growth curve, the production of PGE2, total RNA extraction and RT-PCR analysis, and TEM The results were obtained as follows: 1. After administration of medication, in the result of MTT assay, Celecoxib inoculated group inhibit the cell growth rather than Mefenamic acid inoculated group. 2. The growth curve of cell line showed as time passes by there was a dramatic cell growth in the control group, and gradual growth inhibition was found in medication inoculated group and, in Celecoxib inoculated group there was more inhibition of cell growth. 3. After the administration of medication, Celecoxib tend to inhibit the synthesis of PGE2 more than Mefenamic acid. Mefenamic acid inhibit the synthesis of PGE2 more as the concentration gets high, but Celecoxib inhibited the synthesis of PGE2 even in low concentration. 4. After the administration of medication, the revelation of COX mRNA in cell line, there was a 50% decrease in COX-1, 60% decrease in COX-2 as in $50{\mu}M$ Mefenamic acid, and in Celecoxib $50{\mu}M$ there was not much difference in COX-1 and 90% decrease in COX-2 was found. 5. HN4 cell line showed broken nucleus and tangled cytoskeleton bundles in cytoplasm which meant apoptotic features after the treatment of Celecoxib in TEM view. Depending on the above results, we estimate that the inhibition of the expression of COX-2 cause the growth suppression of the oral squamous cell carcinoma, and it get achieved through pathway of reduced PGE2 production and increased apoptosis. In addition to, because COX-2 selective inhibitor specifically act to COX-2, it is considered that COX-2 selective inhibitor has the adequate potential as chemopreventive agent for oral squamous cell carcinoma.

• The KIPS Transactions:PartD
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• v.12D no.1 s.97
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• pp.103-110
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• 2005

Software Development is converting from structural to object oriented method. The later software development prefers the iterative process applications, not aterfall process and based on use case model, the requirements are expressed and based on this, analysis, design and coding are accomplished. Therefore, size of the software to be developed is estimated basing on use case and it is only possible to maintain the project success by estimating development effort, cost and development period. Even though development effort estimation models related current use case point. there is no appropriate development effort estimating. This paper shows, as a result of applying the development effort estimating model about UCP to the growth curve, a superior performance improvement to current statistical models. Therefore, estimation of development effort by applying this model, project development maintenance can be appropriately carried out.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.12 no.1
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• pp.1-9
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• 2008

The Logistic cone is studied as a most desirable for the software testing effort. Assuming that the error detection rate to the amount of testing effort spent during the testing phase is proportional to the current error content, a software-reliability growth model is formulated by a nonhomogeneous Poisson process. Using this model the method of data analysis for software reliability measurement is developed. After defining a software reliability, This paper discusses the relations between testing time and reliability and between duration following failure fixing and reliability are studied SRGM in several literatures has used the exponential curve, Railleigh curve or Weibull cure as an amount of testing effort during software testing phase. However, it might not be appropriate to represent the consumption curve for testing effort by one of already proposed curves in some software development environments. Therefore, this paper shows that a logistic testing- effort function can be adequately expressed as a software development/testing effort curve and that it gives a good predictive capability based on real failure data.

• Journal of the Korean Crystal Growth and Crystal Technology
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• v.23 no.6
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• pp.279-282
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• 2013

Recently, it has been interested much that AlN (Aluminum Nitride) crystals can be applied to UV LEDs and high power devices as like GaN and SiC crystals. The reports about commercial grade of AlN wafers in the world have been absent, however several results for growth of large size of AlN single crystals have been reported from abroad. In this report, the result of AlN single crystals of a diameter of about 8 mm grown are reported. Optical microscopic characterization was applied to observe the form of the crystals and the crystal quality was evaluated by FWHM measurement by DCXRD rocking curve analysis.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.23 no.7 s.166
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• pp.1164-1172
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• 1999

In this study, to investigate the fatigue crack retardation behavior and the variability of retardation cycles, fatigue crack growth tests were conducted on 7075-T6 aluminum alloy under single tensile overload. A retardation coefficient, D was introduced to describe fatigue crack retardation behavior and a random variable, Z to describe the variability of fatigue crack growth. The retardation coefficient was separately formulated according to retardation behavior which is composed of delayed retardation part and retardation part. The random variable, Z was evaluated from experimental data which was obtained from fatigue crack growth tests under constant amplitude load. Using these variables, a probabilistic model was developed on the basis of the modified Forman's equation, and retardation behavior and cycles were predicted under certain overload condition. The predicted retardation curve well agrees with the trend of experimental crack retardation behavior. And this model well predicts the scatter of experimental retardation cycles.

• Proceedings of the SAREK Conference
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• 2009.06a
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• pp.398-403
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• 2009

The theoretical bases on characteristics of heat release rate in compartment of building for scenario of smoke management are introduced and the numerical applications to simple compartment model are carried out. The growth stage which is important for smoke management design is modelled as t-squared fire curve including fire growth coefficient with related to growth rate. The conditions for the happening of flashover is presented such as $600^{\circ}C$ of temperature or $20kW/m^2$ of radiation heat flux. After the flashover happen, the fire in compartment changes to fully developed fire having the characteristics of ventilation-controlled fire. As the result of numerical analysis to simple compartment model, the time to reach 900K under ceiling for condition of medium growth is twice for condition of fast growth.

• The Korean Journal of Malacology
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• v.26 no.3
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• pp.227-234
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• 2010

A comparative analysis of size and age structures of coastal subfossil shell assemblages of the shortnecked clam Ruditapes philippinarum from open and protected bays of Cheju Island (Korea) was carried out. On the whole, taking into account the damage of small fragile shells, size and age structures of the shell assemblages corresponded to the classical curve of bivalve population distribution when its mortality diminishes with age increase up to a certain threshold. It was found that shell samples from open bays of the western, southern and eastern coasts included shells of smaller and younger individuals (L ${\leq}$ 40 mm, ${\leq}$ 4 years) than samples from the eastern protected bay (L ${\leq}$ 54.5 mm, ${\leq}$ 6 years). Evidently, strong wave activity was the reason for a short life-span of the clams from the open areas. Growth was investigated retrospectively by annual growth rings on the shells. Growth rates of the clams from the various coasts of Cheju Island differed. However, growth rates of the clams from different biotopes at the same (eastern) side of the Island were similar. Shell height/length and width/length ratios statistically significantly increased with the clam age increase. Most likely, the reason for such shell shape alteration is that more conglobated individuals more survive being more energy-optimal than oblong specimens.

• Nuclear Engineering and Technology
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• v.55 no.4
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• pp.1571-1584
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• 2023

In this study, a numerical analysis was performed as part of an international joint research project to reproduce a real cable tray fire that occurred in the heater bay area of the turbine building of a nuclear power plant. A sensitivity analysis was performed on various input parameters to derive results consistent with the sprinkler activation time obtained from the fire event analysis. For all sensitive parameters, the normalized sprinkler activation time correlated well with the power function of the normalized sprinkler height. A correlation equation was developed to identify the sprinkler activation time at any location when determining the slope or fire growth rate under the conditions assuming a linear or t-squared heat release rate (HRR) time curve. Various cable fire growth assumptions were used to determine which assumption was better to provide the prediction coincident with the information given from the fire event analysis in terms of the sprinkler activation time and total energy generated from cables damaged by fire. In the comprehensive analysis of all the sensitive parameters, the standard deviation of the input parameters increased as the sprinkler height decreased. Within the range of the sensitivity parameter values given in this study, when considering all sprinkler heights, the standard deviation of the cable model change was the largest and that of the overhang position change was the smallest.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.36 no.4
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• pp.100-108
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• 2013

In aerospace industry, MTBF (Mean Time Between Failure) and MFTBF (Mean Flight Time Between Failure) are generally used for reliability analysis. So far, especially to Korean military aircraft, MFTBF of avionic equipments is predicted by MIL-HDBK-217 and MIL-HDBK-338, however, the predicted MFTBF by military standard has a wide discrepancy to that of real-world operation, which leads to overstock and increase operation cost. This study analyzes operational data of avionic equipments. Operational MFTBF, which is calculated from operational data, is compared with predicted MFTBF calculated conventionally by military standard. In addition, failure rate trend is investigated to verify reliability growth in operational data, the investigation shows that failure rate curve from operational data has somewhat pattern with decreased failure rate and constant failure rate.

• Journal of Distribution Science
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• v.12 no.11
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• pp.25-34
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• 2014

Purpose - Considering that the governments' official statistics on the optimum scale of the domestic service industry will be crucial in future, this study's results will be used as an important benchmark to develop and verify the parameters in the government's official statistics. Research design, data, and methodology - To identify the appropriate scale of Korea's service industry and its adequacy, I have determined them through estimation using a regression method involving panel data analysis on the panel data of 30 OECD countries. Results - The regression coefficient provided indications of being non-linear. This means that a U-shaped curve relationship exists-that is, the level of the economic growth leverage decreases along with the service industry's growth up to the level of 70.9% in terms of the Korean service industry's adequacy; it increases along with the service industry's growth at a level higher than 70.9%. Conclusions - While the current proportion of the size of the service industry among all industries in Korea stands at 50.7%, its proper proportion estimated by a regression analysis was 70.9%.