• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제23권5호
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• pp.457-463
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• 2020

Purpose: To analyze risk factors and various nutrients associated with stunting among children aged 6-60 months. Methods: This is a case-control and cross-sectional study between 40 stunting cases and 40 controls. Data on possible risk factors associated with stunting were obtained through direct interviews and using a questionnaire. Examination of vitamin D, zinc, albumin, and ferritin levels was performed on both groups. Data were analyzed using IBM SPSS Statistics for Windows, Version 23.0 (IBM Co., Armonk, NY, USA) to determine risk factors for stunting and to assess the relationship between nutritional levels and stunting. Results: The incidence of stunting was highest in children aged 12-36 months. Children with low weight and very low weight for age comprised of 55% and 22.5%, respectively, of the study participants. The highest mother's educational level was junior high school (40%). History of low birth weight (LBW) was more commonly observed in the stunting group than that in the control group (25.0% and 7.5%, respectively; p=0.034, odds ratio, 0.310 [95% confidence interval, 0.122-0.789]). Approximately 7.5% of cases had premature birth. Exclusive breast feeding was found to be not correlated with stunting. The mean zinc level in the stunting group was 34.17 ng/mL, which was different from that in the control group (50.83 ng/mL) (p=0.023). Blood ferritin, vitamin D, albumin, and calcium levels were not strongly correlated with stunting. Conclusion: LBW is the main risk factor contributing to stunting and is strongly associated with low zinc level.

• 한국산학기술학회논문지
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• 제19권10호
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• pp.661-667
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• 2018

최근 무선 통신 기술과 센서 디바이스들의 발달로 스마트 홈 시장이 성장하고 있으며, 다양한 디바이스가 활용되고 있다. 이러한 사물인터넷 환경은 지능형 서비스를 위해 다양하고 방대한 양의 디바이스 정보를 수집하여 사용자 정보를 기반으로 서비스를 제공받으며, 다양한 디바이스를 제어해야 하고, 이기종 간의 통신을 제공해야 한다. 하지만, 이러한 성장과 함께, 스마트 홈 환경에서는 다양한 보안 위협이 발생하고 있다. 실제, 프루프 포인트와 HP에서는 스마트 홈 환경에서의 피해 사례 및 보안 취약점의 심각성에대해 경고하였으며, 다양한 환경에서의 침해 사례가 발표되었다. 그러므로, 본 논문에서는 스마트 홈 환경에서 발생할 수 있는 보안 문제를 해결하기 위해 스마트 홈에서 사용하는 스마트 노드들 간의 안전한 상호인증 기법에 대해 연구를 수행하였다. 제안하는 논문의 경우 보안성 평가를 통해 스니핑, 스푸핑, 디바이스 상호 인증, 중간자 공격, 무결성 등 사물인터넷 환경과 센서 디바이스에서 발생할 수 있는 잘 알려진 취약점에 대해 난수와 수시로 갱신되는 세션키 및 비밀키를 이용하여 안전함을 검증하였다. 또한, 기존에 연구된 사물인터넷 보안 프로토콜과의 비교를 통해 보안성 및 키 관리 측면에서 우수함을 확인할 수 있었다.

• Asian-Australasian Journal of Animal Sciences
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• 제18권10호
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• pp.1440-1444
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• 2005

To determine the effects of short-term dietary supplementation of branched-chain amino acids (BCAAs) during nursing (from 3 to 28 days of age) on plasma BCAA levels and subsequent growths in cattle, 12 nursing male Holstein calves, randomly assigned to control and treatment groups (n = 6 in each group), orally received a daily supplement of essential BCAAs (2 g/kg body weight/day; 1:1:1 of valine, leucine and isoleucine) or not. The plasma BCAA levels increased linearly after the administration. During the treatment period, average daily gain (ADG) was lower in the treatment group (0.43${\pm}$0.07 kg/day) than the controls (0.71${\pm}$0.07 kg/day, p<0.05). However, at 2 months of age, ADG was significantly higher in the BCAA-treated group (1.16${\pm}$0.26 kg/day vs. 0.51${\pm}$0.06 kg/day, p<0.05). Furthermore, at age 8, 9 and 10 month, ADG in the treated group (1.35${\pm}$0.23, 1.46${\pm}$0.07 and 1.60${\pm}$0.16 kg/day, respectively) showed a linear increase and was significantly higher than that in the control group (0.88${\pm}$0.14, 0.70${\pm}$0.21 and 1.11${\pm}$0.11 kg/kg, respectively, p<0.05). Overall, ADG was 15.6% higher in the treatment group (1.26${\pm}$0.05 kg vs. 1.09${\pm}$0.04 kg; p<0.05). The final body weight at slaughter was 14.8% higher in the treatment group (759.5${\pm}$17.7 kg vs. 661.7${\pm}$21.2 kg, p<0.01). Thus, the supplementation of BCAAs during nursing improves ADG and carcass weight in cattle and is a useful husbandry technique for beef cattle.

• Asian Pacific Journal of Cancer Prevention
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• 제16권6호
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• pp.2333-2340
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• 2015

Background: Due to the strong inhibitory effects of $PPAR{\gamma}$ gene on the growth of cancer cells, the role of Pro12Ala polymorphism in $PPAR{\gamma}$ gene has been extensively investigated in cancer recently. However, the results were inconsistent according to cancer type. The aim of this study was to comprehensively evaluate the $PPAR{\gamma}$ Pro12Ala polymorphism and gastric cancer susceptibility. Materials and Methods: Search strategies were conducted in Pubmed, Medline (Ovid), Chinese biomedical database (CBM), China national knowledge infrastructure (CNKI), VIP, and Wanfang database, covering all publications, with the last search up to November 01, 2014. The strength of association between $PPAR{\gamma}$ Pro12Ala polymorphism and gastric cancer risk was assessed by OR with 95%CI. Results: A total of 546 cases and 827 controls in 5 case-control studies were included in this meta-analysis. The results indicated that the variant G allele carriers (CG+GG) had a 2.31 times higher risk for gastric cancer when compared with the homozygote CC (odds ratio (OR)=2.31, 95% confidence interval (CI)=1.67-3.21 for CG+GG vs. CC). In the subgroup analysis by ethnicity, significantly elevated risks were both found in Asians (OR=2.56, 95% CI=1.42-4.64) and Caucasians (OR=2.20, 95% CI=1.48-3.25). Similarly, in the subgroup analysis by H. pylori status, a significantly increased risk was identified in H. pylori (+) populations (OR=3.68, 95%CI=2.07-6.52), but not in H. pylori(-) populations (OR=1.17, 95%CI=0.58-2.39). Conclusions: This pooled analysis suggested that the $PPAR{\gamma}$ Pro12Ala polymorphism could be an independent predictive risk factor for gastric cancer especially in H. pylori infected populations in Asians and Caucasians. Nevertheless, prospectively designed cohort studies are needed to further investigate gene-gene and gene-environment interactions to confirm the combined effects of $PPAR{\gamma}$ Pro12Ala polymorphisms and H. pylori infection on gastric cancer risk.

• Journal of Microbiology and Biotechnology
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• 제18권2호
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• pp.263-269
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• 2008

Hydrazinocurcumin (HC), a synthetic derivative of curcumin, has been reported to inhibit angiogenesis via unknown mechanisms. Understanding the molecular mechanisms of the drug's action is important for the development of improved compounds with better pharmacological properties. A genome-wide drug-induced haploinsufficiency screening of fission yeast gene deletion mutants has been applied to identify drug targets of HC. As a first step, the 50% inhibition concentration $(IC_{50})$ of HC was determined to be $2.2{\mu}M$. The initial screening of 4,158 mutants in 384-well plates using robotics was performed at concentrations of 2, 3, and $4{\mu}M$. A second screening was performed to detect sensitivity to HC on the plates. The first screening revealed 178 candidates, and the second screening resulted in 13 candidates, following the elimination of 165 false positives. Final filtering of the condition-dependent haploinsufficient genes gave eight target genes. Analysis of the specific targets of HC has shown that they are related to septum formation and the general transcription processes, which may be related to histone acetyltransferase. The target mutants showed 65% growth inhibition in response to HC compared with wild-type controls, as shown by liquid culture assay.

• 한국콘텐츠학회논문지
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• 제18권5호
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• pp.34-45
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• 2018

한국에는 사행성과 관련하여 독특한 제도가 다수 존재하는데, 그중 대표적인 사행성 규제가 사행산업 총량제이다. 사행산업 총량제는 사행산업 전체의 매출액을 경제 규모의 일정 수준 내로 한정하고자 하는 규제로 외국에서 예를 찾기 힘든 독특한 규제이다. 이러한 사행산업 총량제는 2009년부터 실시되어 현재까지 지속되고 있다. 본 연구는 사행산업 총량제가 실시된 이후 한국의 사행산업 구조가 어떻게 변화하였는지를 살펴보고자 한다. 사행산업 총량제 실시 이후 사행산업 구조 변화를 살펴본 결과, 첫째, 사행산업 총량제 도입 이후에는 사행산업 매출 변화량이 감소하였고, 매출 증가율이 GDP 증가율과 거의 유사하게 변화한다. 둘째, 사행산업 총량제 도입 이전에는 사행산업의 독점도가 크게 감소하는 추세였으나 사행산업 총량제가 도입되면서 사행산업의 독점도가 안정되었다. 즉, 사행산업의 경쟁 구도가 고착화되는 현상이 나타나고 있다는 것을 의미한다. 셋째, 사행산업 각 종목별로도 매출액 변화가 거의 이루어지지 않고 안정적인 추세를 보였다. 결론적으로 사행산업 총량제는 사행산업의 구조를 고착화하고 변화가 적은 정체 시장으로 변화시켰다. 사행산업 총량제는 사행산업 간 경쟁을 막으며, 성장도 쇠퇴도 없는 고정적 산업 구조를 만드는 효과를 가진다.

• 한국식품저장유통학회지
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• 제14권1호
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• pp.8-17
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• 2007

수도수(TW), 0.85% 식염수(0.85% NaCl) 및 0.5% Sodium metabisulfite(0.5% SMS)를 대조구로 하고 강산성 전기분해수(SAEW ; Strong Acidic Electrolyzed Water, pH 2.53, ORP 1,088 mV, HClO 91.25 ppm)와 약알칼리 전기분해수 (LAEW ; Law Altaline Electrolyzed Water, pH 8.756, ORP 534 mV, HClO 105.70 ppm)를 침지액으로 하여 박피 감자와 고구마의 초기품질 및 $5^{\circ}C$ 저장중 품질변화를 비교 검토하였다. 저장중 총페놀성 화합물 함량 변화는 감자에서는 처리구간 차이가 거의 없었으나 고구마에서는 LAEW 침지 박피 고구마가 다소 낮은 경향을 나타내었다. PPO 활성은 저장기간 전반에 걸쳐 전기분해수 침지구인 SAEW 및 LAEW 침지 박피 고구마가 상대적으로 낮은 활성을 나타내었다. 색차 변화량과 조직감의 감소량은 전기분해수 침지 박피 감자와 고구마가 TW, 0.5% NaCl 및 0.5% SMS 침지 박피 처리구에 비해 상대적으로 작았다. 총균수와 대장균 군수는 저장초기 및 저장 3-6일까지는 전기분해수와 0.5% SMS 침지 박피 감자와 고구마가 생대적으로 낮은 균수를 나타내었으며, 관능평가 결과 종합적 기호도는 저장기간 전반기인 9일 정도까지는 LaEW가 타 처리구에 비해 다소 높게 평가되었으나 유의적 차이는 거의 없었다.

• 대한한의학원전학회지
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• 제11권1호
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• pp.224-307
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• 1998

The above study is based upon the Theory of Five Woon(Reasons) and Six Qi(Climates), namely Five dynamic Yin and Yang, the principle of five-six combination, the rules of ten periodically changing Woon and twelve periodically changing Qi, and its reference to the main chapters of the theory by several experts. After careful, comprehensive research and study, the followings are concluded. 1. The Theory of Five Woon and Six Qi controls all of the physical phenomena of the universe, yet it originates from Essence of the Sky that is replete and in constant motion within the abysmal expanse of the universe. So it is natural to claim that it is the Essence of the universe that is the source of the variety of phenomena in nature. 2. There is order of dynamics in the Essence and it is Yin Yang Five Movement and expressed by Five Woon and Six Qi. Therefore the Five Woon and Six Qi, which is the climatic changes of nature, is the basis and condition for all of the natural, physical occurrences including the organic phenomena of human beings. 3. Since the Sky embodied the number Five, and the Earth the number Six, Qi of the Sky itself is consequently Five Woon and Qi of the Earth itself is Six Qi. 4. In Sixty Repetition Intervals (Yuk Sip Kap Ja), the Sky took the number Six, designating the six times repetition of the ten Intervals of the Sky and the Earth chose the number Five, symbolizing five times recurrence of the twelve Intervals of the Earth. Though the number for the Sky is Five and the number for the Earth is Six, the two combine and interact in order for the Sky to exploit the number Six and for the Earth to use the number Five. This interplay implies the relationship of operation and principle of Yin in Yang and Yang in Yin. 5. There seems to be clear and intimate association between five dynamics, five bearings and five Qi' in nature and five organs, five stamina, and five emotions in physiological activities of human beings. Such an correlation apparently demonstrates the idea of climatic changes of the universe in balance among human beings, the Sky, and the Earth. 6. Because nature is of an endlessly dynamic organism itself, to have changes must mear there being movements. Thus the climatic changes in nature are the subsequent consummation of the interaction in mutual balance and unbalance of the rise and fall of the Five Woon and Six Qi. 7. The interpretation, by Chang Ji Chong of "Yin and Yang of the Sky are for birth and growth and Yin and Yang of the Earth for demise and interment" as an explanation that the first half is mainly for life and the second half for death, appears to be correct by his view that there is balance and harmony between the long and short and the strong and weak. 8. In addition to Three Yang and Three Yin, as attributes of the Intervals of the Sky and the twelve Intervals of the Earth, Five Woon and Six Qi are utilized in the annual observation of the perpetual changes of climates.

• 한국약용작물학회지
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• 제28권5호
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• pp.339-346
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• 2020

Background: Cnidium officinale Makino have been used in traditional medicine in Northeast Asia. Although gamma-ray mutagenesis has been used to develop breeding resources with novel characteristics, research on the radiation sensitivity of C. officinale Makino is limited. Hence, the optimal gamma-ray dosage for mutation breeding in C. officinale Makino was investigated. Methods and Results: Seedstocks were exposed to doses of gamma rays (5 Gy - 50 Gy), and subsequently planted in a greenhouse. After 30 days of sowing, the survival rates and growth decreased rapidly at doses above 20 Gy, while all individuals died at 50 Gy. The median lethal dose (LD₅₀) was 25.65 Gy, and the median reduction doses (RD₅₀) for plant height, number of stems, and fresh weight were 12.81, 9.32, and 23.26 Gy, respectively. Post-irradiation levels of malondialdehyde (MDA), peroxidase (POD), and chlorophyll in the aerial parts of the plant were quantified using spectrophotometry. Relative to the controls, the levels of MDA and POD increased, while the level of chlorophyll decreased at doses ≥ 10 Gy, indicating cellular damage. Conclusions: A dose of 20 Gy was found to be optimal for mutation breeding in C. officinale Makino.

• Journal of Periodontal and Implant Science
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• 제31권1호
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• pp.123-135
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• 2001

Several growth factors and polypeptides were studied for the regeneration of periodontal supporting tissues which had been lost due to periodontal disease. But these are not commonly used for regenerators of bone tissue or alveolar bone, because of the insufficiency of studies on their side effects, genetic engineering for mass production and stability for clinical application. Recently, many natural products, which have advantage of less side effects and possibility of long-term use, have been studied for their capacity and effects of anti-bacterial, anti-inflammatory and regenerative potential or periodontal tissues. Cnidii Rhizoma, Rhinocerotis Cornu and Drynariae Rhizoma have been traditionally used as a drug for treatment of bone disease in oriental medicine. The purpose of this study was to examine the ability of alkaline phosphatase synthesis of MC3T3-E1 cells when above medicines were supplimented. MC3T3-E1 cells were cultured with ${\alpha}-MEM(negative control)$, dexamethasone(positive control), and each natural products for 3 and 5 days. And then ALP synthesis was measured by spectrophotometer for enzyme activity and by naphthol AS-BI staining for morphometry. Except Cnidii Rhizoma, all of the natural products of this study induced higher activity of ALP synthesis than controls. Among them Drynariae Rhizoma induced the highest activity. In the aspects of culturing time, all medicines did not showed the difference between 3 and 5 days, but $10^{-7}g/ml$ group of Rhinocerotis Corun showed significant increase at 3 days than at 5 days. These results indicate that several natural products have a inducing ability of ALP synthesis on osteoblasts.