• Nutrition Research and Practice
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• 제3권2호
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• pp.89-94
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• 2009

The aim of this study was to investigate if dietary Chlorella vulgaris(chlorella) intake would be effective on cadmium(Cd) detoxification in rats fed dietary Cd. Fourteen-week old male Sprague-Dawley(SD) rats weighing $415.0{\pm}1.6\;g$ were randomly divided into two groups and fed slightly modified American Institute of Nutrition-93 Growing(AIN-93G) diet without(n=10) or with(n=40) dietary Cd(200 ppm) for 8 weeks. To confirm alteration by dietary Cd intake, twenty rats fed AIN-93G diet without(n=10) and with(n=10) dietary Cd were sacrificed and compared. Other thirty rats were randomly blocked into three groups and fed slightly modified AIN-93G diets replacing 0 (n=10), 5 (n=10) or 10% (n=10) chlorella of total kg diet for 4 weeks. Daily food intake, body weight change, body weight gain/calorie intake, organ weight (liver, spleen, and kidney), perirenal fat pad and epididymal fat pad weights were measured. To examine Cd detoxification, urinary Cd excretion and metallothonein (MT) concentrations in kidney and intestine were measured. Food intake, calorie intake, body weight change, body weight gain/calorie intake, organ weight and fat pad weights were decreased by dietary Cd intake. Urinary Cd excretion and MT concentrations in kidney and small intestine were increased by dietary Cd. After given Cd containing diet, food intake, calorie intake, body weight change, body weight gain/calorie intake, organ weights and fat pad weights were not influenced by dietary chlorella intake. Renal MT synthesis tended to be higher in a dose-dependent manner, but not significantly. And chlorella intake did not significantly facilitate renal and intestinal MT synthesis and urinary Cd excretion. These findings suggest that, after stopping cadmium supply, chlorella supplementation, regardless of its percentage, might not improve cadmium detoxification from the body in growing rats.

• Journal of Nutrition and Health
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• 제41권3호
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• pp.199-205
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• 2008

성장기 암컷 쥐를 대상으로 이소플라본 섭취수준에 따라 골대사 지표 및 골대사 관련 호르몬에 미치는 영향을 알아 보기 위해 실시한 연구 결과를 요약하면 다음과 같다. 1) 체중증가량과 식이섭취량, 식이효율은 이소플라본의 섭취수준에 따라 실험군간에 유의적인 차이가 없었다. 2) 골형성 지표인 혈청 ALP, osteocalcin은 이소플라본 섭취수준에 따라 실험군간에 유의적인 차이는 없었다. 3) 골흡수 지표인 DPD crosslink value도 이소플라본 섭취수준에 따라 실험군간에 유의적인 차이는 없었다. 4) 혈청 에스트로겐 농도, 부갑상선 호르몬과 인슐린유사 성장인자-I 농도는 이소플라본 섭취수준에 따라 유의적인 차이가 없었다. 5) 칼시토닌농도는 1IF군과 1/2IF군 보다 1IF군이 골형성과 골흡수에 유리한 경향을 나타내었고 칼시토닌과 성장호르몬이 유의적으로 증가하여 장기적으로는 골대사에 더 유리한 영향을 미칠 것으로 사료된다.

• 한국영양학회:학술대회논문집
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• 한국영양학회 2002년도 춘계학술대회
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• pp.96-96
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• 2002

• 한국영양학회:학술대회논문집
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• 한국영양학회 2001년도 추계학술대회 초록
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• pp.60-60
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• 2001

• 한국영양학회:학술대회논문집
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• 한국영양학회 2003년도 연합학술대회
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• pp.124.1-124.1
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• 2003

• 대한치과교정학회지
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• 제53권6호
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• pp.393-401
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• 2023

Objective: To investigate the long-term effects of 4-hexylresorcinol (4HR) on facial skeletal growth in growing male rats, with a focus on diabetic animal models. Methods: Forty male rats were used. Of them, type 1 diabetes mellitus was induced in 20 animals by administering 40 mg/kg streptozotocin (STZ), and they were assigned to either the STZ or 4HR-injected group (STZ/4HR group). The remaining 20 healthy rats were divided into control and 4HR groups. We administered 4HR subcutaneously at a weekly dose of 10 mg/kg until the rats were euthanized. At 16 weeks of age, whole blood was collected, and microcomputed tomography of the skull and femur was performed. Results: All craniofacial linear measurements were smaller in the STZ group than in the control group. The mandibular molar width was significantly smaller in the 4HR group than in the control group (P = 0.031) but larger in the STZ/4HR group than in the STZ group (P = 0.011). Among the diabetic animals, the STZ/4HR group exhibited significantly greater cortical bone thickness, bone mineral density, and bone volume than the STZ group. Serum testosterone levels were also significantly higher in the STZ/4HR group than in the STZ group. Conclusions: 4HR administration may have divergent effects on mandibular growth and bone mass in healthy and diabetic rats. In the context of diabetes, 4HR appears to have beneficial effects, potentially through the modulation of mitochondrial respiration.

• Journal of Animal Science and Technology
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• 제45권5호
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• pp.749-758
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• 2003

우리나라와 중국에서 인삼과 함께 고귀한 한방 강장제로 사용되고 있는 녹용의 효능에 대하여 알고자 본 실험은 녹용분말을 급여하였을 때 흰쥐의 발육에 미치는 영향에 대하여 고찰하고자 실시하였다. Sprague-Dawley종 5주령의 어린쥐와 10주령의 큰쥐를 각각 12두씩 처리구별로 임의 배치하였고, 녹용분말을 급여하지 않는 대조구, 녹용분말 I구 (권장량) 그리고 녹용분말 II구 (권장량 3배)로 구분하여 10주간 사육하였으며 실험쥐의 성장발육, 사료섭취량, 사료요구율 및 장기발육에 대하여 조사하였다. 그리고 본 실험의 녹용분말 권장량은 몸무게가 70 kg (대사체중: 24.2 kg)인 성인에게 권장된 녹용분말 7.5 g/day를 기준으로 하여 실험쥐의 대사체중 (Wkg0.75)를 적용하여 계산하였다. 실험쥐들에 대한 성장발육은 어린쥐의 녹용분말 급여구에서 실험 종료시 체중이 다소 좋게 나타났지만 처리구간에 현격한 차이는 발견되지 않았다. 그러나 큰쥐의 경우는 녹용분말을 급여 I구와 II구 모두에서 녹용분말을 급여하지 않은 실험쥐 보다 전 실험 기간동안 좋은 성장을 보였으며, 실험 종료시 대조구, 녹용분말 I구와 II구의 체중은 각각 어린쥐가 470${\pm}$39.00g, 478${\pm}$30.33g과 475${\pm}$22.72g 그리고 큰쥐가 485${\pm}$38.50g, 521${\pm}$38.67g과 508${\pm}$34.44g으로 어린쥐 및 큰쥐 모두 녹용분말 I구의 체중이 가장 높았다. 사료섭취량은 녹용분말 급여에 의하여 특별한 영향을 받지 않았으며, 사료요구율은 대조구, 녹용분말 I구와 II구에서 각각 어린쥐가 5.99, 5.47과 5.54, 그리고 큰쥐가 9.04, 7.73와 8.18로 어린쥐와 큰쥐 모두에서 녹용분말 급여구에서 사료효율이 좋았으며 권장량의 녹용분말을 급여하였을 때 가장 좋은 사료효율을 보였다. 그리고 장기 무게에 있어서는 처리구간 큰 차이를 보이지는 않았지만 녹용분말을 급여한 어린쥐와 큰쥐의 간장, 심장 신장 및 위장의 발육이 좋은 경향을 보였으며 녹용분말 급여량을 달리함에 따라 장기 발육에 미친 영향에 대한 특별한 경향은 발견하지 못하였다. 또한 간장과 신장은 혈액과 중요한 관계가 있는 장기로 녹용분말 급여가 이들 발육에 영향을 주었다는 결과는 녹용의 조혈 작용에 대한 가능성을 시사한다고 볼 수 있다. 결론적으로 녹용분말 급여가 어린쥐와 큰쥐의 성장, 사료요구율 및 장기 발육에 좋은 영향을 주었으며, 녹용 급여량에 대한 세부적 연구는 더 필요하지만 본 실험에서는 권장량을 급여하였을 때 더 바람직한 결과를 얻었다.

• Preventive Nutrition and Food Science
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• 제7권3호
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• pp.278-281
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• 2002

The objective of the current study was to determine the influences of dietary proteins and methionine on plasma lipid concentrations. Thirty growing male Sprague-Dawley rats were fed diets similar in all respects except that dietary protein was from either casein, soy protein isolate, or soy protein isolate supplemented with L-methionine (0.24 %). The animals were fed experimental diets ad libitum for nine weeks. Plasma total-cholesterol concentrations were unaffected by the protein source or methionine supplementation. Plasma triglyceride concentrations were lower in rats of methionine supplemented soy protein diets (76 mg/dL) than in the rats fed casein or soy diet (120 mg/dL, 109 mg/dL, respectively). These results indicate that soy protein reduces plasma triglycerides relative to casein in rats fed cholesterol free diets, and that methionine-supplemented soy diets decrease plasma triglyceride concentrations more than soy protein alone.

• 대한가정학회지
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• 제24권2호
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• pp.51-62
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• 1986

This study was designed to observe the effects of nutritional supplementation of general Korean diet on protein metabolism in growing rats. Seventy weanling Sprague-Dawely male rats weighing 76.8$\pm$1.45g were blocked into ten groups and fed ten different experimental diets for eight weeks. The rats in cereal-vegetable group were fed ad libitum for all the experimental period and those in other experimental groups were pairfed following the feed intake of rats in C-V gp. Control group was given 72% cornstarch-29% casein diet : C-V gp was fed cerealvegetable diet composed of rice, barley, soybean and Chinese cabbage : the other eight groups were fed C-V diets supplemented with casein, vitamin B\sub 2\ calcium, vitamin A, vitamin B\sub 2\ and vitamin A, vitamin A and calcium, vitamin B\sub 2\ and calcium, vitamin A and vitamin B\sub 2\ and calcium, respectively, on the basis of each nutrients content of standard diet.

• Journal of Nutrition and Health
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• 제24권1호
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• pp.20-29
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• 1991

This study was carried out to compare the protein quality of lamb and beef meat. by feeding to growing rats. Sixty weanling rats, 30 males and 30 females, were blocked into 12 groups(6 gruops of males and 6 groups of females). They were fed casein. beef, or lamb as a protein source at two levels, 6 and 15%, for 5 weeks. The amount of food intake. food efficiency ratio, protein efficiency ratio. body weight gain. and the weights of skeletal muscles and liver were measured. Nitrogen retention, protein content in the liver and skeletal muscles, and the levels of protein and cholesterol in the serum were also assayed. Summarzing the results, there were no significant differences between lamb and beef on the growth and nitrogen utilization in the rats fed same percentage of protein diet. However. rats fed 15% protein diet showed significantly higher growth rate than those fed 6%. Therefore, it can be concluded that lamb is as good a protein food as beef in terms of protein quality.