• Title/Summary/Keyword: grading distribution

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The C609T (Pro187Ser) Null Polymorphism of the NQO1 Gene Contributes Significantly to Breast Cancer Susceptibility in North Indian Populations: a Case Control Study

  • Yadav, Prasant;Mir, Rashid;Nandi, Kajal;Javid, Jamsheed;Masroor, Mirza;Ahmad, Imtiyaz;Zuberi, Mariyam;Kaza, RCM;Jain, SK;Khurana, Nita;Ray, Prakash Chandra;Saxena, Alpana
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.3
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    • pp.1215-1219
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    • 2016
  • Background: Worldwide, breast cancer is the most common cancer among women and is a leading cause of cancer death. In the present study, we investigated the NQO1 C609T genotypic and allelic distribution in north Indian breast cancer patients. Materials and Methods: The genotypic distribution of the NQ01 C609T polymorphism was assessed in 100 invasive ductal carcinoma (IDC) breast cancer patients and 100 healthy controls using allele specific PCR (AS-PCR). Results: A lower frequency of the CC genotype was found in breast cancer patients (24%) than in the controls. On the other hand, TT genotype frequency was also found to be higher in female healthy controls (32%) than the female breast cancer patients (20%). The frequencies of all three genotypes CC, CT, TT in patients were 24%, 56% and 20% and in healthy controls 50%, 22% and 32% respectively. We did not find any significant correlation between the NQO1 C609T polymorphism and age group, grading, menopausal status and distant metastasis. A less significant association was found between the NQ01 C609T polymorphism and the stage of breast cancer (X2=5.931, P=0.05). Conclusions: The present study shows a strong association between NQO1 C609T polymorphism with the breast cancer risk in the north Indian breast cancer patients so that possible use as a risk factor should be further expel.

Geochemical Exploration for Metallic Mineral Resources on the Pacitan District, East Java, Indonesia (인도네시아 빠찌딴지역 금속광물자원에 대한 지화학탐사)

  • Han, Jin-Kyun;Choi, Sang-Hoon
    • Economic and Environmental Geology
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    • v.44 no.1
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    • pp.1-10
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    • 2011
  • The geology of the Pacitan district which occupies Southern mountain zone in the southwestern margin of East Java, Indonesia, consists of a pile of clastics and pyroclastics grading upwards into a series of sediments of Middle Miocene age which are intruded by a number of quartz porphyries and subvolcanic dacitic to andesitic bodies in after that time. The geochemical exploration in the Pacitan district to find out anomalous areas related with metallic mineral dispersion from the concealed ore deposits had been carried out using traditional exploration techniques of geological mapping, stream sediment, panned concentrate and outcrop sampling. The anomalous zones of each element were detected in the following areas: Gempol for Cu; Jompong for Au; Kasihan for Cu-Pb-Zn. The strongest Cu-Pb-Zn anomalous values are overlapped at the Kasihan area. The geochemical survey of soil was conducted with the geological survey at the Kasihan area. The statistical values were calculated by the statistical analysis method. The patterns for Cu, Pb and Zn are similar to the normal distribution. The anomalous values of copper-lead-zinc and/or copper and zinc are overlapped at five zones surrounding quartz porphyry at the central part of the Kasihan area. The area was interpreted and chosen as an anomalous zone related with stockwork and skam mineralization, extending to approximately NNW-SSE direction.

Discrimination study between carcass yield and meat quality by gender in Korean native cattle (Hanwoo)

  • Kim, Do-Gyun;Shim, Joon-Yong;Cho, Byoung-Kwan;Wakholi, Collins;Seo, Youngwook;Cho, Soohyun;Lee, Wang-Hee
    • Asian-Australasian Journal of Animal Sciences
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    • v.33 no.7
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    • pp.1202-1208
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    • 2020
  • Objective: The aim of this study was to identify a distribution pattern of meat quality grade (MQG) as a function of carcass yield index (CYI) and the gender of Hanwoo (bull, cow, and steer) to determine the optimum point between both yield and quality. We also attempted to identify how pre- and post-deboning variables affect the gender-specific beef quality of Hanwoo. Methods: A total of 31 deboning variables, consisting of 7 pre-deboning and 24 post-deboning variables from bulls (n = 139), cows (n = 69), and steers (n = 153), were obtained from the National Institute of Animal Science (NIAS) in South Korea. The database was reconstructed to be suitable for a statistical significance test between the CYI and the MQG as well as classification of meat quality. Discriminant function analysis was used for classifying MQG using the deboning parameters of Hanwoo by gender. Results: The means of CYI according to 1+, 1, 2, and 3 of MQG were 68.64±2.02, 68.85±1.94, 68.62±5.88, and 70.99±3.32, respectively. High carcass yield correlated with low-quality grade, while high-quality meat most frequently was obtained from steers. The classification ability of pre-deboning parameters was higher than that of post-deboning parameters. Moisture and the shear force were the common significant parameters in all discriminant functions having a classification accuracy of 80.6%, 71%, and 56.9% for the bull, cow, and steer, respectively. Conclusion: This study provides basic information for predicting the meat quality by gender using pre-deboning variables consistent with the actual grading index.

Relative Frequency of Oral Malignancies and Oral Precancer in the Biopsy Service of Jazan Province, 2009-2014

  • Idris, AM;Vani, NV;Saleh, Sanna;Tubaigy, Faisal;Alharbi, Fahd;Sharwani, Abubkr;Tadrus, Nabil;Warnakulasuriya, Saman
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.2
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    • pp.519-525
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    • 2016
  • Background: The objective of this study was to report the types and relative frequency of oral malignancies and precancer in the Jazan region of Saudi Arabia during the period 2009-2014. Materials and Methods: Pathology reports were retrieved from the archives of Histopathology Department, King Fahd hospital in Jazan. Demographic data on tobacco habits, clinical presentation and histologic grading of oral precancer and cancer cases were transcribed from the files. Results: 303 (42.7%) oral pre-malignant and malignant cases were found out of 714 oral biopsy lesions. A pathology diagnosis of squamous cell carcinoma (85.1%) was most frequent, followed by premalignant lesions/epithelial dysplasia (8.6%), verrucous carcinoma (3.3%) and malignancy of other histological types (3%) such as ameloblastic carcinoma, salivary gland malignancy and sarcomas. Oral squamous cell carcinoma was predominant in females with a male to female ratio of 1:1.9. Patient age ranged from 22 to 100 years with a mean of $65{\pm}13.9$. Almost 44.6% of oral cancer had occurred after 65 years of age. Only 16.3% cases were reported in patients younger than 50 years, predominantly females. The majority of female patients had the habit of using shammah with a long duration of usage for more than 45 years. Buccoalveolar mucosa (52.3%) was the common site of involvement followed by tongue/floor of the mouth (47.7%) and clinically presented mostly as ulceration/swelling clinically. Moderately differentiated tumours (53.9%) were common followed by well differentiated (32.2%) and poorly differentiated tumours (5.8%). The prevalence of oral verrucous carcinoma (3.3%) was comparatively low with an equal distribution in both males and females. Both bucco-alveolar mucosa and tongue were predominantly affected. Oral precancer/epithelial dysplasia (8.6%) was common in females with a shammah habit. Bucco-alveolar mucosa was commonly involved and clinically presented mostly as white/red patches. Most cases were mild followed by moderate and severe dysplasia. Tumours of other histological types (3%) include 1 ameloblastic carcinoma, 3 malignant salivary gland tumours and 5 sarcomas. Conclusions: In this study, it was found that oral cancers reported in the pathology service to be a common occurrence. This study reconfirms previous reports of the high burden of oral cancer in this population This indicates that conventional preventive programs focused on oral cancer are in need of revision. In addition, further research into identifying new risk factors and molecular markers for oral cancer are needed for screening high risk individuals.

A Clinical Database of Breast Cancer Patients Reveals Distinctive Clinico-pathological Characteristics: a Study From Central China

  • Wang, Lin-Wei;Yang, Gui-Fang;Chen, Jia-Mei;Yang, Fang;Yuan, Jing-Ping;Sun, Sheng-Rong;Chen, Chuang;Hu, Ming-Bai;Li, Yan
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.4
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    • pp.1621-1626
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    • 2014
  • Background: Breast cancer is the most common malignant tumor in females worldwide. Many differences exist in clinico-pathological characteristics of breast cancer patients between China and Western countries. This study aimed to analyze clinico-pathological characteristics of breast cancer from central China. Methods: Clinico-pathological information on breast cancer from three hospitals in central China was collected and analyzed. Results: From 1994 to 2012, 2,525 patients with a median age 50 years were included in this study. The 45-49-year age group and invasive ductal carcinoma not otherwise specified accounted for the highest proportions (19.1%, 480/2,525 and 81.0%, 1,982/2,446). Stages 0-I, II and III accounted for 28.0% (682/2,441), 48.4% (1,180/2,441), and 23.7% (578/2,441), respectively. Distribution of N stage showed that N0 accounted for 53.2% (1,344/2,525), and proportion of N0 rose from 51.1% (157/307) in 30-39-year age group to 64.3% (110/171) in ${\geq}$ 70-year age group, with an average increase of 2.1% in each age group. Modified radical mastectomy, radical mastectomy, breast-conserving surgery and simple mastectomy were performed for 71.8% (1,812/2,525), 18.0% (454/2,525), 5.2% (131/2,525) and 2.6% (66/2,525), respectively. Proportions of breast-conserving surgery in age ${\leq}$ 44-year group (68/132, 51.5%) and simple mastectomy in age ${\geq}$ 60-year group (57/89, 64.0%) were higher than in the other age groups. Breast cancers positive for estrogen receptor accounted for 53.0% (1,107/ 2,112). The comparisons among this study and other reports showed higher proportion of younger patients, lower proportion of breast-conserving surgery and positive estrogen receptor patients in China than western countries. Conclusions: Clinico-pathological characteristics in this study demonstrated clear differences between the center of China than Western countries. Additional classification systems should be developed to guide grading of early breast cancer more accurately, especially for N0 patients. Invasive ductal carcinoma is a focus for intensive research.

Demographic Characteristics of Korean Men A Study on Correlation with Preference for Female Hair Style (한국 남성의 인구통계학적 특성 요인과 여성 헤어스타일에 대한 선호도와의 상관성 연구)

  • Son, Gwang Hyun;Park, Jang Soon
    • Journal of the Korea Convergence Society
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    • v.9 no.9
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    • pp.263-270
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    • 2018
  • The purpose of this study is to investigate the correlation between the demographic characteristics of Korean men and the preference of women's grading such as age, education, marital status, occupation, monthly income, and residence. After the questionnaire distribution, 333 questionnaires were analyzed statistically. Through this study, we will investigate the preference of men according to the step length of women's graduation cuts, and contribute to the establishment of the most preferred type of graduation cuts. As a result of the questionnaire analysis, 51.1% of all males preferred the gradation type with a large step of the cut length, and it was found that there was a difference in the preference for the step according to demographic characteristics (p <0.05) It is possible to conduct various studies on the style of the graduation cut among the hairstyles of women who are visually preferred and beautiful. In addition, it will be possible to derive the importance of customer satisfaction in hair salons, and it will be a basic index for searching for changes in the gradation cuts that can be applied in various ways while maximizing the aesthetic image of women.

Engineering Characteristics of Ultra High Strength Concrete with 100 MPa depending on Fine Aggregate Kinds and Mixing Methods (잔골재 종류 및 혼합방법 변화에 따른 100 MPa 급 초고강도 콘크리트의 공학적 특성)

  • Han, Min-Cheol;Lee, Hong-Kyu
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.17 no.2
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    • pp.536-544
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    • 2016
  • Recently, with the increase in the number of high rise and huge scaled buildings, ultra-high strength concrete with 80~100 MPa has been used increasingly to withstand excessive loads. Among the components of concrete, the effects of the kinds and properties of fine aggregates on the performance and economic advantages of ultra-high strength concrete need to be evaluated carefully. Therefore, this study examined the effects of the type of fine aggregates and mixing methods on the engineering properties of ultra-high strength concrete by varying the fine aggregates including limestone fine aggregate (LFA), electrical arc slag fine aggregate (EFA), washed sea sand (SFA), and granite fine aggregate (GFA) and their mixtures. Ultra-high strength concrete was fabricated with a 20 % water to binder ratio (W/B) and incorporated with 70 % of Ordinary Portland cement: 20 % of fly ash:10 % silica fume. The test results indicate that for a given superplasticizer dose, the use of LFA resulted in increases in slump flow and L-flow compared to the mixtures using other aggregates due to the improved particle shape and grading of LFA. In addition, the use of LFA and EFA led to enhanced compressive strength and a decrease in autogenous shrinkage due to the improved elastic properties of LFA and the presence of free-CaO in EFA, which resulted in the formation of C-S-H.

Analysis of the Descriptive Evaluation's Status in Middle School Science: Focused on the Item's Type, Subject Unit, and Evaluation Object (중학교 과학에서 서술형 평가의 실태 분석: 문항유형, 단원, 평가목표를 중심으로)

  • Noh, Eun Sill;Kim, Yong-Jin
    • Journal of Science Education
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    • v.42 no.2
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    • pp.198-213
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    • 2018
  • In recent years, descriptive evaluation has been gaining importance at school. The purpose of this study is to analyse descriptive evaluation items which have been made by school teachers. 300 items for regular examinations are collected from 7 middle schools (grades 1 through 3) in Gyeongnam Province. Distribution and types of items are examined to compare educational objectives of standard achievements and those of evaluation according to Bloom's revised taxonomy of educational objectives. The result shows that there exist a majority of shared subject units for descriptive evaluation. Huge difference of frequency is also found among subject units and standard achievements. Less than 65% of evaluation items are descriptive and the rest is simple completion or short answers. In addition, it reveals only 40.3% of agreement between educational objectives of standard achievements and those of evaluation items. The interviews with 27 teachers indicate that lack of ability to develop proper items and grading are the major obstacles. In conclusion, systematic training courses are to be provided in order to resolve issues over descriptive evaluation.

Comparison of Korean Classification Models' Korean Essay Score Range Prediction Performance (한국어 학습 모델별 한국어 쓰기 답안지 점수 구간 예측 성능 비교)

  • Cho, Heeryon;Im, Hyeonyeol;Yi, Yumi;Cha, Junwoo
    • KIPS Transactions on Software and Data Engineering
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    • v.11 no.3
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    • pp.133-140
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    • 2022
  • We investigate the performance of deep learning-based Korean language models on a task of predicting the score range of Korean essays written by foreign students. We construct a data set containing a total of 304 essays, which include essays discussing the criteria for choosing a job ('job'), conditions of a happy life ('happ'), relationship between money and happiness ('econ'), and definition of success ('succ'). These essays were labeled according to four letter grades (A, B, C, and D), and a total of eleven essay score range prediction experiments were conducted (i.e., five for predicting the score range of 'job' essays, five for predicting the score range of 'happiness' essays, and one for predicting the score range of mixed topic essays). Three deep learning-based Korean language models, KoBERT, KcBERT, and KR-BERT, were fine-tuned using various training data. Moreover, two traditional probabilistic machine learning classifiers, naive Bayes and logistic regression, were also evaluated. Experiment results show that deep learning-based Korean language models performed better than the two traditional classifiers, with KR-BERT performing the best with 55.83% overall average prediction accuracy. A close second was KcBERT (55.77%) followed by KoBERT (54.91%). The performances of naive Bayes and logistic regression classifiers were 52.52% and 50.28% respectively. Due to the scarcity of training data and the imbalance in class distribution, the overall prediction performance was not high for all classifiers. Moreover, the classifiers' vocabulary did not explicitly capture the error features that were helpful in correctly grading the Korean essay. By overcoming these two limitations, we expect the score range prediction performance to improve.

A Survey on the Effect of Consumer's Social-Economic Status on Beef Purchase Attitude (소비자의 사회 경제적 위치가 쇠고기 구매 태도에 미치는 영향)

  • Lee, Seong-Kap;Yang, Seok-Jin;Kim, Dong-Hoon;Cho, Bong-Jae;Jang, Jung-Young;Lee, Hyo-Ku;Yoon, Bo-Ra;Lee, Young-Jun;Lee, Ok-Hwan
    • The Korean Journal of Food And Nutrition
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    • v.25 no.1
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    • pp.132-141
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    • 2012
  • This current survey was conducted to examine consumer attitudes toward factors determining beef purchasing and improving distribution systems. The frequency of beef purchasing was shown to reflect social and economic status, where inhabitants in large cities, such as Seoul, with higher salaries showed a higher frequency. In addition, consumers that were in their forties bought beef more frequently than consumers that were in their twenties. Consumers in Seoul and the megalopolis with a monthly income of higher than 200 million won preferred to purchase meat from department stores and discount markets. In contrast, people in small cities with lower incomes tended to buy meat from butcher shops and brand shops. In a question regarding unsatisfaction factors of retail beef, individuals that were in their thirties with a high income had concerns associated with packaging problems. For people under thirty with low income, the consistency of quality and price were the prime concerns. In regards to the beef grading system, consumer response varied between inhabitants, monthly income and age group, where consumers from small cities that were in their twenties and forties with a low income had a negative viewpoint. For the differential beef distribution system, housewives between the ages of 30 and 40 from a small city with an income higher than 200 million won had a positive response; however, a large number of consumers were not familiar with this system. The most demanding beef cuts were in the following order: loin, flank and rib. In addition, the most important factors determining purchasing beef were as follows: price, breed and portion.