Introduction: The nuclear factor ${\kappa}B$ (NF-${\kappa}B$) is a super family of transcription factors which plays important roles in development and progression of cancer. The present investigation concerns NF-${\kappa}B$ /p65 activity in human breast cancers with overexpression of ER, PR, HER-2/neu, as well as the significance of p65 expression with regard to menopausal status, stage, grade, tumor size, nodal status, and NPI of invasive ductal carcinomas in Eastern India. Materials and Methods: In this hospital based study 57 breast cancer patients attending a Breast Clinic of a reputed institute of Eastern India were assessed for p65 protein expression in breast tumor tissue samples by Western blotting. ER, PR and HER-2/neu expression was determined by immunohistochemistry. Results: NF-${\kappa}B$/p65 was significantly associated with advanced stage, large tumor size (${\geq}5$ cm), high grade, negative ER, negative PR, and positive HER-2/neu. High NF-${\kappa}B$/p65 expression was more frequent in patients with a high NPI ($NPI{\geq}5.4$, 84.6%) compared with low NPI (<5.4, 44.4%) and this association was statistically significant (p = 0.002). Conclusion: NF-${\kappa}B$/p65 overexpression was associated with advanced stage, large tumor size, high grade, and high NPI which are poor prognostic factors linked to enhanced aggressiveness of the disease. NF-${\kappa}B$/p65 expression implies aggressive biological behavior of breast cancer and this study validates significant association of NF-${\kappa}B$ /p65 overexpression with negative estrogen and progesterone receptor status and overexpression of HER-2/neu oncoprotein. In our good clinical practice, patients with NF-${\kappa}B$ positive tumors need to be treated aggressively.
The fire hazards and combustion heat of puzzle mats in group day care home were analysed using variable external irradiation level. The fire hazards such as ignition time, ignition temperature, mass loss rate, and flame temperature profile were measured. Incident heat fluxes of $15kW/m^2$, $20kW/m^2$, $25kW/m^2$, $35kW/m^2$, $50kW/m^2$ and $75kW/m^2$ were selected for these experiments. All samples were tested in the horizontal orientation and were wrapped in a single layer of aluminium foil. Each sample was nominally 20mm thick and 100mm square. Five samples of puzzle mat were tested in the study : Type A, B, C, D and E. Type A, B and C are all general grades whereas Type D and E are both Flame retardant grades. As results, Type E of FR-grade showed the best characteristics in safety of the early fire from ignition time, critical heat flux, and ignition and flame temperature data of this study. All specimen of G-grade(Type A, B and C), however, showed the weak in safety of fire.
To obtain information about knowledge and attitude toward sex, sexural experience and need of sex education, a questionnaire survey was conducted on 599 students who were attended in 2nd grade of 2 girls' high schools(A group: 190 girls), 2 vocational girls' high schools(B group: 205 girls), and 2 special girls' high school attached to industrial company(C group: 204 girls) in Taegu city between 20th and 25th April 1992. Mean score of knowledge toward sex of the total was 9.3. Mean score of A group was higher than that of Band C groups. Among the total students, vocational high school girls were the highest affirmative attitude towards the acquaintance and relationship with the other sex, and the next was special high school girls. Students of B group assumed the highest negative attitude towards artificial abortion, and the lowest was A group. Among the respondent girls, 31.1% did not experienced in the acquaintance and relationship with the other sex and 86 girls(14.4%) had experience with sexual affairs. Most of girls(96.9% of A group, 90.4% of B group and 86.8% of C group) agreed to necessity of sex education, and answered that current education on sex was insufficient to them(80.6% of A group, 82.6% of B group and 62.4% of C group). Among what the surveyed girls wanted to know about knowledge towards sex, they showed the highest interest on the acquaintance and relationship with the other sex(A group: 44.7%, B group: 45.4%, C group: 56.4%). And they showed the second highest interest on pregnancy and delivery(A group: 33.2%, B group: 32.6% , C group: 26.5%). There was no unique difference among each surveying item. Most of the students(A group: 46.8%, B group: 40.1%, C group: 36.3%) thought it better that the time they wanted to get education on sex in 5th or 6th grade of elementary schools and to have a regular curriculum on sex education.
In this study, the research objects are gilt plated silver-iron nails excavated from the west of the tombs in Neungsan-ri, Buyeo. A gilt plated silver-iron nail was fabricated by combining silver and iron via heating and then gilding amalgam on top of this combination, demonstrating that this ancient artifact that can be replicated using current technology. Since the metal (Au, Ag) surface of these gilt plated artifacts are covered with iron oxide, which slips into the cracks and scratches of the artifacts as well, desalination is essential. Based on the results of the preliminary experiment, the research objects were classified into grades A, B, and C, according to the degree of corrosion and then desalinated using an alkali solution (NaOH, Sodium Sesquicarbonate of 0.1 M) at 60℃. The results demonstrate that the more serious is the degree of corrosion, the more is the amount of Cl- detected. Further, more Cl- was released when NaOH was used than when sodium sesquicarbonate was used, for all grades except Grade A. Furthermore, the more serious is the degree of corrosion, the longer is the desalination period and the reaction with NaOH for all grades except Grade A. A comparison of the Fe composition of the surface before and after desalination shows that Fe composition is the use of NaOH resulted in a smaller increase compared with the use of sodium sesquicarbonate, for all grades except Grade B. However, four of the nails were damaged owing to NaOH (Grade B 3ea, Grade C 1ea) during desalination. Thus, Cl- ions are more stably released when sodium sesquicarbonate is used than when NaOH is used.
Park, Cheon-Jin;Ra, Jung-Hwa;Cho, Hyun-Ju;Kim, Jin-Hyo;Kwon, Oh-Sung
Journal of the Korean Institute of Landscape Architecture
/
v.40
no.4
/
pp.114-126
/
2012
The purpose of this study is to find ways of the view evaluation of biotope classification before development by selecting an area, which is as large as about $10.0km^2$ around Non Gong Up, Auk Po Myun, Dalsung Gun, Daugu where the large project has been planned, as a subject of this study. The results of this study are as follows. Because of the classification of biotope, there are 23 kinds of types that are subdivided into 140 types. Three surveys for selecting the assessment indicators were performed. The first survey analyzed the importance of 22 selected assessment indicators based on the evaluation of an existing literature review and on the spot research. The second survey performed factor analysis and reclassified the value indicators. The third survey computed additive values of the selected assessment indicators. It used a method of standardizing the average importance of indicators by making their sum equal by 10. Theses additive values were then multiplied by each grade of indicators in order to make a final evaluation. The number of assessment indicators finally selected through the survey of asking specialist is vitality elements, visual obstructs elements etc 19. According to the result of evaluation of 1st, 1 grade spaces which especially valuable is analyzed that 7 spaces, 2 grade spaces for 4, 3 grade spaces for 5, 4 grade space for 2, 5 grade space for 5. Because of the evaluation of 2st, 1 grade spaces which especially valuable(1a, 1b) is analyzed that 15 spaces, 2 grade spaces which valuable is analyzed that 28 space. As the evaluation of site suitability model of this study couldn't have high applicability to other similar area because of having only one site as a subject, it is needed to do synthesize and standardization of various examples to have higher objectivity later.
Sung-Wook Kim;Sang-Yoon Park;Chang-Hyun Roh;Sun-Byeong Kim
Nuclear Engineering and Technology
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v.55
no.6
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pp.2256-2262
/
2023
The electrochemical corrosion behaviors of SA106 Grade B (SA106B) carbon steel in H2SO44-N2H4 and H2SO4-N2H4-CuSO4 solutions at 95 ℃ have been investigated with the addition of commercial corrosion inhibitors (CI#30 and No. 570S), to determine the stability of SA106B in the hydrazine-based reductive metal ion decontamination (HyBRID) process. The potentiodynamic polarization experiment revealed that the corrosion inhibitors were capable of lowering the corrosion rate of SA106B in H2SO4-N2H4 solution. It was found that the corrosion inhibitors induced formation of fixed surface layer on the carbon steel upon the corrosion. This corrosion inhibition performance was reduced in the presence of CuSO4 in the solution owing to the chemical reactions between organic compounds in the corrosion inhibitors and CuSO4. CI#30 showed a better corrosion inhibition effect in the H2SO4-N2H4-CuSO4 solution. Although the corrosion inhibitors can provide better stability to SA106B in the HyBRID solution, their application should be carefully considered because it may result in reduced decontamination performance and increased secondary waste generation.
Purpose: The purpose of this article is to assess the efficacy of a bioabsorbable polylactide (PLA) plate and screw for treating injuries of ankle fractures. Materials and Methods: 24 patients who underwent an open reduction and internal fixation operation for ankle fractures from July 2005 to March 2007 were enrolled into the study. There were 15 men and 9 women. The average age of the patients was 44 years and the average follow-up period was 16 years and two months (16.2 months). All cases were divided into low grade fracture patient (11) who belongs in type A and B of Danis-Weber classification and high grade fracture patient (13) who belongs in type C1, C2 of Danis-Weber classification, and each groups were analyzed by clinical (Meyer score) and radiological finding at the time of their last follow-up evaluation. Results: The clinical results according to Meyer scoring system, showed that all patient with low grade fracture had good to excellent result, but only 54% of patient with high grade fracture had good to excellent result. According to Cedell's radiologic finding, there were 91% cases above fair in low grade fracture. But there were 62% of patient above fair result in high grade fracture, the reduction losses were seen in 38% of patient with high grade fracture. Conclusion: Bioabsorbable PLA plate and screw is good internal fixation device which doesn't have additional operation for removal of implant because of slow absorption within the human body. It showed sufficient strength for acquisition and maintenance of reduction in low grade fracture, but need attention to use because of many cases of reduction loss in high grade fracture. So, it seems to be safe and effective when used in heeling of low grade fracture under considering about type of fracture sufficiently.
Journal of the Korean Society of Environmental Restoration Technology
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v.22
no.3
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pp.31-54
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2019
The purpose of this study is to present the basic data for establishing the management plan of forest ecosystem in Honam-Jeongmeak and Geumnamhonam-Jeongmaek by surveying and analysing the vascular plants distributed in Jangansan(A-site), Palgongsan(B-site), Mandeoksan(C-site), Chuwolsan (D-site), Cheonunsan(E-site) and Jeamsan(F-site). The numbers of flora were 813 taxa including 115 families, 406 genera, 700 species, 4 subspecies, 94 varieties and 15 forms. There were 500 taxa in A-site, 427 taxa in B-site, 402 taxa in C-site, 449 taxa in D-site, 345 taxa in E-site and 524 taxa in F-site. The rare plants were 12 taxa including Paeonia japonica, Iris minutoaurea, Chloranthus fortunei and so forth. In IUCN Red List categories, there were 1 taxon of EN, 2 taxa of VU, 8 taxa of LC and 1 taxon of DD. The Korean endemic plants were 20 taxa including Salix koriyanagi, Thalictrum actaefolium var. brevistylum, Saussurea pseudogracilis and so forth. The specific plants by floristic region were 108 taxa including 58 taxa of grade I, 30 taxa of grade II, 16 taxa of grade III, 2 taxa of grade IV and grade V, respectively. The plants adaptable to climate change were 18 taxa including 11 taxa of southern plant and 7 taxa of northern plants. The naturalized plants were 49 taxa including Rumex nipponicus, Brassica juncea, Trifolium repens and so forth. The invasive alien plants were 4 taxa including Rumex acetocella, Solanum carolinense, Ambrosia artemisiifolia and Aster pilosus.
These studies were carried out to establish an effective in vivo embryo transfer methods in Hanwoo by analyzing several factors that influence this process. In an embryo transfer, recipients with grade A corpus luteum of the right ovary and that of grade B of the left one showed a higher pregnancy rate(p<0.1) than others. The pregnancy rates of frozen embryos were significantly lower(P<0.01) than those of fresh ones; the former resulting in 35% and the latter resulting in 56.2%. Transfer of embryos according to the estrus cycle(6.0 ∼ 9.0 days) did not show a significant difference in pregnancy rate with fresh embryos recording 45.4 ∼65.7% and frozen ones recording 22.0 ∼ 50.0%. According to the status of corpus luteum and embryo freezing or not, the pregnancy rate was higher on grade A corpus luteum with 40.8 ∼67.9% than B and C which ranged from 25.0∼56.0%. The results of embryo transfer according to the development stage and grade of embryos showed that regardless of the embryo's grade. transfer of morula recorded an average pregnancy rate of 46.3%. This results higher than the transfer of blastocyst which was 34.1%.
The purpose of this study is to examine the vertical and horizontal continuity between grades and publishers, respectively, by analyzing the readability of reading passages included in English textbooks for 5th and 6th grades of elementary school. In order to do so, a corpus was constructed with the reading passages contained in 10 textbooks, and the reading passages in each textbook were analyzed through Coh-Metrix. Also, it was examined whether there was a statistically significant difference between grades and publishers in readability through one-way ANOVA. The results are as follows. First, as a result of analyzing the difference in readability between publishers within the same grade, there was a statistically significant difference between fifth-grade textbooks in the L2 readability index. Second, as a result of analyzing the vertical continuity between grades within the publisher, the difficulty of textbook A was higher in grade 6 than grade 5 based on FRE and FKGL, which showed a statistically significant difference. On the other hand, when L2 readability was used as the standard, the difficulty of textbook B was lower in 6th grade than in 5th grade. This result seems to be because FRE and FKGL calculate readability based on sentence and word length, whereas L2 readability is based on content word overlap, word frequency, and syntactic similarity of sentences.
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