• 토지주택연구
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• 제8권3호
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• pp.171-180
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• 2017

In 1990s, as the extreme weather events according to the global warming climate change are occurred frequently all around the world and the scale of the damage increases, the developed countries are promoting various policies for reducing greenhouse gas emissions setting the goal of greenhouse gas reduction with the level of State and local government. Especially for the greenhouse gas reduction of buildings and the inducement of eco-friendly design, the green certification system is strengthened with the assessment of energy and greenhouse management, and recently, according to the policy change of climate and energy, the certification system expanded from the buildings to the level of city and district is piloted. So this research is to understand the main contents and the assessment system of domestic green building certification system implemented in March 2013 in response to the policy change of climate and energy and to suggest the basic data for the improvement of present domestic greenhouse certification standard through the analysis of actual certification and the main case analysis of international green certification system. Recently in developed countries, in 1990s, for the reduction of building's greenhouse gas emission and the inducement of eco-friendly design, from the building of LEED, BREEAM, DGNB to the level of city and district such as LEED Neighborhood Development, BREEAM Communities, DGNB Stadtquartiere, the system is expanded and piloted. On the contrary, as for the domestic standard of green building certification system, the distribution ratio according to the assessment items in each category consists of the assessment system based on the buildings, and just the simple adjustment of some items and the improvement of weighted value are performed. Actually, as a result of selecting the 30 districts of apartment housing with the most certification performance by use among the 49 buildings certified by Institute of Land & Housing from December 2014 to July 2016 and analyzing the assessment score, the certification level is determined by the sectors of high distribution like indoor environment and energy not by the ineffective sector of external environment with low distribution so this system has a limitation to perform the practical means for the policy change of climate and energy. Thus for the national green building certification standards, the assessment system in the sector of external environment is to complemented and furthermore, reflecting domestic reality, through the introduction of certification system and the assessment system with the level of city and district, this system should be improved to meet the international certification standard.

• Nutrition Research and Practice
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• 제10권1호
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• pp.33-41
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• 2016

BACKGROUND/OBJECTIVES: Diabetes mellitus (DM) is a major chronic disease which increases global health problems. Diabetes-induced renal damage is associated with inflammation and fibrosis. Alpha (AT) and gamma-tocopherols (GT) have shown antioxidant and anti-inflammatory effects in inflammation-mediated injuries. The primary aim of this study was to investigate effects of AT and GT supplementations on hyperglycemia induced acute kidney inflammation in alloxan induced diabetic mice with different levels of fasting blood glucose (FBG). MATERIALS/METHODS: Diabetes was induced by injection of alloxan monohydrate (150 mg/kg, i.p) in ICR mice (5.5-week-old, male) and mice were subdivided according to their FBG levels and treated with different diets for 2 weeks; CON: non-diabetic mice, m-DMC: diabetic control mice with mild FBG levels (250 mg/dl ${\leq}$ FBG ${\leq}$ 450 mg/dl), m-AT: m-DM mice fed AT supplementation (35 mg/kg diet), m-GT: m-DM mice with GT supplementation (35 mg/kg diet), s-DMC: diabetic control mice with severe FBG levels (450 mg/dl < FBG), s-AT: s-DM mice with AT supplementation, s-GT: s-DM mice with GT supplementation. RESULTS: Both AT and GT supplementations showed similar beneficial effects on $NF{\kappa}B$ associated inflammatory response (phosphorylated inhibitory kappa B-${\alpha}$, interleukin-$1{\beta}$, C-reactive protein, monocyte chemotactic protein-1) and pre-fibrosis (tumor growth factor ${\beta}$-1 and protein kinase C-II) as well as an antioxidant emzyme, heme oxygenase-1 (HO-1) in diabetic mice. On the other hands, AT and GT showed different beneficial effects on kidney weight, FBG, and oxidative stress associated makers (malondialdehyde, glutathione peroxidase, and catalase) except HO-1. In particular, GT significantly preserved kidney weight in m-DM and improved FBG levels in s-DM and malondialdehyde and catalase in m- and s-DM, while AT significantly attenuated FBG levels in m-DM and improved glutathione peroxidase in m- and s-DM. CONCLUSIONS: the results suggest that AT and GT with similarities and differences would be considered as beneficial nutrients to modulate hyperglycemia induced acute renal inflammation. Further research with careful approach is needed to confirm beneficial effects of tocopherols in diabetes with different FBG levels for clinical applications.

• 대한임상검사과학회지
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• 제53권4호
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• pp.353-362
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• 2021

암은 전 세계적인 건강문제이다. 암의 종류는 다양하나 암의 발생과정에서의 유사성은 상당히 높다. 모든 암은 유전자의 발현 변화가 있다는 점에서 공통점을 갖는다. 암 발생과정에서 변화되는 유전자의 발현을 이해하는 것은 암치료제나 암백신 개발에 큰 도움을 줄 것이다. 이번 연구에서는 잘 알려진 암발생 물질인 MNNG를 이용하여 정상 위세포에서 암발생 시 변화되는 유전자 발현을 분석하였다. MNNG 처리에 의해 정상 세포와는 다르게 발현되는 유전자인 DEG들을 찾고 이들을 암세포에서 발현되는 DEG들과 비교하였다. 여기에 더해 DEG의 단백질 결과물들의 기능과 단백질들 간의 결합을 분석하여 단순히 유전자의 발현뿐만 아니라 이들 단백질의 신호전달 과정에서의 연관성도 함께 분석하였다. 이 결과 위암 발생과정에서 관여하는 유전자들과 이들 유전자의 단백질 결과물들의 상호 작용을 밝히게 되었다.

• Biomolecules & Therapeutics
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• 제27권3호
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• pp.327-335
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• 2019

As the elderly population is increasing, Alzheimer's disease (AD) has become a global issue and many clinical trials have been conducted to evaluate treatments for AD. As these clinical trials have been conducted and have failed, the development of new theraphies for AD with fewer adverse effects remains a challenge. In this study, we examined the effects of Theracurmin on cognitive decline using 5XFAD mice, an AD mouse model. Theracurmin is more bioavailable form of curcumin, generated with submicron colloidal dispersion. Mice were treated with Theracurmin (100, 300 and 1,000 mg/kg) for 12 weeks and were subjected to the novel object recognition test and the Barnes maze test. Theracurmin-treated mice showed significant amelioration in recognition and spatial memories compared those of the vehicle-treated controls. In addition, the antioxidant activities of Theracurmin were investigated by measuring the superoxide dismutase (SOD) activity, malondialdehyde (MDA) and glutathione (GSH) levels. The increased MDA level and decreased SOD and GSH levels in the vehicle-treated 5XFAD mice were significantly reversed by the administration of Theracurmin. Moreover, we observed that Theracurmin administration elevated the expression levels of synaptic components, including synaptophysin and post synaptic density protein 95, and decreased the expression levels of ionized calcium-binding adapter molecule 1 (Iba-1), a marker of activated microglia. These results suggest that Theracurmin ameliorates cognitive function by increasing the expression of synaptic components and by preventing neuronal cell damage from oxidative stress or from the activation of microglia. Thus, Theracurmin would be useful for treating the cognitive dysfunctions observed in AD.

• 한국수자원학회논문집
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• 제52권3호
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• pp.227-234
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• 2019

급격한 도시화와 산업화로 도심 재난 취약성이 증가하고, 전 세계적인 기후변화로 인한 극한 강우사상의 발생빈도가 증가하고 있다. 기존 방재시설의 용량한계를 넘어선 극한 강우사상의 발생으로 도심 지역의 침수피해 또한 증가하고 있다. 도심 침수피해를 예방하기 위해 지하공간을 활용한 지하저류 시설과 지하배수터널 활용이 급부상하고 있으며, 강우가 유입되는 지하유입구에 대한 수리학적 검토를 통한 성능 분석이 중요하다. 본 연구에서는 지하 유입구로 활용되고 있는 접선식(tangential) 유입구와 나선식(spiral) 유입구에 대해 유입유량 변화에 따른 유입부 수위를 계측하고 흐름 특성 변화를 분석했다. 나선식 유입구의 경우, 저유량 조건에서의 와류 유도 효과를 개선하기 위해 유입부 바닥면에 계단형 다단식 구조를 도입했다. 접선식 유입구에서는 고유량 유입조건 아래 도수(hydraulic jump)가 발생하며 유량 배제 효과가 급격하게 감소했다. 다단식 나선(multi-stage) 유입구의 경우, 접선식 유입구보다 유입유량 증가에 따른 수위 상승률은 높지만 저유량 및 고유량 유입조건에 대해 안정적인 유량 배제 효과를 유지했다. 또한, 실험에서 사용된 유입구 모형이 활용될 수 있도록 접선식 유입구와 다단식 나선 유입구 모형에 대한 수위-유량 관계 실험식(empirical formula)을 제시했다.

• 한국기후변화학회지
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• 제6권1호
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• pp.1-10
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• 2015

Climate change lead to environmental pollution caused by the radical economic growth and development of industry. The amount of damage from abnormal climate is increasing rapidly for this reason in Korea. In particular, the cities is a lot of carbon emission quantity from the radical growth. Thus the government present "low carbon green growth" for eco-friendly city planning. As one of the important factors effecting climate change, active researches on land use change is performed. In this study, we knew land use change of each scenarios using land use equilibrium model which is kind of predictive model of land use in Japan. First, we selected study area to Jeju lsland. For this study, indicators for input data were selected and spatial data for input data were established using GIS program. Second, we established future scenarios based in 2040s. There are 2 future scenarios: dispersion scenario, compact scenario. Third, we compared with residential area of current and residential area for future scenarios. Results showed that residential area of the difference between current and dispersion scenario were 1,230 ha and residential area of the difference between current and compact scenario were 1,515 ha. Finally, for comparing carbon dioxide absorption volume between dispersion scenarios and compact scenarios, we calculated carbon dioxide absorption volume according to residential area decreased of each future scenarios. Results showed that carbon dioxide absorption volume in dispersion scenario was 477,878 ton and carbon dioxide absorption volume in compact scenario was 588,606 ton. Therefore, the study showed that land use equilibrium model is expected to put to use for future enhancement in creating data for climate change stabilization. And it is also expected to be utilized for city planning research in Korea.

• 한국농림기상학회지
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• 제20권4호
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• pp.313-320
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• 2018

2018년 봄, 갑작스러운 이상저온으로 인해, 전북, 경기 남부지역 등을 중심으로 개화된 과수 작목의 꽃이 얼어 죽는 일이 발생하였다. 2000년대 들어서면서 전 세계적으로 빈번하게 발생하고 있는 이상기후 현상으로 인해, 사회 여러 분야에 경제적인 피해와 악영향이 증가 하고 있다. 최근의 기후변화는 지구온난화와 더불어, 지역 기후의 정상 범위로부터 벗어나는 기상이변의 발생빈도 또한 증가할 것으로 예상된다. 기후변화가 농작물 생산에 미치는 영향을 파악하기 위해서는 이러한 이상기상 현상을 정확하게 파악하고 이에 따른 농작물의 영향을 분석할 필요가 있다. 본 연구에서는 배, 복숭아, 사과 작물이 실제 재배되고 있는 국내 주산 지역에 대하여 기후변화 시나리오를 이용하여, 미래 개화일의 변화를 각각 예측하고, 개화 후 온도 분포를 정량화함으로써, 미래의 저온 발생 추세를 전망하였다. 그 결과 온난화로 인해 개화기는 현재 재배중인 지역을 대상으로 모든 과종에 대하여 현재 평년을 기준으로, 미래 평년(2071-2100)에는 약 20일 정도 앞당겨 질 것으로 예상되었으며, 개화 후 저온의 분포는 과종, 지역 별로 일정 부분 차이가 있음을 확인할 수 있었다. 본 연구는 일부 과수 작목 및 품종에 한해 진행된 연구결과를 제시한 것으로, 차후 다양한 품종 및 작목으로 연구를 확대한다면, 미래 농업부문 대책 마련에 기여할 수 있을 것으로 기대된다.

• 한국풍공학회지
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• 제22권4호
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• pp.155-161
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• 2018

현대 사회에서 도시화와 온난화로 인한 태풍 등 강풍에 의한 피해는 증가될 것으로 예상된다. 본 연구에서는 기 개발된 창호보호장치의 보강성능을 시험하기 위해 비 보강된 판유리와 보강된 판유리의 2점 가력실험과 등분포하중 실험을 수행하였다. 창호보호장치의 보강성능은 휨 성능평가를 토대로 평가하였다. 창호보호장치의 이론적 성능 산정은 탄성하중법과 처짐 곡선의 미분방정식을 이용한 수식해석과 Midas-Gen을 이용한 전산해석을 통해 수행하였다. 실험값과 이론 산정 값의 최대하중 가력시의 판유리 중앙부 최대 처짐 비교를 통해 산정방법의 유효성을 검토하였다. 창호보호장치 부착 시 실험조건하에서 40%까지의 응력감소효과와 동일 하중하에서 71.4%까지의 처짐 감소 효과가 있었다. 판유리를 보요소로 해석한 결과보다 판유리를 판 요소로 해석한 결과가 오차가 적으므로 성능 판단 시 가능하면 판 요소로 해석을 수행하는 것이 유리하다.

• 자원ㆍ환경경제연구
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• 제29권4호
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• pp.469-497
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• 2020

취사용 청정연료의 접근성 및 사용을 확대하고자 하는 세계적인 관심과 노력에도 불구하고, 여전히 전세계 인구의 약 1/3 이상이 청정 취사시설을 이용하지 못하고 있다. 그들은 전통적인 방식의 바이오매스, 즉 농작물, 가축분뇨, 목재 등을 취사용 연료로 사용하고 있으며 이로 인한 건강 및 경제적 피해는 심각한 수준이다. 개발도상국의 취사용 연료 선택 및 전환을 이해하고자 하는 다수의 연구는 가구주의 특성을 주요 결정요인 중 하나로 다뤄왔다. 그러나 가구 내 의사결정은 가구주에 의해 독단적으로 수행되지 않으며 가구원 간의 상대적인 특성 등에 따라 다양하게 나타난다. 본 연구는 가구주를 포함한 캄보디아 부부를 대상으로 남녀 배우자 각각의 특성을 모두 고려하여 취사용 연료 결정요인을 분석하고자 하였다. 그 결과, 근로활동, 교육 수준, 미디어 이용 빈도 등 남녀 배우자 간의 특성이 연료 결정에 미치는 영향이 서로 다르게 나타났다. 본 연구는 취사용 연료 결정요인을 분석하는 데 이전에 다뤄지지 않은 배우자의 특성을 고려한다는 점과 캄보디아를 대상으로 한 연구를 찾아보기 어렵다는 점에서 캄보디아의 청정연료 확대를 위한 보다 정교한 정책 개발에 기여할 것이라 기대한다.

• International Journal of Computer Science & Network Security
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• 제22권1호
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• pp.331-339
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• 2022

The global process of transition from industrial to information society, as well as socio-economic changes taking place in Ukraine, require significant changes in many areas of state activity. It is especially connected with the reforms in the sphere of education. Today, national programs provide for the development of education on the basis of new progressive concepts, the introduction of the educational process of new pedagogical technologies and scientific achievements, the creation of a new system of information education, entrance of Ukaine into the transcontinental computer information system. Information technologies are qualitatively changing the key resources of development: this is no longer a space with fixed production, but primarily mobile finance and intelligence. They have a direct impact on the formation of personal growth, professional content and self-organization, emotional and psychological maturity and consciousness, and so on. One of the main factors in ensuring the stability and social education of the country's citizens is the culture of security, the formation and development of which is an urgent problem today. Comprehensive and systematic development of security culture will significantly increase the readiness of the population, the level of environmental, labor and patriotic education, reduce human losses, material damage from emergencies. Ecological education can be carried out more successfully only gradually and in accordance with the socio-psychological periods of one's development: kindergarten - school - college - university. The creation of such a system of environmental education should be enshrined as the basis of state environmental policy as a constitutional norm with the usage of information technology. Graduates of universities, who are the future of our country, after mastering the skills of basic environmental education must have a high level of environmental culture, which is, in turn, part of general human culture, and investigate environmental issues from the standpoint of their profession. It is known that with the help of environmental education the collective intelligence of society is formed, which can predict human activities and processes occurring in nature, and in some way to help with the elimination of crises. It is through environmental education that another system of human values is being formed, which places great emphasis on intangible wealth and solidarity, and great responsibility of humanity for the ecological state of the native country; provides a higher standard of living as a result of sustainable development, through the introduction of information technology in this system. To improve the quality of life, we need better knowledge, which must be implemented through information technology at the international level.