• Earthquakes and Structures
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• v.14 no.6
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• pp.589-598
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• 2018

An attempt is conducted to explore the relationship between the macroscopic global damage and the local damage of shear-type RC frames. A story damage index, which can be expressed as multi-variate functions of modal parameters, is deduced based on the tridiagonal matrix of the shear-type frame. The global damage model is also originated from structural modal parameters. Due to the connection of modal damage indexes, the relationship between the macroscopic global damage and the local story damage is reasonably established. In order to validate the derivation, a case study is carried out via an 8-story shear-type frame. The sensitivities of modal damage indexes to the location and severity of local story damages are studied. The evolution of the global damage is investigated as well. Results show that the global damage is sensitive to the degree of story damage, but it's not sensitive to its location. As the number of the damaged stories increases, more and more modes will be involved. Meanwhile, the global damage evolution curve changes from the concave shape to the S-type and then finally transforms into the convex shape. Through the proposed story damage, modal damage and global damage model, a multi-level damage assessment method is established.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2000.04b
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• pp.133-140
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• 2000

The objective of this study is to develop a damage model based on damage mechanics that can be used to analyze the mechanical behavior of structures with defects and the global behavior of damaged structures. A modified second order damage tensor that can be applied to finite element analysis is used to reflect the effect of damage. The damage stress computed from the effective stress is considered as an additional loading term acting on nodes and can represent the effect of crack surface. The accuracy of the proposed algorithm is verified by comparing the analysis results with the experimental data from other studies and the analysis results based on transverse isotropic theory. The developed damage model is applied to the analyses of structures with cracks under linear elastic condition. Numerical results show that the developed model can effectively analyze the global behavior of damaged structures.

• Nuclear Engineering and Technology
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• v.46 no.1
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• pp.73-80
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• 2014

A concrete cask is an option for spent nuclear fuel interim storage. A concrete cask usually consists of a metallic canister which confines the spent nuclear fuel assemblies and a concrete overpack. When the overpack undergoes a missile impact, which might be caused by a tornado or an aircraft crash, it should sustain an acceptable level of structural integrity so that its radiation shielding capability and the retrievability of the canister are maintained. A missile impact against a concrete overpack produces two damage modes, local damage and global damage. In conventional approaches [1], those two damage modes are decoupled and evaluated separately. The local damage of concrete is usually evaluated by empirical formulas, while the global damage is evaluated by finite element analysis. However, this decoupled approach may lead to a very conservative estimation of both damages. In this research, finite element analysis with material failure models and element erosion is applied to the evaluation of local and global damage of concrete overpacks under high speed missile impacts. Two types of concrete overpacks with different configurations are considered. The numerical simulation results are compared with test results, and it is shown that the finite element analysis predicts both local and global damage qualitatively well, but the quantitative accuracy of the results are highly dependent on the fine-tuning of material and failure parameters.

• BMB Reports
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• v.47 no.5
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• pp.249-255
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• 2014

Polo-like kinase-1 (Plk1) belongs to a family of serine-threonine kinases and plays a critical role in mitotic progression. Plk1 involves in the initiation of mitosis, centrosome maturation, bipolar spindle formation, and cytokinesis, well-reported as traditional functions of Plk1. In this review, we discuss the role of Plk1 during DNA damage response beyond the functions in mitotsis. When DNA is damaged in cells under various stress conditions, the checkpoint mechanism is activated to allow cells to have enough time for repair. When damage is repaired, cells progress continuously their division, which is called checkpoint recovery. If damage is too severe to repair, cells undergo apoptotic pathway. If damage is not completely repaired, cells undergo a process called checkpoint adaptation, and resume cell division cycle with damaged DNA. Plk1 targets and regulates many key factors in the process of damage response, and we deal with these subjects in this review.

• Smart Structures and Systems
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• v.6 no.5_6
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• pp.711-730
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• 2010

This study presents the design of autonomous smart sensor nodes for damage monitoring of tendons and girders in prestressed concrete (PSC) bridges. To achieve the objective, the following approaches are implemented. Firstly, acceleration-based and impedance-based smart sensor nodes are designed for global and local structural health monitoring (SHM). Secondly, global and local SHM methods which are suitable for damage monitoring of tendons and girders in PSC bridges are selected to alarm damage occurrence, to locate damage and to estimate severity of damage. Thirdly, an autonomous SHM scheme is designed for PSC bridges by implementing the selected SHM methods. Operation logics of the SHM methods are programmed based on the concept of the decentralized sensor network. Finally, the performance of the proposed system is experimentally evaluated for a lab-scaled PSC girder model for which a set of damage scenarios are experimentally monitored by the developed smart sensor nodes.

• International Journal of Oral Biology
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• v.47 no.2
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• pp.17-24
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• 2022

Preserving intact genetic material and delivering it to the next generation are the most significant tasks of living organisms. The integrity of DNA sequences is under constant threat from endogenous and exogenous factors. The accumulation of damaged or incompletely-repaired DNA can cause serious problems in cells, including cell death or cancer development. Various DNA damage detection systems and repair mechanisms have evolved at the cellular level. Although the mechanisms of these responses have been extensively studied, the global RNA expression profiles associated with genomic instability are not well-known. To detect global gene expression changes under different DNA damage and hypoxic conditions, we performed RNA-seq after treating human cervical cancer cells with ionizing radiation (IR), hydroxyurea, mitomycin C (MMC), or 1% O₂ (hypoxia). Results showed that the expression of 184-1037 genes was altered by each stimulus. We found that the expression of 51 genes changed under IR, MMC, and hypoxia. These findings revealed damage-specific genes that varied differently according to each stimulus and common genes that are universally altered in genetic instability.

• Computational Structural Engineering : An International Journal
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• v.2 no.1
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• pp.25-32
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• 2002

Natural draught cooling towers often develop visible crack structures as consequences of progressive damage processes over their life-time. The aim of this paper is a numerical demonstration of the progressive damage process of cooling towers, representatively for the reinforced concrete structures, in order to improve the durability and extend the life-time of structures subjected to such damage processes. For the analyses, the applied material model for reinforced concrete will be briefly introduced. An existing natural draught cooling tower with a pronounced crack structure, in which this crack structure indicates the typical damage pattern of large cooling towers will be numerically simulated. The change of dynamical behavior of the structure with regard to natural frequencies, reflecting the global damage process due to the degrading stiffness of the structure in dependence of the load type and intensity, will be presented and discussed.

• Smart Structures and Systems
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• v.14 no.2
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• pp.85-104
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• 2014

Damage detection is a challenging, complex, and at the same time very important research topic in civil engineering. Identifying the location and severity of damage in a structure, as well as the global effects of local damage on the performance of the structure are fundamental elements of damage detection algorithms. Local damage detection is essential for structural health monitoring since local damages can propagate and become detrimental to the functionality of the entire structure. Existing studies present several methods which utilize sensor data, and track global changes in the structure. The challenging issue for these methods is to be sensitive enough in identifYing local damage. Autoregressive models with exogenous terms (ARX) are a popular class of modeling approaches which are the basis for a large group of local damage detection algorithms. This study presents an algorithm, called Influence-based Damage Detection Algorithm (IDDA), which is developed for identification of local damage based on regression of the vibration responses. The formulation of the algorithm and the post-processing statistical framework is presented and its performance is validated through implementation on an experimental beam-column connection which is instrumented by dense-clustered wired and wireless sensor networks. While implementing the algorithm, two different sensor networks with different sensing qualities are utilized and the results are compared. Based on the comparison of the results, the effect of sensor noise on the performance of the proposed algorithm is observed and discussed in this paper.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.13 no.2
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• pp.257-270
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• 2000

The objective of this study is to develop a damage model based on damage mechanics that can be used to analyze the mechanical behavior of structures with defects and the global behavior of damaged structures. A modified second order damage tensor that can be applied to finite element analysis is used to reflect the effect of damage. The damage stress computed from the effective stress is considered as an additional loading term acting on nodes and can represent the effect of crack surface. The accuracy of the proposed algorithm is verified by comparing the analysis results with the experimental data from other studies and the analysis results based on transverse isotropic theory. The developed damage model is applied to the analyses of structures with cracks under linear elastic condition. The comparisons confirmed that the quantitative analysis of the structural behavior due to crack orientation and multiple sets of cracks is possible. Also, the damage caused by rock excavation and fault zone is analyzed. The results also showed that the developed model can effectively analyze the global behavior of damaged structures.

• Smart Structures and Systems
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• v.16 no.1
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• pp.47-65
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• 2015

A novel finite element (FE) model updating method based on multi-resolution analysis (MRA) is proposed. The true stiffness of the FE model is considered as the superposition of two pieces of stiffness information of different resolutions: the pre-defined stiffness information and updating stiffness information. While the resolution of former is solely decided by the meshing density of the FE model, the resolution of latter is decided by the limited information obtained from the experiment. The latter resolution is considerably lower than the former. Second generation wavelet is adopted to describe the updating stiffness information in the framework of MRA. This updating stiffness in MRA is realized at low level of resolution, therefore, needs less number of updating parameters. The efficiency of the optimization process is thus enhanced. The proposed method is suitable for the identification of multiple irregular cracks and performs well in capturing the global features of the structural damage. After the global features are identified, a refinement process proposed in the paper can be carried out to improve the performance of the MRA of the updating information. The effectiveness of the method is verified by numerical simulations of a box girder and the experiment of a three-span continues pre-stressed concrete bridge. It is shown that the proposed method corresponds well to the global features of the structural damage and is stable against the perturbation of modal parameters and small variations of the damage.