• Journal of the Korea Academia-Industrial cooperation Society
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• v.10 no.12
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• pp.3797-3803
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• 2009

Innovative capacities and performance are essential for the growth of the IT industry and the development of the Korean economy. Global R&D centers are important sources of innovation in the IT industry. In order to identify the structure of the innovation environment of global R&D centers in IT industry, we conducted a field survey of 50 global R&D centers and 50 global R&D policy experts in IT industry. According to the empirical results obtained using the Linear Structure Model, it is suggested that, first, with regard to a short-term IT global policy, the direction of the Korean government's policy should act as a trigger to connect the research domain and the market domain; second, the government policy should act as a facilitator to connect the development domain and the research domain in the mid-term period; and, finally, the government's R&D policy should serve as a disseminator to connect technological capability and the market space domain in the long-term perspective. For an effective way of internationalizing innovation, IT policy planners should regard global IT R&D centers as the important components of national innovation system and encourage the effective involvements by them in the process of IT industrial innovation.

• The Journal of Korean Medicine
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• v.25 no.2
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• pp.127-137
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• 2004

Objectives : The purpose of this investigation was to evaluate the effects of Sohaphyang-won (SH) on the alteration in gene expression in a hypoxia model using cultured rat cortical cells. Methods : E18 rat cortical cells were grown in neurobasal medium containing B27 supplement. On 12 DIV, SH was added ($20\mu\textrm{g}/ml$) to the culture media for 24 hrs. On 14 DIV, cells were given a hypoxic insult (2% O2/5% CO2, $37^{\circ}C$, 3 hrs), returned to normoxia and cultured for another 24 hrs. Total RNA was prepared from SH-untreated (control) and -treated cultures and alteration in gene expression was analyzed by microarray using rat 5K-TwinChips. Results : Effects on some of the genes whose functions are implicated in neural viability are as follows: 1) For most of the genes altered in expression, the global M values were between -05 to +0.5, Among these, 1517 genes were increased in their expression by more than global M +0.1, while 1480 genes were decreased by more than global M -0.1. 2) The expression of apoptosis-related genes such as Bad (global M =0.35), tumor protein p53 (T53) (global M =0.28) were increased, while v-akt murine thymoma viral oncogene homolog 1 (Akt1) was decreased. 3) The expression of hemoglobin alpha 1 (probably neuroglobin) was increased by about 3.2-fold (global M =1.7). 4) The expression of antioxidation-related catalase gene was increased (global M =0.26). 5) The expression of PKCzeta (prkcz), an upstream kinase of MAPK, was increased (global M =0.29). 6) The expression of retinoic acid receptor alpha (RAR), which may regulate transcription in hypoxic stress, was increased (global M =10.27). Conclusions : In summary, the microarray data suggest that SH doesn't increase the expression of oxygen capture-, anti-oxidation- and 'response to stress' -related genes but decreases some anti-apoptosis genes which would help protect the hypoxic cells from apoptosis.

• The Korean Journal of Physiology and Pharmacology
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• v.9 no.2
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• pp.95-101
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• 2005

In the heart, $Na^{+}-Ca^{2+}$ exchange (NCX) is the major $Ca^{2+}$ extrusion mechanism. NCX has been considered as a relaxation mechanism, as it reduces global $[Ca^{2+}]_i$ raised during activation. However, if NCX locates in the close proximity to the ryanodine receptor, then NCX would curtail $Ca^{2+}$ before its diffusion to global $Ca^{2+}_i$ This will result in a global $[Ca^{2+}]_i$ decrease especially during its ascending phase rather than descending phase. Therefore, NCX would decrease the myocardial contractility rather than inducing relaxation in the heart. This possibility was examined in this study by comparing NCX-induced extrusion of $Ca^{2+}$ after its release from SR in the presence and absence of global $Ca^{2+}_i$ transient in the isolated single rat ventricular myocytes by using patch-clamp technique in a whole-cell configuration. Global $Ca^{2+}_i$ transient was controlled by an internal dialysis with different concentrations of BAPTA added in the pipette. During stimulation with a ramp pulse from +100 mV to -100 mV for 200 ms, global $Ca^{2+}_i$ transient was suppressed only mildly, and completely at 1 mmol/L, and 10 mmol/L BAPTA, respectively. In these situations, ryanodine-sensitive inward NCX current was compared using $100{\mu}mol/L$ ryanodine, $Na^+$ depletion, 5 mmol/L $NaCl_2$ and $1{\mu}mol/L$ nifedipine. Surprisingly, the result showed that the ryanodine-sensitive inward NCX current was well preserved after 10 mmol/L BAPTA to 91 % of that obtained after 1 mmol/L BAPTA. From this result, it is concluded that most of the NCX-induced $Ca^{2+}$ extrusion occurs before the $Ca^{2+}$ diffuses to global $Ca^{2+})i$ in the rat ventricular myocyte.

• Nutrition Research and Practice
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• v.9 no.4
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• pp.358-363
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• 2015

BACKGROUND/OBJECTIVES: Previous studies have indicated that when compared to young mice, old mice have lower global DNA methylation and higher p16 promoter methylation in colonic mucosa, which is a common finding in colon cancer. It is also known that a Western-style diet (WSD) high in fat and calories, and low in calcium, vitamin D, fiber, methionine and choline (based on the AIN 76A diet) is tumorigenic in colons of mice. Because DNA methylation is modifiable by diet, we investigate whether a WSD disrupts DNA methylation patterns, creating a tumorigenic environment. SUBJECTVIES/METHODS: We investigated the effects of a WSD and aging on global and p16 promoter DNA methylation in the colon. Two month old male C57BL/6 mice were fed either a WSD or a control diet (AIN76A) for 6, 12 or 17 months. Global DNA methylation, p16 promoter methylation and p16 expression were determined by LC/MS, methyl-specific PCR and real time RT-PCR, respectively. RESULTS: The WSD group demonstrated significantly decreased global DNA methylation compared with the control at 17 months (4.05 vs 4.31%, P = 0.019). While both diets did not change global DNA methylation over time, mice fed the WSD had lower global methylation relative to controls when comparing all animals (4.13 vs 4.30%, P = 0.0005). There was an increase in p16 promoter methylation from 6 to 17 months in both diet groups (P < 0.05) but no differences were observed between diet groups. Expression of p16 increased with age in both control and WSD groups. CONCLUSIONS: In this model a WSD reduces global DNA methylation, whereas aging itself has no affect. Although the epigenetic effect of aging was not strong enough to alter global DNA methylation, changes in promoter-specific methylation and gene expression occurred with aging regardless of diet, demonstrating the complexity of epigenetic patterns.

• Journal of Information Technology and Architecture
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• v.11 no.3
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• pp.311-320
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• 2014

The purpose of this research is to understand, through a case study, how the flexibility of Headquarter(HQ) and subsidiaries makes an effect on performance of global ERP system implementation in a global firm. The questions of this research are as follows. First, what types of flexibility are there for HQ and Subsidiary, respectively, which are related with global ERP system implementation? Second, how much impact do these types of flexibility have on the performance of global ERP system implementation? This research suggests three types of flexibility for HQ and three types of flexibility for subsidiaries that are related with the global ERP system implementation. In this study, BorgWarner, a global automobile parts manufacturer, was selected and analyzed to find out what kinds of flexibility contributed to enhancing its global ERP system implementation performance.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.35 no.7A
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• pp.688-696
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• 2010

The Proxy Mobile IPv6 (PMIPv6) is a network localized mobility management protocol that is independent of global mobility management protocols. In a single mobility domain (LMD), the mobile node (MN) is not involved in any IP mobility-related signaling and uses only its PMIPv6 home address for all its communication. Subsequently, when the MN moves into another LMD, the MN must change its PMIPv6 home address. In such a circumstance, host-based mobility signaling is activated. Thus, the nature of the network-based mobility of the PMIPv6 cannot be retained. Additionally, if the MN does not support global mobility, it cannot maintain communication with its correspondent node (CN). In this paper, we propose a solution for global mobility support in PMIPv6 networks, called Global-PMIPv6 that allows current communication sessions of a MN without mobility protocol stacks to be maintained, even when the MN moves into another LMD. Thus, Global-PMIPv6 retains the advantages of the PMIPv6 for global mobility support. We then evaluate and compare network performance between our proposed solution and PMIPv6.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.10 no.1
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• pp.187-198
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• 2015

The purpose of this research is to explore the characteristics of Korean Global Hidden Champions focused on the success factors of foreign hidden champions. For this, we investigated the application process of these success factors of foreign hidden champions to Korean Global Hidden Champions and analyzed characteristics of Korean Global Hidden Champions with the cases of 11 companies. This research shows that there are the success factors of foreign hidden champions such as leadership and goals, self production, high-performance employees, market focus, continuous innovation, closeness to customer, globalization. This research also shows that there are some differences in the individual application process of success factors to each company. The Korean SME's trying to achieve the position of global hidden champions should know the success factors of foreign hidden champions clearly and investigate the application process of these success factors to Korean Global Hidden Champions carefully so that they may apply these lessons to their management processes and activities.

• Journal of the Korean Solar Energy Society
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• v.29 no.6
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• pp.102-109
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• 2009

The research on meteorological data in Korea has been carried out but without much consistency and has been limited to some areas only. Of relatively more importance has been the area in the utilization of the solar energy, however, the measurement of the global solar horizontal irradiation has been quite limited. In the current study, the actually measured value of the global solar horizontal irradiation from the meteorological data and the theoretically calculated value of the global solar horizontal irradiation from the cloud amount will be analyzed comparatively. The method of analysis will employ the standard meteorological data drafted by the Korean Solar Energy Society, the standard meteorological data from the presently used simulation program and the corresponding results have been compared with the calculated value of the global solar horizontal irradiation from the cloud amount. The results of comparing the values obtained from MBE(Mean Bias Error), RMSE(Root Mean Squares for Error), t-Statistic methods and those from each of the standard meteorological data show that the actually measured value of the meteorological data which have been converted into standard meteorological data with the help of the ISO TRY method give the monthly average value of the global solar horizontal irradiation. These values compared with the monthly average value from the IWEC from the Department of Energy of the USA show that the value of the global solar horizontal irradiation in the USA is quite similar. In the case of the values obtained from calculation from the cloud amount, the weather data provided by TRNSYS, except only slight difference, which means that the actually measured values of the global solar horizontal irradiation are significant. This goes to show that in the case of Korea, the value of the global solar horizontal irradiation provided by the Korea Meteorological Administration is will be deemed correct.

• Ocean and Polar Research
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• v.23 no.2
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• pp.141-160
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• 2001

The challenge of predicting the Japanese coastal ocean motivated Frontier Observational Research System for Global Change (FORSGC) and the Japan Marine Science and Technology Center (JAMSTEC) to start a multiyear observational programme in the upstream Kuroshio in November 2000. This field effort, the Kuroshio Observation Program (KOP), should enable us to determine the barotropic and baroclinic components of the western boundary current system, thus, to better understand interactions of the currents with mesoscale eddies, the Kuroshio instabilities, and path bimodality. We, then, will be able to improve modeling predictability of the mesoscale, seasonal, and inter-annual processes in the midstream Kuroshio near the Japanese main islands by using this knowledge. The KOP is focused on an enhanced regional coverage of the sea surface height variability and the baroclinic structure of the mainstream Kuroshio in the East China Sea, the Ryukyu Current east of the Ryukyu's, and the Kuroshio recirculation. An attractive approach of the KOP is a development of a new data acquisition system via acoustic telemetry of the observational data. The monitoring system will provide observations for assimilation into extensive numerical models of the ocean circulation, targeting the real-time monitoring of the Japanese coastal waters.

• Environmental and Resource Economics Review
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• v.17 no.2
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• pp.287-311
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• 2008

This paper is designed to examine how the global timber market impacted by climate change would affect global warming through the carbon flux of forests. For this purpose, we integrated the modified TSM 2000 and the extended TCM in order to simulate the projection of net carbon release of forests from 1995 to 2085. On the basis of the simulation results under normal demand growth scenario, we identified that the global timber market impacted by climate change ameliorates the atmospheric carbon about 3.60% of carbon dioxide concentration in 1990 over 90 years. This implies that the global timber market impacted by climate change has a negative feedback effect on global warming over 90 years. For sensitivity analysis, we performed these simulation procedure under high demand growth scenario and very high demand growth scenario.